{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T17:16:46Z","timestamp":1786555006550,"version":"build-2736575974"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001981","name":"ME Research UK","doi-asserted-by":"publisher","award":["SC036942"],"award-info":[{"award-number":["SC036942"]}],"id":[{"id":"10.13039\/501100001981","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1199502"],"award-info":[{"award-number":["1199502"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014834","name":"McCusker Charitable Foundation","doi-asserted-by":"publisher","award":["49979"],"award-info":[{"award-number":["49979"]}],"id":[{"id":"10.13039\/100014834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a complex chronic condition with core symptoms of fatigue and cognitive dysfunction, suggesting a key role for the central nervous system in the pathophysiology of this disease. Several studies have reported altered functional connectivity (FC) related to motor and cognitive deficits in ME\/CFS patients. In this study, we compared functional connectivity differences between 31 ME\/CFS and 15 healthy controls (HCs) using 7 Tesla MRI. Functional scans were acquired during a cognitive Stroop color-word task, and blood oxygen level-dependent (BOLD) time series were computed for 27 regions of interest (ROIs) in the cerebellum, brainstem, and salience and default mode networks. A region-based comparison detected reduced FC between the pontine nucleus and cerebellum vermis IX (<jats:italic>p\u2009=\u20090.027<\/jats:italic>) for ME\/CFS patients compared to HCs. Our ROI-to-voxel analysis found significant impairment of FC within the ponto-cerebellar regions in ME\/CFS. Correlation analyses of connectivity with clinical scores in ME\/CFS patients detected associations between FC and \u2018duration of illness\u2019 and \u2018memory scores\u2019 in salience network hubs and cerebellum vermis and between FC and \u2018respiratory rate\u2019 within the medulla and the default mode network FC. This novel investigation is the first to report the extensive involvement of aberrant ponto-cerebellar connections consistent with ME\/CFS symptomatology. This highlights the involvement of the brainstem and the cerebellum in the pathomechanism of ME\/CFS.<\/jats:p>","DOI":"10.3389\/fnins.2023.1318094","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T04:21:56Z","timestamp":1706502116000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Subcortical and default mode network connectivity is impaired in myalgic encephalomyelitis\/chronic fatigue syndrome"],"prefix":"10.3389","volume":"17","author":[{"given":"Maira","family":"Inderyas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Thapaliya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonya","family":"Marshall-Gradisnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Barth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leighton","family":"Barnden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"ref1","first-page":"771","article-title":"The Spanish version of the SF-36 health survey (the SF-36 health questionnaire): an instrument for measuring clinical results","volume":"104","author":"Alonso","year":"1995","journal-title":"Med. Clin. (Barc.)"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1006\/nimg.2001.0746","article-title":"Modeling geometric deformations in EPI time series","volume":"13","author":"Andersson","year":"2001","journal-title":"NeuroImage"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","article-title":"A fast diffeomorphic image registration algorithm","volume":"38","author":"Ashburner","year":"2007","journal-title":"NeuroImage"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1002\/mrm.24719","article-title":"Multiband accelerated spin-echo echo planar imaging with reduced peak RF power using time-shifted RF pulses","volume":"69","author":"Auerbach","year":"2013","journal-title":"Magn. Reson. Med."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1002\/nbm.3261","article-title":"Evidence in chronic fatigue syndrome for severity-dependent upregulation of prefrontal myelination that is independent of anxiety and depression","volume":"28","author":"Barnden","year":"2015","journal-title":"NMR Biomed."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1002\/nbm.1692","article-title":"A brain MRI study of chronic fatigue syndrome: evidence of brainstem dysfunction and altered homeostasis","volume":"24","author":"Barnden","year":"2011","journal-title":"NMR Biomed."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.nicl.2016.03.017","article-title":"Autonomic correlations with MRI are abnormal in the brainstem vasomotor Centre in chronic fatigue syndrome","volume":"11","author":"Barnden","year":"2016","journal-title":"NeuroImage Clin."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.nicl.2018.07.011","article-title":"Hyperintense sensorimotor T1 spin echo MRI is associated with brainstem abnormality in chronic fatigue syndrome","volume":"20","author":"Barnden","year":"2018","journal-title":"NeuroImage Clin."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"102045","DOI":"10.1016\/j.nicl.2019.102045","article-title":"Intra brainstem connectivity is impaired in chronic fatigue syndrome","volume":"24","author":"Barnden","year":"2019","journal-title":"NeuroImage Clin."},{"key":"ref10","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1182607","article-title":"Altered brain connectivity in long Covid during cognitive exertion: a pilot study","volume":"17","author":"Barnden","year":"2023","journal-title":"Front. Neurosci."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.neuroimage.2007.04.042","article-title":"A component based noise correction method (CompCor) for BOLD and perfusion based fMRI","volume":"37","author":"Behzadi","year":"2007","journal-title":"NeuroImage"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/S0025-6196(12)62272-1","article-title":"The central autonomic network: functional organization, dysfunction, and perspective","volume":"68","author":"Benarroch","year":"1993","journal-title":"Mayo Clin. Proc."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B Methodol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.mri.2015.12.008","article-title":"Abnormal resting state functional connectivity in patients with chronic fatigue syndrome: an arterial spin-labeling fMRI study","volume":"34","author":"Boissoneault","year":"2016","journal-title":"Magn. Reson. Imaging"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.pneurobio.2013.02.003","article-title":"Pain and analgesia: the value of salience circuits","volume":"104","author":"Borsook","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"103","DOI":"10.7326\/0003-4819-116-2-103","article-title":"A chronic illness characterized by fatigue, neurologic and immunologic disorders, and active human herpesvirus type 6 infection","volume":"116","author":"Buchwald","year":"1992","journal-title":"Ann. Intern. Med."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.sleep.2020.01.010","article-title":"Altered resting-state thalamo-occipital functional connectivity is associated with cognition in isolated rapid eye movement sleep behavior disorder","volume":"69","author":"Byun","year":"2020","journal-title":"Sleep Med."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"5331","DOI":"10.1002\/hbm.23737","article-title":"The impact of T1 versus EPI spatial normalization templates for fMRI data analyses","volume":"38","author":"Calhoun","year":"2017","journal-title":"Hum. Brain Mapp."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1300\/J092v11n01_02","article-title":"Myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"11","author":"Carruthers","year":"2003","journal-title":"J. Chronic. Fatigue. Syndr."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/j.1365-2796.2011.02428.x","article-title":"Myalgic encephalomyelitis: international consensus criteria","volume":"270","author":"Carruthers","year":"2011","journal-title":"J. Intern. Med."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1016\/j.neuroimage.2011.08.048","article-title":"Anticorrelations in resting state networks without global signal regression","volume":"59","author":"Chai","year":"2012","journal-title":"NeuroImage"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1001\/archneurpsyc.1955.02330180071008","article-title":"Functional localization in the cerebellum: Somatotopic Organization in Cortex and Nuclei","volume":"74","author":"Chambers","year":"1955","journal-title":"A.M.A. Arch. Neurol. Psychiatry"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1002\/hbm.25719","article-title":"Functional magnetic resonance imaging responses during perceptual decisionmaking at 3 and 7 T in human cortex, striatum, and brainstem","volume":"43","author":"Colizoli","year":"2022","journal-title":"Hum Brain Mapp"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3390\/diagnostics9030091","article-title":"Myalgic encephalomyelitis\/chronic fatigue syndrome: a comprehensive review","volume":"9","author":"Cortes Rivera","year":"2019","journal-title":"Diagnostics"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1038\/nature04766","article-title":"Cortical substrates for exploratory decisions in humans","volume":"441","author":"Daw","year":"2006","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.neuroimage.2005.02.037","article-title":"Gray matter volume reduction in the chronic fatigue syndrome","volume":"26","author":"de Lange","year":"2005","journal-title":"NeuroImage"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1093\/brain\/awh225","article-title":"Neural correlates of the chronic fatigue syndrome\u2014an fMRI study","volume":"127","author":"de Lange","year":"2004","journal-title":"Brain"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/nrn2201","article-title":"Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging","volume":"8","author":"Fox","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1126\/science.1174521","article-title":"Modalities, modes, and models in functional neuroimaging","volume":"326","author":"Friston","year":"2009","journal-title":"Science"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1002\/hbm.460030303","article-title":"Spatial registration and normalization of images","volume":"3","author":"Friston","year":"1995","journal-title":"Hum. Brain Mapp."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.smrv.2012.06.002","article-title":"Coherence and frequency in the reticular activating system (RAS)","volume":"17","author":"Garcia-Rill","year":"2013","journal-title":"Sleep Med. Rev."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1089\/brain.2015.0366","article-title":"Abnormal resting-state functional connectivity in patients with chronic fatigue syndrome: results of seed and data-driven analyses","volume":"6","author":"Gay","year":"2016","journal-title":"Brain Connect."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1093\/cercor\/bhn059","article-title":"Resting-state functional connectivity reflects structural connectivity in the default mode network","volume":"19","author":"Greicius","year":"2009","journal-title":"Cereb. Cortex"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/35094500","article-title":"Searching for a baseline: functional imaging and the resting human brain","volume":"2","author":"Gusnard","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.neuroimage.2013.05.116","article-title":"The nuisance of nuisance regression: spectral misspecification in a common approach to resting-state fMRI preprocessing reintroduces noise and obscures functional connectivity","volume":"82","author":"Hallquist","year":"2013","journal-title":"NeuroImage"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1080\/21641846.2013.862993","article-title":"Examining case definition criteria for chronic fatigue syndrome and myalgic encephalomyelitis","volume":"2","author":"Jason","year":"2014","journal-title":"Fatigue Biomed. Health Behav."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.pscychresns.2015.10.014","article-title":"Altered resting-state functional connectivity in women with chronic fatigue syndrome","volume":"234","author":"Kim","year":"2015","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/S0896-6273(02)00742-0","article-title":"Medial prefrontal and subcortical mechanisms underlying the Acquisition of Motor and Cognitive Action Sequences in humans","volume":"35","author":"Koechlin","year":"2002","journal-title":"Neuron"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1080\/02699050902788519","article-title":"The neural correlates of cognitive fatigue in traumatic brain injury using functional MRI","volume":"23","author":"Kohl","year":"2009","journal-title":"Brain Inj."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.tins.2014.11.006","article-title":"The dynamic pain connectome","volume":"38","author":"Kucyi","year":"2015","journal-title":"Trends Neurosci."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1002\/cne.20289","article-title":"Three-dimensional topography of corticopontine projections from rat sensorimotor cortex: comparisons with corticostriatal projections reveal diverse integrative organization","volume":"478","author":"Leergaard","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"675","DOI":"10.3390\/tomography7040056","article-title":"Limbic perfusion is reduced in patients with Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS)","volume":"7","author":"Li","year":"2021","journal-title":"Tomography"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s12967-020-02455-0","article-title":"Review of case definitions for myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS)","volume":"18","author":"Lim","year":"2020","journal-title":"J. Transl. Med."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"e107829","DOI":"10.1371\/journal.pone.0107829","article-title":"Altered functional connectivity between emotional and cognitive resting state networks in euthymic bipolar I disorder patients","volume":"9","author":"Lois","year":"2014","journal-title":"PLoS One"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.cogbrainres.2005.01.018","article-title":"Impaired cognitive control and reduced cingulate activity during mental fatigue","volume":"24","author":"Lorist","year":"2005","journal-title":"Cogn. Brain Res."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1152\/japplphysiol.00969.2004","article-title":"Hypoxia reveals posterior thalamic, cerebellar, midbrain, and limbic deficits in congenital central hypoventilation syndrome","volume":"98","author":"Macey","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1089\/brain.2016.0438","article-title":"The default mode network in healthy individuals: a systematic review and Meta-analysis","volume":"7","author":"Mak","year":"2017","journal-title":"Brain Connect."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"117326","DOI":"10.1016\/j.jns.2021.117326","article-title":"Modulatory effects of cognitive exertion on regional functional connectivity of the salience network in women with ME\/CFS: a pilot study","volume":"422","author":"Manca","year":"2021","journal-title":"J. Neurol. Sci."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s11065-010-9137-7","article-title":"Functional topography of the cerebellum in verbal working memory","volume":"20","author":"Marvel","year":"2010","journal-title":"Neuropsychol. Rev."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.tics.2011.08.003","article-title":"Large-scale brain networks and psychopathology: a unifying triple network model","volume":"15","author":"Menon","year":"2011","journal-title":"Trends Cogn. Sci."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1749-6632.1995.tb17472.x","article-title":"Cholinergic pathways and the ascending reticular activating system of the human Braina","volume":"757","author":"Mesulam","year":"1995","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/S0165-0173(99)00040-5","article-title":"Basal ganglia and cerebellar loops: motor and cognitive circuits","volume":"31","author":"Middleton","year":"2000","journal-title":"Brain Res. Rev."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"e98156","DOI":"10.1371\/journal.pone.0098156","article-title":"Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue","volume":"9","author":"Miller","year":"2014","journal-title":"PLoS One"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1080\/14734220310012181","article-title":"Pontine nuclei-mediated cerebello-cerebral interactions and its functional role","volume":"3","author":"Nagao","year":"2004","journal-title":"Cerebellum"},{"key":"ref55","doi-asserted-by":"crossref","DOI":"10.56441\/hilbertpress.2207.6598","volume-title":"Handbook of functional connectivity magnetic resonance imaging methods in CONN","author":"Nieto-Castanon","year":"2020"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"21183","DOI":"10.1038\/srep21183","article-title":"Post mTBI fatigue is associated with abnormal brain functional connectivity","volume":"6","author":"Nordin","year":"2016","journal-title":"Sci. Rep."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1471-2377-4-14","article-title":"Mechanisms underlying fatigue: a voxel-based morphometric study of chronic fatigue syndrome","volume":"4","author":"Okada","year":"2004","journal-title":"BMC Neurol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1073\/pnas.98.4.2041","article-title":"Neuroimaging evidence implicating cerebellum in the experience of hypercapnia and hunger for air","volume":"98","author":"Parsons","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1743-0003-5-16","article-title":"Gait characteristics of subjects with chronic fatigue syndrome and controls at self-selected and matched velocities","volume":"5","author":"Paul","year":"2008","journal-title":"J. NeuroEngineering Rehabil."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1016\/j.neurobiolaging.2014.03.012","article-title":"Longitudinal assessment of default-mode brain function in aging","volume":"35","author":"Persson","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.neuroimage.2013.08.048","article-title":"Methods to detect, characterize, and remove motion artifact in resting state fMRI","volume":"84","author":"Power","year":"2014","journal-title":"NeuroImage"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/j.neuroimage.2007.02.041","article-title":"A default mode of brain function: a brief history of an evolving idea","volume":"37","author":"Raichle","year":"2007","journal-title":"NeuroImage"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"303","DOI":"10.2147\/JPR.S127038","article-title":"Gross and fine motor function in fibromyalgia and chronic fatigue syndrome","volume":"10","author":"Rasouli","year":"2017","journal-title":"J. Pain Res."},{"key":"ref65","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.748426","article-title":"Submaximal exercise provokes increased activation of the anterior default mode network during the resting state as a biomarker of Postexertional malaise in Myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"15","author":"Rayhan","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s00259-018-4229-3","article-title":"Severe posterior hypometabolism but normal perfusion in a patient with chronic fatigue syndrome\/myalgic encephalomyelitis revealed by PET\/MRI","volume":"46","author":"Sahbai","year":"2019","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.nicl.2018.04.025","article-title":"Brain function characteristics of chronic fatigue syndrome: a task fMRI study","volume":"19","author":"Shan","year":"","journal-title":"NeuroImage Clin."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1089\/brain.2017.0549","article-title":"Decreased connectivity and increased blood oxygenation level dependent complexity in the default mode network in individuals with chronic fatigue syndrome","volume":"8","author":"Shan","year":"","journal-title":"Brain Connect."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1002\/jmri.25283","article-title":"Progressive brain changes in patients with chronic fatigue syndrome: a longitudinal MRI study","volume":"44","author":"Shan","year":"2016","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.neuroimage.2011.06.078","article-title":"Slice-timing effects and their correction in functional MRI","volume":"58","author":"Sladky","year":"2011","journal-title":"NeuroImage"},{"key":"ref71","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.590619","article-title":"A narrative review of cerebellar malfunctions and sleep disturbances","volume":"15","author":"Song","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1080\/21641846.2018.1453919","article-title":"Task related cerebral blood flow changes of patients with chronic fatigue syndrome: an arterial spin labeling study","volume":"6","author":"Staud","year":"2018","journal-title":"Fatigue Biomed. Health Behav."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1089\/brain.2022.0049","article-title":"Connectivity between salience and default mode networks and subcortical nodes distinguishes between two classes of Myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"13","author":"Su","year":"2023","journal-title":"Brain Connect."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1471-2377-6-9","article-title":"Reduced responsiveness is an essential feature of chronic fatigue syndrome: a fMRI study","volume":"6","author":"Tanaka","year":"2006","journal-title":"BMC Neurol."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"102366","DOI":"10.1016\/j.nicl.2020.102366","article-title":"Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans","volume":"28","author":"Thapaliya","year":"2020","journal-title":"NeuroImage Clin."},{"key":"ref76","doi-asserted-by":"publisher","first-page":"6214","DOI":"10.1111\/ejn.15413","article-title":"Diffusion tensor imaging reveals neuronal microstructural changes in myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"54","author":"Thapaliya","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"ref77","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1002\/jnr.25048","article-title":"Volumetric differences in hippocampal subfields and associations with clinical measures in myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"100","author":"Thapaliya","year":"2022","journal-title":"J. Neurosci. Res."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mri.2019.05.011","article-title":"7T GRE-MRI signal compartments are sensitive to dysplastic tissue in focal epilepsy","volume":"61","author":"Thapaliya","year":"2019","journal-title":"Magn. Reson. Imaging"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1523\/JNEUROSCI.4227-13.2014","article-title":"Precuneus is a functional Core of the default-mode network","volume":"34","author":"Utevsky","year":"2014","journal-title":"J. Neurosci."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s10548-012-0219-0","article-title":"A 7 tesla fMRI study of amygdala responses to fearful faces","volume":"25","author":"van der Zwaag","year":"2012","journal-title":"Brain Topogr."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1089\/brain.2012.0073","article-title":"Conn: a functional connectivity toolbox for correlated and Anticorrelated brain networks","volume":"2","author":"Whitfield-Gabrieli","year":"2012","journal-title":"Brain Connect."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/(SICI)1097-0193(1997)5:4<254::AID-HBM9>3.0.CO;2-2","article-title":"An overview and some new developments in the statistical analysis of PET and fMRI data","volume":"5","author":"Worsley","year":"1997","journal-title":"Hum. Brain Mapp."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"e0159351","DOI":"10.1371\/journal.pone.0159351","article-title":"Aberrant resting-state functional connectivity in the salience network of adolescent chronic fatigue syndrome","volume":"11","author":"Wortinger","year":"2016","journal-title":"PLoS One"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s10484-016-9331-3","article-title":"Intrinsic functional Hypoconnectivity in Core neurocognitive networks suggests central nervous system pathology in patients with Myalgic encephalomyelitis: a pilot study","volume":"41","author":"Zinn","year":"2016","journal-title":"Appl. Psychophysiol. 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