{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:04:49Z","timestamp":1784304289396,"version":"3.55.0"},"reference-count":129,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Like many other vertebrates, rodents communicate via pheromones, which favors intraspecies communication. In contrast, kairomones are semiochemicals involved in interspecific communication, facilitating information between organisms of different species but advantageous for the receiver. Kairomones induce behavioral, physiological, and endocrinological changes in rodents, and have been proven to activate specific neuronal pathways in one or multiple components of the olfactory system (the main olfactory system, accessory olfactory system, and Gruenberg ganglion). The sophisticated olfactory networks help rodents innately recognize kairomones and elicit appropriate behavioral (aversive, avoidance, defense, and escape mechanisms), physiological, and endocrinological changes. Thus far, odor sources (e.g., urine, feces, hair, and body rubbings) of predators, such as felines, canines, and serpentes, have been studied in rodents. Specific kairomones have been identified, behaviorally tested, and validated for their potential to induce behavioral, neuronal, and endocrinological changes in rodents. One of the most studied kairomones is the fox odor, 2,5-dihydro 2,4,5-trimethylthiazoline, although other compounds have been reported to a limited extent. This review summarizes the current knowledge on kairomones and their effects on the behavioral, neuronal, and endocrine systems of rats and mice.<\/jats:p>","DOI":"10.3389\/fnins.2025.1485312","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T06:50:10Z","timestamp":1739947810000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Behavioral and neurobiological implications of kairomones for rodents: an updated review"],"prefix":"10.3389","volume":"19","author":[{"given":"Diya","family":"Manjunath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayavadhan","family":"Sampath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy N.","family":"Kirkwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinsha","family":"Santhosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devaraj","family":"Sankarganesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.neulet.2010.04.051","article-title":"Detection of estrus by male mice: synergistic role of olfactory-vomeronasal system","volume":"477","author":"Achiraman","year":"2010","journal-title":"Neurosci. Lett."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1002\/1098-2337(1980)6:4<295::AID-AB2480060402>3.0.CO;2-Q","article-title":"Motivational systems of agonistic behavior in muroid rodents: A comparative review and neural model","volume":"6","author":"Adams","year":"1980","journal-title":"Aggr. Behav."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3389\/fnins.2015.00263","article-title":"Are single odorous components of a predator sufficient to elicit defensive behaviors in prey species?","volume":"9","author":"Apfelbach","year":"2015","journal-title":"Front. Neurosci."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.bbr.2013.06.034","article-title":"Freezing to the predator odor 2,4,5 dihydro 2,5 trimethylthiazoline (TMT) is disrupted by olfactory bulb removal but not trigeminal deafferentation","volume":"253","author":"Ayers","year":"2013","journal-title":"Behav. 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Lett."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1126\/science.1160770","article-title":"Grueneberg ganglion cells mediate alarm pheromone detection in mice","volume":"321","author":"Brechb\u00fchl","year":"2008","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"4762","DOI":"10.1073\/pnas.1214249110","article-title":"Mouse alarm pheromone shares structural similarity with predator scents","volume":"110","author":"Brechb\u00fchl","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3389\/fnins.2015.00253","article-title":"Identification of pyridine analogs as new predator-derived kairomones","volume":"9","author":"Brechb\u00fchl","year":"2015","journal-title":"Front. 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Neurosci."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.bbr.2016.01.051","article-title":"Activation of corticotropin releasing factor-containing neurons in the rat central amygdala and bed nucleus of the stria terminalis following exposure to two different anxiogenic stressors","volume":"304","author":"Butler","year":"2016","journal-title":"Behav. Brain Res."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/s0091-3057(01)00685-2","article-title":"The medial hypothalamic defensive system: hodological organization and functional implications","volume":"71","author":"Canteras","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"10089","DOI":"10.1073\/pnas.89.21.10089","article-title":"The dorsal premammillary nucleus: an unusual component of the mammillary body","volume":"89","author":"Canteras","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1146\/annurev.physiol.67.040403.120816","article-title":"Endocrinology of the stress response","volume":"67","author":"Charmandari","year":"2015","journal-title":"Annu. Rev. Physiol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/cphy.c140019","article-title":"Hypothalamus as an endocrine organ","volume":"5","author":"Clarke","year":"2015","journal-title":"Compr. 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Brain Res."},{"key":"ref26","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/B978-0-12-374245-2.00027-9","article-title":"The olfactory system","volume-title":"The rat nervous system","author":"Ennis","year":"2015"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1016\/j.neubiorev.2008.05.010","article-title":"2,3,5-Trimethyl-3-thiazoline (TMT), a component of fox odor - just repugnant or really fear-inducing?","volume":"32","author":"Fendt","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.neubiorev.2005.04.018","article-title":"TMT-induced autonomic and behavioral changes and the neural basis of its processing","volume":"29","author":"Fendt","year":"2005","journal-title":"Neurosci. Biobehav. 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Neurosci."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1124\/pr.117.015305","article-title":"Trace amines and their receptors","volume":"70","author":"Gainetdinov","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1002\/eap.1483","article-title":"Exploiting interspecific olfactory communication to monitor predators","volume":"27","author":"Garvey","year":"2017","journal-title":"Ecol. Appl."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.conb.2013.09.010","article-title":"Olfactory maps, circuits and computations","volume":"24","author":"Giessel","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.3390\/ani11113149","article-title":"Sex differences in mouse exploratory behaviour to Feld 1, a cat ABP-like protein","volume":"11","author":"Grau","year":"2021","journal-title":"Animals"},{"key":"ref39","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-030-17616-7_13","article-title":"House mouse (Mus musculus) avoidance of olfactory cues from ferrets and other mammalian and reptilian predators: preliminary results","volume-title":"Chemical signals in vertebrates 14","author":"Grau","year":"2019"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/BF00520716","article-title":"A ganglion probably belonging to the N. terminalis system in the nasal mucosa of the mouse","volume":"140","author":"Gr\u00fcneberg","year":"1973","journal-title":"Z. Anat. Entwicklungsgesch."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.bbr.2012.10.014","article-title":"Comparison between low doses of TMT and cat odor exposure in anxiety-and fear-related behaviors in mice","volume":"238","author":"Hacquemand","year":"2013","journal-title":"Behav. Brain Res."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3389\/fnbeh.2010.00188","article-title":"Comparative fear-related behaviors to Predator odors (TMT and natural fox feces) before and after intranasal ZnSO4 treatment in mice","volume":"4","author":"Hacquemand","year":"2010","journal-title":"Front. Behav. Neurosci."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/B978-0-12-819975-6.00025-X","article-title":"Chemoarchitecture of the bed nucleus of the stria terminalis: Neurophenotypic diversity and function","volume":"179","author":"Hammack","year":"2021","journal-title":"Handb. Clin. Neurol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/S0893-133X(02)00354-8","article-title":"Odor-induced variation in anxiety-like behavior in mice is associated with discrete and differential effects on mesocorticolimbic cholecystokinin mRNA expression","volume":"27","author":"Hebb","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10211-014-0187-3","article-title":"The ethological relevance of predator odors to induce changes in prey species","volume":"18","author":"Hegab","year":"2015","journal-title":"Acta Ethologica"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1002\/hipo.22749","article-title":"Predator odor evokes sex-independent stress responses in male and female Wistar rats and reduces phosphorylation of cyclic-adenosine monophosphate response element binding protein in the male, but not the female hippocampus","volume":"27","author":"Homiack","year":"2017","journal-title":"Hippocampus"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3758\/BF03327031","article-title":"A synthetic predator odor (TMT) enhances conditioned analgesia and fear when paired with a benzodiazepine receptor inverse agonist (FG-7142)","volume":"25","author":"Hotsenpiller","year":"1997","journal-title":"Psychobiology"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1007\/s00018-016-2172-7","article-title":"Cell migration in the developing rodent olfactory system","volume":"73","author":"Huilgol","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/nature14188","article-title":"From circuits to behaviour in the amygdala","volume":"517","author":"Janak","year":"2015","journal-title":"Nature"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.bbr.2009.03.038","article-title":"Behavioral effects and pattern of brain c-fos mRNA induced by 2,5-dihydro-2,4,5-trimethylthiazoline, a component of fox feces odor in GAD67-GFP knock-in C57BL\/6 mice","volume":"202","author":"Janitzky","year":"2009","journal-title":"Behav. Brain Res."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1038\/nn.4104","article-title":"Molecular profiling of activated olfactory neurons identifies odorant receptors for odors in vivo","volume":"18","author":"Jiang","year":"2015","journal-title":"Nat. Neurosci."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.cell.2019.05.022","article-title":"Correlated neural activity and encoding of behavior across brains of socially interacting animals","volume":"178","author":"Kingsbury","year":"2019","journal-title":"Cell"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/nature06281","article-title":"Innate versus learned odour processing in the mouse olfactory bulb","volume":"450","author":"Kobayakawa","year":"2007","journal-title":"Nature"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1097\/01.wnr.0000186597.72081.10","article-title":"The Grueneberg ganglion projects to the olfactory bulb","volume":"16","author":"Koos","year":"2005","journal-title":"Neuroreport"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.physbeh.2004.11.006","article-title":"Detecting danger\u2014or just another odorant? Olfactory sensitivity for the fox odor component 2,4,5-trimethylthiazoline in four species of mammals","volume":"84","author":"Laska","year":"2005","journal-title":"Physiol. Behav."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.yfrne.2017.12.006","article-title":"The neuroendocrinology of sexual attraction","volume":"51","author":"Le Moene","year":"2018","journal-title":"Front. Neuroendocrinol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1038\/mp.2016.1","article-title":"Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders","volume":"21","author":"Lebow","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1146\/annurev-physiol-021113-170334","article-title":"Mammalian pheromones","volume":"76","author":"Liberles","year":"2014","journal-title":"Ann. Rev. Physiol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.conb.2015.01.001","article-title":"Trace amine-associated receptors: ligands, neural circuits, and behaviors","volume":"34","author":"Liberles","year":"2015","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1523\/JNEUROSCI.0483-20.2020","article-title":"Representation of fear of heights by basolateral amygdala neurons","volume":"41","author":"Liu","year":"2021","journal-title":"J. Neurosci."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3390\/ani12030356","article-title":"From in vitro data to in vivo interspecies danger communication: A study of Chemosensing via the mouse Grueneberg ganglion","volume":"12","author":"Lopes","year":"2022","journal-title":"Animals"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1038\/npp.2013.82","article-title":"Hypothalamic Corticotropin-releasing factor is centrally involved in learning under moderate stress","volume":"38","author":"Lucas","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"113210","DOI":"10.1016\/j.physbeh.2020.113210","article-title":"Coyote urine, but not 2-phenylethylamine, induces a complete profile of unconditioned anti-predator defensive behaviors","volume":"229","author":"Maestas-Olguin","year":"2021","journal-title":"Physiol. Behav."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.neulet.2004.09.006","article-title":"Modulation of predatory odor processing following lesions to the dorsal premammillary nucleus","volume":"372","author":"Markham","year":"2004","journal-title":"Neurosci. Lett."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.neuroscience.2010.10.033","article-title":"Amygdalar roles during exposure to a live predator and to a predator-associated context","volume":"172","author":"Martinez","year":"2011","journal-title":"J. Neurosci."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.bbr.2009.09.038","article-title":"Accessory and main olfactory systems influences on predator odor-induced behavioral and endocrine stress responses in rats","volume":"207","author":"Masini","year":"2010","journal-title":"Behav. Brain Res."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.physbeh.2012.03.007","article-title":"Rubbings deposited by cats elicit defensive behavior in rats","volume":"107","author":"May","year":"2012","journal-title":"Physiol. Behav."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"4134","DOI":"10.1523\/JNEUROSCI.0187-04.2004","article-title":"Neural correlates of cat odor-induced anxiety in rats: region-specific effects of the benzodiazepine midazolam","volume":"24","author":"McGregor","year":"2004","journal-title":"J. Neurosci."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0166-4328(01)00324-2","article-title":"Not all \u2018predator odours\u2019 are equal: cat odour but not 2,4,5 trimethylthiazoline (TMT; fox odour) elicits specific defensive behaviours in rats","volume":"129","author":"McGregor","year":"2002","journal-title":"Behav. Brain Res."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"112469","DOI":"10.1016\/j.bbr.2020.112469","article-title":"Defensive behaviors and brain regional activation changes in rats confronting a snake","volume":"381","author":"Mendes-Gomes","year":"2020","journal-title":"Behav. Brain Res."},{"key":"ref71","first-page":"2013","volume-title":"Stress and pheromonatherapy in small animal clinical behaviour","author":"Mills","year":"2013"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.chembiol.2006.08.013","article-title":"A major urinary protein of the domestic cat regulates the production of felinine, a putative pheromone precursor","volume":"13","author":"Miyazaki","year":"2006","journal-title":"Chem. Biol."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12915-017-0479-y","article-title":"Alarm pheromone and kairomone detection via bitter taste receptors in the mouse Grueneberg ganglion","volume":"16","author":"Moine","year":"2018","journal-title":"BMC Biol."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"2398212820930321","DOI":"10.1177\/2398212820930321","article-title":"The role of the locus coeruleus in the generation of pathological anxiety","volume":"4","author":"Morris","year":"2020","journal-title":"Brain. Neurosci. 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Tanzania."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"e61753","DOI":"10.1371\/journal.pone.0061753","article-title":"Pyrazine analogues are active components of wolf urine that induce avoidance and freezing behaviours in mice","volume":"8","author":"Osada","year":"2013","journal-title":"PLoS One"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3389\/fnins.2015.00363","article-title":"The scent of wolves: pyrazine analogs induce avoidance and vigilance behaviors in prey","volume":"9","author":"Osada","year":"2015","journal-title":"Front. 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Neurosci."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"561","DOI":"10.17221\/7137-VETMED","article-title":"Kairomones-important substances in interspecic communication in vertebrates: A review","volume":"58","author":"Rajchard","year":"2013","journal-title":"Vet. Medicina."},{"key":"ref91","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1093\/chemse\/bjx075","article-title":"Where is the TMT? GC-MS analyses of fox feces and behavioral responses of rats to fear-inducing odors","volume":"43","author":"Rampin","year":"2018","journal-title":"Chem. Senses"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.biopsych.2010.04.027","article-title":"Amygdala activity, fear, and anxiety: modulation by stress","volume":"67","author":"Ressler","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"20160206","DOI":"10.1098\/rstb.2016.0206","article-title":"Freeze for action: neurobiological mechanisms in animal and human freezing","volume":"372","author":"Roelofs","year":"2017","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"ref94","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/j.neubiorev.2008.05.006","article-title":"Analysis of behavioral constraints and the neuroanatomy of fear to the predator odor trimethylthiazoline: a model for animal phobias","volume":"32","author":"Rosen","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref95","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.neuron.2016.01.040","article-title":"DREADDs for neuroscientists","volume":"89","author":"Roth","year":"2016","journal-title":"Neuron"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"16011","DOI":"10.1038\/ncomms16011","article-title":"Immobility responses are induced by photoactivation of single glomerular species responsive to fox odour TMT","volume":"8","author":"Saito","year":"2017","journal-title":"Nat. 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Rec."},{"key":"ref100","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/B978-0-444-63855-7.00002-2","article-title":"Chapter 2-anatomy of the olfactory system","volume":"164","author":"Smith","year":"2019","journal-title":"Handbook Clin. Neurobiol."},{"key":"ref101","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/j.neuroscience.2007.11.039","article-title":"Cat odor, but not trimethylthiazoline (fox odor), activates accessory olfactory and defense-related brain regions in rats","volume":"151","author":"Staples","year":"","journal-title":"Neuroscience"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1016\/j.neubiorev.2008.05.011","article-title":"Rats discriminate individual cats by their odor: possible involvement of the accessory olfactory system","volume":"32","author":"Staples","year":"","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref103","doi-asserted-by":"publisher","first-page":"136","DOI":"10.3389\/fnbeh.2018.00136","article-title":"Maternal predator odor exposure in mice programs adult offspring social behavior and increases stress-induced behaviors in semi-naturalistic and commonly-used laboratory tasks","volume":"12","author":"St-Cyr","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"ref104","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3389\/fnbeh.2015.00145","article-title":"Programming of stress-related behavior and epigenetic neural gene regulation in mice offspring through maternal exposure to predator odor","volume":"9","author":"St-Cyr","year":"2015","journal-title":"Front. Behav. Neurosci."},{"key":"ref105","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.pbb.2016.08.008","article-title":"Predator odor exposure of rat pups has opposite effects on play by juvenile males and females","volume":"152","author":"Stockman","year":"2017","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref106","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.physbeh.2018.06.009","article-title":"Predator odor induced defensive behavior in wild and laboratory rats: A comparative study","volume":"194","author":"Storsberg","year":"2018","journal-title":"Physiol. Behav."},{"key":"ref107","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1037\/0735-7044.121.1.100","article-title":"Predator odor-induced conditioned fear involves the basolateral and medial amygdala","volume":"121","author":"Takahashi","year":"2007","journal-title":"Behav. Neurosci."},{"key":"ref108","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3389\/fnbeh.2014.00072","article-title":"Olfactory systems and neural circuits that modulate predator odor fear","volume":"8","author":"Takahashi","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"ref109","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/j.neubiorev.2005.04.008","article-title":"The smell of danger: A behavioral and neural analysis of predator odor-induced fear","volume":"29","author":"Takahashi","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref110","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3389\/fnins.2015.00239","article-title":"ASIC1A in the bed nucleus of the stria terminalis mediates TMT-evoked freezing","volume":"9","author":"Taugher","year":"2015","journal-title":"Front. 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Ecol."},{"key":"ref118","first-page":"281","article-title":"Influence of cat odor on reproductive behavior and physiology in the house mouse (Mus musculus)","volume-title":"Neurobiology of chemical communication","author":"Voznessenskaya","year":"2014"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/978-3-319-22026-0_27","article-title":"Responses to domestic cat chemical signals in the house mouse are modulated by early olfactory experience","volume-title":"Chemical signals in vertebrates","author":"Voznessenskaya","year":"2016"},{"key":"ref120","author":"Voznessenskaya","year":"2019"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3389\/fnbeh.2015.00223","article-title":"The olfactory hole-board test in rats: A new paradigm to study aversion and preferences to odors","volume":"9","author":"Wernecke","year":"2015","journal-title":"Front. Behav. 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