{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:39:27Z","timestamp":1760369967572,"version":"3.41.2"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Lysosomes primarily recognized as center for cellular \u2018garbage-disposing-unit\u2019, which has recently emerged as a crucial regulator of cellular metabolism. This organelle is a well-known vital player in the pathology including neurodegenerative disorders. In pathological context, removal of intracellular damaged misfolded proteins, organelles and aggregates are ensured by \u2018Autophagy\u2019 pathway, which initially recognizes, engulfs and seals the toxic cargo at the cytosolic environment. Thereafter the cell completes the task of encapsulated cargo elimination upon delivery of them to the terminal compartment - lysosome, which contains acid hydrolases, that are capable of degrading the abnormal protein-lipid-repertoire. The merge between inseparable \u2018Autophagy\u2019 and \u2018Lysosomal\u2019 pathways evolved into \u2018Autophagy-Lysosome Pathway (ALP)\u2019, through which cell ultimately degrades and recycles bio-materials for metabolic needs. Dysregulation of any of the steps of the multi-step ALP can contribute to the development and progression of disorders including Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), and Huntington\u2019s disease (HD). Therefore, targeting differential steps of ALP or directly lysosomes using nano-bioengineering approaches holds great promise for therapeutic interventions. This review aims to explore the role of distal autophagy pathway and proximal lysosomal function, as cellular degradative and metabolic hubs, in healing neurological disorders and highlights the contributions of nano-bioengineering in this field. Despite multiple challenges, this review underscores the immense potential of integrating autophagy-lysosomal biology with nano-bioengineering to revolutionize the field and provide novel therapeutic avenues for tackling neurological-neurodegenerative-disorders.<\/jats:p>","DOI":"10.3389\/fnins.2023.1331211","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T04:13:35Z","timestamp":1704687215000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of lysosome in healing neurological disorders by nano-bioengineering"],"prefix":"10.3389","volume":"17","author":[{"given":"Aiswarya","family":"Raj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urmi","family":"Bandyopadhyay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1126\/science.aan6298","article-title":"Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes","volume":"358","author":"Abu-Remaileh","year":"2017","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/nbt.1807","article-title":"Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes","volume":"29","author":"Alvarez-Erviti","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"9304","DOI":"10.1021\/acs.chemrev.9b00553","article-title":"Chemistry, structures, and advanced applications of nanocomposites from biorenewable resources","volume":"120","author":"Ates","year":"2020","journal-title":"Chem. Rev."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"11055","DOI":"10.1073\/pnas.1409314111","article-title":"Absence of lipofuscin in motor neurons of SOD1-linked ALS mice","volume":"111","author":"Bandyopadhyay","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e2114912119","DOI":"10.1073\/pnas.2114912119","article-title":"Leucine retention in lysosomes is regulated by starvation","volume":"119","author":"Bandyopadhyay","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"118847","DOI":"10.1016\/j.lfs.2020.118847","article-title":"Codelivery of STAT3 and PD-L1 siRNA by hyaluronate-TAT trimethyl\/thiolated chitosan nanoparticles suppresses cancer progression in tumor-bearing mice","volume":"266","author":"Bastaki","year":"2021","journal-title":"Life Sci."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1146\/annurev-biochem-060815-014556","article-title":"Mammalian autophagy: how does it work?","volume":"85","author":"Bento","year":"2016","journal-title":"Annu. Rev. Biochem."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1038\/s41573-019-0036-1","article-title":"Lysosomes as a therapeutic target","volume":"18","author":"Bonam","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.biomaterials.2014.12.005","article-title":"Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer's disease mice using magnetic resonance imaging (MRI)","volume":"44","author":"Cheng","year":"2015","journal-title":"Biomaterials"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.arr.2016.05.004","article-title":"Disorders of lysosomal acidification-the emerging role of v-ATPase in aging and neurodegenerative disease","volume":"32","author":"Colacurcio","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"13693","DOI":"10.1021\/acsami.5b03619","article-title":"Hybrid graphene oxide based Plasmonic-magnetic multifunctional Nanoplatform for selective separation and label-free identification of Alzheimer's disease biomarkers","volume":"7","author":"Demeritte","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1038\/mt.2016.126","article-title":"Exosome-mediated delivery of Hydrophobically modified siRNA for huntingtin mRNA silencing","volume":"24","author":"Didiot","year":"2016","journal-title":"Mol. Ther."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2196","DOI":"10.3390\/polym15092196","article-title":"Nanoparticle-based drug delivery systems: an inspiring therapeutic strategy for neurodegenerative diseases","volume":"15","author":"Duan","year":"2023","journal-title":"Polymers (Basel)"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/j.tibtech.2017.06.002","article-title":"Advances in Alzheimer's diagnosis and therapy: the implications of nanotechnology","volume":"35","author":"Hajipour","year":"2017","journal-title":"Trends Biotechnol."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"11818","DOI":"10.1038\/s41598-020-68874-7","article-title":"Genetically modified macrophages accomplish targeted gene delivery to the inflamed brain in transgenic Parkin Q311X(a) mice: importance of administration routes","volume":"10","author":"Haney","year":"2020","journal-title":"Sci. Rep."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","article-title":"Regulation mechanisms and signaling pathways of autophagy","volume":"43","author":"He","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1038\/s41596-021-00665-4","article-title":"Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages","volume":"17","author":"Huang","year":"2022","journal-title":"Nat. Protoc."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1016\/j.ymthe.2019.08.010","article-title":"Systemic Exosomal delivery of shRNA Minicircles prevents parkinsonian pathology","volume":"27","author":"Izco","year":"2019","journal-title":"Mol. Ther."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"564","DOI":"10.3389\/fnins.2020.00564","article-title":"Therapeutic effects of transplanted exosomes containing miR-29b to a rat model of Alzheimer's disease","volume":"14","author":"Jahangard","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"3780","DOI":"10.1038\/s41467-019-11762-0","article-title":"Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy","volume":"10","author":"Javed","year":"2019","journal-title":"Nat. Commun."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s40580-018-0168-8","article-title":"Therapeutic nanoplatforms and delivery strategies for neurological disorders","volume":"5","author":"Kang","year":"2018","journal-title":"Nano Converg"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41573-022-00391-w","article-title":"The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics","volume":"21","author":"Karran","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1021\/cn3002015","article-title":"Glyconanoparticle aided detection of beta-amyloid by magnetic resonance imaging and attenuation of beta-amyloid induced cytotoxicity","volume":"4","author":"Kouyoumdjian","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"102649","DOI":"10.1016\/j.jbc.2022.102649","article-title":"TFEB acetylation promotes lysosome biogenesis and ameliorates Alzheimer's disease-relevant phenotypes in mice","volume":"298","author":"Li","year":"2022","journal-title":"J. Biol. Chem."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2869","DOI":"10.1021\/acs.molpharmaceut.5b00060","article-title":"pH-sensitive polymeric nanoparticles with gold(I) compound payloads synergistically induce Cancer cell death through modulation of autophagy","volume":"12","author":"Lin","year":"2015","journal-title":"Mol. Pharm."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"eaba3967","DOI":"10.1126\/sciadv.aba3967","article-title":"Targeted exosome coating gene-chem nanocomplex as \"nanoscavenger\" for clearing alpha-synuclein and immune activation of Parkinson's disease","volume":"6","author":"Liu","year":"2020","journal-title":"Sci. Adv."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.actbio.2019.07.006","article-title":"Cell-free synthesis of connexin 43-integrated exosome-mimetic nanoparticles for siRNA delivery","volume":"96","author":"Lu","year":"2019","journal-title":"Acta Biomater."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1111\/bcp.12804","article-title":"Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders","volume":"82","author":"Maiese","year":"2016","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1021\/acsabm.0c01319","article-title":"Dendrimer architectonics to treat Cancer and neurodegenerative diseases with implications in Theranostics and personalized medicine","volume":"4","author":"Moorthy","year":"2021","journal-title":"ACS Appl Bio Mater"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"2834","DOI":"10.1021\/nn900813b","article-title":"Ultrasensitive and highly selective detection of Alzheimer's disease biomarker using two-photon Rayleigh scattering properties of gold nanoparticle","volume":"3","author":"Neely","year":"2009","journal-title":"ACS Nano"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"166326","DOI":"10.1016\/j.bbadis.2021.166326","article-title":"Targeted regulation of autophagy using nanoparticles: new insight into cancer therapy","volume":"1868","author":"Paskeh","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1101\/2023.05.08.539898","article-title":"Endo-lysosome-targeted nanoparticle delivery of antiviral therapy for coronavirus infections","author":"Petcherski","year":"2023","journal-title":"bioRxiv"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1084\/jem.20151938","article-title":"Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection","volume":"213","author":"Qi","year":"2016","journal-title":"J. Exp. Med."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.jddst.2017.11.013","article-title":"Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain","volume":"43","author":"Sanchez-Ramos","year":"2018","journal-title":"J Drug Deliv Sci Technol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"eabd5046","DOI":"10.1126\/sciadv.abd5046","article-title":"Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model","volume":"7","author":"Sato","year":"2021","journal-title":"Sci. Adv."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.3390\/pharmaceutics14112425","article-title":"Protein and gene delivery Systems for Neurodegenerative Disorders: where do we stand today?","volume":"14","author":"Siafaka","year":"2022","journal-title":"Pharmaceutics"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"349","DOI":"10.3233\/JAD-121171","article-title":"SPION-enhanced magnetic resonance imaging of Alzheimer's disease plaques in AbetaPP\/PS-1 transgenic mouse brain","volume":"34","author":"Sillerud","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"10328","DOI":"10.1021\/nn505073u","article-title":"Ceria nanoparticles stabilized by organic surface coatings activate the lysosome-autophagy system and enhance autophagic clearance","volume":"8","author":"Song","year":"2014","journal-title":"ACS Nano"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3389\/fendo.2019.00247","article-title":"The gut-immune-brain Axis in autism Spectrum disorders; a focus on amino acids","volume":"10","author":"van Sadelhoff","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"10365","DOI":"10.1021\/acsnano.3c00796","article-title":"Lysosome-targeting aggregation-induced emission nanoparticle enables adoptive macrophage transfer-based precise therapy of bacterial infections","volume":"17","author":"Wang","year":"2023","journal-title":"ACS Nano"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1016\/j.cell.2016.04.049","article-title":"Corpse engulfment generates a molecular memory that primes the macrophage inflammatory response","volume":"165","author":"Weavers","year":"2016","journal-title":"Cells"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/nn.2575","article-title":"Autophagy gone awry in neurodegenerative diseases","volume":"13","author":"Wong","year":"2010","journal-title":"Nat. Neurosci."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.bbi.2016.09.016","article-title":"Dietary interventions that reduce mTOR activity rescue autistic-like behavioral deficits in mice","volume":"59","author":"Wu","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"4918","DOI":"10.1038\/s41467-022-32625-1","article-title":"Lysosomal exocytosis releases pathogenic alpha-synuclein species from neurons in synucleinopathy models","volume":"13","author":"Xie","year":"2022","journal-title":"Nat. Commun."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/s41576-022-00562-w","article-title":"Autophagy genes in biology and disease","volume":"24","author":"Yamamoto","year":"2023","journal-title":"Nat. Rev. Genet."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"6249","DOI":"10.2147\/IJN.S216432","article-title":"Intravesical delivery of rapamycin via folate-modified liposomes dispersed in thermo-reversible hydrogel","volume":"14","author":"Yoon","year":"2019","journal-title":"Int. J. Nanomedicine"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"7513","DOI":"10.1111\/jcmm.16787","article-title":"ADMSC Exo-MicroRNA-22 improve neurological function and neuroinflammation in mice with Alzheimer's disease","volume":"25","author":"Zhai","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12951-017-0261-x","article-title":"Chitosan nanoparticle-mediated co-delivery of shAtg-5 and gefitinib synergistically promoted the efficacy of chemotherapeutics through the modulation of autophagy","volume":"15","author":"Zheng","year":"2017","journal-title":"J Nanobiotechnology"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2023.1331211\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T04:13:39Z","timestamp":1704687219000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2023.1331211\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,8]]},"references-count":48,"alternative-id":["10.3389\/fnins.2023.1331211"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2023.1331211","relation":{},"ISSN":["1662-453X"],"issn-type":[{"type":"electronic","value":"1662-453X"}],"subject":[],"published":{"date-parts":[[2024,1,8]]},"article-number":"1331211"}}