{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:44:14Z","timestamp":1791859454107,"version":"4.3.4"},"reference-count":94,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Postoperative delirium (POD) is a prevalent clinical entity characterized by reversible fluctuating altered mental status and cognitive impairment with acute and rapid onset a few days after major surgery. Postoperative cognitive decline (POCD) is a more permanent extension of POD characterized by prolonged global cognitive impairment for several months to years after surgery and anesthesia. Both syndromes have been shown to increase morbidity and mortality in postoperative patients making their multiple risk factors targets for optimization. In particular, nutrition imparts a significant and potentially reversible risk factor. Malnutrition and frailty have been linked as risk factors and predictive indicators for POD and less so for POCD. This review aims to outline the association between nutrition and perioperative cognitive outcomes as well as potential interventions such as prehabilitation.<\/jats:p>","DOI":"10.3389\/fnins.2023.1275201","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T09:45:40Z","timestamp":1698918340000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Perioperative cognition in association with malnutrition and frailty: a narrative review"],"prefix":"10.3389","volume":"17","author":[{"given":"Vikalpa","family":"Dammavalam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenu","family":"Johnkutty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murad","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Corn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Bergese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1016\/j.clnu.2013.12.005","article-title":"The validity of geriatric nutrition risk index: simple tool for prediction of nutritional-related complication of hospitalized elderly patients. 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Arthroplast."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1093\/ageing\/afq140","article-title":"Which medications to avoid in people at risk of delirium: a systematic review","volume":"40","author":"Clegg","year":"2011","journal-title":"Age Ageing"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s40520-016-0709-0","article-title":"Nutrition, frailty, and sarcopenia","volume":"29","author":"Cruz-Jentoft","year":"2017","journal-title":"Aging Clin. Exp. Res."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1097\/NOR.0000000000000710","article-title":"Preoperative nutritional status and risk for subsyndromal delirium in older adults following joint replacement surgery","volume":"39","author":"Denny","year":"2020","journal-title":"Orthop. 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Anesth."},{"key":"ref38","first-page":"868","article-title":"Liver metabolism and glucogenesis in trauma and sepsis","volume":"77","author":"Imamura","year":"1975","journal-title":"Surgery"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.jalz.2016.03.005","article-title":"The short-term and long-term relationship between delirium and cognitive trajectory in older surgical patients","volume":"12","author":"Inouye","year":"2016","journal-title":"Alzheimers Dement."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/S0140-6736(13)60688-1","article-title":"Delirium in elderly people","volume":"383","author":"Inouye","year":"2014","journal-title":"Lancet"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s00394-019-01978-7","article-title":"Higher protein intake is associated with a lower likelihood of frailty among older women, Kuopio OSTPRE-fracture prevention study","volume":"59","author":"Isanejad","year":"2020","journal-title":"Eur. 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Surg."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1007\/s12603-009-0214-7","article-title":"Validation of the Mini nutritional assessment short-form (MNA-SF): a practical tool for identification of nutritional status","volume":"13","author":"Kaiser","year":"2009","journal-title":"J. Nutr. Health Aging"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"775","DOI":"10.3390\/jcm8060775","article-title":"Nutritional laboratory markers in malnutrition","volume":"8","author":"Keller","year":"2019","journal-title":"J. Clin. Med."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1111\/cns.13873","article-title":"Perioperative neurocognitive disorders: a narrative review focusing on diagnosis, prevention, and treatment","volume":"28","author":"Kong","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"206","DOI":"10.4174\/astr.2014.86.4.206","article-title":"The nutritional risk is a independent factor for postoperative morbidity in surgery for colorectal cancer","volume":"86","author":"Kwag","year":"2014","journal-title":"Ann. Surg. Treat. Res."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.3390\/nu12082422","article-title":"Effects of protein supplementation combined with exercise training on muscle mass and function in older adults with lower-extremity osteoarthritis: a systematic review and meta-analysis of randomized trials","volume":"12","author":"Liao","year":"2020","journal-title":"Nutrients"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"e2357","DOI":"10.1002\/brb3.2357","article-title":"Poor awareness of stroke educational tools among older adults in China","volume":"11","author":"Ling","year":"2021","journal-title":"Brain Behav."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.jopan.2020.12.006","article-title":"The association between preoperative frailty and postoperative delirium: a systematic review and meta-analysis","volume":"37","author":"Liu","year":"2022","journal-title":"J. Perianesth. Nurs."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1213\/ANE.0000000000004773","article-title":"Frailty is associated with postoperative delirium but not with postoperative cognitive decline in older noncardiac surgery patients","volume":"130","author":"Mahanna-Gabrielli","year":"2020","journal-title":"Anesth. Analg."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3390\/medicina56100493","article-title":"Current evidence regarding biomarkers used to aid postoperative delirium diagnosis in the field of cardiac surgery-review","volume":"56","author":"Majewski","year":"2020","journal-title":"Medicina"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1111\/jgs.14764","article-title":"Association between preoperative malnutrition and postoperative delirium after hip fracture surgery in older adults","volume":"65","author":"Mazzola","year":"2017","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1001\/jamasurg.2015.5085","article-title":"Association of frailty and 1-year postoperative mortality following major elective noncardiac surgery: a population-based cohort study","volume":"151","author":"McIsaac","year":"2016","journal-title":"JAMA Surg."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1213\/ANE.0000000000004602","article-title":"Frailty for perioperative clinicians: a narrative review","volume":"130","author":"McIsaac","year":"2020","journal-title":"Anesth. Analg."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1213\/ANE.0000000000001960","article-title":"The Association of frailty with outcomes and resource use after emergency general surgery: a population-based cohort study","volume":"124","author":"McIsaac","year":"2017","journal-title":"Anesth. 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Geriatr."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"300060520961212","DOI":"10.1177\/0300060520961212","article-title":"Preoperative risk factors for delirium in patients aged \u226575 years undergoing spinal surgery: a retrospective study","volume":"48","author":"Onuma","year":"2020","journal-title":"J. Int. Med. Res."},{"key":"ref72","first-page":"26","article-title":"Thiamine deficiency and delirium","volume":"10","author":"Osiezagha","year":"2013","journal-title":"Innov. Clin. Neurosci."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"e14032","DOI":"10.1111\/ijcp.14032","article-title":"Effect of preoperative hospitalisation period on postoperative cognitive dysfunction in patients undergoing hip surgery under regional anaesthesia","volume":"75","author":"Ozalp Horsanali","year":"2021","journal-title":"Int. J. Clin. 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Enteral Nutr."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1097\/ALN.0b013e318195b569","article-title":"Long-term consequences of postoperative cognitive dysfunction","volume":"110","author":"Steinmetz","year":"2009","journal-title":"Anesthesiology"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1097\/ALN.0000000000003523","article-title":"Brief preoperative screening for frailty and cognitive impairment predicts delirium after spine surgery","volume":"133","author":"Susano","year":"2020","journal-title":"Anesthesiology"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4097\/kja.20294","article-title":"Postoperative neurocognitive disorders","volume":"74","author":"Tasbihgou","year":"2021","journal-title":"Korean J. Anesthesiol."},{"key":"ref85","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.3390\/jcm12041610","article-title":"Peri-operative risk factors associated with post-operative cognitive dysfunction (POCD): an umbrella review of Meta-analyses of observational studies","volume":"12","author":"Travica","year":"2023","journal-title":"J. Clin. Med."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"100557","DOI":"10.1016\/j.bj.2022.08.003","article-title":"Association of preoperative frailty and postoperative delirium in older cancer patients undergoing elective abdominal surgery: a prospective observational study in Taiwan","volume":"46","author":"Tsai","year":"2022","journal-title":"Biom. J."},{"key":"ref87","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.bja.2022.12.001","article-title":"Effect of perioperative benzodiazepine use on intraoperative awareness and postoperative delirium: a systematic review and meta-analysis of randomised controlled trials and observational studies","volume":"131","author":"Wang","year":"2023","journal-title":"Br. J. Anaesth."},{"key":"ref88","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1016\/j.surg.2021.05.048","article-title":"Association of preoperative frailty with postoperative delirium after elective brain tumor resection: retrospective analysis of a prospective cohort","volume":"170","author":"Wang","year":"2021","journal-title":"Surgery"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/j.bja.2020.12.026","article-title":"Association between early postoperative nutritional supplement utilisation and length of stay in malnourished hip fracture patients","volume":"126","author":"Williams","year":"2021","journal-title":"Br. J. Anaesth."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/s12871-023-02178-x","article-title":"Alcohol consumption may be associated with postoperative delirium in the elderly: the PNDABLE study","volume":"23","author":"Wu","year":"2023","journal-title":"BMC Anesthesiol."},{"key":"ref91","doi-asserted-by":"publisher","first-page":"175628642211143","DOI":"10.1177\/17562864221114356","article-title":"Identification of individuals at risk for postoperative cognitive dysfunction (POCD)","volume":"15","author":"Yang","year":"2022","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"ref92","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1111\/aas.13116","article-title":"Preoperative vitamin D deficiency increases the risk of postoperative cognitive dysfunction: a predefined exploratory sub-analysis","volume":"62","author":"Zhang","year":"2018","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref93","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s12877-020-1501-8","article-title":"The geriatric nutrition risk index versus the mini-nutritional assessment short form in predicting postoperative delirium and hospital length of stay among older non-cardiac surgical patients: a prospective cohort study","volume":"20","author":"Zhao","year":"2020","journal-title":"BMC Geriatr."},{"key":"ref94","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1111\/ggi.13963","article-title":"Geriatric nutritional risk index can predict postoperative delirium and hospital length of stay in elderly patients undergoing non-cardiac surgery","volume":"20","author":"Zhao","year":"2020","journal-title":"Geriatr. Gerontol. 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