{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:42:51Z","timestamp":1777866171111,"version":"3.51.4"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Accurate categorisation of the upward rotation of the foetal cerebellar vermis continues to pose diagnostic challenges in prenatal medicine. Recently, a new parameter of the posterior fossa (PF), known as the vermian-crest angle (VCA), has been evaluated using three-dimensional ultrasound (3D-US) and prenatal magnetic resonance imaging (MRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the performance of the VCA in categorizing PF anomalies using 3D-US and to determine its level of agreement with MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>We conducted a cohort study involving confirmed cases of PF anomalies. We measured the VCA using 3D-US and compared our data with previously published reference values obtained through both 3D-US and MRI. For statistical analysis, we employed univariate analysis of variance (ANOVA) followed by Tukey\u2019s post-hoc test, receiver operating characteristic (ROC) curve analysis, and the intraclass correlation coefficient (ICC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 53 foetuses at a mean gestational age (GA) of 24.5 (SD 5.45) weeks with Blake\u2019s pouch cyst (BPC) (\n                      <jats:italic>n<\/jats:italic>\n                      =\u202f11), Dandy\u2013Walker malformation (DWM) (\n                      <jats:italic>n<\/jats:italic>\n                      =\u202f9), mega cisterna magna (MCM) (\n                      <jats:italic>n<\/jats:italic>\n                      =\u202f22), and vermian hypoplasia (VH) (\n                      <jats:italic>n<\/jats:italic>\n                      =\u202f11). Compared to published reference values, the VCA was significantly increased in DWMs (mean 130.6\u00b0, SD 16.75\u00b0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2264\u202f0.01) and BPCs (mean 91.00\u00b0, SD 19.73\u00b0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2264\u202f0.05). A VCA\u202f&amp;gt;\u202f80.1\u00b0 distinguished BPCs and DWMs from other PF anomalies, while a VCA\u202f&amp;gt;\u202f107\u00b0 differentiated BPCs from DWMs. When comparing subgroups with published MRI data, we found good agreement between 3D-US and MRI (ICC\u202f=\u202f0.71) (95% CI: 0.55\u20130.87).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The VCA may be helpful in categorising PF anomalies using 3D-US, particularly BPC and DWM. The good agreement with MRI measurements reinforces the synergy of these tools in the diagnostic work-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2025.1623105","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T04:20:50Z","timestamp":1758082850000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The vermian-crest angle: a prediction model for foetal cystic posterior fossa anomalies"],"prefix":"10.3389","volume":"19","author":[{"given":"Marialuigia","family":"Spinelli","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Bern, University of Bern","place":["Bern, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Amylidi-Mohr","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Bern, University of Bern","place":["Bern, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Surbek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Bern, University of Bern","place":["Bern, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-Sven","family":"Heling","sequence":"additional","affiliation":[{"name":"Centre for Prenatal Diagnosis","place":["Berlin, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Scheier","sequence":"additional","affiliation":[{"name":"Foetal Medicine Service, Outpatient Department for Foetal Medicine","place":["Feldkirch, Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Pomar","sequence":"additional","affiliation":[{"name":"Ultrasound and Foetal Medicine Unit, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne University","place":["Lausanne, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Baud","sequence":"additional","affiliation":[{"name":"Ultrasound and Foetal Medicine Unit, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne University","place":["Lausanne, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Raio","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Bern, University of Bern","place":["Bern, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1159\/000501500","article-title":"Diagnosis of foetal posterior fossa malformations in high-risk pregnancies at 12-14 gestational weeks by transvaginal ultrasound examination","volume":"47","author":"Altmann","year":"2020","journal-title":"Fetal Diagn. Ther."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1093\/brain\/awp247","article-title":"A developmental and genetic classification for midbrain-hindbrain malformations","volume":"132","author":"Barkovich","year":"2009","journal-title":"Brain"},{"key":"ref3","first-page":"43","article-title":"Joubert syndrome with variable features: presentation of two cases","volume":"7","author":"Barzegar","year":"2013","journal-title":"Iran. J. Child Neurol."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.17712\/1658-3183.2089","article-title":"Joubert syndrome labeled as hypotonic cerebral palsy","volume":"19","author":"Dekain","year":"2014","journal-title":"Neurosciences (Riyadh)"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1002\/bdra.20589.","article-title":"Normal and abnormal anatomy of the cerebellar vermis in midgestational human foetuses","volume":"85","author":"Kapur","year":"2009","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.3174\/ajnr.A4725","article-title":"Development of the foetal vermis: new biometry reference data and comparison of 3 diagnostic modalities\u20133D ultrasound, 2D ultrasound, and MRI maging","volume":"37","author":"Katorza","year":"2016","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s12311-014-0632-x","article-title":"Date-independent parameters: an innovative method to assess foetal cerebellar vermis","volume":"14","author":"Lei","year":"2015","journal-title":"Cerebellum"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.ajog.2005.10.191","article-title":"Diagnosis of inferior vermian hypoplasia by foetal MRI: potential pitfalls and neurodevelopmental outcome","volume":"194","author":"Limperopoulos","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1002\/pd.137","article-title":"The foetal cerebellar vermis: normal development as shown by transvaginal ultrasound","volume":"21","author":"Malinger","year":"2001","journal-title":"Prenat. Diagn."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1590\/0100-3984.2018.0141","article-title":"Foetal posterior fossa malformations: review of the current knowledge","volume":"52","author":"Milani","year":"2019","journal-title":"Radiol. Bras."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/uog.20120","article-title":"Hindbrain morphometry and choroid plexus position in differential diagnosis of posterior fossa cystic malformations","volume":"54","author":"Paladini","year":"2019","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref12","first-page":"692","article-title":"The \u201cvermian-crest angle\u201d: does it allow accurate categorisation of fetal upward rotation of cerebellar vermis on intrauterine MRI? A pilot study","volume":"40","author":"Pertl","year":"2019","journal-title":"Ultraschall Med."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1002\/ajmg.c.31398","article-title":"Cerebellar hypoplasia: differential diagnosis and diagnostic approach","volume":"1","author":"Poretti","year":"2014","journal-title":"Am. J. Med. Genet. Semin. Med. Genet."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"519","DOI":"10.3109\/14767058.2011.622006","article-title":"Assessment of cerebellar vermis biometry at 18-32 weeks of gestation by three-dimensional ultrasound examination","volume":"25","author":"Rizzo","year":"2012","journal-title":"J Maternal-Foetal Neonatal Med."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/uog.13296","article-title":"Editorial. Inferior vermian hypoplasia \u2013 preconception, misconception","volume":"43","author":"Robinson","year":"2014","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1097\/RUQ.0b013e31814b162c","article-title":"The foetal cerebellar vermis: assessment for abnormal development by ultrasonography and magnetic resonance imaging","volume":"23","author":"Robinson","year":"2007","journal-title":"Ultrasound Q."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1159\/000494721","article-title":"The Vermian-crest angle: a new method to assess Foetal vermis position within the posterior Fossa using 3-dimensional multiplanar sonography","volume":"46","author":"Spinelli","year":"2019","journal-title":"Foetal Diagn Ther."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"489.e1","DOI":"10.1016\/j.crad.2019.02.017","article-title":"The \"vermian-crest angle\": does it allow accurate categorisation of foetal upward rotation of cerebellar vermis on intrauterine MRI? A pilot study","volume":"74","author":"Spinelli","year":"2019","journal-title":"Clin Radiol."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1002\/pd.5549","article-title":"Quantitative diagnostic advantages of three-dimensional ultrasound volume imaging for foetal posterior fossa anomalies: preliminary establishment of a prediction model","volume":"39","author":"Sun","year":"2019","journal-title":"Prenat. Diagn."},{"key":"ref20","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-54687-7","volume-title":"Clinical Neuroembryology: Development and developmental disorders of the human central nervous system","author":"ten Donkelaar","year":"2014"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1002\/uog.4012","article-title":"Comparison between magnetic resonance imaging and fetopathology in the evaluation of foetal posterior fossa non-cystic abnormalities","volume":"29","author":"Tilea","year":"2007","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1007\/s12311-013-0470-2","article-title":"Multidimensional analysis of foetal posterior fossa in health and disease","volume":"12","author":"Vatansever","year":"2013","journal-title":"Cerebellum"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1002\/uog.2606","article-title":"The foetal cerebellar vermis: anatomy and biometric assessment using volume contrast imaging in the C-plane (VCI-C)","volume":"26","author":"Vi\u00f1als","year":"2005","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1002\/uog.23651","article-title":"The position of the choroid plexus of the fourth ventricle in the first- and second-trimester foetuses: an early different approach to diagnostic imaging of cystic posterior fossa anomalies","volume":"58","author":"Volpe","year":"2021","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref25","first-page":"113","article-title":"Three-dimensional sonographic minute structure analysis of foetal cerebellar vermis development and malformations: utilizing volume contrast imaging","volume-title":"J. Med. Ultrason.","author":"Xie","year":"2001"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1002\/uog.2768","article-title":"Rotation of the vermis as a cause of enlarged cisterna magna on prenatal imaging","volume":"27","author":"Zalel","year":"2006","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1046\/j.0960-7692.2001.00621.x.","article-title":"The development of the foetal vermis: an in utero sonographic evaluation","volume":"19","author":"Zalel","year":"2002","journal-title":"Ultrasound Obstet. Gynecol."}],"updated-by":[{"DOI":"10.3389\/fnins.2026.1858645","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000}}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2025.1623105\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:05:32Z","timestamp":1777536332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2025.1623105\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,17]]},"references-count":27,"alternative-id":["10.3389\/fnins.2025.1623105"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2025.1623105","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,17]]},"article-number":"1623105"}}