{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:18:35Z","timestamp":1774541915514,"version":"3.50.1"},"reference-count":102,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Therapeutic hypothermia inhibits organ damage by suppressing metabolism, which makes it a therapy of choice for treating various diseases. Specifically, it is often used to treat conditions involving central nervous system disorders where it is expected to positively impact functional prognosis. Although keeping the body temperature at a hypothermic level has been conventionally used, how to manage the body temperature correctly remains a topic of debate. Recently, the concept of temperature management has been proposed to improve the quality of body temperature control and avoid hyperthermia. This review focuses on the effect of temperature on the central nervous system in conditions involving central nervous system disorders and the practice of temperature management in clinical situations.<\/jats:p>","DOI":"10.3389\/fnins.2024.1397300","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T06:10:57Z","timestamp":1730355057000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["A review on targeted temperature management for cardiac arrest and traumatic brain injury"],"prefix":"10.3389","volume":"18","author":[{"given":"Hiroshi","family":"Ito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanae","family":"Hosomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youhei","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Iba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Oda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1056\/NEJMoa1507581","article-title":"Hypothermia for intracranial hypertension after traumatic brain injury","volume":"373","author":"Andrews","year":"2015","journal-title":"N. 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Care Med."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1136\/jnnp.71.4.448","article-title":"Brain temperature, body core temperature, and intracranial pressure in acute cerebral damage","volume":"71","author":"Rossi","year":"2001","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1007\/s00134-008-1357-4","article-title":"Intravascular cooling for rapid induction of moderate hypothermia in severely head-injured patients: results of a multicenter study (IntraCool)","volume":"35","author":"Sahuquillo","year":"2009","journal-title":"Intensive Care Med."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1089\/neu.2011.2152","article-title":"Mild hyperthermia worsens the neuropathological damage associated with mild traumatic brain injury in rats","volume":"29","author":"Sakurai","year":"2012","journal-title":"J. Neurotrauma"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1089\/ther.2013.0024","article-title":"Therapeutic hypothermia in children and adults with severe traumatic brain injury","volume":"4","author":"Sandestig","year":"2014","journal-title":"Ther. Hypothermia Temp. Manag."},{"key":"ref85","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s00134-022-06620-5","article-title":"ERC-ESICM guidelines on temperature control after cardiac arrest in adults","volume":"48","author":"Sandroni","year":"2022","journal-title":"Intensive Care Med."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1056\/NEJM199406303302609","article-title":"The neurologic basis of fever","volume":"330","author":"Saper","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"ref87","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1097\/CCM.0000000000004160","article-title":"Relationship between duration of targeted temperature management, ischemic interval, and good functional outcome from out-of-hospital cardiac arrest","volume":"48","author":"Sawyer","year":"2020","journal-title":"Crit. Care Med."},{"key":"ref88","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/neu.1996.13.1","article-title":"Mild pre- and posttraumatic hypothermia attenuates blood-brain barrier damage following controlled cortical impact injury in the rat","volume":"13","author":"Smith","year":"1996","journal-title":"J. Neurotrauma"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"1265978","DOI":"10.3389\/fcvm.2023.1265978","article-title":"Gender disparities in patients undergoing extracorporeal cardiopulmonary resuscitation","volume":"10","author":"Springer","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1007\/s00134-002-1513-1","article-title":"Pyrexia in head-injured patients admitted to intensive care","volume":"28","author":"Stocchetti","year":"2002","journal-title":"Intensive Care Med."},{"key":"ref91","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1111\/aas.14125","article-title":"Targeted temperature management evolving over time-a local process analysis","volume":"66","author":"Str\u00e5lin","year":"2022","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref92","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3171\/jns.2001.94.3.0493","article-title":"Exacerbation of traumatically induced axonal injury by rapid posthypothermic rewarming and attenuation of axonal change by cyclosporin a","volume":"94","author":"Suehiro","year":"2001","journal-title":"J. Neurosurg."},{"key":"ref93","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1001\/jamaneurol.2023.4820","article-title":"Hypothermia vs Normothermia in patients with cardiac arrest and nonshockable rhythm: a meta-analysis","volume":"81","author":"Taccone","year":"2024","journal-title":"JAMA Neurol."},{"key":"ref94","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13054-019-2721-1","article-title":"High quality targeted temperature management (TTM) after cardiac arrest","volume":"24","author":"Taccone","year":"2020","journal-title":"Crit. Care"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0969-9961(02)00030-X","article-title":"Hyperthermia following traumatic brain injury: a critical evaluation","volume":"12","author":"Thompson","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"ref96","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.expneurol.2014.10.020","article-title":"Emergence of cognitive deficits after mild traumatic brain injury due to hyperthermia","volume":"263","author":"Titus","year":"2015","journal-title":"Exp. Neurol."},{"key":"ref97","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1097\/00000542-199508000-00013","article-title":"Temperature changes of \u22651\u00b0C alter functional neurologic outcome and histopathology in a canine model of complete cerebral ischemia","volume":"83","author":"Wass","year":"1995","journal-title":"Anesthesiology"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.resuscitation.2022.10.005","article-title":"2022 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations: summary from the basic life support; advanced life support; pediatric life support; neonatal life support; education, implementation, and teams; and first aid task forces","volume":"181","author":"Wyckoff","year":"2022","journal-title":"Resuscitation"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"370","DOI":"10.3171\/2012.10.JNS12725","article-title":"Neuroprotective effect of preoperatively induced mild hypothermia as determined by biomarkers and histopathological estimation in a rat subdural hematoma decompression model","volume":"118","author":"Yokobori","year":"2013","journal-title":"J. Neurosurg."},{"key":"ref100","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s40560-016-0137-4","article-title":"Targeted temperature management in traumatic brain injury","volume":"4","author":"Yokobori","year":"2016","journal-title":"J. Intensive Care"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1001\/archinte.161.16.2007","article-title":"Hyperthermia after cardiac arrest is associated with an unfavorable neurologic outcome","volume":"161","author":"Zeiner","year":"2001","journal-title":"Arch. Intern. Med."},{"key":"ref102","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.bbrc.2016.04.095","article-title":"Hypothermia followed by rapid rewarming exacerbates ischemia-induced brain injury and augments inflammatory response in rats","volume":"474","author":"Zhu","year":"2016","journal-title":"Biochem. Biophys. Res. 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