{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T12:17:35Z","timestamp":1794313055907,"version":"4.9.0"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Record-breaking heat waves over the past 20\u2009years have led to a global increase in heat-related deaths, including heatstroke. Heat-related illnesses occur when the body cannot adapt to the elevated temperatures in the environment, leading to various symptoms. In severe situations, such as heatstroke, the body temperature can rise above 40\u00b0C, leading to significant injury to body systems, with particular susceptibility of the central nervous system (CNS). Neuroimaging studies conducted months or years after a heatstroke have revealed cellular damage in the cerebellum and other brain regions, including the hippocampus, midbrain, and thalamus, with the potential for long-term neurological complications in survivors of a heatstroke. This mini review aimed to describe the mechanisms and pathways underlying the development of brain injury induced by heatstroke and identify diagnostic imaging tools and biomarkers for injury to the CNS due to a heatstroke.<\/jats:p>","DOI":"10.3389\/fnins.2024.1437216","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T07:54:02Z","timestamp":1728546842000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":46,"title":["How can heatstroke damage the brain? A mini review"],"prefix":"10.3389","volume":"18","author":[{"given":"Kazuhiro","family":"Yoneda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanae","family":"Hosomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Togami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisatake","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Shimazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s002340050392","article-title":"Heat-stroke-induced cerebellar atrophy: clinical course, CT and MRI findings","volume":"39","author":"Albukrek","year":"1997","journal-title":"Neuroradiology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.3390\/biomedicines12071539","article-title":"Plasma neurofilament light chain: a potential biomarker for neurological dysfunction in myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"12","author":"Azcue","year":"2024","journal-title":"Biomedicines"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1097\/CCM.0000000000006170","article-title":"Management of heat-related illness and injury in the ICU: a concise definitive review","volume":"52","author":"Barletta","year":"2024","journal-title":"Crit. Care Med."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1097\/01.jnen.0000186924.88333.0d","article-title":"Brain damage after heat stroke","volume":"64","author":"Bazille","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref5","first-page":"1325","article-title":"Heat-related illness","volume":"83","author":"Becker","year":"2011","journal-title":"Am. Fam. Physician"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1111\/j.1749-6632.1997.tb51774.x","article-title":"Early and longtime modifications of temperature regulation after severe head injury. Prognostic implications","volume":"813","author":"Behr","year":"1997","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41572-021-00334-6","article-title":"Classic and exertional heatstroke","volume":"8","author":"Bouchama","year":"2022","journal-title":"Nat. Rev. Dis. 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Res."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"173","DOI":"10.7326\/0003-4819-129-3-199808010-00001","article-title":"Near-fatal heat stroke during the 1995 heat wave in Chicago","volume":"129","author":"Dematte","year":"1998","journal-title":"Ann. Intern. Med."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1097\/WNR.0000000000002042","article-title":"Heat stress induces IL-1\u03b2 and IL-18 overproduction via ROS-activated NLRP3 inflammasome: implication in neuroinflammation in mice with heat stroke","volume":"35","author":"Du","year":"2024","journal-title":"Neuroreport"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1056\/NEJMra1810762","article-title":"Heatstroke","volume":"380","author":"Epstein","year":"2019","journal-title":"N. Engl. J. 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Brain Res."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"R2095","DOI":"10.1152\/ajpregu.2000.279.6.R2095","article-title":"Heat-stress-induced hyperthermia alters CSF osmolality and composition in conscious rabbits","volume":"279","author":"Frosini","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1159\/000517681","article-title":"Veno-arterial extracorporeal membrane oxygenation for severe heatstroke with refractory hemodynamic failure","volume":"4","author":"Fujita","year":"2021","journal-title":"Case Rep. Acute Med."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1136\/jnnp-2018-320106","article-title":"Neurofilament light chain as a biomarker in neurological disorders","volume":"90","author":"Gaetani","year":"2019","journal-title":"J. Neurol. Neurosurg. 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Anesth."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/1742-6723.12990","article-title":"Review article: environmental heatstroke and long-term clinical neurological outcomes: a literature review of case reports and case series 2000\u20132016","volume":"31","author":"Lawton","year":"2019","journal-title":"Emerg. Med. Australas."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.radcr.2020.02.007","article-title":"Atypical brain imaging findings associated with heat stroke: a patient with rhabdomyolysis and acute kidney injury: a case report","volume":"15","author":"Lee","year":"2020","journal-title":"Radiol. Case Rep."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"E58","DOI":"10.3174\/ajnr.A1432","article-title":"Heat stroke: increased signal intensity in the bilateral cerebellar dentate nuclei and splenium on diffusion-weighted MR imaging","volume":"30","author":"Lee","year":"2009","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1002\/cphy.c140017","article-title":"Heat stroke","volume":"5","author":"Leon","year":"2015","journal-title":"Compr. Physiol."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1152\/japplphysiol.00301.2010","article-title":"Heat stroke: role of the systemic inflammatory response","volume":"109","author":"Leon","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"ref42","first-page":"1282","article-title":"The expression and clinical significance of neuron specific enolase and S100B protein in patients of severe heatstroke-induced brain injury","volume":"45","author":"Li","year":"2020","journal-title":"Med. J. Chin. Peoples Liberation Army"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s13760-014-0343-6","article-title":"Diffusion tensor imaging of the cerebellum in patients after heat stroke","volume":"115","author":"Li","year":"2015","journal-title":"Acta Neurol. Belg."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jneuroim.2018.01.014","article-title":"Expressions of chemokines and their receptors in the brain after heat stroke-induced cortical damage","volume":"318","author":"Lin","year":"2018","journal-title":"J. Neuroimmunol."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/S1875-9572(09)60065-6","article-title":"Human umbilical cord blood cells protect against hypothalamic apoptosis and systemic inflammation response during heatstroke in rats","volume":"50","author":"Liu","year":"2009","journal-title":"Pediatr. Neonatol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"946","DOI":"10.4085\/1062-6050-51.12.07","article-title":"Cooling effectiveness of a modified cold-water immersion method after exercise-induced hyperthermia","volume":"51","author":"Luhring","year":"2016","journal-title":"J. Athl. Train."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1080\/08998280.2008.11928446","article-title":"Symmetric bilateral caudate, hippocampal, cerebellar, and subcortical white matter MRI abnormalities in an adult patient with heat stroke","volume":"21","author":"Mahajan","year":"2008","journal-title":"Proc. (Bayl Univ Med Cent)"},{"key":"ref48","first-page":"397","article-title":"Heat stroke; a clinico-pathologic study of 125 fatal cases","volume":"99","author":"Malamud","year":"1946","journal-title":"Mil. Mil. Surg."},{"key":"ref49","first-page":"1372","article-title":"MR imaging of heat stroke: external capsule and thalamic T1 shortening and cerebellar injury","volume":"24","author":"McLaughlin","year":"2003","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/ams2.373","article-title":"Endogenous genetic risk factor for serious heatstroke: the thermolabile phenotype of carnitine palmitoyltransferase II variant","volume":"6","author":"Oda","year":"2019","journal-title":"Acute Med. Surg."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1001\/jamaneurol.2016.0039","article-title":"Time course and diagnostic accuracy of glial and neuronal blood biomarkers GFAP and UCH-L1 in a large cohort of trauma patients with and without mild traumatic brain injury","volume":"73","author":"Papa","year":"2016","journal-title":"JAMA Neurol."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1046\/j.1563-2571.2002.02016.x","article-title":"Antithrombin and near-fatal exertional heat stroke","volume":"29","author":"Pechlaner","year":"2002","journal-title":"Acta Med. Austriaca"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1159195","DOI":"10.3389\/fimmu.2023.1159195","article-title":"Endothelial glycocalyx injury is involved in heatstroke-associated coagulopathy and protected by N-acetylcysteine","volume":"14","author":"Peng","year":"2023","journal-title":"Front. Immunol."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1161\/01.STR.18.5.911","article-title":"S-100 protein and neuron-specific enolase in cerebrospinal fluid and serum: markers of cell damage in human central nervous system","volume":"18","author":"Persson","year":"1987","journal-title":"Stroke"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.crvi.2007.12.001","article-title":"Death toll exceeded 70,000 in Europe during the summer of 2003","volume":"331","author":"Robine","year":"2008","journal-title":"C. R. Biol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1136\/jnnp.71.4.448","article-title":"Brain temperature, body core temperature, and intracranial pressure in acute cerebral damage","volume":"71","author":"Rossi","year":"2001","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"186","DOI":"10.5811\/westjem.2020.11.49007","article-title":"Evidence-based heatstroke management in the emergency department","volume":"22","author":"Rublee","year":"2021","journal-title":"West. J. Emerg. Med."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"2542","DOI":"10.3390\/biomedicines10102542","article-title":"Heat-related illness in emergency and critical care: recommendations for recognition and management with medico-legal considerations","volume":"10","author":"Savioli","year":"2022","journal-title":"Biomedicines"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1113\/EP090142","article-title":"Biomarkers of heatstroke-induced organ injury and repair","volume":"107","author":"Schlader","year":"2022","journal-title":"Exp. Physiol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.tins.2020.12.002","article-title":"Blood-brain barrier dynamics to maintain brain homeostasis","volume":"44","author":"Segarra","year":"2021","journal-title":"Trends Neurosci."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1097\/00001756-199103000-00012","article-title":"Acute heat exposure causes cellular alteration in cerebral cortex of young rats","volume":"2","author":"Sharma","year":"1991","journal-title":"Neuroreport"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S0079-6123(06)62023-2","article-title":"Blood-cerebrospinal fluid barrier in hyperthermia","volume":"162","author":"Sharma","year":"2007","journal-title":"Prog. Brain Res."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"104511","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.104511","article-title":"Analysis of clinical symptoms and brain MRI of heat stroke: 2 case reports and a literature review","volume":"29","author":"Shimada","year":"2020","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.jsams.2023.09.011","article-title":"Neurobiomarker and body temperature responses to recreational marathon running","volume":"26","author":"Stacey","year":"2023","journal-title":"J. Sci. Med. Sport"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1007\/s00247-007-0612-0","article-title":"Bilateral hippocampal hyperintensities: a new finding in MR imaging of heat stroke","volume":"37","author":"Sudhakar","year":"2007","journal-title":"Pediatr. Radiol."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"e18285","DOI":"10.1016\/j.heliyon.2023.e18285","article-title":"Single-photon emission computed tomography (SPECT) predicted neurological prognosis in heat stroke: a case report","volume":"9","author":"Suzuki","year":"2023","journal-title":"Heliyon"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0720-048X(01)00467-3","article-title":"Gray-white matter discrimination\u2013a possible marker for brain damage in heat stroke?","volume":"43","author":"Szold","year":"2002","journal-title":"Eur. J. Radiol."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1089\/neu.2010.1323","article-title":"Attenuation of heat-induced hypothalamic ischemia, inflammation, and damage by hyperbaric oxygen in rats","volume":"38","author":"Tai","year":"2021","journal-title":"J. Neurotrauma"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1097\/TA.0b013e318220b957","article-title":"Early elevated HMGB1 level predicting the outcome in exertional heatstroke","volume":"71","author":"Tong","year":"2011","journal-title":"J. Trauma"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1097\/01.CCM.0000159193.42628.E8","article-title":"Resuscitation from experimental heatstroke by hyperbaric oxygen therapy","volume":"33","author":"Tsai","year":"2005","journal-title":"Crit. Care Med."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1136\/jnnp.69.3.403","article-title":"Downbeat nystagmus from heat stroke","volume":"69","author":"Van Stavern","year":"2000","journal-title":"J. Neurol. Neurosurg. 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Intensive Care Soc."},{"key":"ref74","first-page":"199","article-title":"The neurological and cognitive consequences of hyperthermia","volume-title":"Crit Care","author":"Walter","year":"2016"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"R1689","DOI":"10.1152\/ajpregu.00676.2004","article-title":"Blood-brain barrier integrity may be threatened by exercise in a warm environment","volume":"288","author":"Watson","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. 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