{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T18:12:03Z","timestamp":1767204723153,"version":"build-2238731810"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"\n Introduction<\/jats:title>\n There is a need for biomarkers predicting neurocognitive improvement following treatment of obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP). The role of sleep apnea endotypes as predictors are promising.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To assess the relationship between a high loop gain biomarker, elevated low frequency narrow band (e-LFC\n NB<\/jats:sub>\n ), and improvements in neurocognitive function in the Apnea Positive Pressure Long-term Efficacy Study (APPLES).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The e-LFC\n NB<\/jats:sub>\n % metric was estimated on baseline polysomnography. Logistic regression analysis was performed to identify the potential association between e-LFC\n NB<\/jats:sub>\n % of total sleep time and the observed improvement in neurocognitive function following the specified treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 362 subjects received CPAP and had e-LFC\n NB<\/jats:sub>\n % measurements. For Sustained Working Memory Test-Overall Mid-Day (SWMT-OMD), e-LFC\n NB<\/jats:sub>\n %\u202f&gt;\u202f2.35% correlates positively with the proportion of participants who showed an increase in test scores &gt; 0.65 after 2\u202fmonths CPAP treatment (OR: 2.617, 95% CI: 1.095\u20136.252,\n p<\/jats:italic>\n : 0.030); e-LFC\n NB<\/jats:sub>\n %\u202f&gt;\u202f9.45% correlates positively with improvement in test scores &gt; 0.8 after 6\u202fmonths CPAP treatment (OR: 2.553, 95% CI: 1.017\u20136.409,\n p<\/jats:italic>\n : 0.046). For Buschke Selective Reminding Test sum recall (BSRT-SR), e-LFC\n NB<\/jats:sub>\n %\u202f&gt;\u202f3.65% correlates positively with an increase in test scores &gt; 12 after 2\u202fmonths CPAP treatment (OR: 2.696, 95% CI: 1.041\u20136.982,\n p<\/jats:italic>\n : 0.041). Results of the Pathfinder Number Test-Total Time (PFN-TOTL) were not significant.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n e-LFC\n NB<\/jats:sub>\n % (probable high loop gain) may be a clinically useful predictor of cognitive improvement following CPAP.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fnins.2025.1619467","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T05:43:30Z","timestamp":1758692610000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pathological respiratory chemoreflex activation predicts improvement of neurocognitive function in response to continuous positive airway pressure therapy"],"prefix":"10.3389","volume":"19","author":[{"given":"Yu-Tong","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-Nan","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugi","family":"Hilmisson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert Joseph","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1513\/AnnalsATS.202005-510OC","article-title":"Automated apnea-hypopnea index from oximetry and spectral analysis of cardiopulmonary coupling","volume":"18","author":"Al Ashry","year":"2021","journal-title":"Ann. 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