{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:59:05Z","timestamp":1779364745512,"version":"3.53.0"},"reference-count":123,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>The Quaking protein (QKI) belongs to the STAR protein family and plays a significant role in the development of the nervous system. It serves as a crucial regulator in the processes of tumor progression and cardiovascular system development. Within the central nervous system, QKI has been associated with the onset and progression of numerous neuropsychiatric disorders, including schizophrenia, depression, ataxia, and Alzheimer\u2019s disease. In malignant tumors, the methylation of the QKI promoter inhibits its expression. QKI primarily involves in the generation, stability, and selective splicing of non-coding RNA, as well as in mRNA translation. The role of QKI in the tumor microenvironment should not be overlooked. Especially in Glioblastoma Multiforme (GBM), although QKI is not the primary mutation, it still plays a vital role in maintaining the stemness of GBM. However, the mechanisms and further studies on this topic demand extensive basic and clinical trials.<\/jats:p>","DOI":"10.3389\/fnins.2024.1341114","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T04:31:30Z","timestamp":1729053090000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["The multifaceted role of quaking protein in neuropsychiatric disorders and tumor progression"],"prefix":"10.3389","volume":"18","author":[{"given":"Zeshang","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HeFei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingquan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"7482","DOI":"10.1073\/pnas.0601213103","article-title":"Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia","volume":"103","author":"Aberg","year":"2006","journal-title":"Proc. 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Genet."},{"key":"ref87","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1038\/s41388-023-02678-7","article-title":"Exosomal circSPIRE1 mediates glycosylation of E-cadherin to suppress metastasis of renal cell carcinoma","volume":"42","author":"Shu","year":"2023","journal-title":"Oncogene"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.canlet.2005.06.049","article-title":"Common fragile sites, extremely large genes, neural development and cancer","volume":"232","author":"Smith","year":"2006","journal-title":"Cancer Lett."},{"key":"ref89","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3390\/antiox11010022","article-title":"Pathophysiology of lipid droplets in neuroglia","volume":"11","author":"Smoli\u010d","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12943-023-01719-9","article-title":"A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR","volume":"22","author":"Song","year":"2023","journal-title":"Mol. Cancer"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1093\/jnen\/nlac123","article-title":"MYB\/MYBL1::QKI fusion-positive diffuse glioma","volume":"82","author":"Suh","year":"2023","journal-title":"J. Neuropathol. Exp. 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Biol. Chem."},{"key":"ref96","doi-asserted-by":"publisher","first-page":"24599","DOI":"10.18632\/oncotarget.5248","article-title":"Quaking and miR-155 interactions in inflammation and leukemogenesis","volume":"6","author":"Tili","year":"2015","journal-title":"Oncotarget"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1007\/s00210-019-01772-6","article-title":"Inhibition of miR-574-5p suppresses cell growth and metastasis and enhances chemosensitivity by targeting RNA binding protein QKI in cervical cancer cells","volume":"393","author":"Tong","year":"2020","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref98","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/ng.491","article-title":"Somatic mutations of the Parkinson\u2019s disease-associated gene PARK2 in glioblastoma and other human malignancies","volume":"42","author":"Veeriah","year":"2010","journal-title":"Nat. Genet."},{"key":"ref99","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1128\/MCB.01604-12","article-title":"The QKI-5 and QKI-6 RNA binding proteins regulate the expression of microRNA 7 in glial cells","volume":"33","author":"Wang","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"ref100","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.3389\/fimmu.2017.01754","article-title":"Quaking deficiency amplifies inflammation in experimental endotoxemia via the aryl hydrocarbon receptor\/signal transducer and activator of transcription 1-NF-\u03baB pathway","volume":"8","author":"Wang","year":"2017","journal-title":"Front. Immunol."},{"key":"ref101","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1080\/15384101.2020.1806449","article-title":"Circular RNA circ-SLC7A6 acts as a tumor suppressor in non-small cell lung cancer through abundantly sponging miR-21","volume":"19","author":"Wang","year":"2020","journal-title":"Cell Cycle"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3389\/fphar.2020.00164","article-title":"MiR-362-5p, which is regulated by long non-coding RNA MBNL1-AS1, promotes the cell proliferation and tumor growth of bladder cancer by targeting QKI","volume":"11","author":"Wei","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref103","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1159\/000217729","article-title":"Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia","volume":"27","author":"Wharton","year":"2009","journal-title":"Dement. Geriatr. 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Sci."},{"key":"ref106","doi-asserted-by":"publisher","first-page":"e36351","DOI":"10.1371\/journal.pone.0036351","article-title":"Transcriptome sequencing revealed significant alteration of cortical promoter usage and splicing in schizophrenia","volume":"7","author":"Wu","year":"2012","journal-title":"PLoS One"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s12943-022-01615-8","article-title":"CircBCAR3 accelerates esophageal cancer tumorigenesis and metastasis via sponging miR-27a-3p","volume":"21","author":"Xi","year":"2022","journal-title":"Mol. 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