{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T10:24:53Z","timestamp":1785493493174,"version":"3.56.0"},"reference-count":102,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG034157, R01 AG062288"],"award-info":[{"award-number":["R01 AG034157, R01 AG062288"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA260961"],"award-info":[{"award-number":["R01 CA260961"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK128972"],"award-info":[{"award-number":["R01 DK128972"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Postoperative cognitive dysfunction (POCD) is a neurological disorder characterized by the emergence of cognitive impairment after surgery. A growing body of literature suggests that the onset of POCD is closely tied to circadian rhythm disruption (CRD). Circadian rhythms are patterns of behavioral and physiological change that repeat themselves at approximately, but not exactly, every 24\u2009h. They are entrained to the 24\u2009h day by the daily light\u2013dark cycle. Postoperative CRD affects cognitive function likely by disrupting sleep architecture, which in turn provokes a host of pathological processes including neuroinflammation, blood\u2013brain barrier disturbances, and glymphatic pathway dysfunction. Therefore, to address the pathogenesis of POCD it is first necessary to correct the dysregulated circadian rhythms that often occur in surgical patients. This narrative review summarizes the evidence for CRD as a key contributor to POCD and concludes with a brief discussion of how circadian-effective hospital lighting can be employed to re-entrain stable and robust circadian rhythms in surgical patients.<\/jats:p>","DOI":"10.3389\/fnins.2024.1390216","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T04:29:05Z","timestamp":1713328145000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Postoperative cognitive dysfunction: spotlight on light, circadian rhythms, and sleep"],"prefix":"10.3389","volume":"18","author":[{"given":"Ellie","family":"Campbell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana G.","family":"Figueiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e000692","DOI":"10.1136\/bmjoq-2019-000692","article-title":"Effect on nurse and patient experience: overnight use of blue-depleted illumination","volume":"8","author":"Albala","year":"2019","journal-title":"BMJ Open Qual."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3389\/fnagi.2015.00112","article-title":"Biomarkers of postoperative delirium and cognitive dysfunction","volume":"7","author":"Androsova","year":"2015","journal-title":"Front. 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