{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:35:29Z","timestamp":1792791329590,"version":"4.5.0"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Advanced computational models and simulations to unravel the complexities of brain function have known a growing interest in recent years in the field of neurosciences, driven by significant technological progress in computing platforms. Multicompartment models, which capture the detailed morphological and functional properties of neural circuits, represent a significant advancement in this area providing more biological coherence than single compartment modeling. These models serve as a cornerstone for exploring the neural basis of sensory processing, learning paradigms, adaptive behaviors, and neurological disorders. Yet, the high complexity of these models presents a challenge for their real-time implementation, which is essential for exploring alternative therapies for neurological disorders such as electroceutics that rely on biohybrid interaction. Here, we present an accessible, user-friendly, and real-time emulator for multicompartment Hodgkin-Huxley neurons on SoC FPGA. Our system enables real-time emulation of multicompartment neurons while emphasizing cost-efficiency, flexibility, and ease of use. We showcase an implementation utilizing a technology that remains underrepresented in the current literature for this specific application. We anticipate that our system will contribute to the enhancement of computation platforms by presenting an alternative architecture for multicompartment computation. Additionally, it constitutes a step toward developing neuromorphic-based neuroprostheses for bioelectrical therapeutics through an embedded real-time platform running at a similar timescale to biological networks.<\/jats:p>","DOI":"10.3389\/fnins.2024.1457774","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T01:15:37Z","timestamp":1731374137000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Real-time multicompartment Hodgkin-Huxley neuron emulation on SoC FPGA"],"prefix":"10.3389","volume":"18","author":[{"given":"Romain","family":"Beaubois","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9my","family":"Cheslet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiho","family":"Ikeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Branchereau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothee","family":"Levi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1109\/EMPDP.2019.8671560","article-title":"\u201cArbor\u2014a morphologically-detailed neural network simulation library for contemporary high-performance computing architectures,\u201d","volume-title":"2019 27th Euromicro International Conference on Parallel, Distributed and Network-Based Processing (PDP)","author":"Abi Akar","year":"2019"},{"key":"B2","doi-asserted-by":"publisher","first-page":"884046","DOI":"10.3389\/fninf.2022.884046","article-title":"Modernizing the neuron simulator for sustainability, portability, and performance","volume":"16","author":"Awile","year":"2022","journal-title":"Front. 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