{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:21:07Z","timestamp":1787026867858,"version":"build-2736575974"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Neuropathic pain (NP), a prevalent chronic condition with increasing global incidence, mainly relies on electrophysiology (EP) to decode its mechanisms. However, existing research lacks systematic integration, failing to track hotspots and frontiers effectively. In this study, we used bibliometric analysis and systematic review to clarify technological breakthrough directions and facilitate the development of electrophysiological phenotype-based precision diagnostics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Literature was retrieved from the Web of Science Core Collection (WoSCC). A total of 2,234 reviews and articles were obtained from 2005 to 2024. Statistics and visualization analysis were performed using Bibliometrix (R), VOSviewer, CiteSpace, and Microsoft Excel 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Publications and citations in this field are rising. The USA leads in publications (613, 27.44%) and academic impact (H-index\u202f=\u202f96). China\u2019s academic impact remains behind when compared to other countries. North American and Western European institutions form robust collaboration networks, whereas Asian institutions exhibit weaker regional partnerships. Authors with high production, such as Khanna, Rajesh and Waxman, Stephen G, and highly cited authors such as Woolf, CJ play a key leading role in the development of the field. Journals like Pain and Journal of Neuroscience are the cardinal dissemination mediums. Keyword analysis reveals research hotspot expands from the basic structure of \u201cdorsal root ganglion\u201d and\u201d sensory neuron\u201d to pain-related dynamic changes and disease prevalence characteristics. \u201cPlasticity\u201d and \u201cconnectivity\u201d signaled a shift in research toward network mechanisms and precise interventions. \u201cWoolf CJ, 2011\u201d and \u201cDib-Hajj SD, 2010\u201d have high citation and co-citation frequencies. The emergence of new directions such as \u201cdynamic pain connectome\u201d and \u201ccomputational modeling research\u201d reflects the trend of multidisciplinary integration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For the first time, we have constructed a complete lineage from basic research to clinical translation in this field, confirming the key role of EP technology in analyzing the mechanism of nociceptive sensitization, neuroplasticity, and neural network connectivity reconfiguration, which provides a basis for developing precise diagnostic and therapeutic solutions based on electrophysiological phenotypes. Future research should focus on technology standardization, cross-institutional data sharing, clinical translation, and connectomics-oriented individualized analgesic strategies to promote NP diagnosis and treatment toward precision, dynamics, and systematization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2025.1616973","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:22:03Z","timestamp":1748913723000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Electrophysiology in neuropathic pain: a bibliometric analysis and literature review"],"prefix":"10.3389","volume":"19","author":[{"given":"Yidan","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjian","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.molmed.2021.11.005","article-title":"iPSCs and DRGs: stepping stones to new pain therapies","volume":"28","author":"Alsaloum","year":"2022","journal-title":"Trends Mol. Med."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1056\/NEJMoa1803588","article-title":"Recovery of over-ground walking after chronic motor complete spinal cord injury","volume":"379","author":"Angeli","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.joi.2017.08.007","article-title":"Bibliometrix: an R-tool for comprehensive science mapping analysis","volume":"11","author":"Aria","year":"2017","journal-title":"J. Informetr."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"S23","DOI":"10.1097\/j.pain.0000000000001522","article-title":"Translational neuropathic pain research","volume":"160","author":"Attal","year":"2019","journal-title":"Pain"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.bja.2023.04.021","article-title":"Advances and challenges in neuropathic pain: a narrative review and future directions","volume":"131","author":"Attal","year":"2023","journal-title":"Brit. J. Anaesth."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1146\/annurev-pharmtox-010818-021524","article-title":"Neuropathic pain: mechanism-based therapeutics","volume":"60","author":"Bannister","year":"2020","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41582-022-00741-7","article-title":"Maximizing treatment efficacy through patient stratification in neuropathic pain trials","volume":"19","author":"Baron","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/S1474-4422(12)70189-8","article-title":"Subgrouping of patients with neuropathic pain according to pain-related sensory abnormalities: a first step to a stratified treatment approach","volume":"11","author":"Baron","year":"2012","journal-title":"Lancet Neurol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e1066","DOI":"10.1097\/PR9.0000000000001066","article-title":"Epidemiology of neuropathic pain: an analysis of prevalence and associated factors in UK biobank","volume":"8","author":"Baskozos","year":"2023","journal-title":"Pain Rep."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1152\/physrev.00052.2017","article-title":"The role of voltage-gated sodium channels in pain signaling","volume":"99","author":"Bennett","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1227\/neu.0000000000002878","article-title":"Improved selectivity in eliciting evoked electromyography responses with high-resolution spinal cord stimulation","volume":"95","author":"Berwal","year":"2024","journal-title":"Neurosurgery"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1097\/j.pain.0000000000001136","article-title":"Emerging therapies for neuropathic pain: new molecules or new indications for old treatments?","volume":"159","author":"Bouhassira","year":"2018","journal-title":"Pain"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.1038\/d41586-019-02681-7","article-title":"Opioids","volume":"573","author":"Brody","year":"2019","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"114631","DOI":"10.1016\/j.expneurol.2023.114631","article-title":"Long ascending propriospinal neurons are heterogenous and subject to spinal cord injury induced anatomic plasticity","volume":"373","author":"Brown","year":"2024","journal-title":"Exp. Neurol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/asi.20317","article-title":"CiteSpace II: detecting and visualizing emerging trends and transient patterns in scientific literature","volume":"57","author":"Chen","year":"2006","journal-title":"J. Am. Soc. Inf. Sci. Tec."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1038\/s41586-024-07816-z","article-title":"Neural circuit basis of placebo pain relief","volume":"632","author":"Chen","year":"2024","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41467-023-36093-z","article-title":"Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain","volume":"14","author":"Chen","year":"2023","journal-title":"Nat. Commun."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.pain.2005.01.002","article-title":"Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain","volume":"114","author":"Chessell","year":"2005","journal-title":"Pain"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"17002","DOI":"10.1038\/nrdp.2017.2","article-title":"Neuropathic pain","volume":"3","author":"Colloca","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1038\/d41586-019-02686-2","article-title":"Tracing the US opioid crisis to its roots","volume":"573","author":"DeWeerdt","year":"2019","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1146\/annurev-neuro-060909-153234","article-title":"Sodium channels in normal and pathological pain","volume":"33","author":"Dib-Hajj","year":"2010","journal-title":"Annu. Rev. Neurosci."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.jbusres.2021.04.070","article-title":"How to conduct a bibliometric analysis: an overview and guidelines","volume":"133","author":"Donthu","year":"2021","journal-title":"J. Bus. Res."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/s41586-021-03897-2","article-title":"Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia","volume":"597","author":"Draper-Joyce","year":"2021","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1148\/radiol.09090626","article-title":"Bibliometric indicators: quality measurements of scientific publication","volume":"255","author":"Durieux","year":"2010","journal-title":"Radiology"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.jpain.2022.08.010","article-title":"Optimizing and accelerating the development of precision pain treatments for chronic pain: IMMPACT review and recommendations","volume":"24","author":"Edwards","year":"2023","journal-title":"J. Pain"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1038\/d41586-019-02687-1","article-title":"Treading the tightrope of opioid restrictions","volume":"573","author":"Eisenstein","year":"2019","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1097\/j.pain.0000000000001340","article-title":"Neuropathic pain clinical trials: factors associated with decreases in estimated drug efficacy","volume":"159","author":"Finnerup","year":"2018","journal-title":"Pain"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1152\/physrev.00045.2019","article-title":"Neuropathic pain: from mechanisms to treatment","volume":"101","author":"Finnerup","year":"2021","journal-title":"Physiol. Rev."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e103","DOI":"10.1097\/j.pain.0000000000002709","article-title":"Elevated 18:0 lysophosphatidylcholine contributes to the development of pain in tissue injury","volume":"164","author":"Friston","year":"2023","journal-title":"Pain"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/s41586-023-06888-7","article-title":"Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis","volume":"625","author":"Fu","year":"2024","journal-title":"Nature"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"102009","DOI":"10.1016\/j.pneurobio.2021.102009","article-title":"Repetitive non-invasive prefrontal stimulation reverses neuropathic pain via neural remodelling in mice","volume":"201","author":"Gan","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"290","DOI":"10.23736\/S1973-9087.22.07411-1","article-title":"Cortical stimulation for chronic pain: from anecdote to evidence","volume":"58","author":"Garcia-Larrea","year":"2022","journal-title":"Eur. J. Phys. Rehab. Med."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1056\/NEJMoa1708538","article-title":"Hemophilia B gene therapy with a high-specific-activity factor IX variant","volume":"377","author":"George","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.jpain.2022.09.010","article-title":"Multifocal tDCS targeting the motor network modulates event-related cortical responses during prolonged pain","volume":"24","author":"Gregoret","year":"2023","journal-title":"J. Pain"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.pain.2010.07.031","article-title":"NeuPSIG guidelines on neuropathic pain assessment","volume":"152","author":"Haanp\u00e4\u00e4","year":"2011","journal-title":"Pain"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s13311-015-0377-3","article-title":"Molecular targets of cannabidiol in neurological disorders","volume":"12","author":"Ibeas Bih","year":"2015","journal-title":"Neurotherapeutics"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.bbi.2024.09.031","article-title":"Upregulation of delta opioid receptor by meningeal interleukin-10 prevents relapsing pain","volume":"123","author":"Inyang","year":"2025","journal-title":"Brain Behav. Immun."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"eadi1564","DOI":"10.1126\/scitranslmed.adi1564","article-title":"Follistatin drives neuropathic pain in mice through IGF1R signaling in nociceptive neurons","volume":"16","author":"Jiang","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/nature24636","article-title":"Fully integrated silicon probes for high-density recording of neural activity","volume":"551","author":"Jun","year":"2017","journal-title":"Nature"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/s41586-024-07743-z","article-title":"Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants","volume":"632","author":"Kim","year":"2024","journal-title":"Nature"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1016\/S0140-6736(21)00794-7","article-title":"Neuromodulation for chronic pain","volume":"397","author":"Knotkova","year":"2021","journal-title":"Lancet"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1093\/brain\/awae341","article-title":"The parkinson's disease DJ-1\/PARK7 gene controls peripheral neuronal excitability and painful neuropathy. Brain","volume":"148","author":"Lee","year":"2024","journal-title":"J. Neurol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"e1538232024","DOI":"10.1523\/JNEUROSCI.1538-23.2024","article-title":"Re-examining the mysterious role of the cerebellum in pain","volume":"44","author":"Li","year":"2024","journal-title":"J. Neurosci."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1038\/s42003-024-07129-x","article-title":"Analgesic effects of high-frequency rTMS on pain anticipation and perception","volume":"7","author":"Li","year":"2024","journal-title":"Commun. Biol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1016\/j.neuron.2024.01.014","article-title":"Anterior cingulate cortex projections to the dorsal medial striatum underlie insomnia associated with chronic pain","volume":"112","author":"Li","year":"2024","journal-title":"Neuron"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"10168","DOI":"10.1038\/ncomms10168","article-title":"The H-index of a network node and its relation to degree and coreness","volume":"7","author":"L\u00fc","year":"2016","journal-title":"Nat. Commun."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"e4737","DOI":"10.1002\/ejp.4737","article-title":"Peak alpha frequency differs between chronic back pain and chronic widespread pain","volume":"29","author":"McLain","year":"2025","journal-title":"Eur. J. Pain"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"106381","DOI":"10.1016\/j.nbd.2023.106381","article-title":"Exploring altered oscillatory activity in the anterior cingulate cortex after nerve injury: insights into mechanisms of neuropathic allodynia","volume":"190","author":"Mirmoosavi","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1097\/j.pain.0000000000001993","article-title":"Pregabalin: a better neuropathic pain treatment in rodents than in humans","volume":"161","author":"Moisset","year":"2020","journal-title":"Pain"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.1007\/s00330-022-09340-y","article-title":"Publications on COVID-19 in radiology journals in 2020 and 2021: bibliometric citation and co-citation network analysis","volume":"33","author":"Navarro-Ballester","year":"2023","journal-title":"Eur. Radiol."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/s41583-022-00673-7","article-title":"Gene therapy for chronic pain: emerging opportunities in target-rich peripheral nociceptors","volume":"24","author":"Ovsepian","year":"2023","journal-title":"Nat. Rev. Neurosci."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.molmed.2016.03.008","article-title":"Sodium channels, mitochondria, and axonal degeneration in peripheral neuropathy","volume":"22","author":"Persson","year":"2016","journal-title":"Trends Mol. Med."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.ymthe.2023.01.022","article-title":"Long-term reversal of chronic pain behavior in rodents through elevation of spinal agmatine","volume":"31","author":"Peterson","year":"2023","journal-title":"Mol. Ther. J. Am. Soc. Gene Ther."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nature16465","article-title":"An essential receptor for adeno-associated virus infection","volume":"530","author":"Pillay","year":"2016","journal-title":"Nature"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"2578","DOI":"10.1097\/j.pain.0000000000002252","article-title":"Efficacy and safety of EMA401 in peripheral neuropathic pain: results of 2 randomised, double-blind, phase 2 studies in patients with postherpetic neuralgia and painful diabetic neuropathy","volume":"162","author":"Rice","year":"2021","journal-title":"Pain"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1016\/S0140-6736(13)62337-5","article-title":"EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial","volume":"383","author":"Rice","year":"2014","journal-title":"Lancet"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3390\/antiox12010024","article-title":"TRPV4 role in neuropathic pain mechanisms in rodents","volume":"12","author":"Rodrigues","year":"2022","journal-title":"Antioxidant"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"307","DOI":"10.5539\/jas.v12n11p307","article-title":"The ethnopharmacological literature: an analysis of the scientific landscape in the cerrado in Central-Western Brazil","volume":"12","author":"Santos","year":"2020","journal-title":"J. Agric. Sci."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"6437","DOI":"10.1038\/s41467-023-42164-y","article-title":"Structural insights into the allosteric inhibition of P2X4 receptors","volume":"14","author":"Shen","year":"2023","journal-title":"Nat. Commun."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1038\/nbt1117-998","article-title":"First AAV gene therapy poised for landmark approval","volume":"35","author":"Smalley","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/s41593-023-01519-w","article-title":"An ACC-VTA-ACC positive-feedback loop mediates the persistence of neuropathic pain and emotional consequences","volume":"27","author":"Song","year":"2024","journal-title":"Nat. Neurosci."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.conb.2018.01.009","article-title":"Challenges and opportunities for large-scale electrophysiology with neuropixels probes","volume":"50","author":"Steinmetz","year":"2018","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1126\/science.aad5177","article-title":"In vivo gene editing in dystrophic mouse muscle and muscle stem cells","volume":"351","author":"Tabebordbar","year":"2016","journal-title":"Science"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"e1701130","DOI":"10.1126\/sciadv.1701130","article-title":"Document co-citation analysis to enhance transdisciplinary research","volume":"4","author":"Trujillo","year":"2018","journal-title":"Sci. Adv."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: VOSviewer, a computer program for bibliometric mapping","volume":"84","author":"van Eck","year":"2010","journal-title":"Scientometrics"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/978-3-319-10377-8_13","article-title":"Visualizing bibliometric networks","volume-title":"Measuring scholarly impact: Methods and practice","author":"van Eck","year":"2014"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.neuron.2018.02.023","article-title":"A circuit for integration of head- and visual-motion signals in layer 6 of mouse primary visual cortex","volume":"98","author":"V\u00e9lez-Fort","year":"2018","journal-title":"Neuron"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/s41582-019-0146-8","article-title":"The role of neurologists in tackling the opioid epidemic","volume":"15","author":"Volkow","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/s41586-018-0649-2","article-title":"Targeted neurotechnology restores walking in humans with spinal cord injury","volume":"563","author":"Wagner","year":"2018","journal-title":"Nature"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s12264-023-01086-x","article-title":"Ventral hippocampal CA1 pyramidal neurons encode nociceptive information","volume":"40","author":"Wang","year":"2024","journal-title":"Neurosci. Bull."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1016\/j.pain.2010.09.030","article-title":"Central sensitization: implications for the diagnosis and treatment of pain","volume":"152","author":"Woolf","year":"2011","journal-title":"Pain"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"3405","DOI":"10.1093\/brain\/awab245","article-title":"GPR151 in nociceptors modulates neuropathic pain via regulating P2X3 function and microglial activation. Brain","volume":"144","author":"Xia","year":"2021","journal-title":"J. Neurol."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"175288","DOI":"10.1016\/j.ejphar.2022.175288","article-title":"Mechanisms underlying paclitaxel-induced neuropathic pain: channels, inflammation and immune regulations","volume":"933","author":"Xu","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"2350030","DOI":"10.1142\/S0129065723500302","article-title":"One-dimensional local binary pattern and common spatial pattern feature fusion brain network for central neuropathic pain","volume":"33","author":"Xu","year":"2023","journal-title":"Int. J. Neural Syst."},{"key":"ref76","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1172\/JCI133270","article-title":"GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents","volume":"130","author":"Yosten","year":"2020","journal-title":"J. Clin. Invest."},{"key":"ref77","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S1474-4422(17)30005-4","article-title":"Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial","volume":"16","author":"Zakrzewska","year":"2017","journal-title":"Lancet Neurol."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"5963","DOI":"10.1523\/JNEUROSCI.0303-21.2021","article-title":"\u03b12\u03b4-1 upregulation in primary sensory neurons promotes NMDA receptor-mediated glutamatergic input in resiniferatoxin-induced neuropathy","volume":"41","author":"Zhang","year":"","journal-title":"J. Neurosci."},{"key":"ref79","doi-asserted-by":"publisher","first-page":"102041","DOI":"10.1016\/j.pneurobio.2021.102041","article-title":"Sodium leak channel contributes to neuronal sensitization in neuropathic pain","volume":"202","author":"Zhang","year":"","journal-title":"Prog. Neurobiol."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"107349","DOI":"10.1016\/j.cmpb.2023.107349","article-title":"EEG frequency band analysis in chronic neuropathic pain: a linear and nonlinear approach to classify pain severity","volume":"230","author":"Zolezzi","year":"2023","journal-title":"Comput. Methods Prog. Biomed."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2025.1616973\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:22:04Z","timestamp":1748913724000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2025.1616973\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,3]]},"references-count":79,"alternative-id":["10.3389\/fnins.2025.1616973"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2025.1616973","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,3]]},"article-number":"1616973"}}