{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:03:13Z","timestamp":1792756993887,"version":"4.5.0"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>A reserve in the motor domain may underlie the capacity exhibited by some patients to maintain motor functionality in the face of a certain level of disease. This form of \u201cmotor reserve\u201d (MR) could include cortical, cerebellar, and muscular processes. However, a systematic definition has not been provided yet. Clarifying this concept in healthy individuals and patients would be crucial for implementing prevention strategies and rehabilitation protocols. Due to its wide application in the assessment of motor system functioning, non-invasive brain stimulation (NIBS) may support such definition. Here, studies focusing on reserve in the motor domain and studies using NIBS were revised. Current literature highlights the ability of the motor system to create a reserve and a possible role for NIBS. MR could include several mechanisms occurring in the brain, cerebellum, and muscles, and NIBS may support the understanding of such mechanisms.<\/jats:p>","DOI":"10.3389\/fnins.2024.1403065","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T01:02:18Z","timestamp":1714438938000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Defining the concept of reserve in the motor domain: a systematic review"],"prefix":"10.3389","volume":"18","author":[{"given":"Andreina","family":"Giustiniani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Quartarone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s12311-011-0274-1","article-title":"Plasticity of the superior and middle cerebellar peduncles in musicians revealed by quantitative analysis of volume and number of streamlines based on diffusion tensor tractography","volume":"10","author":"Abdul-Kareem","year":"2011","journal-title":"Cerebellum"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.tics.2013.08.012","article-title":"Efficiency, capacity, compensation, maintenance, plasticity: emerging concepts in cognitive reserve","volume":"17","author":"Barulli","year":"2013","journal-title":"Trends Cognit. Sci."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"S253","DOI":"10.1016\/j.pmrj.2010.10.015","article-title":"Assessment and modulation of neural plasticity in rehabilitation with transcranial magnetic stimulation","volume":"2","author":"Bashir","year":"2010","journal-title":"PM R"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.neurol.2021.12.012","article-title":"Motor reserve: how to build neuronal resilience against ageing and neurodegeneration?","volume":"178","author":"Bastos","year":"2022","journal-title":"Rev. Neurol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.4103\/1673-5374.300440","article-title":"Degenerative and regenerative processes in amyotrophic lateral sclerosis: motor reserve, adaptation and putative compensatory changes","volume":"16","author":"Bede","year":"2021","journal-title":"Neural Regen. Res."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.expneurol.2017.10.002","article-title":"Compensatory mechanisms in Parkinson\u2019s disease: circuits adaptations and role in disease modification","volume":"298","author":"Blesa","year":"2017","journal-title":"Exp. Neurol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1002\/ana.24472","article-title":"Proportional recovery after stroke depends on corticomotor integrity","volume":"78","author":"Byblow","year":"2015","journal-title":"Ann. 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Parkinsons Dis."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2020.02.028","article-title":"Initial motor reserve and long-term prognosis in Parkinson's disease","volume":"92","author":"Chung","year":"","journal-title":"Neurobiol. Aging"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1196\/annals.1376.029","article-title":"A multiple-levels-of-analysis perspective on resilience: implications for the developing brain, neural plasticity, and preventive interventions","volume":"1094","author":"Cicchetti","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1007\/s00415-020-10331-6","article-title":"Effect of cognitive reserve on structural and functional MRI measures in healthy subjects: a multiparametric assessment","volume":"268","author":"Conti","year":"2021","journal-title":"J. Neurol."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1177\/1049732312452938","article-title":"Beyond PICO: the SPIDER tool for qualitative evidence synthesis","volume":"22","author":"Cooke","year":"2012","journal-title":"Qual. Health Res."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1080\/17461391.2019.1584249","article-title":"Sport experience is correlated with complex motor skill recovery in youth following concussion","volume":"19","author":"Dalecki","year":"2019","journal-title":"Eur. J. Sport Sci."},{"key":"ref19","first-page":"81","article-title":"General methods for Cochrane reviews","volume-title":"Cochrane handbook for systematic reviews of interventions version 5.1.0 (updated march 2011)","author":"Deeks","year":"2011"},{"key":"ref9002","doi-asserted-by":"crossref","first-page":"4000","DOI":"10.3390\/ma15114000","article-title":"A Low-Cost Wireless Bite Force Measurement Device","volume":"15","author":"De Pasquale","year":"2022","journal-title":"Materials"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1007\/s12311-010-0236-z","article-title":"Exposure to an enriched environment accelerates recovery from cerebellar lesion","volume":"10","author":"Foti","year":"2011","journal-title":"Cerebellum"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"3405","DOI":"10.1007\/s00429-015-1109-5","article-title":"Lesion-induced and activity-dependent structural plasticity of Purkinje cell dendritic spines in cerebellar vermis and hemisphere","volume":"221","author":"Gelfo","year":"2016","journal-title":"Brain Struct. 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Neurophysiol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1097\/PSY.0000000000000785","article-title":"Quantifying cortical resilience in experimental, clinical, and epidemiological studies: a conceptually grounded method using noninvasive brain stimulation","volume":"82","author":"Hall","year":"2020","journal-title":"Psychosom. Med."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1002\/mds.26418","article-title":"Is dominant-side onset associated with a better motor compensation in Parkinson\u2019s disease?","volume":"30","author":"Ham","year":"2015","journal-title":"Mov. Disord."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"117449","DOI":"10.1016\/j.neuroimage.2020.117449","article-title":"Probing rapid network reorganization of motor and language functions via neuromodulation and neuroimaging","volume":"224","author":"Hartwigsen","year":"2021","journal-title":"NeuroImage"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/mds.29266","article-title":"The concept of Motor Reserve in Parkinson\u2019s disease: new wine in old bottles?","volume":"38","author":"Hoenig","year":"2023","journal-title":"Mov. Disord."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"395","DOI":"10.3233\/RNN-2011-0611","article-title":"Understanding and enhancing motor recovery after stroke using transcranial magnetic stimulation","volume":"29","author":"Hoyer","year":"2011","journal-title":"Restor. Neurol. 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Rehabil."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s12883-022-02629-x","article-title":"Effects of high frequency rTMS of contralesional dorsal premotor cortex in severe subcortical chronic stroke: protocol of a randomized controlled trial with multimodal neuroimaging assessments","volume":"22","author":"Li","year":"2022","journal-title":"BMC Neurol."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2516","DOI":"10.1016\/j.clinph.2020.06.016","article-title":"Stratifying chronic stroke patients based on the influence of contralesional motor cortices: an inter-hemispheric inhibition study","volume":"131","author":"Lin","year":"2020","journal-title":"Clin. Neurophysiol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1097\/PSY.0000000000000361","article-title":"Effects of moderate exercise on cortical resilience: a transcranial magnetic stimulation study targeting the dorsolateral prefrontal cortex","volume":"79","author":"Lowe","year":"2017","journal-title":"Psychosom. Med."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1002\/ana.20599","article-title":"Pathways mediating abnormal intracortical inhibition in Parkinson\u2019s disease","volume":"58","author":"MacKinnon","year":"2005","journal-title":"Ann. Neurol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/nrneurol.2017.128","article-title":"Long-term effects of exercise and physical therapy in people with Parkinson disease","volume":"13","author":"Mak","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1007\/s00415-022-11455-7","article-title":"Neuromodulation of the cerebellum: the importance of the assessment of the cerebellar reserve","volume":"270","author":"Manto","year":"2023","journal-title":"J. Neurol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40673-020-00126-w","article-title":"The critical need to develop tools assessing cerebellar reserve for the delivery and assessment of non-invasive cerebellar stimulation","volume":"8","author":"Manto","year":"2021","journal-title":"Cerebellum Ataxias"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.5772\/67908","article-title":"Non-invasive brain stimulation (TMS\/tDCS) and rehabilitation for stroke and Parkinson\u2019s","author":"Matsuda","year":"2017","journal-title":"Neurol. Phys. Ther."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s12311-019-01091-9","article-title":"Consensus paper. Cerebellar reserve: from cerebellar physiology to cerebellar disorders","volume":"19","author":"Mitoma","year":"2020","journal-title":"Cerebellum"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"3013","DOI":"10.3390\/cells11193013","article-title":"Development of cerebellar reserve","volume":"11","author":"Mitoma","year":"2022","journal-title":"Cells"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"8408","DOI":"10.3389\/fneur.2023.1178408","article-title":"The role of neurophysiological tools in the evaluation of ischemic stroke evolution: a narrative review","volume":"14","author":"Motolese","year":"2023","journal-title":"Front. Neurol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1016\/j.clinph.2015.08.011","article-title":"Intracortical inhibition abnormality during the remission phase of multiple sclerosis is related to upper limb dexterity and lesions","volume":"127","author":"Nantes","year":"2016","journal-title":"Clin. Neurophysiol."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"9254","DOI":"10.1038\/s41598-022-13322-x","article-title":"Premorbid cancer and motor reserve in patients with Parkinson\u2019s disease","volume":"12","author":"Oh","year":"2022","journal-title":"Sci. Rep."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3233\/JPD-191762","article-title":"Delayed clinical manifestation of Parkinson\u2019s disease among physically active: do participants in a long-distance ski race have a motor reserve?","volume":"10","author":"Olsson","year":"2020","journal-title":"J. Parkinsons Dis."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.brs.2021.02.005","article-title":"Cortical responses to noninvasive perturbations enable individual brain fingerprinting","volume":"14","author":"Ozdemir","year":"2021","journal-title":"Brain Stimul."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1111\/j.1460-9568.2009.06753.x","article-title":"Motor reserve and novel area recruitment: amplitude and spatial characteristics of compensation in Parkinson\u2019s disease","volume":"29","author":"Palmer","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00033","article-title":"Activating developmental reserve capacity via cognitive training or non-invasive brain stimulation: potentials for promoting fronto-parietal and hippocampal-striatal network functions in old age","volume":"9","author":"Passow","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.1161\/01.STR.30.12.2666","article-title":"Absence of response to early transcranial magnetic stimulation in ischemic stroke patients: prognostic value for hand motor recovery","volume":"30","author":"Pennisi","year":"1999","journal-title":"Stroke"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1017\/s135561772300022x","article-title":"How long have you exercised in your life? The effect of motor reserve and current physical activity on cognitive performance","volume":"30","author":"Pucci","year":"2023","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1093\/brain\/awz310","article-title":"New insights into cortico-basal-cerebellar connectome: clinical and physiological considerations","volume":"143","author":"Quartarone","year":"2020","journal-title":"Brain"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1113\/jphysiol.2007.144824","article-title":"Contribution of transcranial magnetic stimulation to the understanding of cortical mechanisms involved in motor control","volume":"586","author":"Reis","year":"2008","journal-title":"J. Physiol."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"fcac203","DOI":"10.1093\/braincomms\/fcac203","article-title":"Structural cerebellar reserve positively influences outcome after severe stroke","volume":"4","author":"Sadeghihassanabadi","year":"2022","journal-title":"Brain Commun."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1136\/jnnp-2022-330613","article-title":"Spinal cord reserve in multiple sclerosis","volume":"94","author":"Sastre-Garriga","year":"2023","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.09.003","article-title":"Effective reserve: a latent variable to improve outcome prediction in stroke","volume":"28","author":"Schirmer","year":"2019","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.3390\/biomedicines10092166","article-title":"\u201cMens Sana in Corpore Sano\u201d: the emerging link of motor reserve with motor and cognitive abilities and compensatory brain networks in SCA2 patients","volume":"10","author":"Siciliano","year":"2022","journal-title":"Biomedicines"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.neurobiolaging.2022.10.015","article-title":"A framework for concepts of reserve and resilience in aging","volume":"124","author":"Stern","year":"2023","journal-title":"Neurobiol. Aging"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1016\/j.jalz.2018.07.219","article-title":"Whitepaper: defining and investigating cognitive reserve, brain reserve, and brain maintenance","volume":"16","author":"Stern","year":"2020","journal-title":"Alzheimer\u2019s and Dementia"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1080\/13803390902740643","article-title":"Cognitive reserve protects against cognitive dysfunction in multiple sclerosis","volume":"31","author":"Sumowski","year":"2009","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1212\/WNL.0000000000002702","article-title":"Brain reserve against physical disability progression over 5 years in multiple sclerosis","volume":"86","author":"Sumowski","year":"2016","journal-title":"Neurology"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.parkreldis.2016.10.023","article-title":"Premorbid exercise engagement and motor reserve in Parkinson\u2019s disease","volume":"34","author":"Sunwoo","year":"2017","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13195-018-0408-5","article-title":"Is intracranial volume a suitable proxy for brain reserve? Rik Ossenkoppele","volume":"10","author":"Van Loenhoud","year":"2018","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"9546","DOI":"10.1523\/JNEUROSCI.0335-12.2012","article-title":"Compensatory activity in the extrastriate body area of Parkinson\u2019s disease patients","volume":"32","author":"van Nuenen","year":"2012","journal-title":"J. Neurosci."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"e977","DOI":"10.1212\/WNL.0000000000200814","article-title":"Association of Structural Measurements of brain reserve with motor progression in patients with Parkinson disease","volume":"99","author":"Wang","year":"2022","journal-title":"Neurology"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1093\/brain\/aws360","article-title":"The cerebellum in Parkinson\u2019s disease","volume":"136","author":"Wu","year":"2013","journal-title":"Brain"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3233\/JPD-223542","article-title":"Extra-basal ganglia brain structures are related to Motor Reserve in Parkinson\u2019s disease","volume":"13","author":"Youn","year":"2023","journal-title":"J. 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