{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:50:02Z","timestamp":1794271802845,"version":"4.9.0"},"reference-count":174,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Olfactory dysfunction has emerged as a hallmark feature shared among several neurological conditions, including both neurodevelopmental and neurodegenerative disorders. While diseases of both categories have been extensively studied for decades, their association with olfaction has only recently gained attention. Olfactory deficits often manifest already during prodromal stages of these diseases, yet it remains unclear whether common pathophysiological changes along olfactory pathways cause such impairments. Here we probe into the intricate relationship between olfactory dysfunction and neurodegenerative and neurodevelopmental disorders, shedding light on their commonalities and underlying mechanisms. We begin by providing a brief overview of the olfactory circuit and its connections to higher-associated brain areas. Additionally, we discuss olfactory deficits in these disorders, focusing on potential common mechanisms that may contribute to olfactory dysfunction across both types of disorders. We further debate whether olfactory deficits contribute to the disease propagation or are simply an epiphenomenon. We conclude by emphasizing the significance of olfactory function as a potential pre-clinical diagnostic tool to identify individuals with neurological disorders that offers the opportunity for preventive intervention before other symptoms manifest.<\/jats:p>","DOI":"10.3389\/fnins.2024.1502779","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T09:06:36Z","timestamp":1730279196000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Beyond anosmia: olfactory dysfunction as a common denominator in neurodegenerative and neurodevelopmental disorders"],"prefix":"10.3389","volume":"18","author":[{"given":"Yu-Nan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna Katharina","family":"Kostka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1093\/brain\/awaa035","article-title":"Impaired theta phase coupling underlies frontotemporal dysconnectivity in schizophrenia","volume":"143","author":"Adams","year":"2020","journal-title":"Brain"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1002\/cne.901370404","article-title":"Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb","volume":"137","author":"Altman","year":"1969","journal-title":"J. Comp. Neurol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e75745","DOI":"10.1371\/journal.pone.0075745","article-title":"Amyloid Beta inhibits olfactory bulb activity and the ability to smell","volume":"8","author":"Alvarado-Mart\u00ednez","year":"2013","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1002\/ana.21910","article-title":"Olfactory epithelium amyloid-\u03b2 and paired helical filament-tau pathology in Alzheimer disease","volume":"67","author":"Arnold","year":"2010","journal-title":"Ann. Neurol."},{"key":"ref5","first-page":"265","article-title":"Olfactory tau pathology in Alzheimer disease and mild cognitive impairment","volume":"25","author":"Attems","year":"2006","journal-title":"Clin. Neuropathol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1159\/000381619","article-title":"Olfaction and aging: a Mini-review","volume":"61","author":"Attems","year":"2015","journal-title":"Gerontology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/S0140-6736(10)61349-9","article-title":"Alzheimer\u2019s disease","volume":"377","author":"Ballard","year":"2011","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"3966","DOI":"10.1523\/JNEUROSCI.5625-07.2008","article-title":"The distinct temporal origins of olfactory bulb interneuron subtypes","volume":"28","author":"Batista-Brito","year":"2008","journal-title":"J. Neurosci."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"10411","DOI":"10.1523\/JNEUROSCI.23-32-10411.2003","article-title":"Electrophysiological differentiation of new neurons in the olfactory bulb","volume":"23","author":"Belluzzi","year":"2003","journal-title":"J. Neurosci."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.biopsych.2007.04.019","article-title":"Olfaction and taste processing in autism","volume":"62","author":"Bennetto","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.2307\/1131734","article-title":"Intact and impaired memory functions in autism","volume":"67","author":"Bennetto","year":"1996","journal-title":"Child Dev."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jns.2011.06.020","article-title":"Motor and non-motor correlates of olfactory dysfunction in Parkinson\u2019s disease","volume":"310","author":"Berendse","year":"2011","journal-title":"J. Neurol. Sci."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"8358","DOI":"10.1523\/JNEUROSCI.1199-07.2007","article-title":"Olfactory bulb gamma oscillations are enhanced with task demands","volume":"27","author":"Beshel","year":"2007","journal-title":"J. Neurosci."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"45508","DOI":"10.1038\/srep45508","article-title":"Organization of prefrontal network activity by respiration-related oscillations","volume":"7","author":"Biskamp","year":"2017","journal-title":"Sci. Rep."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.brainres.2010.06.003","article-title":"Gray and white matter reduction in hyposmic subjects \u2014 a voxel-based morphometry study","volume":"1347","author":"Bitter","year":"2010","journal-title":"Brain Res."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1086\/321969","article-title":"Schizophrenia and affective disorders\u2014Cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family","volume":"69","author":"Blackwood","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1523\/JNEUROSCI.4342-12.2013","article-title":"Distinct modes of dopamine and GABA release in a dual transmitter neuron","volume":"33","author":"Borisovska","year":"2013","journal-title":"J. Neurosci."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol. (Berl.)"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2814","DOI":"10.1093\/brain\/awv236","article-title":"The preclinical phase of the pathological process underlying sporadic Alzheimer\u2019s disease","volume":"138","author":"Braak","year":"2015","journal-title":"Brain"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/s0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"12768","DOI":"10.1523\/JNEUROSCI.3355-09.2009","article-title":"Understanding the role of DISC1 in psychiatric disease and during Normal development","volume":"29","author":"Brandon","year":"2009","journal-title":"J. Neurosci."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00441-020-03365-9","article-title":"Extrinsic neuromodulation in the rodent olfactory bulb","volume":"383","author":"Brunert","year":"2021","journal-title":"Cell Tissue Res."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/ncomms2013","article-title":"A\u03b2 alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo","volume":"3","author":"Cao","year":"2012","journal-title":"Nat. Commun."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"e103038","DOI":"10.1371\/journal.pone.0103038","article-title":"Autism and sensory processing disorders: shared White matter disruption in sensory pathways but divergent connectivity in social-emotional pathways","volume":"9","author":"Chang","year":"2014","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.neures.2015.04.006","article-title":"Characterization of in utero valproic acid mouse model of autism by local field potential in the hippocampus and the olfactory bulb","volume":"98","author":"Cheaha","year":"2015","journal-title":"Neurosci. Res."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13024-021-00434-7","article-title":"Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models","volume":"16","author":"Chen","year":"","journal-title":"Mol. Neurodegener."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"4353","DOI":"10.1016\/j.cub.2023.08.072","article-title":"Olfactory bulb activity shapes the development of entorhinal-hippocampal coupling and associated cognitive abilities","volume":"33","author":"Chen","year":"2023","journal-title":"Curr. Biol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/s41531-021-00259-7","article-title":"\u03b1-Synuclein aggregation in the olfactory bulb induces olfactory deficits by perturbing granule cells and granular\u2013mitral synaptic transmission","volume":"7","author":"Chen","year":"","journal-title":"Npj Park. Dis."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.ejrad.2013.11.024","article-title":"Imaging of olfactory bulb and gray matter volumes in brain areas associated with olfactory function in patients with Parkinson\u2019s disease and multiple system atrophy","volume":"83","author":"Chen","year":"2014","journal-title":"Eur. J. Radiol."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.tins.2020.10.017","article-title":"Prefrontal cortex development in health and disease: lessons from rodents and humans","volume":"44","author":"Chini","year":"2021","journal-title":"Trends Neurosci."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.neuron.2019.09.042","article-title":"Resolving and rescuing developmental Miswiring in a mouse model of cognitive impairment","volume":"105","author":"Chini","year":"2020","journal-title":"Neuron"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/sj.mp.4002106","article-title":"The DISC locus in psychiatric illness","volume":"13","author":"Chubb","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.schres.2005.07.028","article-title":"Olfactory deficits, cognition and negative symptoms in early onset psychosis","volume":"80","author":"Corcoran","year":"2005","journal-title":"Schizophr. Res."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.1007\/s10803-020-04376-9","article-title":"Olfactory dysfunction in neurodevelopmental disorders: a Meta-analytic review of autism Spectrum disorders, attention deficit\/hyperactivity disorder and obsessive-compulsive disorder","volume":"50","author":"Crow","year":"2020","journal-title":"J. Autism Dev. Disord."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"101416","DOI":"10.1016\/j.arr.2021.101416","article-title":"Olfactory dysfunction in aging and neurodegenerative diseases","volume":"70","author":"Dan","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1212\/CPJ.0000000000000285","article-title":"Parkinson disease and cognitive impairment","volume":"6","author":"Davis","year":"2016","journal-title":"Neurol. Clin. Pract."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1016\/j.neurobiolaging.2008.09.008","article-title":"Olfactory identification deficits and MCI in a multi-ethnic elderly community sample","volume":"31","author":"Devanand","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"4809","DOI":"10.1038\/s41467-024-48462-3","article-title":"Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging","volume":"15","author":"Diez","year":"2024","journal-title":"Nat. Commun."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"e700","DOI":"10.1212\/WNL.0000000000006919","article-title":"Impaired olfaction is associated with cognitive decline and neurodegeneration in the brain","volume":"92","author":"Dintica","year":"2019","journal-title":"Neurology"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.nbd.2011.10.026","article-title":"Olfaction in Parkinson\u2019s disease and related disorders","volume":"46","author":"Doty","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/S1474-4422(17)30123-0","article-title":"Olfactory dysfunction in neurodegenerative diseases: is there a common pathological substrate?","volume":"16","author":"Doty","year":"2017","journal-title":"Lancet Neurol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1212\/wnl.38.8.1237","article-title":"Olfactory dysfunction in parkinsonism: a general deficit unrelated to neurologic signs, disease stage, or disease duration","volume":"38","author":"Doty","year":"1988","journal-title":"Neurology"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1288\/00005537-198402000-00004","article-title":"University of Pennsylvania Smell Identification Test: a rapid quantitative olfactory function test for the clinic","volume":"94","author":"Doty","year":"1984","journal-title":"Laryngoscope"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"ENEURO.0046-18.2018","DOI":"10.1523\/ENEURO.0046-18.2018","article-title":"Behavioral phenotyping of an improved mouse model of Phelan\u2013McDermid syndrome with a complete deletion of the Shank3 gene","volume":"5","author":"Drapeau","year":"2018","journal-title":"eneuro"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"136974","DOI":"10.1016\/j.neulet.2022.136974","article-title":"Maternal immune activation induces autism-like behavior and reduces brain-derived neurotrophic factor levels in the hippocampus and offspring cortex of C57BL\/6 mice","volume":"793","author":"Dutra","year":"2023","journal-title":"Neurosci. Lett."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1007\/s12035-021-02620-6","article-title":"Adult neural stem cell migration is impaired in a mouse model of Alzheimer\u2019s disease","volume":"59","author":"Esteve","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"14825","DOI":"10.1523\/JNEUROSCI.1611-13.2013","article-title":"The pattern of cortical dysfunction in a mouse model of a schizophrenia-related microdeletion","volume":"33","author":"F\u00e9nelon","year":"2013","journal-title":"J. Neurosci."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1002\/ana.410260403","article-title":"Midbrain dopaminergic cell loss in parkinson\u2019s disease: computer visualization","volume":"26","author":"German","year":"1989","journal-title":"Ann. Neurol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.nbd.2012.06.020","article-title":"Cholinergic denervation exacerbates amyloid pathology and induces hippocampal atrophy in Tg2576 mice","volume":"48","author":"Gil-Bea","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e2406928121","DOI":"10.1073\/pnas.2406928121","article-title":"Embryonic exposure to environmental factors drives transmitter switching in the neonatal mouse cortex causing autistic-like adult behavior","volume":"121","author":"Godavarthi","year":"2024","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1126\/science.1132814","article-title":"A century of Alzheimer\u2019s disease","volume":"314","author":"Goedert","year":"2006","journal-title":"Science"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1152\/jn.01075.2009","article-title":"Directional coupling from the olfactory bulb to the Hippocampus during a go\/no-go odor discrimination task","volume":"103","author":"Gour\u00e9vitch","year":"2010","journal-title":"J. Neurophysiol."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"e2006994","DOI":"10.1371\/journal.pbio.2006994","article-title":"Coordinated electrical activity in the olfactory bulb gates the oscillatory entrainment of entorhinal networks in neonatal mice","volume":"17","author":"Gretenkord","year":"2019","journal-title":"PLoS Biol."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/s41380-018-0231-1","article-title":"Memory and cognition in schizophrenia","volume":"24","author":"Guo","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.parkreldis.2008.12.005","article-title":"Prevalence of smell loss in Parkinson\u2019s disease \u2013 a multicenter study","volume":"15","author":"Haehner","year":"2009","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1002\/mds.21413","article-title":"Olfactory loss may be a first sign of idiopathic Parkinson\u2019s disease","volume":"22","author":"Haehner","year":"2007","journal-title":"Mov. Disord."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s00415-018-9135-x","article-title":"Incidence of Parkinson\u2019s disease in a large patient cohort with idiopathic smell and taste loss","volume":"266","author":"Haehner","year":"2019","journal-title":"J. Neurol."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1002\/cne.20424","article-title":"In vivo and in vitro neurogenesis in human olfactory epithelium","volume":"483","author":"Hahn","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"4265","DOI":"10.1093\/cercor\/bhw274","article-title":"From shortage to surge: a developmental switch in hippocampal-prefrontal coupling in a gene-environment model of neuropsychiatric disorders","volume":"26","author":"Hartung","year":"2016","journal-title":"Cereb. Cortex N. Y. N"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/nm.4443","article-title":"Amyloid-\u03b2 plaques enhance Alzheimer\u2019s brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation","volume":"24","author":"He","year":"2018","journal-title":"Nat. Med."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"108316","DOI":"10.1016\/j.biopsycho.2022.108316","article-title":"Recent insights into respiratory modulation of brain activity offer new perspectives on cognition and emotion","volume":"170","author":"Heck","year":"2022","journal-title":"Biol. Psychol."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s00401-015-1451-y","article-title":"A new dopaminergic nigro-olfactory projection","volume":"130","author":"H\u00f6glinger","year":"2015","journal-title":"Acta Neuropathol. (Berl.)"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1152\/jn.1999.82.2.1082","article-title":"Dopamine depresses synaptic inputs into the olfactory bulb","volume":"82","author":"Hsia","year":"1999","journal-title":"J. Neurophysiol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13229-019-0257-5","article-title":"Haploinsufficiency of autism causative gene Tbr1 impairs olfactory discrimination and neuronal activation of the olfactory system in mice","volume":"10","author":"Huang","year":"2019","journal-title":"Mol. Autism."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1002\/mds.10713","article-title":"A 100% increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson\u2019s disease","volume":"19","author":"Huisman","year":"2004","journal-title":"Mov. Disord. Off. J. Mov. Disord. Soc."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/chemse\/22.1.39","article-title":"\u201cSniffin\u201d sticks\u2019: olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold","volume":"22","author":"Hummel","year":"1997","journal-title":"Chem. Senses"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"7970","DOI":"10.1523\/JNEUROSCI.0154-12.2012","article-title":"Parallel mitral and tufted cell pathways route distinct odor information to different targets in the olfactory cortex","volume":"32","author":"Igarashi","year":"2012","journal-title":"J. Neurosci."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/nature13162","article-title":"Coordination of entorhinal\u2013hippocampal ensemble activity during associative learning","volume":"510","author":"Igarashi","year":"2014","journal-title":"Nature"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.semcdb.2014.07.012","article-title":"Construction of functional neuronal circuitry in the olfactory bulb","volume":"35","author":"Imai","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"16422","DOI":"10.1038\/s41598-021-95968-7","article-title":"Acquired olfactory loss alters functional connectivity and morphology","volume":"11","author":"Iravani","year":"2021","journal-title":"Sci. Rep."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"445","DOI":"10.31887\/DCNS.2013.15.4\/hjahn","article-title":"Memory loss in Alzheimer\u2019s disease","volume":"15","author":"Jahn","year":"2013","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1093\/schbul\/sbx107","article-title":"Olfactory functioning in first-episode psychosis","volume":"44","author":"Kamath","year":"2018","journal-title":"Schizophr. Bull."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"113122","DOI":"10.1016\/j.celrep.2023.113122","article-title":"Dopaminergic neurons dynamically update sensory values during olfactory maneuver","volume":"42","author":"Kato","year":"2023","journal-title":"Cell Rep."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1093\/ijnp\/pyx045","article-title":"Disrupted olfactory integration in schizophrenia: functional connectivity study","volume":"20","author":"Kiparizoska","year":"2017","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1093\/chemse\/bjy051","article-title":"Impaired odor perception in autism Spectrum disorder is associated with decreased activity in olfactory cortex","volume":"43","author":"Koehler","year":"2018","journal-title":"Chem. Senses"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"700968","DOI":"10.3389\/fncir.2021.700968","article-title":"Dopaminergic dysregulation in syndromic autism Spectrum disorders: insights from genetic mouse models","volume":"15","author":"Kosillo","year":"2021","journal-title":"Front. Neural Circuits"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"3605","DOI":"10.1113\/JP284401","article-title":"Olfactory-driven beta band entrainment of limbic circuitry during neonatal development","volume":"601","author":"Kostka","year":"2023","journal-title":"J. Physiol."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1113\/JP283896","article-title":"Layer-specific impairment in the developing lateral entorhinal cortex of immune-challenged Disc1+\/\u2212 mice","volume":"601","author":"Kringel","year":"2023","journal-title":"J. Physiol."},{"key":"ref79","doi-asserted-by":"publisher","first-page":"14430","DOI":"10.1523\/JNEUROSCI.5366-13.2014","article-title":"Adult neurogenesis restores dopaminergic neuronal loss in the olfactory bulb","volume":"34","author":"Lazarini","year":"2014","journal-title":"J. Neurosci."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1002\/mds.25829","article-title":"Olfactory-related cortical atrophy is associated with olfactory dysfunction in Parkinson\u2019s disease","volume":"29","author":"Lee","year":"2014","journal-title":"Mov. Disord. Off. J. Mov. Disord. Soc."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1038\/nn.4303","article-title":"Spatially segregated feedforward and feedback neurons support differential odor processing in the lateral entorhinal cortex","volume":"19","author":"Leitner","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.neuron.2013.07.025","article-title":"Odor discrimination requires proper olfactory fast oscillations in awake mice","volume":"80","author":"Lepousez","year":"2013","journal-title":"Neuron"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3389\/fnagi.2019.00002","article-title":"Impairment of Dendrodendritic inhibition in the olfactory bulb of APP\/PS1 mice","volume":"11","author":"Li","year":"","journal-title":"Front. Aging Neurosci."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.brainresbull.2019.03.006","article-title":"Olfactory deficit is associated with mitral cell dysfunction in the olfactory bulb of P301S tau transgenic mice","volume":"148","author":"Li","year":"","journal-title":"Brain Res. Bull."},{"key":"ref85","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nn.4517","article-title":"A distinct entorhinal cortex to hippocampal CA1 direct circuit for olfactory associative learning","volume":"20","author":"Li","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.conb.2014.05.010","article-title":"Functional neuromodulation of chemosensation in vertebrates","volume":"29","author":"Linster","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref87","doi-asserted-by":"publisher","first-page":"3369","DOI":"10.1038\/s41467-019-11354-y","article-title":"Target specific functions of EPL interneurons in olfactory circuits","volume":"10","author":"Liu","year":"2019","journal-title":"Nat. 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Neurosci."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.neuron.2014.01.007","article-title":"Odor processing by adult-born neurons","volume":"81","author":"Livneh","year":"2014","journal-title":"Neuron"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"a018945","DOI":"10.1101\/cshperspect.a018945","article-title":"Adult olfactory bulb neurogenesis","volume":"8","author":"Lledo","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref92","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1038\/s41390-022-02239-w","article-title":"Maternal immune activation alters fetal and neonatal microglia phenotype and disrupts neurogenesis in mice","volume":"93","author":"Loayza","year":"2023","journal-title":"Pediatr. Res."},{"key":"ref93","doi-asserted-by":"publisher","first-page":"338","DOI":"10.3390\/brainsci9120338","article-title":"Functional connectivity between the resting-state olfactory network and the Hippocampus in Alzheimer\u2019s disease","volume":"9","author":"Lu","year":"","journal-title":"Brain Sci."},{"key":"ref94","doi-asserted-by":"publisher","first-page":"e01296","DOI":"10.1002\/brb3.1296","article-title":"Disruptions of the olfactory and default mode networks in Alzheimer\u2019s disease","volume":"9","author":"Lu","year":"","journal-title":"Brain Behav."},{"key":"ref95","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/j.cell.2008.12.044","article-title":"Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3\u03b2\/\u03b2-catenin signaling","volume":"136","author":"Mao","year":"2009","journal-title":"Cell"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1523\/JNEUROSCI.1526-22.2022","article-title":"\u03b1-Synuclein pathology and reduced neurogenesis in the olfactory system affect olfaction in a mouse model of Parkinson\u2019s disease","volume":"43","author":"Martin-Lopez","year":"2023","journal-title":"J. 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DC"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/sj.mp.4000446","article-title":"Alpha synuclein is present in Lewy bodies in sporadic Parkinson\u2019s disease","volume":"3","author":"Mezey","year":"1998","journal-title":"Mol. Psychiatry"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1007\/s11064-023-04097-2","article-title":"Shank3 deficiency results in a reduction in GABAergic postsynaptic puncta in the olfactory brain areas","volume":"49","author":"Mihalj","year":"2024","journal-title":"Neurochem. Res."},{"key":"ref750","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/S0893-133X(99)00019-6","article-title":"Olfactory dysfunction in schizophrenia: a qualitative and quantitative review","volume":"21","author":"Moberg","year":"1999","journal-title":"Am. 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Hear."},{"key":"ref105","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41582-018-0097-5","article-title":"Olfactory and other sensory impairments in Alzheimer disease","volume":"15","author":"Murphy","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref106","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1097\/00001756-199604260-00019","article-title":"Neurogenesis in adult human","volume":"7","author":"Murrell","year":"1996","journal-title":"Neuroreport"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s11682-011-9129-0","article-title":"Olfactory sulcal depth and olfactory bulb volume in patients with schizophrenia: an MRI study","volume":"5","author":"Nguyen","year":"2011","journal-title":"Brain Imaging Behav."},{"key":"ref108","doi-asserted-by":"publisher","first-page":"279","DOI":"10.3109\/10673229.2010.511060","article-title":"Olfactory dysfunction in schizophrenia: a review of neuroanatomy and psychophysiological measurements","volume":"18","author":"Nguyen","year":"2010","journal-title":"Harv. Rev. Psychiatry"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"14727","DOI":"10.1038\/ncomms14727","article-title":"Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer\u2019s disease","volume":"8","author":"Nobili","year":"2017","journal-title":"Nat. Commun."},{"key":"ref110","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1177\/1073858418791128","article-title":"Amyloid plaques of Alzheimer\u2019s disease as hotspots of glutamatergic activity","volume":"25","author":"Ovsepian","year":"2019","journal-title":"Neurosci. Rev. J. Bringing Neurobiol. Neurol. 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Neurosci."},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2017.00007","article-title":"Dopaminergic Neurones in the Main olfactory bulb: An overview from an electrophysiological perspective","volume":"11","author":"Pignatelli","year":"2017","journal-title":"Front. Neuroanat."},{"key":"ref117","doi-asserted-by":"publisher","first-page":"e09849","DOI":"10.7554\/eLife.09849","article-title":"Rhythmic coordination of hippocampal neurons during associative memory processing","volume":"5","author":"Rangel","year":"2016","journal-title":"eLife"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1084\/jem.20160368","article-title":"Widespread transneuronal propagation of \u03b1-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson\u2019s disease","volume":"213","author":"Rey","year":"2016","journal-title":"J. Exp. Med."},{"key":"ref119","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1037\/0033-2909.105.3.352","article-title":"Cognition and olfaction: a review","volume":"105","author":"Richardson","year":"1989","journal-title":"Psychol. Bull."},{"key":"ref120","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1038\/s41380-018-0025-5","article-title":"Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling","volume":"24","author":"Richter","year":"2019","journal-title":"Mol. 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Res."},{"key":"ref127","doi-asserted-by":"publisher","first-page":"4571","DOI":"10.1038\/s41467-022-32230-2","article-title":"Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice","volume":"13","author":"Schepanski","year":"2022","journal-title":"Nat. Commun."},{"key":"ref128","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1038\/sj.mp.4001574","article-title":"Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment","volume":"9","author":"Schurov","year":"2004","journal-title":"Mol. 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Sci."},{"key":"ref135","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2010\/108190","article-title":"Selective vulnerability of neurons in layer II of the entorhinal cortex during aging and Alzheimer\u2019s disease","volume":"2010","author":"Stranahan","year":"2010","journal-title":"Neural Plast."},{"key":"ref136","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/0197-4580(92)90074-8","article-title":"Olfactory bulb lesions in Alzheimer\u2019s disease","volume":"13","author":"Struble","year":"1992","journal-title":"Neurobiol. 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Alzheimers Dis."},{"key":"ref140","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.neurobiolaging.2007.08.001","article-title":"Reduced olfactory bulb and tract volume in early Alzheimer\u2019s disease\u2014a MRI study","volume":"30","author":"Thomann","year":"","journal-title":"Neurobiol. Aging"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.dcn.2017.04.010","article-title":"The impact of atypical sensory processing on social impairments in autism spectrum disorder","volume":"29","author":"Thye","year":"2018","journal-title":"Dev. Cogn. Neurosci."},{"key":"ref142","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.bbr.2006.04.025","article-title":"Olfactory discrimination deficits in mice lacking the dopamine transporter or the D2 dopamine receptor","volume":"172","author":"Tillerson","year":"2006","journal-title":"Behav. 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Sci."},{"key":"ref149","doi-asserted-by":"publisher","first-page":"744597","DOI":"10.3389\/fnmol.2021.744597","article-title":"Dysregulation of neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in autism Spectrum disorder","volume":"14","author":"Vall\u00e9s","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"ref150","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.neuron.2020.07.033","article-title":"Transient and persistent representations of odor value in prefrontal cortex","volume":"108","author":"Wang","year":"2020","journal-title":"Neuron"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"677","DOI":"10.3174\/ajnr.A2350","article-title":"Association of olfactory bulb volume and olfactory sulcus depth with olfactory function in patients with Parkinson disease","volume":"32","author":"Wang","year":"2011","journal-title":"AJNR Am. J. 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Alzheimers Dis."},{"key":"ref161","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.expneurol.2014.12.008","article-title":"Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of A\u03b2PP metabolites in the Tg2576 mouse model of Alzheimer\u2019s disease","volume":"264","author":"Xu","year":"2015","journal-title":"Exp. Neurol."},{"key":"ref162","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/nm0602-600","article-title":"Dopamine-dependent neurotoxicity of \u03b1-synuclein: a mechanism for selective neurodegeneration in Parkinson disease","volume":"8","author":"Xu","year":"2002","journal-title":"Nat. Med."},{"key":"ref163","doi-asserted-by":"publisher","first-page":"6810","DOI":"10.1038\/s41467-021-27114-w","article-title":"Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice","volume":"12","author":"Xu","year":"2021","journal-title":"Nat. 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Neurosci."},{"key":"ref169","doi-asserted-by":"publisher","first-page":"e3001509","DOI":"10.1371\/journal.pbio.3001509","article-title":"Smell-induced gamma oscillations in human olfactory cortex are required for accurate perception of odor identity","volume":"20","author":"Yang","year":"2022","journal-title":"PLoS Biol."},{"key":"ref170","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1111\/neup.12391","article-title":"Olfactory dysfunction in the APP\/PS1 transgenic mouse model of Alzheimer\u2019s disease: morphological evaluations from the nose to the brain","volume":"37","author":"Yao","year":"2017","journal-title":"Neuropathology"},{"key":"ref171","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.1093\/brain\/awx208","article-title":"A ventral glomerular deficit in Parkinson\u2019s disease revealed by whole olfactory bulb reconstruction","volume":"140","author":"Zapiec","year":"2017","journal-title":"Brain J. 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