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Patients with uremia frequently experience a range of complications, including renal anemia, osteoporosis, and cardiovascular disease, all of which significantly impair their quality of life. Chronic kidney disease-associated pruritus (CKD-aP) is a common comorbidity in uremic patients, particularly among those undergoing hemodialysis, with prevalence rates ranging from 10 to 77%. This case report enrolled three patients diagnosed with chronic kidney disease-associated pruritus (CKD-ap) who underwent ultrasound-guided sympathetic nerve blockade procedures. The results demonstrated significant reductions in pruritus intensity concurrent with measurable enhancements in sleep quality and daily functioning.<\/jats:p>","DOI":"10.3389\/fnins.2025.1529183","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T05:25:27Z","timestamp":1744781127000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Sympathetic nerve block treat chronic kidney disease-associated pruritus"],"prefix":"10.3389","volume":"19","author":[{"given":"Ying","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaohua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"527","DOI":"10.3390\/toxins13080527","article-title":"Chronic kidney disease-associated pruritus","volume":"13","author":"Agarwal","year":"2021","journal-title":"Toxins"},{"key":"B2","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1097\/AAP.0000000000000591","article-title":"Review of sympathetic blocks: anatomy, sonoanatomy, evidence, and techniques","volume":"42","author":"Baig","year":"2017","journal-title":"Reg. 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