{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:51:14Z","timestamp":1783025474347,"version":"3.54.6"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>We present a case of an adult female diagnosed with Delayed Sleep-Wake Phase Disorder (DSWPD) and Optic Nerve Hypoplasia (ONH), with a confirmed delayed Dim Light Melatonin Onset (DLMO), who reports the inability to fall asleep at their desired bedtime and obtain adequate sleep nightly, despite the ability to have a full night\u2019s sleep when not required to be up at a specific time for societal requirements. The participant was enrolled in an 11-month Open-Label Extension (OLE) following the randomized portion of a clinical study and was successfully treated with tasimelteon. DSWPD symptoms were resolved, and their previously delayed sleep-wake cycle was advanced.<\/jats:p><jats:sec><jats:title>Clinical trial registration<\/jats:title><jats:p><jats:ext-link>https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04652882<\/jats:ext-link>, identifier NCT04652882.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnins.2023.1287514","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T10:38:47Z","timestamp":1699958327000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case report: A patient with Delayed Sleep-Wake Phase Disorder and Optic Nerve Hypoplasia treated with tasimelteon: a case study"],"prefix":"10.3389","volume":"17","author":[{"given":"Sandra P.","family":"Smieszek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa R.","family":"Kaden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline E.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Brzezynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changfu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos M.","family":"Polymeropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunther","family":"Birznieks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene A.","family":"Emsellem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihael H.","family":"Polymeropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/sleep\/zsaa184","article-title":"Melanopsin-dependent phototransduction is impaired in delayed sleep-wake phase disorder and sighted non-24-hour sleep-wake rhythm disorder.","volume":"44","author":"Abbott","year":"2021","journal-title":"Sleep"},{"key":"B2","year":"2014","journal-title":"International Classification of Sleep Disorders-Third Edition (ICSD-3)."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/sleep\/zsaa214","article-title":"Individual differences in light sensitivity affect sleep and circadian rhythms.","volume":"44","author":"Chellappa","year":"2021","journal-title":"Sleep"},{"key":"B4","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/sleep\/28.1.113","article-title":"Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test.","volume":"28","author":"Littner","year":"2005","journal-title":"Sleep"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1093\/sleep\/30.11.1445","article-title":"Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. 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