{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:24:00Z","timestamp":1787315040244,"version":"build-2736575974"},"reference-count":121,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:00:00Z","timestamp":1706227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Cerebral amyloid angiopathy (CAA) is a type of cerebrovascular disorder characterised by the accumulation of amyloid within the leptomeninges and small\/medium-sized cerebral blood vessels. Typically, cerebral haemorrhages are one of the first clinical manifestations of CAA, posing a considerable challenge to the timely diagnosis of CAA as the bleedings only occur during the later disease stages. Fluid biomarkers may change prior to imaging biomarkers, and therefore, they could be the future of CAA diagnosis. Additionally, they can be used as primary outcome markers in prospective clinical trials. Among fluid biomarkers, blood-based biomarkers offer a distinct advantage over cerebrospinal fluid biomarkers as they do not require a procedure as invasive as a lumbar puncture. This article aimed to provide an overview of the present clinical data concerning fluid biomarkers associated with CAA and point out the direction of future studies. Among all the biomarkers discussed, amyloid \u03b2, neurofilament light chain, matrix metalloproteinases, complement 3, uric acid, and lactadherin demonstrated the most promising evidence. However, the field of fluid biomarkers for CAA is an under-researched area, and in most cases, there are only one or two studies on each of the biomarkers mentioned in this review. Additionally, a small sample size is a common limitation of the discussed studies. Hence, it is hard to reach a solid conclusion on the clinical significance of each biomarker at different stages of the disease or in various subpopulations of CAA. In order to overcome this issue, larger longitudinal and multicentered studies are needed.<\/jats:p>","DOI":"10.3389\/fnins.2024.1347320","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T23:27:06Z","timestamp":1706225226000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Fluid biomarkers in cerebral amyloid angiopathy"],"prefix":"10.3389","volume":"18","author":[{"given":"Seyed Mehrdad","family":"Savar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Hone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzana","family":"Jahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun","family":"Markovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Pedrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soudabeh","family":"Shemehsavar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandhana","family":"Easwaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Taddei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Gardener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmeer P.","family":"Chhatwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellis S.","family":"van Etten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias J. 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Neuroinflammation"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"e75091","DOI":"10.1371\/journal.pone.0075091","article-title":"Increased neurofilament light chain blood levels in neurodegenerative neurological diseases","volume":"8","author":"Gaiottino","year":"2013","journal-title":"PLoS One"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"3435","DOI":"10.3390\/ijms21103435","article-title":"Understanding the pathophysiology of cerebral amyloid angiopathy","volume":"21","author":"Gatti","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"102083","DOI":"10.1016\/j.npep.2020.102083","article-title":"Spermidine, an autophagy inducer, as a therapeutic strategy in neurological disorders","volume":"83","author":"Ghosh","year":"2020","journal-title":"Neuropeptides"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1177\/1073858420954811","article-title":"Cerebral amyloid Angiopathy and blood-brain barrier dysfunction","volume":"27","author":"Gireud-Goss","year":"2021","journal-title":"Neuroscientist"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.neulet.2019.02.033","article-title":"A distinct brain beta amyloid signature in cerebral amyloid angiopathy compared to Alzheimer's disease","volume":"701","author":"Gkanatsiou","year":"2019","journal-title":"Neurosci. Lett."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"791","DOI":"10.3233\/JAD-215208","article-title":"Cerebrospinal fluid profile of tau, phosphorylated tau, A\u03b242, and A\u03b240 in probable cerebral amyloid Angiopathy","volume":"87","author":"Grangeon","year":"","journal-title":"J. Alzheimers Dis."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"4972","DOI":"10.1007\/s00415-022-11145-4","article-title":"Different clinical outcomes between cerebral amyloid angiopathy-related inflammation and non-inflammatory form","volume":"269","author":"Grangeon","year":"","journal-title":"J. Neurol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41582-019-0281-2","article-title":"Cerebral amyloid angiopathy and Alzheimer disease \u2013 one peptide, two pathways","volume":"16","author":"Greenberg","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1111\/j.1749-6632.2000.tb06361.x","article-title":"Plasma beta-amyloid peptide, transforming growth factor-beta 1, and risk for cerebral amyloid angiopathy","volume":"903","author":"Greenberg","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/112_2007_0701","article-title":"Amyloid peptides and proteins in review","volume":"159","author":"Harrison","year":"2007","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"15078","DOI":"10.1074\/jbc.M114.610931","article-title":"Sequential amyloid-beta degradation by the matrix metalloproteases Mmp-2 and Mmp-9","volume":"290","author":"Hernandez-Guillamon","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1385\/JMN:17:2:147","article-title":"Role of apoe\/Abeta interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy","volume":"17","author":"Holtzman","year":"2001","journal-title":"J. Mol. Neurosci."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s40478-018-0540-2","article-title":"Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer's disease","volume":"6","author":"Hondius","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"746","DOI":"10.3389\/fneur.2018.00746","article-title":"Serum markers of blood-brain barrier remodeling and fibrosis as predictors of etiology and Clinicoradiologic outcome in intracerebral hemorrhage","volume":"9","author":"Howe","year":"2018","journal-title":"Front. 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Neuroinflammation"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1161\/STROKEAHA.122.041690","article-title":"Iatrogenic cerebral amyloid Angiopathy post neurosurgery: frequency, clinical profile, radiological features, and outcome","volume":"54","author":"Kaushik","year":"2023","journal-title":"Stroke"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/S1474-4422(23)00114-X","article-title":"Progression of cerebral amyloid angiopathy: a pathophysiological framework","volume":"22","author":"Koemans","year":"2023","journal-title":"Lancet Neurol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"fcac245","DOI":"10.1093\/braincomms\/fcac245","article-title":"Blood-brain barrier leakage and perivascular inflammation in cerebral amyloid angiopathy","volume":"4","author":"Kozberg","year":"2022","journal-title":"Brain Commun."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1111\/nan.12595","article-title":"Apolipoprotein D: a potential biomarker for cerebral amyloid angiopathy","volume":"46","author":"Kuiperij","year":"2020","journal-title":"Neuropathol. 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A."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1001\/jamaneurol.2020.1782","article-title":"Association between immunosuppressive treatment and outcomes of cerebral amyloid Angiopathy-related inflammation","volume":"77","author":"Regenhardt","year":"2020","journal-title":"JAMA Neurol."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"2429","DOI":"10.1007\/s00415-012-6520-8","article-title":"Interest of Csf biomarker analysis in possible cerebral amyloid angiopathy cases defined by the modified Boston criteria","volume":"259","author":"Renard","year":"2012","journal-title":"J. Neurol."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.3233\/JAD-170843","article-title":"Cerebrospinal fluid, Mri, and Florbetaben-pet in cerebral amyloid Angiopathy-related inflammation","volume":"61","author":"Renard","year":"2018","journal-title":"J. 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Care Med."},{"key":"ref100","doi-asserted-by":"publisher","first-page":"8296","DOI":"10.1007\/s12035-019-01672-z","article-title":"Influence of matrix metallopeptidase 9 on Beta-amyloid elimination across the blood-brain barrier","volume":"56","author":"Shackleton","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref101","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.3233\/JAD-200656","article-title":"Cerebrospinal fluid metals and the association with cerebral small vessel disease","volume":"78","author":"Shams","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"ref102","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1111\/jnc.14157","article-title":"Cerebral amyloid angiopathy as a cause of neurodegeneration","volume":"144","author":"Smith","year":"2018","journal-title":"J. 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