{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:22:52Z","timestamp":1787026972447,"version":"build-2736575974"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background and aim<\/jats:title>\n                    <jats:p>This study aimed to develop a predictive model for early neurological deterioration (END) in branch atheromatous disease (BAD) affecting the lenticulostriate artery (LSA) territory using machine learning. Additionally, it aimed to explore the underlying mechanisms of END occurrence in this context.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of consecutive ischemic stroke patients with BAD in the LSA territory admitted to Dongyang People\u2019s Hospital from January 1, 2018, to September 30, 2023. Significant predictors were identified using LASSO regression, and nine machine learning algorithms were employed to construct models. The logistic regression model demonstrated superior performance and was selected for further analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 380 patients were included, with 268 in the training set and 112 in the validation set. Logistic regression identified stroke history, systolic pressure, conglomerated beads sign, middle cerebral artery (MCA) shape, and parent artery stenosis as significant predictors of END. The developed nomogram exhibited good discriminative ability and calibration. Additionally, the decision curve analysis indicated the practical clinical utility of the nomogram.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The novel nomogram incorporating systolic pressure, stroke history, conglomerated beads sign, parent artery stenosis, and MCA shape provides a practical tool for assessing the risk of early neurological deterioration in BAD affecting the LSA territory. This model enhances clinical decision-making and personalized treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2024.1496810","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T02:06:35Z","timestamp":1733882795000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["A machine learning-based predictive model for predicting early neurological deterioration in lenticulostriate atheromatous disease-related infarction"],"prefix":"10.3389","volume":"18","author":[{"given":"Zhuangzhuang","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s13311-016-0483-x","article-title":"Inflammation and stroke: an overview","volume":"13","author":"Anrather","year":"2016","journal-title":"Neurotherapeutics"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1111\/j.1755-5949.2011.00292.x","article-title":"Classifying ischemic stroke, from toast to Ciss","volume":"18","author":"Chen","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e168","DOI":"10.1016\/j.jstrokecerebrovasdis.2012.10.012","article-title":"Treatment outcomes of tissue plasminogen activator infusion for branch atheromatous disease","volume":"22","author":"Deguchi","year":"2013","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"701","DOI":"10.5551\/jat.RV22003","article-title":"Pathophysiology and optimal treatment of intracranial branch atheromatous disease","volume":"30","author":"Deguchi","year":"2023","journal-title":"J. Atheroscler. Thromb."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.21037\/qims-20-1291","article-title":"Geometrical characteristics associated with atherosclerotic disease in the basilar artery: a magnetic resonance vessel wall imaging study","volume":"11","author":"Deng","year":"2021","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s11906-005-0054-8","article-title":"Inflammation, blood pressure, and stroke: an opportunity to target primary prevention?","volume":"7","author":"Di Napoli","year":"2005","journal-title":"Curr. Hypertens. Rep."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/j.1524-6175.2005.04590.x","article-title":"Systemic inflammation, blood pressure, and stroke outcome","volume":"8","author":"Di Napoli","year":"2006","journal-title":"J. Clin. Hypertens."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"935150","DOI":"10.3389\/fneur.2022.935150","article-title":"Clinical scoring model based on age, Nihss, and stroke-history predicts outcome 3 months after acute ischemic stroke","volume":"13","author":"Ding","year":"2022","journal-title":"Front. Neurol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1111\/jcpt.13816","article-title":"The efficacy and safety of intravenous tirofiban in the treatment of acute ischemic stroke patients with early neurological deterioration","volume":"47","author":"Du","year":"2022","journal-title":"J. Clin. Pharm. Ther."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Executive summary of the third report of the National Cholesterol Education Program (Ncep) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III)","volume":"285","year":"2001","journal-title":"JAMA"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"16752","DOI":"10.1038\/s41598-022-21329-7","article-title":"Factors associated with two different stroke mechanisms in perforator infarctions regarding the shape of arteries","volume":"12","author":"Ha","year":"2022","journal-title":"Sci. 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Disord."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"553326","DOI":"10.3389\/fneur.2020.553326","article-title":"The length of an infarcted lesion along the perforating artery predicts neurological deterioration in single subcortical infarction without any relevant artery stenosis","volume":"11","author":"Jang","year":"2020","journal-title":"Front. Neurol."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1161\/STROKEAHA.114.007466","article-title":"Neuroimaging markers for early neurologic deterioration in single small subcortical infarction","volume":"46","author":"Jeong","year":"2015","journal-title":"Stroke"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2801","DOI":"10.1161\/STROKEAHA.120.030215","article-title":"Plaque distribution correlates with morphology of Lenticulostriate arteries in single subcortical infarctions","volume":"51","author":"Jiang","year":"2020","journal-title":"Stroke"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1161\/STROKEAHA.115.011320","article-title":"Relationship between collateral status, contrast transit, and contrast density in acute ischemic stroke","volume":"47","author":"Kawano","year":"2016","journal-title":"Stroke"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1111\/ijs.12497","article-title":"The shape of middle cerebral artery and plaque location: high-resolution MRI finding","volume":"10","author":"Kim","year":"2015","journal-title":"Int. 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Dis."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"100529","DOI":"10.1016\/j.bj.2022.03.014","article-title":"Evaluation of clinical relevance and underlying pathology for hemodynamic compromise in acute small subcortical infarction using Mri-based neuroimaging markers","volume":"46","author":"Pan","year":"2023","journal-title":"Biom. J."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"e2178","DOI":"10.1212\/WNL.0000000000010603","article-title":"Neurologic deterioration in patients with acute ischemic stroke or transient ischemic attack","volume":"95","author":"Park","year":"2020","journal-title":"Neurology"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1055\/s-0039-1694969","article-title":"Platelet indices and risk of death and cardiovascular events: results from a large population-based cohort study","volume":"119","author":"Patti","year":"2019","journal-title":"Thromb. Haemost."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1016\/S0895-4356(96)00236-3","article-title":"A simulation study of the number of events per variable in logistic regression analysis","volume":"49","author":"Peduzzi","year":"1996","journal-title":"J. Clin. Epidemiol."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1159\/000442577","article-title":"Branch atheromatous disease: a clinically meaningful, yet unproven concept","volume":"41","author":"Petrone","year":"2016","journal-title":"Cerebrovasc. Dis."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"e46","DOI":"10.1161\/STR.0000000000000211","article-title":"2018 guidelines for the early Management of Patients with Acute Ischemic Stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"49","author":"Powers","year":"2018","journal-title":"Stroke"},{"key":"ref43","first-page":"585","article-title":"Diagnosis and classification of diabetes mellitus: highlights from the American Diabetes Association","volume":"42","author":"Rayburn","year":"1997","journal-title":"J. Reprod. Med."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1159\/000531584","article-title":"Tortuosity and proximal-specific hemodynamics associated with plaque location in the carotid bulb stenosis","volume":"60","author":"Ren","year":"2023","journal-title":"J. Vasc. Res."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1159\/000439064","article-title":"Collateral circulation predicts the size of the infarct Core and the proportion of salvageable penumbra in Hyperacute ischemic stroke patients treated with intravenous thrombolysis","volume":"40","author":"Rusanen","year":"2015","journal-title":"Cerebrovasc. Dis."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1212\/WNL.0b013e318253d62f","article-title":"Conglomerated beads shape of lacunar infarcts on diffusion-weighted Mri: what does it suggest?","volume":"78","author":"Ryu","year":"2012","journal-title":"Neurology"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"e00694","DOI":"10.1002\/brb3.694","article-title":"Lipid and hyperglycemia factors in first-ever penetrating artery infarction, a comparison between different subtypes","volume":"7","author":"Sun","year":"2017","journal-title":"Brain Behav."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jns.2007.12.014","article-title":"32Neurological deterioration in small vessel disease may be associated with increase of infarct volume","volume":"269","author":"Terasawa","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1161\/STROKEAHA.116.013124","article-title":"Smoking-thrombolysis relationship depends on ischemic stroke subtype","volume":"47","author":"Tong","year":"2016","journal-title":"Stroke"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1161\/01.STR.31.10.2325","article-title":"Proinflammatory cytokines and early neurological worsening in ischemic stroke","volume":"31","author":"Vila","year":"2000","journal-title":"Stroke"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1111\/j.1747-4949.2011.00584.x","article-title":"The China National Stroke Registry for patients with acute cerebrovascular events: design, rationale, and baseline patient characteristics","volume":"6","author":"Wang","year":"2011","journal-title":"Int. J. Stroke"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.atherosclerosis.2019.06.907","article-title":"Culprit intracranial plaque without substantial stenosis in acute ischemic stroke on vessel wall Mri: a systematic review","volume":"287","author":"Wang","year":"2019","journal-title":"Atherosclerosis"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1097\/00004872-200311000-00002","article-title":"World Health Organization (who)\/International Society of Hypertension (Ish) statement on management of hypertension","volume":"21","author":"Whitworth","year":"2003","journal-title":"J. Hypertens."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"581","DOI":"10.3389\/fneur.2020.00581","article-title":"Efficacy and safety of intravenous thrombolysis on acute branch atheromatous disease: a retrospective case-control study","volume":"11","author":"Wu","year":"2020","journal-title":"Front. 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Neurol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1186\/s12883-023-03351-y","article-title":"The \"island sign\" on diffusion-weighted imaging predicts early neurological deterioration in penetrating artery territory infarctions: a retrospective study","volume":"23","author":"Yang","year":"","journal-title":"BMC Neurol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.2169\/internalmedicine.54.4442","article-title":"The infarct shape predicts progressive motor deficits in patients with acute lacunae-sized infarctions in the perforating arterial territory","volume":"54","author":"Yu","year":"2015","journal-title":"Intern. 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