{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:49:56Z","timestamp":1794271796130,"version":"4.9.0"},"reference-count":344,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is increasingly recognized as being intertwined with the dysregulation of lipid metabolism. Lipids are a significant class of nutrients vital to all organisms, playing crucial roles in cellular structure, energy storage, and signaling. Alterations in the levels of various lipids in AD brains and dysregulation of lipid pathways and transportation have been implicated in AD pathogenesis. Clinically, evidence for a high-fat diet firmly links disrupted lipid metabolism to the pathogenesis and progression of AD, although contradictory findings warrant further exploration. In view of the significance of various lipids in brain physiology, the discovery of complex and diverse mechanisms that connect lipid metabolism with AD-related pathophysiology will bring new hope for patients with AD, underscoring the importance of lipid metabolism in AD pathophysiology, and promising targets for therapeutic intervention. Specifically, cholesterol, sphingolipids, and fatty acids have been shown to influence amyloid-beta (A\u03b2) accumulation and tau hyperphosphorylation, which are hallmarks of AD pathology. Recent studies have highlighted the potential therapeutic targets within lipid metabolism, such as enhancing apolipoprotein E lipidation, activating liver X receptors and retinoid X receptors, and modulating peroxisome proliferator-activated receptors. Ongoing clinical trials are investigating the efficacy of these strategies, including the use of ketogenic diets, statin therapy, and novel compounds like NE3107. The implications of these findings suggest that targeting lipid metabolism could offer new avenues for the treatment and management of AD. By concentrating on alterations in lipid metabolism within the central nervous system and their contribution to AD development, this review aims to shed light on novel research directions and treatment approaches for combating AD, offering hope for the development of more effective management strategies.<\/jats:p>","DOI":"10.3389\/fnins.2024.1430465","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T05:12:10Z","timestamp":1726031530000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":72,"title":["New insights in lipid metabolism: potential therapeutic targets for the treatment of Alzheimer\u2019s disease"],"prefix":"10.3389","volume":"18","author":[{"given":"Yuan","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1083\/jcb.200404149","article-title":"Neuronal membrane cholesterol loss enhances amyloid peptide generation.","volume":"167","author":"Abad-Rodriguez","year":"2004","journal-title":"J. Cell Biol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1074\/jbc.M309888200","article-title":"Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein.","volume":"279","author":"Abe-Dohmae","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci8020027","article-title":"ABCA7 and pathogenic pathways of Alzheimers disease.","volume":"8","author":"Aikawa","year":"2018","journal-title":"Brain Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/nrn2059","article-title":"Lipid raft microdomains and neurotransmitter signalling.","volume":"8","author":"Allen","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.neuron.2017.03.043","article-title":"Blood-brain barrier permeability is regulated by lipid transport-dependent suppression of caveolae-mediated transcytosis.","volume":"94","author":"Andreone","year":"2017","journal-title":"Neuron"},{"key":"B6","doi-asserted-by":"publisher","first-page":"13707","DOI":"10.1523\/jneurosci.4040-10.2010","article-title":"Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.","volume":"30","author":"Andrews-Zwilling","year":"2010","journal-title":"J. Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1017\/s1041610217001685","article-title":"Joining forces to prevent dementia: The international research network on dementia prevention (IRNDP).","volume":"29","author":"Anstey","year":"2017","journal-title":"Int. Psychogeriatr."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.2353\/ajpath.2009.090219","article-title":"Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria.","volume":"175","author":"Area-Gomez","year":"2009","journal-title":"Am. J. Pathol."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0215-0","article-title":"A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease.","volume":"9","author":"Area-Gomez","year":"2018","journal-title":"Cell Death Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1194\/jlr.R800007-JLR200","article-title":"Role of ganglioside metabolism in the pathogenesis of Alzheimers disease\u2013a review.","volume":"49","author":"Ariga","year":"2008","journal-title":"J. Lipid Res."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101648","article-title":"CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of Alzheimers disease.","volume":"36","author":"Ates","year":"2020","journal-title":"Redox Biol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.neurobiolaging.2007.07.024","article-title":"ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimers but not normal brain.","volume":"30","author":"Bandaru","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00212","article-title":"Lipid metabolism crosstalk in the brain: Glia and neurons.","volume":"13","author":"Barber","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nri.2015.4","article-title":"Specialized pro-resolving mediators: Endogenous regulators of infection and inflammation.","volume":"16","author":"Basil","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"35881","DOI":"10.1074\/jbc.274.50.35881","article-title":"Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures.","volume":"274","author":"Basu-Modak","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B16","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1001\/archneurol.2011.125","article-title":"Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment.","volume":"68","author":"Bayer-Carter","year":"2011","journal-title":"Arch. Neurol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/nrn3820","article-title":"Polyunsaturated fatty acids and their metabolites in brain function and disease.","volume":"15","author":"Bazinet","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jnutbio.2016.03.002","article-title":"The pleiotropic effects of omega-3 docosahexaenoic acid on the hallmarks of Alzheimers disease.","volume":"38","author":"Belkouch","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"B19","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","article-title":"New insights on the genetic etiology of Alzheimers and related dementia.","volume":"54","author":"Bellenguez","year":"2022","journal-title":"Nat. Genet."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00168","article-title":"Using neurolipidomics to identify phospholipid mediators of synaptic (dys)function in Alzheimers Disease.","volume":"4","author":"Bennett","year":"2013","journal-title":"Front. Physiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/nature13324","article-title":"Mfsd2a is critical for the formation and function of the blood-brain barrier.","volume":"509","author":"Ben-Zvi","year":"2014","journal-title":"Nature"},{"key":"B22","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1093\/nutrit\/nuv019","article-title":"Microbiota and the gut-brain axis.","volume":"73","author":"Bienenstock","year":"2015","journal-title":"Nutr. Rev."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-018-0857-5","article-title":"Predictors of discontinuation, efficacy, and safety of memantine treatment for Alzheimers disease: Meta-analysis and meta-regression of 18 randomized clinical trials involving 5004 patients.","volume":"18","author":"Blanco-Silvente","year":"2018","journal-title":"BMC Geriatr."},{"key":"B24","doi-asserted-by":"publisher","first-page":"7293","DOI":"10.1523\/jneurosci.5198-13.2014","article-title":"Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene.","volume":"34","author":"Boehm-Cagan","year":"2014","journal-title":"J. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.3233\/jad-160467","article-title":"ABCA1 agonist reverses the ApoE4-driven cognitive and brain pathologies.","volume":"54","author":"Boehm-Cagan","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02587-2","article-title":"Microbiota modulation counteracts Alzheimers disease progression influencing neuronal proteolysis and gut hormones plasma levels.","volume":"7","author":"Bonfili","year":"2017","journal-title":"Sci. Rep."},{"key":"B27","doi-asserted-by":"publisher","first-page":"7987","DOI":"10.1007\/s12035-018-0973-4","article-title":"SLAB51 probiotic formulation activates SIRT1 pathway promoting antioxidant and neuroprotective effects in an AD mouse model.","volume":"55","author":"Bonfili","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.neurobiolaging.2019.11.004","article-title":"Gut microbiota manipulation through probiotics oral administration restores glucose homeostasis in a mouse model of Alzheimers disease.","volume":"87","author":"Bonfili","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"B29","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.clnu.2022.01.025","article-title":"Gut microbiota modulation in Alzheimers disease: Focus on lipid metabolism.","volume":"41","author":"Bonfili","year":"2022","journal-title":"Clin. Nutr."},{"key":"B30","doi-asserted-by":"publisher","first-page":"17122","DOI":"10.1074\/jbc.M110.211870","article-title":"Cholesterol modulates the rate and mechanism of acetylcholine receptor internalization.","volume":"286","author":"Borroni","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B31","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/ana.20899","article-title":"Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet.","volume":"60","author":"Bough","year":"2006","journal-title":"Ann. Neurol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1172\/jci113943","article-title":"A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve.","volume":"83","author":"Boyles","year":"1989","journal-title":"J. Clin. Invest."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009759","article-title":"The gut microbiota influences blood-brain barrier permeability in mice.","volume":"6","author":"Braniste","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1523\/jneurosci.4315-03.2004","article-title":"Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.","volume":"24","author":"Brecht","year":"2004","journal-title":"J. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/nrendo.2013.31","article-title":"Neurosteroids as regenerative agents in the brain: Therapeutic implications.","volume":"9","author":"Brinton","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"17217","DOI":"10.1074\/jbc.M110.217380","article-title":"Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors.","volume":"286","author":"Brodbeck","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.nut.2018.10.003","article-title":"The ketogenic diet as a potential treatment and prevention strategy for Alzheimers disease.","volume":"60","author":"Broom","year":"2019","journal-title":"Nutrition"},{"key":"B38","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1523\/jneurosci.21-02-00504.2001","article-title":"Membrane lipid rafts are necessary for the maintenance of the (alpha)7 nicotinic acetylcholine receptor in somatic spines of ciliary neurons.","volume":"21","author":"Brus\u00e9s","year":"2001","journal-title":"J. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/s1474-4422(21)00043-0","article-title":"Safety and efficacy of pioglitazone for the delay of cognitive impairment in people at risk of Alzheimers disease (TOMMORROW): A prognostic biomarker study and a phase 3, randomised, double-blind, placebo-controlled trial.","volume":"20","author":"Burns","year":"2021","journal-title":"Lancet Neurol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1073\/pnas.0510708103","article-title":"Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.","volume":"103","author":"Cai","year":"","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1073\/pnas.0510710103","article-title":"Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimers disease-linked presenilin-1 mutant neurons.","volume":"103","author":"Cai","year":"","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1007\/s00125-003-1246-x","article-title":"Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats.","volume":"46","author":"Carvalheira","year":"2003","journal-title":"Diabetologia"},{"key":"B43","doi-asserted-by":"publisher","first-page":"9173","DOI":"10.1523\/jneurosci.1000-15.2015","article-title":"Omega-3 fatty acids augment the actions of nuclear receptor agonists in a mouse model of Alzheimers disease.","volume":"35","author":"Casali","year":"2015","journal-title":"J. Neurosci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"22978","DOI":"10.1074\/jbc.M109.026567","article-title":"Cholesterol-rich fluid membranes solubilize ceramide domains: Implications for the structure and dynamics of mammalian intracellular and plasma membranes.","volume":"284","author":"Castro","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B45","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.neurobiolaging.2018.06.012","article-title":"Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation, and late-life activities.","volume":"70","author":"Chan","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"B46","doi-asserted-by":"publisher","first-page":"18694","DOI":"10.1073\/pnas.0508254102","article-title":"Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity.","volume":"102","author":"Chang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B47","doi-asserted-by":"publisher","first-page":"5215","DOI":"10.1074\/jbc.M110.151084","article-title":"Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease.","volume":"286","author":"Chen","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B48","doi-asserted-by":"publisher","first-page":"5253","DOI":"10.1074\/jbc.M111.276162","article-title":"Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.","volume":"287","author":"Chen","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B49","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1111\/jnc.14554","article-title":"High-density lipoprotein mimetic peptide 4F mitigates amyloid-\u03b2-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia.","volume":"147","author":"Chernick","year":"2018","journal-title":"J. Neurochem."},{"key":"B50","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/s0197-0186(03)00003-2","article-title":"Cholesterol deficiency increases the vulnerability of hippocampal glia in primary culture to glutamate-induced excitotoxicity.","volume":"43","author":"Chou","year":"2003","journal-title":"Neurochem. Int."},{"key":"B51","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.physbeh.2011.01.010","article-title":"Consumption of a high-fat diet induces central insulin resistance independent of adiposity.","volume":"103","author":"Clegg","year":"2011","journal-title":"Physiol. Behav."},{"key":"B52","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1136\/jnnp.2005.063131","article-title":"Levels of CSF prostaglandin E2, cognitive decline, and survival in Alzheimers disease.","volume":"77","author":"Combrinck","year":"2006","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B53","doi-asserted-by":"publisher","first-page":"8445","DOI":"10.1073\/pnas.1504890112","article-title":"Activation of peroxisome proliferator-activated receptor \u03b1 stimulates ADAM10-mediated proteolysis of APP.","volume":"112","author":"Corbett","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B54","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/ng0694-180","article-title":"Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease.","volume":"7","author":"Corder","year":"1994","journal-title":"Nat. Genet."},{"key":"B55","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimers disease in late onset families.","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"B56","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s11481-015-9627-8","article-title":"ABCA1 is necessary for bexarotene-mediated clearance of soluble amyloid beta from the hippocampus of APP\/PS1 mice.","volume":"11","author":"Corona","year":"2016","journal-title":"J. Neuroimmune Pharmacol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1126\/science.1217697","article-title":"ApoE-directed therapeutics rapidly clear \u03b2-amyloid and reverse deficits in AD mouse models.","volume":"335","author":"Cramer","year":"2012","journal-title":"Science"},{"key":"B58","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.neuron.2013.02.026","article-title":"GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimers disease.","volume":"78","author":"Cruchaga","year":"2013","journal-title":"Neuron"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-016-0173-2","article-title":"Double-blind, placebo-controlled, proof-of-concept trial of bexarotene Xin moderate Alzheimers disease.","volume":"8","author":"Cummings","year":"2016","journal-title":"Alzheimers Res. Ther."},{"key":"B60","doi-asserted-by":"publisher","first-page":"691","DOI":"10.3233\/jad-2012-110629","article-title":"Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimers disease.","volume":"29","author":"Cunnane","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"B61","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.nut.2010.07.021","article-title":"Brain fuel metabolism, aging, and Alzheimers disease.","volume":"27","author":"Cunnane","year":"2011","journal-title":"Nutrition"},{"key":"B62","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1073\/pnas.0305799101","article-title":"Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimers disease.","volume":"101","author":"Cutler","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112041","article-title":"The role of mitochondria dysfunction and hepatic senescence in NAFLD development and progression.","volume":"142","author":"Dabravolski","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12156","article-title":"Sex and APOE genotype differences related to statin use in the aging population.","volume":"7","author":"Dagliati","year":"2021","journal-title":"Alzheimers Dement."},{"key":"B65","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1007\/s12035-020-02232-6","article-title":"Cholesterol metabolism in neurodegenerative diseases: Molecular mechanisms and therapeutic targets.","volume":"58","author":"Dai","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1038\/nri912","article-title":"Emerging roles of PPARs in inflammation and immunity.","volume":"2","author":"Daynes","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00401-019-01994-1","article-title":"The role of ABCA7 in Alzheimers disease: Evidence from genomics, transcriptomics and methylomics.","volume":"138","author":"De Roeck","year":"2019","journal-title":"Acta Neuropathol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1126\/science.290.5499.2140","article-title":"Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain.","volume":"290","author":"de Urquiza","year":"2000","journal-title":"Science"},{"key":"B69","doi-asserted-by":"crossref","first-page":"14256","DOI":"10.1016\/S0021-9258(19)45374-X","article-title":"Intracellular transport of cholesterol to the plasma membrane.","volume":"257","author":"DeGrella","year":"1982","journal-title":"J. Biol. Chem."},{"key":"B70","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/nrn3012","article-title":"Linking lipids to Alzheimers disease: Cholesterol and beyond.","volume":"12","author":"Di Paolo","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1021\/cn300203a","article-title":"Biochemical identification of a linear cholesterol-binding domain within Alzheimers \u03b2 amyloid peptide.","volume":"4","author":"Di Scala","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.expneurol.2016.04.014","article-title":"Identification and modification of amyloid-independent phenotypes of APOE4 mice.","volume":"280","author":"DiBattista","year":"2016","journal-title":"Exp. Neurol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1097\/00041433-200104000-00003","article-title":"Cholesterol metabolism in the brain.","volume":"12","author":"Dietschy","year":"2001","journal-title":"Curr. Opin. Lipidol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1194\/jlr.R400004-JLR200","article-title":"Thematic review series: Brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal.","volume":"45","author":"Dietschy","year":"2004","journal-title":"J. Lipid Res."},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-024-03184-7","article-title":"Differential effect of an evolving amyloid and tau pathology on brain phospholipids and bioactive lipid mediators in rat models of Alzheimer-like pathology.","volume":"21","author":"Do Carmo","year":"2024","journal-title":"J. Neuroinflamm."},{"key":"B76","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1074\/jbc.M804396200","article-title":"Starving neurons show sex difference in autophagy.","volume":"284","author":"Du","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B77","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3233\/jad-141335","article-title":"Restoration of lipoxin A4 signaling reduces Alzheimers disease-like pathology in the 3xTg-AD mouse model.","volume":"43","author":"Dunn","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"B78","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1002\/jnr.490180407","article-title":"Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture.","volume":"18","author":"Edmond","year":"1987","journal-title":"J. Neurosci. Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1111\/bpa.12812","article-title":"Receptors for pro-resolving mediators are increased in Alzheimers disease brain.","volume":"30","author":"Emre","year":"2020","journal-title":"Brain Pathol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1002\/glia.23330","article-title":"GSEA of mouse and human mitochondriomes reveals fatty acid oxidation in astrocytes.","volume":"66","author":"Eraso-Pichot","year":"2018","journal-title":"Glia"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1016\/j.neurobiolaging.2014.02.005","article-title":"Altered lipid composition in cortical lipid rafts occurs at early stages of sporadic Alzheimers disease and facilitates APP\/BACE1 interactions.","volume":"35","author":"Fabelo","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00309","article-title":"Alzheimers disease as a membrane disorder: Spatial cross-talk among beta-amyloid peptides, nicotinic acetylcholine receptors and lipid rafts.","volume":"13","author":"Fabiani","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"B83","doi-asserted-by":"publisher","first-page":"30121","DOI":"10.1074\/jbc.271.47.30121","article-title":"Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein.","volume":"271","author":"Fagan","year":"1996","journal-title":"J. Biol. Chem."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1038\/s41593-019-0479-z","article-title":"Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity.","volume":"22","author":"Fecher","year":"2019","journal-title":"Nat. Neurosci."},{"key":"B85","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1212\/WNL.0b013e3181d6476a","article-title":"Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe.","volume":"74","author":"Feldman","year":"2010","journal-title":"Neurology"},{"key":"B86","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.1096\/fj.14-264218","article-title":"\u03c9-3 Supplementation increases amyloid-\u03b2 phagocytosis and resolvin D1 in patients with minor cognitive impairment.","volume":"29","author":"Fiala","year":"2015","journal-title":"FASEB J."},{"key":"B87","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/j.bbalip.2010.05.004","article-title":"Lipids in Alzheimers disease: A century-old story.","volume":"1801","author":"Foley","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00083","article-title":"Polyunsaturated fatty acid composition of cerebrospinal fluid fractions shows their contribution to cognitive resilience of a pre-symptomatic Alzheimers disease cohort.","volume":"11","author":"Fonteh","year":"2020","journal-title":"Front. Physiol."},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100519","article-title":"Human cerebrospinal fluid fatty acid levels differ between supernatant fluid and brain-derived nanoparticle fractions, and are altered in Alzheimers disease.","volume":"9","author":"Fonteh","year":"2014","journal-title":"PLoS One"},{"key":"B90","doi-asserted-by":"publisher","first-page":"4312","DOI":"10.1073\/pnas.94.9.4312","article-title":"Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta.","volume":"94","author":"Forman","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B91","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.bbalip.2010.06.003","article-title":"Lipids and Alzheimers disease.","volume":"1801","author":"Garner","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-017-0237-y","article-title":"Evidence for benefit of statins to modify cognitive decline and risk in Alzheimers disease.","volume":"9","author":"Geifman","year":"2017","journal-title":"Alzheimers Res. Ther."},{"key":"B93","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1111\/j.1749-6632.1999.tb07825.x","article-title":"Use of cytoplasmic hybrid cell lines for elucidating the role of mitochondrial dysfunction in Alzheimers disease and Parkinsons disease.","volume":"893","author":"Ghosh","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B94","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/1531-8249(200009)48:3<297::AID-ANA3>3.0.CO;2-Z","article-title":"Mitochondrial damage in Alzheimers disease varies with apolipoprotein E genotype.","volume":"48","author":"Gibson","year":"2000","journal-title":"Ann. Neurol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1089\/ars.2014.6223","article-title":"Mitochondria-associated membranes: Composition, molecular mechanisms, and physiopathological implications.","volume":"22","author":"Giorgi","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"B96","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.cell.2007.09.012","article-title":"Systematic gene expression mapping clusters nuclear receptors according to their function in the brain.","volume":"131","author":"Gofflot","year":"2007","journal-title":"Cell"},{"key":"B97","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1159\/000318845","article-title":"Rosiglitazone monotherapy in mild-to-moderate Alzheimers disease: Results from a randomized, double-blind, placebo-controlled phase III study.","volume":"30","author":"Gold","year":"2010","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"B98","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3233\/jad-2007-11109","article-title":"Ultrastructural localization of intraneuronal Abeta-peptide in Alzheimer disease brains.","volume":"11","author":"G\u00f3mez-Ramos","year":"2007","journal-title":"J. Alzheimers Dis."},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210227","article-title":"TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination.","volume":"218","author":"Gouna","year":"2021","journal-title":"J. Exp. Med."},{"key":"B100","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3233\/jad-2011-110080","article-title":"Sodium butyrate improves memory function in an Alzheimers disease mouse model when administered at an advanced stage of disease progression.","volume":"26","author":"Govindarajan","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1038\/ncb1313","article-title":"Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin.","volume":"7","author":"Grimm","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1097\/00005072-199907000-00008","article-title":"Decrease and structural modifications of phosphatidylethanolamine plasmalogen in the brain with Alzheimer disease.","volume":"58","author":"Guan","year":"1999","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.stem.2015.08.001","article-title":"Aberrant lipid metabolism in the forebrain niche suppresses adult neural stem cell proliferation in an animal model of Alzheimers disease.","volume":"17","author":"Hamilton","year":"2015","journal-title":"Cell Stem Cell"},{"key":"B104","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.2741\/2258","article-title":"Neurolipidomics: Challenges and developments.","volume":"12","author":"Han","year":"2007","journal-title":"Front. Biosci."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1046\/j.1471-4159.2001.00332.x","article-title":"Plasmalogen deficiency in early Alzheimers disease subjects and in animal models: Molecular characterization using electrospray ionization mass spectrometry.","volume":"77","author":"Han","year":"2001","journal-title":"J. Neurochem."},{"key":"B106","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3233\/jad-122377","article-title":"In vivo and in vitro effects of an apolipoprotein e mimetic peptide on amyloid-\u03b2 pathology.","volume":"36","author":"Handattu","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"B107","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1001\/jamaneurol.2013.396","article-title":"Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: Randomized clinical trial.","volume":"70","author":"Hanson","year":"2013","journal-title":"JAMA Neurol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1161\/01.atv.0000054199.78458.4b","article-title":"Isoform-dependent cholesterol efflux from macrophages by apolipoprotein E is modulated by cell surface proteoglycans.","volume":"23","author":"Hara","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimers disease.","volume":"41","author":"Harold","year":"2009","journal-title":"Nat. Genet."},{"key":"B110","doi-asserted-by":"publisher","first-page":"592","DOI":"10.2174\/156720511796391935","article-title":"Rosiglitazone does not improve cognition or global function when used as adjunctive therapy to AChE inhibitors in mild-to-moderate Alzheimers disease: Two phase 3 studies.","volume":"8","author":"Harrington","year":"2011","journal-title":"Curr. Alzheimer Res."},{"key":"B111","doi-asserted-by":"publisher","first-page":"10966","DOI":"10.1073\/pnas.1434398100","article-title":"Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimers disease-like neurodegeneration and behavioral deficits in transgenic mice.","volume":"100","author":"Harris","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1006\/bbrc.1994.1576","article-title":"Apolipoprotein E and cholesterol affect neuronal calcium signalling: The possible relationship to beta-amyloid neurotoxicity.","volume":"200","author":"Hartmann","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23052803","article-title":"Free cholesterol accelerates A\u03b2 self-assembly on membranes at physiological concentration.","volume":"23","author":"Hashemi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B114","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.neurobiolaging.2008.05.010","article-title":"Deregulation of sphingolipid metabolism in Alzheimers disease.","volume":"31","author":"He","year":"2010","journal-title":"Neurobiol. Aging."},{"key":"B115","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.bbamem.2013.07.018","article-title":"Interaction of membrane\/lipid rafts with the cytoskeleton: Impact on signaling and function: Membrane\/lipid rafts, mediators of cytoskeletal arrangement and cell signaling.","volume":"1838","author":"Head","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"B116","doi-asserted-by":"publisher","first-page":"8375","DOI":"10.1073\/pnas.140218797","article-title":"Dissecting the role of the golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface.","volume":"97","author":"Heino","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B117","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1093\/jnen\/nlw067","article-title":"Apolipoprotein E genotype affects size of ApoE complexes in cerebrospinal fluid.","volume":"75","author":"Heinsinger","year":"2016","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-12-137","article-title":"Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimers disease; a randomized, double-blind, placebo-controlled study.","volume":"12","author":"Henderson","year":"2011","journal-title":"BMC Med. Genet."},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-6-31","article-title":"Study of the ketogenic agent AC-1202 in mild to moderate Alzheimers disease: A randomized, double-blind, placebo-controlled, multicenter trial.","volume":"6","author":"Henderson","year":"2009","journal-title":"Nutr. Metab."},{"key":"B120","doi-asserted-by":"publisher","first-page":"643","DOI":"10.2174\/157015911798376325","article-title":"Impact and therapeutic potential of PPARs in Alzheimers disease.","volume":"9","author":"Heneka","year":"2011","journal-title":"Curr. Neuropharmacol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.1523\/jneurosci.5038-09.2010","article-title":"Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimers disease.","volume":"30","author":"Hernandez","year":"2010","journal-title":"J. Neurosci."},{"key":"B122","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1097\/MOL.0b013e32832d3a10","article-title":"Apolipoprotein E receptors in the nervous system.","volume":"20","author":"Herz","year":"2009","journal-title":"Curr. Opin. Lipidol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1194\/jlr.M300320-JLR200","article-title":"Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimers disease.","volume":"45","author":"Heverin","year":"2004","journal-title":"J. Lipid Res."},{"key":"B124","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.1523\/jneurosci.21-09-03017.2001","article-title":"Mitochondrial abnormalities in Alzheimers disease.","volume":"21","author":"Hirai","year":"2001","journal-title":"J. Neurosci."},{"key":"B125","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1212\/wnl.58.5.743","article-title":"The effect of APOE epsilon4 allele on cerebral glucose metabolism in AD is a function of age at onset.","volume":"58","author":"Hirono","year":"2002","journal-title":"Neurology"},{"key":"B126","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimers disease.","volume":"43","author":"Hollingworth","year":"2011","journal-title":"Nat. Genet."},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01407-w","article-title":"The relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: A study based on Alzheimers disease continuum participants.","volume":"16","author":"Hong","year":"2024","journal-title":"Alzheimers Res. Ther."},{"key":"B128","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.neuron.2014.02.027","article-title":"Soluble A\u03b2 oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.","volume":"82","author":"Hong","year":"2014","journal-title":"Neuron"},{"key":"B129","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1515\/hsz-2018-0284","article-title":"Characterization of the cholesterol efflux of apolipoprotein E-containing high-density lipoprotein in THP-1 cells.","volume":"400","author":"Horiuchi","year":"2019","journal-title":"Biol. Chem."},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-024-00983-9","article-title":"Very high high-density lipoprotein cholesterol may be associated with higher risk of cognitive impairment in older adults.","volume":"23","author":"Huang","year":"2024","journal-title":"Nutr. J."},{"key":"B131","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.nbd.2014.08.025","article-title":"Apolipoprotein E: Structure and function in lipid metabolism, neurobiology, and Alzheimers diseases.","volume":"72","author":"Huang","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"B132","doi-asserted-by":"publisher","first-page":"8838","DOI":"10.1073\/pnas.151254698","article-title":"Apolipoprotein E fragments present in Alzheimers disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.","volume":"98","author":"Huang","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B133","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.neuron.2017.11.014","article-title":"Age-dependent effects of apoE reduction using antisense oligonucleotides in a model of \u03b2-amyloidosis.","volume":"96","author":"Huynh","year":"2017","journal-title":"Neuron"},{"key":"B134","doi-asserted-by":"publisher","first-page":"941","DOI":"10.3233\/jad-2012-120397","article-title":"Peroxisome proliferators reduce spatial memory impairment, synaptic failure, and neurodegeneration in brains of a double transgenic mice model of Alzheimers disease.","volume":"33","author":"Inestrosa","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"B135","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1016\/j.cell.2019.04.001","article-title":"Neuron-astrocyte metabolic coupling protects against activity-induced fatty acid toxicity.","volume":"177","author":"Ioannou","year":"2019","journal-title":"Cell"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20153787","article-title":"Revisiting the role of LXRs in PUFA metabolism and phospholipid homeostasis.","volume":"20","author":"Jalil","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B137","doi-asserted-by":"publisher","first-page":"51451","DOI":"10.1074\/jbc.M404635200","article-title":"Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimers disease.","volume":"279","author":"Jana","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0197-5","article-title":"TREM2 in neurodegenerative diseases.","volume":"12","author":"Jay","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"B139","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1172\/jci77487","article-title":"Prostaglandin signaling suppresses beneficial microglial function in Alzheimers disease models.","volume":"125","author":"Johansson","year":"2015","journal-title":"J. Clin. Invest."},{"key":"B140","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimers disease.","volume":"368","author":"Jonsson","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"B141","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1006\/bbrc.2000.2923","article-title":"Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimers disease in the Japanese population.","volume":"273","author":"Kamino","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-38749-7","article-title":"Structure of amyloid \u03b2(25-35) in lipid environment and cholesterol-dependent membrane pore formation.","volume":"9","author":"Kandel","year":"2019","journal-title":"Sci. Rep."},{"key":"B143","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.neuron.2014.01.045","article-title":"ApoE and A\u03b2 in Alzheimers disease: Accidental encounters or partners?","volume":"81","author":"Kanekiyo","year":"2014","journal-title":"Neuron"},{"key":"B144","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1210\/er.2011-1049","article-title":"Lipid metabolism and neuroinflammation in Alzheimers disease: A role for liver X receptors.","volume":"33","author":"Kang","year":"2012","journal-title":"Endocr. Rev."},{"key":"B145","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1084\/jem.20180653","article-title":"Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau.","volume":"215","author":"Kang","year":"2018","journal-title":"J. Exp. Med."},{"key":"B146","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.bbadis.2015.09.020","article-title":"Exosomes as new diagnostic tools in CNS diseases.","volume":"1862","author":"Kanninen","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"B147","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.expneurol.2017.11.005","article-title":"Combined administration of resolvin E1 and lipoxin A4 resolves inflammation in a murine model of Alzheimers disease.","volume":"300","author":"Kantarci","year":"2018","journal-title":"Exp. Neurol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.biopsych.2014.05.006","article-title":"Alzheimers disease risk genes and mechanisms of disease pathogenesis.","volume":"77","author":"Karch","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"B149","doi-asserted-by":"publisher","first-page":"4049","DOI":"10.1074\/jbc.M508915200","article-title":"Expression of ABCG1, but not ABCA1, correlates with cholesterol release by cerebellar astroglia.","volume":"281","author":"Karten","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B150","doi-asserted-by":"publisher","first-page":"5440","DOI":"10.1073\/pnas.97.10.5440","article-title":"D-beta-hydroxybutyrate protects neurons in models of Alzheimers and Parkinsons disease.","volume":"97","author":"Kashiwaya","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B151","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1002\/cbic.201400043","article-title":"Exosomes and microvesicles: Identification and targeting by particle size and lipid chemical probes.","volume":"15","author":"Kastelowitz","year":"2014","journal-title":"Chembiochem"},{"key":"B152","doi-asserted-by":"publisher","first-page":"3801","DOI":"10.1523\/jneurosci.5543-03.2004","article-title":"Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimers disease.","volume":"24","author":"Kawarabayashi","year":"2004","journal-title":"J. Neurosci."},{"key":"B153","doi-asserted-by":"publisher","first-page":"14717","DOI":"10.1523\/jneurosci.2053-15.2015","article-title":"microRNA-33 regulates ApoE lipidation and amyloid-\u03b2 metabolism in the brain.","volume":"35","author":"Kim","year":"2015","journal-title":"J. Neurosci."},{"key":"B154","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1111\/j.1471-4159.2007.05099.x","article-title":"Role of ATP-binding cassette transporters in brain lipid transport and neurological disease.","volume":"104","author":"Kim","year":"2008","journal-title":"J. Neurochem."},{"key":"B155","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/psyg.12257","article-title":"Medium-chain triglycerides given in the early stage of mild-to-moderate Alzheimers disease enhance memory function.","volume":"17","author":"Kimoto","year":"2017","journal-title":"Psychogeriatrics"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009093","article-title":"TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.","volume":"6","author":"Kleinberger","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"B157","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/j.jmb.2017.04.004","article-title":"TREM2-ligand interactions in health and disease.","volume":"429","author":"Kober","year":"2017","journal-title":"J. Mol. Biol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"5815","DOI":"10.1073\/pnas.081612998","article-title":"Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.","volume":"98","author":"Kojro","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B159","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1002\/ana.21696","article-title":"Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age.","volume":"65","author":"Kok","year":"2009","journal-title":"Ann. Neurol."},{"key":"B160","doi-asserted-by":"publisher","first-page":"4079","DOI":"10.1074\/jbc.M411420200","article-title":"The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimers disease.","volume":"280","author":"Koldamova","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B161","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.nbd.2014.05.007","article-title":"ATP-binding cassette transporter A1: From metabolism to neurodegeneration.","volume":"72","author":"Koldamova","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"B162","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.2217\/fmb-2018-0185","article-title":"Gut microbiota influences Alzheimers disease pathogenesis by regulating acetate in Drosophila model.","volume":"13","author":"Kong","year":"2018","journal-title":"Future Microbiol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.3390\/ijms14011310","article-title":"Phospholipids and Alzheimers disease: Alterations, mechanisms and potential biomarkers.","volume":"14","author":"Kosicek","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"B164","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.bbadis.2016.10.006","article-title":"High fat diet induces brain insulin resistance and cognitive impairment in mice.","volume":"1863","author":"Kothari","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B165","first-page":"789","article-title":"Brain gangliosides in Alzheimers disease.","volume":"31","author":"Kracun","year":"1990","journal-title":"J. Hirnforsch."},{"key":"B166","first-page":"289","article-title":"Human brain gangliosides in development, aging and disease.","volume":"35","author":"Kracun","year":"1991","journal-title":"Int. J. Dev. Biol."},{"key":"B167","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41588-019-0358-2","article-title":"Genetic meta-analysis of diagnosed Alzheimers disease identifies new risk loci and implicates A\u03b2, tau, immunity and lipid processing.","volume":"51","author":"Kunkle","year":"2019","journal-title":"Nat. Genet."},{"key":"B168","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimers disease.","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat. Genet."},{"key":"B169","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimers disease.","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat. Genet."},{"key":"B170","doi-asserted-by":"publisher","first-page":"19524","DOI":"10.1073\/pnas.0604954103","article-title":"Presenilin mutations linked to familial Alzheimers disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolism.","volume":"103","author":"Landman","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B171","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1194\/jlr.M400486-JLR200","article-title":"Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimers disease.","volume":"46","author":"Lane","year":"2005","journal-title":"J. Lipid Res."},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176336","article-title":"ApoE lipidation as a therapeutic target in Alzheimers disease.","volume":"21","author":"Lanfranco","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B173","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1042\/bj20031594","article-title":"Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization.","volume":"380","author":"Laulagnier","year":"2004","journal-title":"Biochem. J."},{"key":"B174","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/nm0698-730","article-title":"A detergent-insoluble membrane compartment contains A beta in vivo.","volume":"4","author":"Lee","year":"1998","journal-title":"Nat. Med."},{"key":"B175","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1212\/wnl.0000000000004392","article-title":"Effect of simvastatin on CSF Alzheimer disease biomarkers in cognitively normal adults.","volume":"89","author":"Li","year":"2017","journal-title":"Neurology"},{"key":"B176","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.bbalip.2009.09.024","article-title":"Acyl-CoA synthesis, lipid metabolism and lipotoxicity.","volume":"1801","author":"Li","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"B177","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1111\/j.1532-5415.2010.02906.x","article-title":"Age-varying association between statin use and incident Alzheimers disease.","volume":"58","author":"Li","year":"2010","journal-title":"J. Am. Geriatr. Soc."},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-022-00542-y","article-title":"TREM2 in the pathogenesis of AD: A lipid metabolism regulator and potential metabolic therapeutic target.","volume":"17","author":"Li","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"B179","doi-asserted-by":"publisher","first-page":"18000","DOI":"10.1074\/jbc.M101589200","article-title":"Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates.","volume":"276","author":"Li","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B180","doi-asserted-by":"publisher","first-page":"10180","DOI":"10.1523\/jneurosci.3591-05.2005","article-title":"Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimers disease.","volume":"25","author":"Liang","year":"2005","journal-title":"J. Neurosci."},{"key":"B181","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1111\/j.1471-4159.2004.02183.x","article-title":"A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes.","volume":"88","author":"Liang","year":"2004","journal-title":"J. Neurochem."},{"key":"B182","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1172\/jci96429","article-title":"Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.","volume":"128","author":"Liao","year":"2018","journal-title":"J. Clin. Invest."},{"key":"B183","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/j.neuron.2018.05.008","article-title":"APOE4 causes widespread molecular and cellular alterations associated with Alzheimers disease phenotypes in human iPSC-derived brain cell types.","volume":"98","author":"Lin","year":"2018","journal-title":"Neuron"},{"key":"B184","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1242\/jcs.060681","article-title":"Cholesterol reduction impairs exocytosis of synaptic vesicles.","volume":"123","author":"Linetti","year":"2010","journal-title":"J. Cell Sci."},{"key":"B185","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease: Risk, mechanisms and therapy.","volume":"9","author":"Liu","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"B186","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.cmet.2017.08.024","article-title":"The glia-neuron lactate shuttle and elevated ros promote lipid synthesis in neurons and lipid droplet accumulation in glia via APOE\/D.","volume":"26","author":"Liu","year":"2017","journal-title":"Cell Metab."},{"key":"B187","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.neuron.2017.11.013","article-title":"ApoE4 accelerates early seeding of amyloid pathology.","volume":"96","author":"Liu","year":"2017","journal-title":"Neuron"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117088","article-title":"DHA dietary intervention caused different hippocampal lipid and protein profile in ApoE-\/- and C57BL\/6J mice.","volume":"177","author":"Liu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"B189","doi-asserted-by":"publisher","first-page":"3396","DOI":"10.1038\/s41380-022-01600-z","article-title":"High-fat diet-induced diabetes couples to Alzheimers disease through inflammation-activated C\/EBP\u03b2\/AEP pathway.","volume":"27","author":"Liu","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"B190","doi-asserted-by":"publisher","first-page":"17068","DOI":"10.1523\/jneurosci.4067-10.2010","article-title":"Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration.","volume":"30","author":"Liu","year":"2010","journal-title":"J. Neurosci."},{"key":"B191","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.neuron.2007.08.008","article-title":"Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1.","volume":"56","author":"Liu","year":"2007","journal-title":"Neuron"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.146554","article-title":"Elevated serum TC and LDL-C levels in Alzheimers disease and mild cognitive impairment: A meta-analysis study.","volume":"1727","author":"Liu","year":"2020","journal-title":"Brain Res."},{"key":"B193","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1080\/15548627.2019.1596488","article-title":"Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model.","volume":"16","author":"Luo","year":"2020","journal-title":"Autophagy"},{"key":"B194","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.mce.2019.01.016","article-title":"Oxysterols and nuclear receptors.","volume":"484","author":"Ma","year":"2019","journal-title":"Mol. Cell Endocrinol."},{"key":"B195","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1126\/science.3283935","article-title":"Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology.","volume":"240","author":"Mahley","year":"1988","journal-title":"Science"},{"key":"B196","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1007\/s00109-016-1427-y","article-title":"Apolipoprotein E: From cardiovascular disease to neurodegenerative disorders.","volume":"94","author":"Mahley","year":"2016","journal-title":"J. Mol. Med."},{"key":"B197","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.nbd.2006.02.010","article-title":"Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway.","volume":"23","author":"Malaplate-Armand","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"B198","doi-asserted-by":"publisher","first-page":"10117","DOI":"10.1523\/jneurosci.5268-11.2012","article-title":"Mechanisms underlying the rapid peroxisome proliferator-activated receptor-\u03b3-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimers disease.","volume":"32","author":"Mandrekar-Colucci","year":"2012","journal-title":"J. Neurosci."},{"key":"B199","doi-asserted-by":"publisher","first-page":"973","DOI":"10.2174\/1567205013666160314150017","article-title":"Lipid raft alterations in aged-associated neuropathologies.","volume":"13","author":"Marin","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"B200","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/j.1471-4159.2006.03878.x","article-title":"Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain.","volume":"98","author":"Martin","year":"2006","journal-title":"J. Neurochem."},{"key":"B201","doi-asserted-by":"publisher","first-page":"489","DOI":"10.3233\/jad-2010-1242","article-title":"Lipid alterations in lipid rafts from Alzheimers disease human brain cortex.","volume":"19","author":"Mart\u00edn","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2019.1579541","article-title":"Subtypes of tumour cell-derived small extracellular vesicles having differently externalized phosphatidylserine.","volume":"8","author":"Matsumura","year":"2019","journal-title":"J. Extracell. Vesicles"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2020.183233","article-title":"A\u03b2-ganglioside interactions in the pathogenesis of Alzheimers disease.","volume":"1862","author":"Matsuzaki","year":"2020","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"B204","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.taap.2018.03.005","article-title":"Differences in statin associated neuroprotection corresponds with either decreased production of IL-1\u03b2 or TNF-\u03b1 in an in vitro model of neuroinflammation-induced neurodegeneration.","volume":"344","author":"McFarland","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B205","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1016\/j.celrep.2020.01.072","article-title":"Palmitate is increased in the cerebrospinal fluid of humans with obesity and induces memory impairment in mice via pro-inflammatory TNF-\u03b1.","volume":"30","author":"Melo","year":"2020","journal-title":"Cell Rep."},{"key":"B206","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1046\/j.1471-4159.2000.0741008.x","article-title":"Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture.","volume":"74","author":"Michikawa","year":"2000","journal-title":"J. Neurochem."},{"key":"B207","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1194\/jlr.TR119000468","article-title":"Lipid rafts in glial cells: Role in neuroinflammation and pain processing.","volume":"61","author":"Miller","year":"2020","journal-title":"J. Lipid Res."},{"key":"B208","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1002\/jnr.22073","article-title":"Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture.","volume":"87","author":"Minagawa","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"B209","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/s41586-020-03160-0","article-title":"Restoring metabolism of myeloid cells reverses cognitive decline in ageing.","volume":"590","author":"Minhas","year":"2021","journal-title":"Nature"},{"key":"B210","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1111\/j.1471-4159.2011.07245.x","article-title":"Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells.","volume":"117","author":"Mitchell","year":"2011","journal-title":"J. Neurochem."},{"key":"B211","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.1084\/jem.20171406","article-title":"Alzheimers disease: A matter of blood-brain barrier dysfunction?","volume":"214","author":"Montagne","year":"2017","journal-title":"J. Exp. Med."},{"key":"B212","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1212\/wnl.53.7.1495","article-title":"Elevated CSF prostaglandin E2 levels in patients with probable AD.","volume":"53","author":"Montine","year":"1999","journal-title":"Neurology"},{"key":"B213","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/bf02527711","article-title":"Origin of cholesterol in myelin.","volume":"21","author":"Morell","year":"1996","journal-title":"Neurochem. Res."},{"key":"B214","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1093\/jnen\/60.8.778","article-title":"Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice.","volume":"60","author":"Mori","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B215","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1001\/archneur.60.7.940","article-title":"Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease.","volume":"60","author":"Morris","year":"2003","journal-title":"Arch. Neurol."},{"key":"B216","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1196\/annals.1427.007","article-title":"Brain glucose hypometabolism and oxidative stress in preclinical Alzheimers disease.","volume":"1147","author":"Mosconi","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B217","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.pscychresns.2003.12.005","article-title":"Age and ApoE genotype interaction in Alzheimers disease: An FDG-PET study.","volume":"130","author":"Mosconi","year":"2004","journal-title":"Psychiatry Res."},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2112095118","article-title":"Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimers disease-associated genes.","volume":"118","author":"Moulton","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.14336\/ad.2024.0434","article-title":"Dysregulation of lipid metabolism serves as a link between Alzheimers and cardiovascular disease, as witnessed in a cross-sectional study.","author":"Mourino-Alvarez","year":"2024","journal-title":"Aging Dis."},{"key":"B220","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1194\/jlr.R075556","article-title":"Therapeutic potential of nuclear receptor agonists in Alzheimers disease.","volume":"58","author":"Moutinho","year":"2017","journal-title":"J. Lipid Res."},{"key":"B221","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/0006-8993(91)91092-f","article-title":"Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimers disease and kuru plaque amyloid in Creutzfeldt-Jakob disease.","volume":"541","author":"Namba","year":"1991","journal-title":"Brain Res."},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053529","article-title":"The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E.","volume":"8","author":"Namjoshi","year":"2013","journal-title":"PLoS One"},{"key":"B223","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41591-018-0297-y","article-title":"Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction.","volume":"25","author":"Nation","year":"2019","journal-title":"Nat. Med."},{"key":"B224","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/bs.irn.2015.05.008","article-title":"Lipidomics of human brain aging and Alzheimers disease pathology.","volume":"122","author":"Naud\u00ed","year":"2015","journal-title":"Int. Rev. Neurobiol."},{"key":"B225","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.cmet.2017.08.004","article-title":"Ketogenic diet reduces midlife mortality and improves memory in aging mice.","volume":"26","author":"Newman","year":"2017","journal-title":"Cell Metab."},{"key":"B226","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.devcel.2017.06.003","article-title":"DGAT1-dependent lipid droplet biogenesis protects mitochondrial function during starvation-induced autophagy.","volume":"42","author":"Nguyen","year":"2017","journal-title":"Dev Cell"},{"key":"B227","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1021\/acs.jpcb.8b12126","article-title":"Lipid rafts: Buffers of cell membrane physical properties.","volume":"123","author":"Nickels","year":"2019","journal-title":"J. Phys. Chem. B"},{"key":"B228","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1471-4159.2009.05917.x","article-title":"Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats.","volume":"109","author":"Nieweg","year":"2009","journal-title":"J. Neurochem."},{"key":"B229","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1073\/pnas.89.5.1671","article-title":"Evidence for a membrane defect in Alzheimer disease brain.","volume":"89","author":"Nitsch","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B230","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/j.bbamem.2018.04.004","article-title":"Interactions between amyloid \u03b2 peptide and lipid membranes.","volume":"1860","author":"Niu","year":"2018","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"B231","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1016\/j.jalz.2015.04.006","article-title":"Loss-of-function mutation in ABCA1 and risk of Alzheimers disease and cerebrovascular disease.","volume":"11","author":"Nordestgaard","year":"2015","journal-title":"Alzheimers Dement."},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.12.007","article-title":"TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge.","volume":"105","author":"Nugent","year":"2020","journal-title":"Neuron"},{"key":"B233","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.brainresrev.2009.05.007","article-title":"Clusterin: A forgotten player in Alzheimers disease.","volume":"61","author":"Nuutinen","year":"2009","journal-title":"Brain Res. Rev."},{"key":"B234","doi-asserted-by":"publisher","first-page":"93","DOI":"10.4137\/jen.s25480","article-title":"Role of nuclear receptors in central nervous system development and associated diseases.","volume":"9","author":"Olivares","year":"2015","journal-title":"J. Exp. Neurosci."},{"key":"B235","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s11481-011-9282-7","article-title":"Rosiglitazone improves spatial memory and decreases insoluble A\u03b2(1-42) in APP\/PS1 mice.","volume":"7","author":"O\u2019Reilly","year":"2012","journal-title":"J. Neuroimmune Pharmacol."},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/292598","article-title":"Cholesterol: Its regulation and role in central nervous system disorders.","volume":"2012","author":"Orth","year":"2012","journal-title":"Cholesterol"},{"key":"B237","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1016\/s0002-9440(10)64693-7","article-title":"Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain.","volume":"158","author":"Oshima","year":"2001","journal-title":"Am. J. Pathol."},{"key":"B238","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/jcbfm.2013.166","article-title":"Diet-induced obesity suppresses expression of many proteins at the blood-brain barrier.","volume":"34","author":"Ouyang","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B239","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1086\/342259","article-title":"Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype.","volume":"71","author":"Paloneva","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"B240","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.expneurol.2006.01.018","article-title":"Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice.","volume":"199","author":"Pedersen","year":"2006","journal-title":"Exp. Neurol."},{"key":"B241","doi-asserted-by":"publisher","first-page":"3276","DOI":"10.1002\/jcb.23254","article-title":"alpha 7-type acetylcholine receptor localization and its modulation by nicotine and cholesterol in vascular endothelial cells.","volume":"112","author":"Pe\u00f1a","year":"2011","journal-title":"J. Cell Biochem."},{"key":"B242","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.15252\/embj.201796797","article-title":"Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.","volume":"36","author":"Pera","year":"2017","journal-title":"Embo J."},{"key":"B243","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1023\/a:1011603916962","article-title":"Brain membrane phospholipid alterations in Alzheimers disease.","volume":"26","author":"Pettegrew","year":"2001","journal-title":"Neurochem. Res."},{"key":"B244","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.plipres.2011.06.002","article-title":"Cholesterol metabolism in neurons and astrocytes.","volume":"50","author":"Pfrieger","year":"2011","journal-title":"Prog. Lipid Res."},{"key":"B245","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1046\/j.1471-4159.1999.0720230.x","article-title":"Beta-amyloid peptide interacts specifically with the carboxy-terminal domain of human apolipoprotein E: Relevance to Alzheimers disease.","volume":"72","author":"Pillot","year":"1999","journal-title":"J. Neurochem."},{"key":"B246","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.phrs.2018.03.012","article-title":"Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimers disease: A focus on human studies.","volume":"131","author":"Pistollato","year":"2018","journal-title":"Pharmacol. Res."},{"key":"B247","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/0005-2760(87)90295-5","article-title":"Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins.","volume":"917","author":"Pitas","year":"1987","journal-title":"Biochim. Biophys. Acta"},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-023-00671-y","article-title":"Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia.","volume":"18","author":"Poliakova","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"B249","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.bcp.2012.12.007","article-title":"Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimers disease.","volume":"86","author":"Popp","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"B250","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/mp.2012.15","article-title":"High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease.","volume":"17","author":"Pottier","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"B251","author":"Prince","year":"2015","journal-title":"World Alzheimer report 2015. The global impact of dementia. An analysis of prevalence, incidence, cost and trends."},{"key":"B252","doi-asserted-by":"publisher","first-page":"19777","DOI":"10.1074\/jbc.M300466200","article-title":"Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis.","volume":"278","author":"Puglielli","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B253","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1038\/ncb1001-905","article-title":"Acyl-coenzyme A: Cholesterol acyltransferase modulates the generation of the amyloid beta-peptide.","volume":"3","author":"Puglielli","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108572","article-title":"ApoE4 impairs neuron-astrocyte coupling of fatty acid metabolism.","volume":"34","author":"Qi","year":"2021","journal-title":"Cell Rep."},{"key":"B255","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1750-1326-2-12","article-title":"Tau phosphorylation by GSK-3\u03b2 promotes tangle-like filament morphology","volume":"2","author":"Rankin","year":"2007","journal-title":"Mol. Neurodegener"},{"key":"B256","doi-asserted-by":"publisher","first-page":"9611","DOI":"10.1523\/jneurosci.1400-19.2019","article-title":"ApoE4 alters ABCA1 membrane trafficking in astrocytes.","volume":"39","author":"Rawat","year":"2019","journal-title":"J. Neurosci."},{"key":"B257","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/0896-6273(93)90070-8","article-title":"Apolipoprotein E in sporadic Alzheimers disease: Allelic variation and receptor interactions.","volume":"11","author":"Rebeck","year":"1993","journal-title":"Neuron"},{"key":"B258","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.bbalip.2013.10.004","article-title":"Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies.","volume":"1841","author":"Record","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"B259","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1194\/jlr.E086173","article-title":"Extracellular vesicles: Lipids as key components of their biogenesis and functions.","volume":"59","author":"Record","year":"2018","journal-title":"J. Lipid Res."},{"key":"B260","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1146\/annurev.nutr.21.1.193","article-title":"Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: An adaptive metabolic system.","volume":"21","author":"Reddy","year":"2001","journal-title":"Annu. Rev. Nutr."},{"key":"B261","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14279-8","article-title":"Exceptionally low likelihood of Alzheimers dementia in APOE2 homozygotes from a 5,000-person neuropathological study.","volume":"11","author":"Reiman","year":"2020","journal-title":"Nat. Commun."},{"key":"B262","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1073\/pnas.2635903100","article-title":"Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimers dementia.","volume":"101","author":"Reiman","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B263","doi-asserted-by":"publisher","first-page":"8299","DOI":"10.1073\/pnas.0500579102","article-title":"Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism.","volume":"102","author":"Reiman","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B264","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1208\/s12248-017-0079-3","article-title":"Blood-brain barriers in obesity.","volume":"19","author":"Rhea","year":"2017","journal-title":"AAPS J."},{"key":"B265","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1161\/atvbaha.110.207449","article-title":"Prostaglandins and inflammation.","volume":"31","author":"Ricciotti","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B266","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1002\/hipo.20883","article-title":"Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease.","volume":"22","author":"Ricobaraza","year":"2012","journal-title":"Hippocampus"},{"key":"B267","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1016\/s0960-9822(01)00394-3","article-title":"Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts.","volume":"11","author":"Riddell","year":"2001","journal-title":"Curr. Biol."},{"key":"B268","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/ng1943","article-title":"The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.","volume":"39","author":"Rogaeva","year":"2007","journal-title":"Nat. Genet."},{"key":"B269","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.ijdevneu.2004.07.004","article-title":"New players in old amyloid precursor protein-processing pathways.","volume":"22","author":"Rossner","year":"2004","journal-title":"Int. J. Dev. Neurosci."},{"key":"B270","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20163892","article-title":"Ketogenic diet in Alzheimers disease.","volume":"20","author":"Rusek","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B271","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1172\/jci117407","article-title":"Apolipoprotein E associates with beta amyloid peptide of Alzheimers disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.","volume":"94","author":"Sanan","year":"1994","journal-title":"J. Clin. Invest."},{"key":"B272","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1212\/WNL.0b013e318228bf11","article-title":"A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease.","volume":"77","author":"Sano","year":"2011","journal-title":"Neurology"},{"key":"B273","doi-asserted-by":"publisher","first-page":"9796","DOI":"10.1523\/jneurosci.23-30-09796.2003","article-title":"Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.","volume":"23","author":"Sastre","year":"2003","journal-title":"J. Neurosci."},{"key":"B274","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/0163-7827(85)90011-6","article-title":"Lipids of nervous tissue: Composition and metabolism.","volume":"24","author":"Sastry","year":"1985","journal-title":"Prog. Lipid Res."},{"key":"B275","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1136\/jnnp.2004.053645","article-title":"APOE related alterations in cerebral activation even at college age.","volume":"76","author":"Scarmeas","year":"2005","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B276","doi-asserted-by":"publisher","first-page":"9649","DOI":"10.1073\/pnas.90.20.9649","article-title":"Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.","volume":"90","author":"Schmechel","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B277","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.neuint.2017.03.018","article-title":"Brain energy metabolism spurns fatty acids as fuel due to their inherent mitotoxicity and potential capacity to unleash neurodegeneration.","volume":"109","author":"Sch\u00f6nfeld","year":"2017","journal-title":"Neurochem. Int."},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-018-0110-3","article-title":"The role of statins in both cognitive impairment and protection against dementia: A tale of two mechanisms.","volume":"7","author":"Schultz","year":"2018","journal-title":"Transl. Neurodegener."},{"key":"B279","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.1101\/gad.850400","article-title":"Role of LXRs in control of lipogenesis.","volume":"14","author":"Schultz","year":"2000","journal-title":"Genes Dev."},{"key":"B280","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.tins.2020.12.002","article-title":"Blood-brain barrier dynamics to maintain brain homeostasis.","volume":"44","author":"Segarra","year":"2021","journal-title":"Trends Neurosci."},{"key":"B281","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/nrm.2017.16","article-title":"The mystery of membrane organization: Composition, regulation and roles of lipid rafts.","volume":"18","author":"Sezgin","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B282","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/bjc.2017.183","article-title":"Detection of phosphatidylserine-positive exosomes for the diagnosis of early-stage malignancies.","volume":"117","author":"Sharma","year":"2017","journal-title":"Br. J. Cancer"},{"key":"B283","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1002\/ana.23677","article-title":"Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease.","volume":"72","author":"Shi","year":"2012","journal-title":"Ann. Neurol."},{"key":"B284","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/282041","article-title":"Lipophagy: Connecting autophagy and lipid metabolism.","volume":"2012","author":"Singh","year":"2012","journal-title":"Int. J. Cell Biol."},{"key":"B285","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.exger.2010.09.015","article-title":"The lipid peroxidation products as possible markers of Alzheimers disease in blood.","volume":"46","author":"Skoumalov\u00e1","year":"2011","journal-title":"Exp. Gerontol."},{"key":"B286","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/0197-0186(95)00099-2","article-title":"Non-classical actions of cholinesterases: Role in cellular differentiation, tumorigenesis and Alzheimers disease.","volume":"28","author":"Small","year":"1996","journal-title":"Neurochem. Int."},{"key":"B287","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1001\/archneur.58.3.360","article-title":"Age-related memory decline: Current concepts and future directions.","volume":"58","author":"Small","year":"2001","journal-title":"Arch. Neurol."},{"key":"B288","doi-asserted-by":"publisher","first-page":"7181","DOI":"10.1073\/pnas.0400285101","article-title":"Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging.","volume":"101","author":"Small","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B289","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002266","article-title":"Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study.","volume":"14","author":"Snowden","year":"2017","journal-title":"PLoS Med."},{"key":"B290","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1111\/j.1471-4159.1992.tb10994.x","article-title":"Lipid composition in different regions of the brain in Alzheimers disease\/senile dementia of Alzheimers type.","volume":"59","author":"S\u00f6derberg","year":"1992","journal-title":"J. Neurochem."},{"key":"B291","doi-asserted-by":"publisher","first-page":"815","DOI":"10.3233\/jad-170248","article-title":"Relationships of dietary patterns, foods, and micro- and macronutrients with alzheimers disease and late-life cognitive disorders: A systematic review.","volume":"59","author":"Solfrizzi","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"B292","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101503","article-title":"Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimers disease: A meta-analysis of in vivo magnetic resonance spectroscopy studies.","volume":"72","author":"Song","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"B293","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1111\/j.1471-4159.1987.tb05619.x","article-title":"Reduced phosphoinositide concentrations in anterior temporal cortex of Alzheimer-diseased brains.","volume":"48","author":"Stokes","year":"1987","journal-title":"J. Neurochem."},{"key":"B294","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12089","article-title":"Characterization of brain-derived extracellular vesicle lipids in Alzheimers disease.","volume":"10","author":"Su","year":"2021","journal-title":"J. Extracell. Vesicles"},{"key":"B295","doi-asserted-by":"publisher","first-page":"30538","DOI":"10.1074\/jbc.M114.600833","article-title":"Amyloid-\u03b2 pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.","volume":"289","author":"Tai","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B296","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.bbamem.2018.11.013","article-title":"The role of membrane trafficking in the processing of amyloid precursor protein and production of amyloid peptides in Alzheimers disease.","volume":"1861","author":"Tan","year":"2019","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"B297","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/b978-0-12-800100-4.00003-9","article-title":"The role of short-chain fatty acids in health and disease.","volume":"121","author":"Tan","year":"2014","journal-title":"Adv. Immunol."},{"key":"B298","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1016\/s0002-9440(10)64788-8","article-title":"Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord.","volume":"157","author":"Tesseur","year":"2000","journal-title":"Am. J. Pathol."},{"key":"B299","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00150","article-title":"Glia maturation factor and mitochondrial uncoupling proteins 2 and 4 expression in the temporal cortex of Alzheimers disease brain.","volume":"9","author":"Thangavel","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"B300","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.72","article-title":"Activation of WNT signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe\/PSEN1DeltaE9 mouse model of Alzheimers disease.","volume":"27","author":"Toledo","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"B301","doi-asserted-by":"publisher","first-page":"5388","DOI":"10.1093\/hmg\/ddv262","article-title":"Phospholipid transfer protein (PLTP) deficiency accelerates memory dysfunction through altering amyloid precursor protein (APP) processing in a mouse model of Alzheimers disease.","volume":"24","author":"Tong","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"B302","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00010","article-title":"Neuronal lipid metabolism: Multiple pathways driving functional outcomes in health and disease.","volume":"11","author":"Tracey","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"B303","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.3233\/jad-2010-100939","article-title":"A multi-center randomized proof-of-concept clinical trial applying [18F]FDG-PET for evaluation of metabolic therapy with rosiglitazone XR in mild to moderate Alzheimers disease.","volume":"22","author":"Tzimopoulou","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"B304","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/s41582-018-0072-1","article-title":"TREM2 - a key player in microglial biology and Alzheimer disease.","volume":"14","author":"Ulland","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"B305","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1093\/advances\/nmz054","article-title":"The mediterranean, dietary approaches to stop hypertension (DASH), and mediterranean-DASH intervention for neurodegenerative delay (MIND) diets are associated with less cognitive decline and a lower risk of Alzheimers disease-a review.","volume":"10","author":"van den Brink","year":"2019","journal-title":"Adv. Nutr."},{"key":"B306","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.bbalip.2013.11.014","article-title":"MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond.","volume":"1841","author":"Vance","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"B307","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1046\/j.1471-4159.1994.62010329.x","article-title":"Evidence that the major membrane lipids, except cholesterol, are made in axons of cultured rat sympathetic neurons.","volume":"62","author":"Vance","year":"1994","journal-title":"J. Neurochem."},{"key":"B308","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/psc.573","article-title":"Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: Binding sites and implications for Alzheimers disease.","volume":"10","author":"Verdier","year":"2004","journal-title":"J. Pept. Sci."},{"key":"B309","doi-asserted-by":"publisher","DOI":"10.1101\/2023.09.05.556135","article-title":"Single-cell atlas of ABCA7 loss-of-function reveals impaired neuronal respiration via choline-dependent lipid imbalances.","author":"von Maydell","year":"2024","journal-title":"bioRxiv"},{"key":"B310","doi-asserted-by":"publisher","first-page":"40987","DOI":"10.1074\/jbc.M407963200","article-title":"ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.","volume":"279","author":"Wahrle","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B311","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-2-7","article-title":"Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms.","volume":"2","author":"Wahrle","year":"2007","journal-title":"Mol. Neurodegener."},{"key":"B312","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1006\/nbdi.2001.0470","article-title":"Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains.","volume":"9","author":"Wahrle","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"B313","doi-asserted-by":"publisher","first-page":"4702","DOI":"10.1007\/s12035-017-0663-7","article-title":"FGF21 attenuates high-fat diet-induced cognitive impairment via metabolic regulation and anti-inflammation of obese mice.","volume":"55","author":"Wang","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"B314","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/s41591-018-0004-z","article-title":"Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.","volume":"24","author":"Wang","year":"2018","journal-title":"Nat. Med."},{"key":"B315","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2102191118","article-title":"Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol.","volume":"118","author":"Wang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B316","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","article-title":"TREM2 lipid sensing sustains the microglial response in an Alzheimers disease model.","volume":"160","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"B317","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-015-0030-y","article-title":"Conditional inactivation of Akt three isoforms causes tau hyperphosphorylation in the brain.","volume":"10","author":"Wang","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"B318","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1007\/s11418-018-1257-z","article-title":"Neuroprotective effect of naturally occurring RXR agonists isolated from Sophora tonkinensis Gagnep. on amyloid-\u03b2-induced cytotoxicity in PC12 cells.","volume":"73","author":"Wang","year":"","journal-title":"J. Nat. Med."},{"key":"B319","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s11418-018-01277-1","article-title":"Anti-inflammatory effects of naturally occurring retinoid X receptor agonists isolated from Sophora tonkinensis Gagnep. via retinoid X receptor\/liver X receptor heterodimers.","volume":"73","author":"Wang","year":"","journal-title":"J. Nat. Med."},{"key":"B320","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1176\/appi.ajgp.13.11.950","article-title":"Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: A preliminary study.","volume":"13","author":"Watson","year":"2005","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"B321","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147360","article-title":"Surface Phosphatidylserine is responsible for the internalization on microvesicles derived from hypoxia-induced human bone marrow mesenchymal stem cells into human endothelial cells.","volume":"11","author":"Wei","year":"2016","journal-title":"PLoS One"},{"key":"B322","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.11.001","article-title":"2014 update of the Alzheimers disease neuroimaging initiative: A review of papers published since its inception.","volume":"11","author":"Weiner","year":"2015","journal-title":"Alzheimers Dement."},{"key":"B323","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt187","article-title":"Evidence for impaired amyloid \u03b2 clearance in Alzheimers disease.","volume":"5","author":"Wildsmith","year":"2013","journal-title":"Alzheimers Res. Ther."},{"key":"B324","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.jalz.2017.01.008","article-title":"Dysregulation of lipids in Alzheimers disease and their role as potential biomarkers.","volume":"13","author":"Wong","year":"2017","journal-title":"Alzheimers Dement."},{"key":"B325","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.neuint.2006.03.007","article-title":"Influence of cholesterol and lovastatin on alpha-form of secreted amyloid precursor protein and expression of alpha7 nicotinic receptor on astrocytes.","volume":"49","author":"Xiu","year":"2006","journal-title":"Neurochem. Int."},{"key":"B326","doi-asserted-by":"publisher","first-page":"4985","DOI":"10.1523\/jneurosci.5476-05.2006","article-title":"Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.","volume":"26","author":"Xu","year":"2006","journal-title":"J. Neurosci."},{"key":"B327","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-015-0056-1","article-title":"Deletion of aquaporin-4 in APP\/PS1 mice exacerbates brain A\u03b2 accumulation and memory deficits.","volume":"10","author":"Xu","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"B328","doi-asserted-by":"publisher","first-page":"17321","DOI":"10.1523\/jneurosci.1569-12.2012","article-title":"PPAR\u03b3\/RXR\u03b1-induced and CD36-mediated microglial amyloid-\u03b2 phagocytosis results in cognitive improvement in amyloid precursor protein\/presenilin 1 mice.","volume":"32","author":"Yamanaka","year":"2012","journal-title":"J. Neurosci."},{"key":"B329","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.neuron.2016.06.015","article-title":"TREM2 binds to apolipoproteins, including APOE and CLU\/APOJ, and thereby facilitates uptake of amyloid-beta by microglia.","volume":"91","author":"Yeh","year":"2016","journal-title":"Neuron"},{"key":"B330","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav9334","article-title":"Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.","volume":"363","author":"Yin","year":"2019","journal-title":"Science"},{"key":"B331","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/s0896-6273(00)00066-0","article-title":"Presenilin-mediated modulation of capacitative calcium entry.","volume":"27","author":"Yoo","year":"2000","journal-title":"Neuron"},{"key":"B332","doi-asserted-by":"publisher","first-page":"537","DOI":"10.5650\/jos.60.537","article-title":"Structures, biosynthesis, and functions of gangliosides\u2013an overview.","volume":"60","author":"Yu","year":"2011","journal-title":"J. Oleo Sci."},{"key":"B333","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/s00702-014-1294-z","article-title":"Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3xTg-AD mice.","volume":"122","author":"Yu","year":"2015","journal-title":"J. Neural Transm."},{"key":"B334","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1172\/jci27883","article-title":"Liver X receptors as integrators of metabolic and inflammatory signaling.","volume":"116","author":"Zelcer","year":"2006","journal-title":"J. Clin. Invest."},{"key":"B335","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-023-01918-9","article-title":"Identification of key lipid metabolism-related genes in Alzheimers disease.","volume":"22","author":"Zeng","year":"2023","journal-title":"Lipids Health Dis."},{"key":"B336","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s11010-015-2480-5","article-title":"PPAR-\u03b1 agonist regulates amyloid-\u03b2 generation via inhibiting BACE-1 activity in human neuroblastoma SH-SY5Y cells transfected with APPswe gene.","volume":"408","author":"Zhang","year":"2015","journal-title":"Mol. Cell Biochem."},{"key":"B337","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1471-4159.2011.07519.x","article-title":"Proteolytic processing of Alzheimers \u03b2-amyloid precursor protein.","volume":"120","author":"Zhang","year":"2012","journal-title":"J. Neurochem."},{"key":"B338","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1007\/s13238-014-0131-3","article-title":"Cholesterol metabolism and homeostasis in the brain.","volume":"6","author":"Zhang","year":"2015","journal-title":"Protein Cell"},{"key":"B339","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202102122","article-title":"mmBCFA C17iso ensures endoplasmic reticulum integrity for lipid droplet growth.","volume":"220","author":"Zhang","year":"2021","journal-title":"J. Cell Biol."},{"key":"B340","doi-asserted-by":"publisher","first-page":"330","DOI":"10.3945\/ajcn.115.124081","article-title":"Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: A dose-response meta-analysis of 21 cohort studies.","volume":"103","author":"Zhang","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"B341","doi-asserted-by":"publisher","first-page":"11929","DOI":"10.1523\/jneurosci.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex.","volume":"34","author":"Zhang","year":"2014","journal-title":"J. Neurosci."},{"key":"B342","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1093\/hmg\/ddx155","article-title":"APOE \u03b54\/\u03b54 diminishes neurotrophic function of human iPSC-derived astrocytes.","volume":"26","author":"Zhao","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"B343","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1038\/nn.4025","article-title":"Central role for PICALM in amyloid-\u03b2 blood-brain barrier transcytosis and clearance.","volume":"18","author":"Zhao","year":"2015","journal-title":"Nat. Neurosci."},{"key":"B344","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1007\/s12035-015-9544-0","article-title":"Pro-resolving lipid mediators improve neuronal survival and increase A\u03b242 phagocytosis.","volume":"53","author":"Zhu","year":"2016","journal-title":"Mol. Neurobiol."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2024.1430465\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T05:12:21Z","timestamp":1726031541000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2024.1430465\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,11]]},"references-count":344,"alternative-id":["10.3389\/fnins.2024.1430465"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2024.1430465","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,11]]},"article-number":"1430465"}}