{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:21:25Z","timestamp":1787026885067,"version":"build-2736575974"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Dopamine, a neurotransmitter and neuromodulator, is primarily released by dopaminergic neurons in the midbrain, particularly in the substantia nigra and the ventral tegmental area (VTA). Dopamine is known to have 5 receptors which are D1, D2, D3, D4 and D5, which are further categorized into 2 families: D1 family and D2 family. The D1 family and D2 family work in conjunction, playing interconnected roles in reward processing and decision-making. The D1 family is composed of D1 and D5 receptors and primarily functions in motivation and motor control. In contrast, the D2 family, composed of D2, D3, and D4 receptors, affect attention and sleep. THC, a type of cannabinoid, can lead to feelings of euphoria, anxiety, fear, distrust, or panic, and modulates dopamine activity in several regions of the central nervous system. Although there is a vast amount of research between the relationship of THC on dopamine, there continues to be limited research in relation to THC on dopamine receptors. The D1 receptor plays a role in several essential functions, such as memory, attention, impulse control, regulation of renal function, and locomotion. Accordingly, this review is intended to summarize the relationship between THC and D1 receptors, highlighting key gaps in the literature and avenues for future research.<\/jats:p>","DOI":"10.3389\/fnins.2024.1360205","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T23:27:55Z","timestamp":1707866875000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Tetrahydrocannabinol and dopamine D1 receptor"],"prefix":"10.3389","volume":"18","author":[{"given":"Jiwon","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1097\/00001756-199704140-00034","article-title":"Sex differences in dopamine receptor overproduction and elimination","volume":"8","author":"Andersen","year":"1997","journal-title":"Neuroreport"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/s0149-7634(99)00044-5","article-title":"Sex differences in dopamine receptors and their relevance to ADHD","volume":"24","author":"Andersen","year":"2000","journal-title":"Neurosci. 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