{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:25:45Z","timestamp":1792635945109,"version":"4.5.0"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20224BAB216042"],"award-info":[{"award-number":["20224BAB216042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20212BAG70023"],"award-info":[{"award-number":["20212BAG70023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of this study is to evaluate the efficacy and safety of stimulating the vagus nerve in patients with disorders of consciousness (DOCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive systematic review was conducted, encompassing the search of databases such as PubMed, CENTRAL, EMBASE and PEDro from their inception until July 2023. Additionally, manual searches and exploration of grey literature were performed. The literature review was conducted independently by two reviewers for search strategy, selection of studies, data extraction, and judgment of evidence quality according to the American Academy of Cerebral Palsy and Developmental Medicine (AACPDM) Study Quality Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1,269 articles were retrieved, and 10 studies met the inclusion criteria. Among these, there were three case reports, five case series, and only two randomized controlled trials (RCTs). Preliminary studies have suggested that stimulation of vagus nerve can enhance the levels of DOCs in both vegetative state\/unresponsive wakefulness state (VS\/UWS) and minimally conscious state (MCS). However, due to a lack of high-quality RCTs research and evidence-based medical evidence, no definitive conclusion can be drawn regarding the intervention\u2019s effectiveness on consciousness level. Additionally, there were no significant adverse effects observed following stimulation of vagus nerve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A definitive conclusion cannot be drawn from this systematic review as there was a limited number of eligible studies and low-quality evidence. The findings of this systematic review can serve as a roadmap for future research on the use of stimulation of vagus nerve to facilitate recovery from DOCs.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnins.2023.1257378","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T09:30:25Z","timestamp":1694770225000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Stimulation of vagus nerve for patients with disorders of consciousness: a systematic review"],"prefix":"10.3389","volume":"17","author":[{"given":"Xiaoyang","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunliang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/21646821.2015.1114879","article-title":"EEG and coma","volume":"56","author":"Ardeshna","year":"2016","journal-title":"Neurodiagn J."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1097\/00004691-200109000-00005","article-title":"Vagus nerve stimulation, side effects, and long-term safety","volume":"18","author":"Ben-Menachem","year":"2001","journal-title":"J. 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Biol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"3107","DOI":"10.1007\/s10072-023-06812-x","article-title":"Behavioral scales variability in patients with prolonged disorders of consciousness","volume":"44","author":"Cortese","year":"2023","journal-title":"Neurol. Sci."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"244","DOI":"10.4103\/1673-5374.226395","article-title":"Wake-promoting effects of vagus nerve stimulation after traumatic brain injury: upregulation of orexin-a and orexin receptor type 1 expression in the prefrontal cortex","volume":"13","author":"Dong","year":"2018","journal-title":"Neural Regen. Res."},{"key":"ref8","first-page":"4742","article-title":"Vagus nerve stimulation causes wake-promotion by affecting neurotransmitters via orexins pathway in traumatic brain injury induced comatose rats","volume":"11","author":"Dong","year":"2018","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"429108","DOI":"10.1155\/2012\/429108","article-title":"Stroke and disorders of consciousness","volume":"2012","author":"Dostovic","year":"2012","journal-title":"Cardiovasc. Psychiatry Neurol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.pmr.2016.12.003","article-title":"Disorders of consciousness","volume":"28","author":"Eapen","year":"2017","journal-title":"Phys. Med. Rehabil. Clin. N. Am."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/s41582-020-00428-x","article-title":"Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies","volume":"17","author":"Edlow","year":"2021","journal-title":"Nat. Rev. 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