{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:45:47Z","timestamp":1791359147094,"version":"4.3.1"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Bipolar disorder (BD) is a chronic mental disorder characterized by recurrent episodes of mania and depression alternating with periods of euthymia. Although environmental and genetic factors have been described, their pathogenesis is not fully understood. Much evidence suggests a role for inflammatory mediators and immune dysregulation in the development of BD. The first-line treatment in BD are mood-stabilizing agents, one of which is lithium (Li) salts. The Li mechanism of action is not fully understood, but it has been proposed that its robust immunomodulatory properties might be one of the mechanisms responsible for its effectiveness. In this article, the authors present the current knowledge about immune system changes accompanying BD, as well as the immunomodulatory effect of lithium. The results of studies describing connections between immune system changes and lithium effectiveness are often incoherent. Further research is needed to understand the connection between immune system modulation and the therapeutic action of lithium in BD.<\/jats:p>","DOI":"10.3389\/fnins.2023.1213766","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T22:08:49Z","timestamp":1692310129000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["The immunomodulatory effect of lithium as a mechanism of action in bipolar disorder"],"prefix":"10.3389","volume":"17","author":[{"given":"\u0141ukasz P.","family":"Sza\u0142ach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna A.","family":"Lisowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wies\u0142aw J.","family":"Cuba\u0142a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Barbuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Perugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1016\/j.neuropharm.2011.10.004","article-title":"Lithium attenuates methamphetamine-induced hyperlocomotion and behavioral sensitization via modulation of prefrontal monoamine release","volume":"62","author":"Ago","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref2","first-page":"5","article-title":"Inositol, lithium, and the brain","volume":"35","author":"Agranoff","year":"2001","journal-title":"Psychopharmacol. 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Listy"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1111\/j.1399-5618.2007.00444.x","article-title":"An imbalance in the production of IL-1beta and IL-6 by monocytes of bipolar patients: restoration by lithium treatment","volume":"9","author":"Knijff","year":"2007","journal-title":"Bipolar Disord."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1002\/jcp.25604","article-title":"Valproic acid and Lithium meditate anti-inflammatory effects by differentially modulating dendritic cell differentiation and function","volume":"232","author":"Leu","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.bbi.2018.04.017","article-title":"White matter microstructure alterations correlate with terminally differentiated CD8+ effector T cell depletion in the peripheral blood in mania: combined DTI and immunological investigation in the different phases of bipolar disorder","volume":"73","author":"Magioncalda","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"ref42","first-page":"82","article-title":"Lithium upregulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness","volume":"61","author":"Manji","year":"2000","journal-title":"J. Clin. Psychiatry"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/s0893-133x(99)00042-1","article-title":"5-HT1B receptors: a novel target for lithium. 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Psychiatry"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1016\/s0140-6736(20)31544-0","article-title":"Bipolar disorders","volume":"396","author":"McIntyre","year":"2020","journal-title":"Lancet"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s12031-015-0523-8","article-title":"Insulin-like growth factor 1 differentially affects Lithium sensitivity of Lymphoblastoid cell lines from Lithium responder and non-responder bipolar disorder patients","volume":"56","author":"Milanesi","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.biopsych.2013.01.007","article-title":"Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies","volume":"74","author":"Modabbernia","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e02663","DOI":"10.7554\/elife.02663","article-title":"GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation","volume":"3","author":"Morgan-Smith","year":"2014","journal-title":"Elife"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.biopsych.2010.04.031","article-title":"Knockdown of clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior","volume":"68","author":"Mukherjee","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1111\/j.1399-5618.2007.00493.x","article-title":"Immune variations in bipolar disorder: phasic differences","volume":"9","author":"Ortiz-Dom\u00ednguez","year":"2007","journal-title":"Bipolar Disord."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1001\/archpsyc.65.4.395","article-title":"A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes","volume":"65","author":"Padmos","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/ajmg.b.31153","article-title":"Genetic association and sequencing of the insulin-like growth factor 1 gene in bipolar affective disorder","volume":"156","author":"Pereira","year":"2011","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jad.2014.08.052","article-title":"General medical conditions in 347 bipolar disorder patients: clinical correlates of metabolic and autoimmune-allergic diseases","volume":"170","author":"Perugi","year":"2015","journal-title":"J. Affect. Disord."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"5869","DOI":"10.1038\/s41598-019-42482-6","article-title":"Peripheral blood lymphocyte subpopulations in patients with bipolar disorder type II","volume":"9","author":"Pietruczuk","year":"2019","journal-title":"Sci. Rep."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"3327","DOI":"10.1038\/s41598-018-21769-0","article-title":"Proliferation and apoptosis of T lymphocytes in patients with bipolar disorder","volume":"8","author":"Pietruczuk","year":"2018","journal-title":"Sci. Rep."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/mp.2009.47","article-title":"Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients","volume":"15","author":"Rao","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1177\/0004867413499077","article-title":"Immune dysregulation and autoimmunity in bipolar disorder: synthesis of the evidence and its clinical application","volume":"47","author":"Rege","year":"2013","journal-title":"Aust. N. Z. J. 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