{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:30:38Z","timestamp":1790753438350,"version":"4.1.0"},"reference-count":240,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32090031"],"award-info":[{"award-number":["32090031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31761133012"],"award-info":[{"award-number":["31761133012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31530016"],"award-info":[{"award-number":["31530016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Primary microcephaly (MCPH), is a neurological disorder characterized by small brain size that results in numerous developmental problems, including intellectual disability, motor and speech delays, and seizures. Hitherto, over 30 MCPH causing genes (<jats:italic>MCPHs<\/jats:italic>) have been identified. Among these <jats:italic>MCPHs<\/jats:italic>, <jats:italic>MCPH5<\/jats:italic>, which encodes abnormal spindle-like microcephaly-associated protein (ASPM), is the most frequently mutated gene. ASPM regulates mitotic events, cell proliferation, replication stress response, DNA repair, and tumorigenesis. Moreover, using a data mining approach, we have confirmed that high levels of expression of ASPM correlate with poor prognosis in several types of tumors. Here, we summarize the neurological and non-neurological functions of ASPM and provide insight into its implications for the diagnosis and treatment of MCPH and cancer.<\/jats:p>","DOI":"10.3389\/fnins.2023.1242448","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T08:09:30Z","timestamp":1691050170000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["The neurological and non-neurological roles of the primary microcephaly-associated protein ASPM"],"prefix":"10.3389","volume":"17","author":[{"given":"Xingxuan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingzhi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"4372","DOI":"10.1158\/0008-5472.CAN-12-3342","article-title":"The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology","volume":"73","author":"Abaan","year":"2013","journal-title":"Cancer Res."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1002\/ajmg.a.37724","article-title":"Molecular and phenotypic spectrum of ASPM-related primary microcephaly: identification of eight novel mutations","volume":"170","author":"Abdel-Hamid","year":"2016","journal-title":"Am. 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