{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T09:21:02Z","timestamp":1794648062638,"version":"4.9.1"},"reference-count":136,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Critical phases of neurodevelopment and gut microbiota diversification occur in early life and both processes are impacted by genetic and environmental factors. Recent studies have shown the presence of gut microbiota alterations in neurodevelopmental disorders. Here we performed a systematic review of alterations of the intestinal microbiota composition and function in pediatric and adult patients affected by autism spectrum disorder (ASD), attention-deficit\/hyperactivity disorder (ADHD), and Rett syndrome (RETT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched selected keywords in the online databases of PubMed, Cochrane, and OVID (January 1980 to December 2021) with secondary review of references of eligible articles. Two reviewers independently performed critical appraisals on the included articles using the Critical Appraisal Skills Program for each study design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our systematic review identified 18, 7, and 3 original articles describing intestinal microbiota profiles in ASD, ADHD, and RETT, respectively. Decreased Firmicutes and increased Bacteroidetes were observed in the gut microbiota of individuals affected by ASD and ADHD. Proinflammatory cytokines, short-chain fatty acids and neurotransmitter levels were altered in ASD and RETT. Constipation and visceral pain were related to changes in the gut microbiota in patients affected by ASD and RETT. Hyperactivity and impulsivity were negatively correlated with\n                      <jats:italic>Faecalibacterium<\/jats:italic>\n                      (phylum Firmicutes) and positively correlated with\n                      <jats:italic>Bacteroides<\/jats:italic>\n                      sp. (phylum Bacteroidetes) in ADHD subjects. Five studies explored microbiota-or diet-targeted interventions in ASD and ADHD. Probiotic treatments with\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      sp. and fecal microbiota transplantation from healthy donors reduced constipation and ameliorated ASD symptoms in affected children. Perinatal administration of\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      sp. prevented the onset of Asperger and ADHD symptoms in adolescence. Micronutrient supplementation improved disease symptomatology in ADHD without causing significant changes in microbiota communities\u2019 composition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Several discrepancies were found among the included studies, primarily due to sample size, variations in dietary practices, and a high prevalence of functional gastrointestinal symptoms. Further studies employing longitudinal study designs, larger sample sizes and multi-omics technologies are warranted to identify the functional contribution of the intestinal microbiota in developmental trajectories of the human brain and neurobehavior.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/clinicaltrials.gov\/<\/jats:ext-link>\n                      , CRD42020158734.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2024.1341656","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T23:57:02Z","timestamp":1709769422000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":43,"title":["Functional contribution of the intestinal microbiome in autism spectrum disorder, attention deficit hyperactivity disorder, and Rett syndrome: a systematic review of pediatric and adult studies"],"prefix":"10.3389","volume":"18","author":[{"given":"Valentina","family":"Caputi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Popov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Hartung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara Gross","family":"Margolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanish","family":"Baskaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Papiha","family":"Joharapurkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Moshkovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Pai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0183509","article-title":"Gut microbiome in ADHD and its relation to neural reward anticipation","volume":"12","author":"Aarts","year":"2017","journal-title":"PLoS One"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"724","DOI":"10.3389\/fgene.2020.00724","article-title":"Catechol-O-methyltransferase Val158Met genotype and early-life family adversity interactively affect attention-deficit hyperactivity symptoms across childhood","volume":"11","author":"Abraham","year":"2020","journal-title":"Front. Genet."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1007\/s12031-021-01959-8","article-title":"The efficacy of fecal transplantation and Bifidobacterium supplementation in ameliorating propionic acid-induced behavioral and biochemical autistic features in juvenile male rats","volume":"72","author":"Abuaish","year":"2022","journal-title":"J. Mol. Neurosci."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1471-230X-11-22","article-title":"Gastrointestinal flora and gastrointestinal status in children with autism \u2013 comparisons to typical children and correlation with autism severity","volume":"11","author":"Adams","year":"2011","journal-title":"BMC Gastroenterol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1007\/s12031-020-01500-3","article-title":"Study of the gut microbiome profile in children with autism Spectrum disorder: a single tertiary hospital experience","volume":"70","author":"Ahmed","year":"2020","journal-title":"J. Mol. Neurosci."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/s41385-020-0257-y","article-title":"Imprinting of the immune system by the microbiota early in life","volume":"13","author":"Al Nabhani","year":"2020","journal-title":"Mucosal Immunol."},{"key":"ref7","volume-title":"Diagnostic and statistical manual of mental disorders","year":"2013"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fpsyt.2019.00561","article-title":"Psychiatric and cognitive aspects of phenylketonuria: the limitations of diet and promise of new treatments. Front","volume":"10","author":"Ashe","year":"2019","journal-title":"Psychiatry"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1097\/MPG.0000000000000200","article-title":"Gastrointestinal Dysmotility in Rett syndrome","volume":"58","author":"Baikie","year":"2014","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0006-3223(91)90207-3","article-title":"Phenylethylaminergic mechanisms in attention-deficit disorder","volume":"29","author":"Baker","year":"1991","journal-title":"Biol. Psychiatry"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/B978-0-12-411462-3.00016-3","article-title":"The effects of trace element deficiencies on neurological disease and treatment with trace element support","volume-title":"Bioactive nutraceuticals and dietary supplements in neurological and brain disease","author":"Bayir","year":"2015"},{"key":"ref12","first-page":"93","article-title":"Attention deficit disorder with hyperactivity symptoms in early-treated phenylketonuria patients","volume":"14","author":"Beckhauser","year":"2020","journal-title":"Iran J. Child. Neurol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1186\/s40168-020-00875-0","article-title":"Microbiome definition re-visited: old concepts and new challenges","volume":"8","author":"Berg","year":"2020","journal-title":"Microbiome."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e0151100","DOI":"10.1371\/journal.pone.0151100","article-title":"No tryptophan, tyrosine and phenylalanine abnormalities in children with attention-deficit\/hyperactivity disorder","volume":"11","author":"Bergwerff","year":"2016","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"61258","DOI":"10.1002\/ajmg.a.61258","article-title":"Gastrointestinal disorders in down syndrome","author":"Bermudez","year":"2019","journal-title":"Am. J. Med. Genet. A"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"110130","DOI":"10.1016\/j.pnpbp.2020.110130","article-title":"Targeting the microbiome-gut-brain axis for improving cognition in schizophrenia and major mood disorders: A narrative review","volume":"105","author":"Bioque","year":"2021","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms18020344","article-title":"Rett syndrome: A focus on gut microbiota","volume":"18","author":"Borghi","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3390\/ijms20174160","article-title":"Rett syndrome and other neurodevelopmental disorders share common changes in gut microbial community: A descriptive review","volume":"20","author":"Borghi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/0165-1781(90)90046-8","article-title":"Plasma amino acids in attention deficit disorder","volume":"33","author":"Bornstein","year":"1990","journal-title":"Psychiatry Res."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.molmed.2014.05.002","article-title":"Microbiota and neurodevelopmental windows: implications for brain disorders","volume":"20","author":"Borre","year":"2014","journal-title":"Trends Mol. Med."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.neulet.2016.02.009","article-title":"Butyrate, neuroepigenetics and the gut microbiome: can a high fiber diet improve brain health?","volume":"625","author":"Bourassa","year":"2016","journal-title":"Neurosci. Lett."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/dmcn.15139","article-title":"Avoidant\/restrictive food intake disorder and severe food selectivity in children and young people with autism: A scoping review","volume":"2022","author":"Bourne","year":"2022","journal-title":"Dev. Med. Child Neurol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1038\/s41564-019-0409-6","article-title":"Transmission of human-associated microbiota along family and social networks","volume":"4","author":"Brito","year":"2019","journal-title":"Nat. Microbiol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"5913","DOI":"10.1128\/IAI.70.11.5913-5923.2002","article-title":"The growth response of Escherichia coli to neurotransmitters and related catecholamine drugs requires a functional Enterobactin biosynthesis and uptake system","volume":"70","author":"Burton","year":"2002","journal-title":"Infect. 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Psychiatry"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0076993","article-title":"Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified","volume":"8","author":"De Angelis","year":"2013","journal-title":"PLoS One"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"103293","DOI":"10.1016\/j.ebiom.2021.103293","article-title":"Short chain fatty acids and its producing organisms: an overlooked therapy for IBD?","volume":"66","author":"Deleu","year":"2021","journal-title":"EBioMedicine"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.tim.2019.08.001","article-title":"The gut microbiota in the first decade of life","volume":"27","author":"Derrien","year":"2019","journal-title":"Trends Microbiol."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1016\/j.cmet.2021.10.010","article-title":"Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease","volume":"33","author":"Erny","year":"2021","journal-title":"Cell Metab."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.mehy.2011.04.032","article-title":"Desulfovibrio species are potentially important in regressive autism","volume":"77","author":"Finegold","year":"2011","journal-title":"Med. 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Dis."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.anaerobe.2017.02.008","article-title":"Detection of Clostridium perfringens toxin genes in the gut microbiota of autistic children","volume":"45","author":"Finegold","year":"2017","journal-title":"Anaerobe"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nn.4476","article-title":"Interactions between the microbiota, immune and nervous systems in health and disease","volume":"20","author":"Fung","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/918410","article-title":"Catecholaminergic gene variants: contribution in ADHD and associated comorbid attributes in the eastern Indian Probands","volume":"2013","author":"Ghosh","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1002\/aur.1253","article-title":"Molecular characterisation of gastrointestinal microbiota of children with autism (with and without gastrointestinal dysfunction) and their Neurotypical siblings","volume":"5","author":"Gondalia","year":"2012","journal-title":"Autism Res."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/ajmg.b.30400","article-title":"Serotonin genes and attention deficit\/hyperactivity disorder in a Brazilian sample: preferential transmission of the HTR2A 452His allele to affected boys","author":"Guimar\u00e3es","year":"2007","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1177\/1362361309353614","article-title":"Risk factors for autism and Asperger syndrome","volume":"15","author":"Haglund","year":"2011","journal-title":"Autism"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1101\/gr.085464.108","article-title":"Microbial community profiling for human microbiome projects: tools, techniques, and challenges","volume":"19","author":"Hamady","year":"2009","journal-title":"Genome Res."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/ajg.2011.482","article-title":"Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection","volume":"107","author":"Hamilton","year":"2012","journal-title":"Am. J. Gastroenterol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1002\/dev.22234","article-title":"Adverse childhood experiences predict neurite density differences in young children with and without attention deficit hyperactivity disorder","volume":"64","author":"Hare","year":"2022","journal-title":"Dev. Psychobiol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1080\/09540261.2018.1455646","article-title":"Leo Kanner and autism: a 75-year perspective","volume":"30","author":"Harris","year":"2018","journal-title":"Int. Rev. Psychiatry"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1093\/ageing\/afw223","article-title":"Using quality assessment tools to critically appraise ageing research: a guide for clinicians","volume":"46","author":"Harrison","year":"2017","journal-title":"Age Ageing"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1017\/neu.2021.8","article-title":"Protocol for a systematic review on the role of the gut microbiome in paediatric neurological disorders","volume":"33","author":"Hill","year":"2021","journal-title":"Acta Neuropsychiatr."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13099-020-0346-1","article-title":"Gut microbiota changes in children with autism spectrum disorder: a systematic review","volume":"12","author":"Ho","year":"2020","journal-title":"Gut Pathog."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1002\/mrdd.10026","article-title":"Associations betweenmeCP2 mutations, x-chromosome inactivation, and phenotype","volume":"8","author":"Hoffbuhr","year":"2002","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fpsyt.2018.00627","article-title":"Anti-Candida albicans IgG antibodies in children with autism spectrum disorders","volume":"9","author":"Hughes","year":"2018","journal-title":"Front. Psych."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.bbr.2018.03.036","article-title":"Gut microbiota profiles in treatment-na\u00efve children with attention deficit hyperactivity disorder","volume":"347","author":"Jiang","year":"2018","journal-title":"Behav. Brain Res."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3389\/fmicb.2016.00459","article-title":"Characterization of the gut microbiome using 16S or shotgun metagenomics","volume":"7","author":"Jovel","year":"2016","journal-title":"Front. Virol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40168-016-0225-7","article-title":"Microbiota transfer therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study","volume":"5","author":"Kang","year":"2017","journal-title":"Microbiome"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.anaerobe.2017.12.007","article-title":"Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders","volume":"49","author":"Kang","year":"2018","journal-title":"Anaerobe"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1371\/journal.pone.0068322","article-title":"Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children","volume":"8","author":"Kang","year":"2013","journal-title":"PLoS One"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11046-015-9949-3","article-title":"Microbiota\u2013gut\u2013brain Axis: yeast species isolated from stool samples of children with suspected or diagnosed autism Spectrum disorders and in vitro susceptibility against nystatin and fluconazole","volume":"181","author":"Kantarcioglu","year":"2016","journal-title":"Mycopathologia"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"6626","DOI":"10.3748\/wjg.v26.i42.6626","article-title":"Attention deficit hyperactivity disorder and gastrointestinal morbidity in a large cohort of young adults","volume":"26","author":"Kedem","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.nutres.2020.06.019","article-title":"Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress","volume":"82","author":"Kochalska","year":"2020","journal-title":"Nutr. Res."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"e110","DOI":"10.1097\/MPG.0000000000001458","article-title":"Analysis of the duodenal microbiome in autistic individuals: association with carbohydrate digestion","volume":"64","author":"Kushak","year":"2017","journal-title":"J. Pediatr. Gastroenterol. 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Res."},{"key":"ref108","doi-asserted-by":"publisher","first-page":"e0137725","DOI":"10.1371\/journal.pone.0137725","article-title":"Comparison of fecal microbiota in children with autism Spectrum disorders and Neurotypical siblings in the Simons simplex collection","author":"Son","year":"2015","journal-title":"PLoS One"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1097\/00004583-200011000-00018","article-title":"Adoptive and biological families of children and adolescents with ADHD","volume":"39","author":"Sprich","year":"2000","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/s41598-019-46146-3","article-title":"Human gut microbiome changes during a 10 week randomised control trial for micronutrient supplementation in children with attention deficit hyperactivity disorder","volume":"9","author":"Stevens","year":"2019","journal-title":"Sci. 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