{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:18:04Z","timestamp":1792793884677,"version":"4.5.0"},"reference-count":82,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000942","name":"Brain Foundation","doi-asserted-by":"publisher","award":["FO2022-0256"],"award-info":[{"award-number":["FO2022-0256"]}],"id":[{"id":"10.13039\/501100000942","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish research council","doi-asserted-by":"publisher","award":["2019\u201302078"],"award-info":[{"award-number":["2019\u201302078"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Delta-catenin (CTNND2) is an adhesive junction associated protein belonging to the family of p120 catenins. The human gene is located on the short arm of chromosome 5, the region deleted in Cri-du-chat syndrome (OMIM #123450). Heterozygous loss of <jats:italic>CTNND2<\/jats:italic> has been linked to a wide spectrum of neurodevelopmental disorders such as autism, schizophrenia, and intellectual disability. Here we studied how heterozygous loss of <jats:italic>ctnnd2b<\/jats:italic> affects zebrafish embryonic development, and larvae and adult behavior. First, we observed a disorganization of neuronal subtypes in the developing forebrain, namely the presence of ectopic <jats:italic>isl1-<\/jats:italic>expressing cells and a local reduction of GABA-positive neurons in the optic recess region. Next, using time-lapse analysis, we found that the disorganized distribution of <jats:italic>is1l-<\/jats:italic>expressing forebrain neurons resulted from an increased specification of Isl1:GFP neurons. Finally, we studied the swimming patterns of both larval and adult heterozygous zebrafish and observed an increased activity compared to wildtype animals. Overall, this data suggests a role for <jats:italic>ctnnd2b<\/jats:italic> in the differentiation cascade of neuronal subtypes in specific regions of the vertebrate brain, with repercussions in the animal\u2019s behavior.<\/jats:p>","DOI":"10.3389\/fnins.2023.1205653","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T07:29:58Z","timestamp":1688369398000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Loss of ctnnd2b affects neuronal differentiation and behavior in zebrafish"],"prefix":"10.3389","volume":"17","author":[{"given":"Raquel","family":"Vaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Due\u00f1as-Rey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Hofmeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lindstrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,7,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"32781","DOI":"10.1074\/jbc.M804688200","article-title":"A delta-catenin signaling pathway leading to dendritic protrusions","volume":"283","author":"Abu-Elneel","year":"2008","journal-title":"J. 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