{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T06:32:20Z","timestamp":1764311540058,"version":"3.46.0"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) can quantify indices related to brain structure and their change in pathology. However, only few studies have applied these techniques to spinal cord injury (SCI), and subtle microstructural changes in the brain of SCI individuals are not well understood. Our goal was to investigate structural changes in the brain using DTI (fractional anisotropy, FA; mean diffusivity, MD) and DKI parameters (kurtosis anisotropy, KA; mean kurtosis, MK) in subacute SCI and to study whether these changes were associated with clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty-eight individuals with SCI underwent brain MRI 3\u202fmonths post-injury, alongside 20 healthy controls. Imaging included a multi-shell diffusion protocol, from which DTI and DKI metrics (FA, MD, KA and MK) were derived. Group comparisons were conducted for each metric across 17 brain regions selected based on their relevance to SCI from previous studies. Multiple comparison corrections were applied per metric to account for the number of examined regions. Effect sizes were calculated using Cohen\u2019s\n                      <jats:italic>d<\/jats:italic>\n                      . For regions showing significant group differences, Spearman correlations were performed to assess associations between imaging metrics and clinical outcomes, including neurological status (ISNCSCI) and functional independence (SCIM III), with correction for multiple comparisons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MD was significantly higher in the right genu of the corpus callosum in the SCI group (adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.021). In this region, MD negatively correlated with SCIM scores (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f\u22120.51,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.022), whereas MK showed a positive correlation (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f0.482,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.038).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Structural changes in the corpus callosum may reflect impaired interhemispheric communication, linked to reduced functional independence after SCI. DTI and DKI could serve as complementary tools for identifying brain-based biomarkers, potentially informing recovery trajectories.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2025.1652416","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T06:28:04Z","timestamp":1764311284000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural brain changes in subacute spinal cord injury: an analysis of diffusion kurtosis imaging and diffusion tensor imaging metrics with clinical correlation"],"prefix":"10.3389","volume":"19","author":[{"given":"Ernst","family":"Christiaanse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jothini","family":"Sritharan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrik O.","family":"Wyss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Scheel-Sailer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Leemans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeev K.","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe A.","family":"Zito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"7533","DOI":"10.3390\/ijms21207533","article-title":"Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms","volume":"21","author":"Anjum","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.brainresbull.2018.01.015","article-title":"Principles of diffusion kurtosis imaging and its role in early diagnosis of neurodegenerative disorders","volume":"139","author":"Arab","year":"2018","journal-title":"Brain Res. Bull."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1038\/s41393-019-0350-9","article-title":"The 2019 revision of the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)-what's new?","volume":"57","year":"2019","journal-title":"Spinal Cord"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/s0720-048x(02)00303-0","article-title":"Basic principles of diffusion-weighted imaging","volume":"45","author":"Bammer","year":"2003","journal-title":"Eur. J. Radiol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"2018","journal-title":"J. R. Stat. Soc. Ser. B Stat Methodol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"113143","DOI":"10.1016\/j.expneurol.2019.113143","article-title":"Systemic inflammation in traumatic spinal cord injury","volume":"325","author":"Bloom","year":"2020","journal-title":"Exp. Neurol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/sc.2010.167","article-title":"Exercise therapy and recovery after SCI: evidence that shows early intervention improves recovery of function","volume":"49","author":"Brown","year":"2011","journal-title":"Spinal Cord"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1002\/glia.10220","article-title":"Sequential loss of myelin proteins during Wallerian degeneration in the rat spinal cord","volume":"42","author":"Buss","year":"2003","journal-title":"Glia"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1038\/sj.sc.3100504","article-title":"SCIM--spinal cord independence measure: a new disability scale for patients with spinal cord lesions","volume":"35","author":"Catz","year":"1997","journal-title":"Spinal Cord"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/sj.sc.3101118","article-title":"The spinal cord independence measure (SCIM): sensitivity to functional changes in subgroups of spinal cord lesion patients","volume":"39","author":"Catz","year":"2001","journal-title":"Spinal Cord"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1080\/096382801750110919","article-title":"The Catz-Itzkovich SCIM: a revised version of the Spinal Cord Independence Measure","volume":"23","author":"Catz","year":"2001","journal-title":"Disabil. Rehabil."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"e4856","DOI":"10.1002\/nbm.4856","article-title":"Mean kurtosis-Curve (MK-Curve) correction improves the test-retest reproducibility of diffusion kurtosis imaging at 3 T","volume":"36","author":"Christiaanse","year":"2023","journal-title":"NMR Biomed."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1212\/WNL.0b013e318284070c","article-title":"Diffusion tensor imaging in parkinsonian syndromes: a systematic review and meta-analysis","volume":"80","author":"Cochrane","year":"2013","journal-title":"Neurology"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.nicl.2016.01.009","article-title":"Spatially selective 2D RF inner field of view (iFOV) diffusion kurtosis imaging (DKI) of the pediatric spinal cord","volume":"11","author":"Conklin","year":"2016","journal-title":"Neuroimage Clin."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/s41393-018-0191-y","article-title":"Decreased white matter fractional anisotropy is associated with poorer functional motor skills following spinal cord injury: a pilot study","volume":"57","author":"Cunningham","year":"2019","journal-title":"Spinal Cord"},{"key":"ref16","author":"De Luca","year":""},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e3965","DOI":"10.1002\/nbm.3965","article-title":"A robust deconvolution method to disentangle multiple water pools in diffusion MRI","volume":"31","author":"De Luca","year":"2018","journal-title":"NMR Biomed."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.apmr.2021.09.019","article-title":"Cause of death trends among persons with spinal cord injury in the United States: 1960-2017","volume":"103","author":"DeVivo","year":"2022","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.2174\/1381612053507855","article-title":"Neural plasticity after spinal cord injury","volume":"11","author":"Ding","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1241658","DOI":"10.3389\/fneur.2023.1241658","article-title":"White matter microstructural alterations in patients with neuropathic pain after spinal cord injury: a diffusion tensor imaging study","volume":"14","author":"Dong","year":"2023","journal-title":"Front. Neurol."},{"key":"ref21","year":"2018"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/j.acra.2013.03.017","article-title":"Diagnostic accuracy of diffusion tensor imaging in amyotrophic lateral sclerosis: a systematic review and individual patient data meta-analysis","volume":"20","author":"Foerster","year":"2013","journal-title":"Acad. Radiol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1177\/1073858412449192","article-title":"Tracking changes following spinal cord injury: insights from neuroimaging","volume":"19","author":"Freund","year":"2013","journal-title":"Neuroscientist"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/S1474-4422(19)30138-3","article-title":"MRI in traumatic spinal cord injury: from clinical assessment to neuroimaging biomarkers","volume":"18","author":"Freund","year":"2019","journal-title":"Lancet Neurol."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1093\/brain\/awr093","article-title":"Disability, atrophy and cortical reorganization following spinal cord injury","volume":"134","author":"Freund","year":"2011","journal-title":"Brain"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"117317","DOI":"10.1016\/j.neuroimage.2020.117317","article-title":"Mapping the principal gradient onto the corpus callosum","volume":"223","author":"Friedrich","year":"2020","journal-title":"NeuroImage"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1136\/jnnp-2014-309649","article-title":"The corpus callosum in the diagnosis of multiple sclerosis and other CNS demyelinating and inflammatory diseases","volume":"86","author":"Garg","year":"2015","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref28","volume-title":"CAT-A computational anatomy toolbox for the analysis of structural MRI data","author":"Gaser","year":"2016"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"571","DOI":"10.31083\/j.jin.2020.03.165","article-title":"Molecular and microstructural biomarkers of neuroplasticity in neurodegenerative disorders through preclinical and diffusion magnetic resonance imaging studies","volume":"19","author":"Gatto","year":"2020","journal-title":"J. Integr. Neurosci."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.3174\/ajnr.A4714","article-title":"Mapping the Orientation of White Matter Fiber Bundles: A Comparative Study of Diffusion Tensor Imaging, Diffusional Kurtosis Imaging, and Diffusion Spectrum Imaging","volume":"37","author":"Glenn","year":"2016","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.mri.2014.08.028","article-title":"A simple noise correction scheme for diffusional kurtosis imaging","volume":"33","author":"Glenn","year":"2015","journal-title":"Magn. Reson. Imaging"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.neuroimage.2015.10.052","article-title":"Diffusion kurtosis imaging probes cortical alterations and white matter pathology following cuprizone induced demyelination and spontaneous remyelination","volume":"125","author":"Guglielmetti","year":"2016","journal-title":"NeuroImage"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3389\/fnhum.2019.00011","article-title":"White Matter Microstructure Alterations in Patients With Spinal Cord Injury Assessed by Diffusion Tensor Imaging","volume":"13","author":"Guo","year":"2019","journal-title":"Front. Hum. Neurosci."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1002\/mrm.28730","article-title":"Toward more robust and reproducible diffusion kurtosis imaging","volume":"86","author":"Henriques","year":"2021","journal-title":"Magn. Reson. Med."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1186\/s12883-024-03980-x","article-title":"A research protocol to study the critical time window for rehabilitation after incomplete spinal cord injury: early vs. late locomotor training","volume":"24","author":"Henry","year":"2024","journal-title":"BMC Neurol."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"598336","DOI":"10.3389\/fneur.2021.598336","article-title":"Investigation of Cerebral White Matter Changes After Spinal Cord Injury With a Measure of Fiber Density","volume":"12","author":"Huynh","year":"2021","journal-title":"Front. Neurol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"3637","DOI":"10.1002\/hbm.23619","article-title":"Spinal cord injury induces widespread chronic changes in cerebral white matter","volume":"38","author":"Ilvesmaki","year":"2017","journal-title":"Hum. Brain Mapp."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1002\/nbm.1518","article-title":"MRI quantification of non-Gaussian water diffusion by kurtosis analysis","volume":"23","author":"Jensen","year":"2010","journal-title":"NMR Biomed."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1002\/mrm.20508","article-title":"Diffusional kurtosis imaging: the quantification of non-gaussian water diffusion by means of magnetic resonance imaging","volume":"53","author":"Jensen","year":"2005","journal-title":"Magn. Reson. Med."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1002\/hbm.22099","article-title":"Investigating the prevalence of complex fiber configurations in white matter tissue with diffusion magnetic resonance imaging","volume":"34","author":"Jeurissen","year":"2013","journal-title":"Hum. Brain Mapp."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0001-8686(85)80018-X","article-title":"NMR self-diffusion studies in heterogeneous systems","volume":"23","author":"K\u00e4rger","year":"1985","journal-title":"Adv. Colloid Interf. Sci."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1148\/radiology.161.2.3763909","article-title":"MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders","volume":"161","author":"Le Bihan","year":"1986","journal-title":"Radiology"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1002\/jmri.1076","article-title":"Diffusion tensor imaging: concepts and applications","volume":"13","author":"Le Bihan","year":"2001","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1002\/mrm.21890","article-title":"The B-matrix must be rotated when correcting for subject motion in DTI data","volume":"61","author":"Leemans","year":"2009","journal-title":"Magn. Reson. Med."},{"key":"ref46","first-page":"3536","article-title":"ExploreDTI: a graphical toolbox for processing, analyzing, and visualizing diffusion MR data","volume":"17","author":"Leemans","year":"2009","journal-title":"Proc Intl Soc Mag Reson Med"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"e94592","DOI":"10.1371\/journal.pone.0094592","article-title":"A robust post-processing workflow for datasets with motion artifacts in diffusion kurtosis imaging","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s12883-020-01752-x","article-title":"Evaluation of microstructural changes in spinal cord of patients with degenerative cervical myelopathy by diffusion kurtosis imaging and investigate the correlation with JOA score","volume":"20","author":"Liu","year":"2020","journal-title":"BMC Neurol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.nicl.2016.12.012","article-title":"Longitudinal changes in microstructural white matter metrics in Alzheimer's disease","volume":"13","author":"Mayo","year":"2017","journal-title":"NeuroImage Clin."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1152\/jn.00970.2004","article-title":"Reduced functional recovery by delaying motor training after spinal cord injury","volume":"94","author":"Norrie","year":"2005","journal-title":"J. Neurophysiol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1080\/00222895.2023.2221985","article-title":"The Role of the Corpus Callosum (Micro)Structure in Bimanual Coordination: A Literature Review Update","volume":"55","author":"Pauwels","year":"2023","journal-title":"J. Mot. Behav."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.neuroimage.2015.06.068","article-title":"The effect of Gibbs ringing artifacts on measures derived from diffusion MRI","volume":"120","author":"Perrone","year":"2015","journal-title":"NeuroImage"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1109\/TMI.2009.2037915","article-title":"Optimal experimental design for diffusion kurtosis imaging","volume":"29","author":"Poot","year":"2010","journal-title":"IEEE Trans. Med. Imaging"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"e01363","DOI":"10.1002\/brb3.1363","article-title":"Test-retest reproducibility of a multi-atlas automated segmentation tool on multimodality brain MRI","volume":"9","author":"Rezende","year":"2019","journal-title":"Brain Behav."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1212\/01.wnl.0000184471.83948.e0","article-title":"Diffusion MRI in multiple sclerosis","volume":"65","author":"Rovaris","year":"2005","journal-title":"Neurology"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.46292\/sci2702-1","article-title":"International Standards for Neurological Classification of Spinal Cord Injury: Revised 2019","volume":"27","author":"Rupp","year":"2021","journal-title":"Top Spinal Cord Inj Rehabil."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.neuroimage.2006.12.010","article-title":"Diffusion tensor imaging of post mortem multiple sclerosis brain","volume":"35","author":"Schmierer","year":"2007","journal-title":"NeuroImage"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.nicl.2018.08.026","article-title":"Quantitative MRI of rostral spinal cord and brain regions is predictive of functional recovery in acute spinal cord injury","volume":"20","author":"Seif","year":"2018","journal-title":"Neuroimage Clin."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s13311-018-0633-4","article-title":"Neuropathic Pain After Spinal Cord Injury: Challenges and Research Perspectives","volume":"15","author":"Shiao","year":"2018","journal-title":"Neurotherapeutics"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1016\/j.neuroimage.2003.07.005","article-title":"Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia","volume":"20","author":"Song","year":"2003","journal-title":"NeuroImage"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1006\/nimg.2002.1267","article-title":"Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water","volume":"17","author":"Song","year":"2002","journal-title":"NeuroImage"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/B978-0-12-374105-9.00020-4","article-title":"Diffusion tensor imaging in Parkinson\u2019s disease","volume-title":"Encyclopedia of movement disorders","author":"Stebbins","year":"2010"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"W26","DOI":"10.2214\/AJR.13.11365","article-title":"Diffusion kurtosis imaging: an emerging technique for evaluating the microstructural environment of the brain","volume":"202","author":"Steven","year":"2014","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/brainsci7020021","article-title":"Diffusion Assessment of Cortical Changes, Induced by Traumatic Spinal Cord Injury","volume":"7","author":"Sun","year":"2017","journal-title":"Brain Sci."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s00701-021-05018-4","article-title":"Diffusional kurtosis imaging as a possible prognostic marker of cervical incomplete spinal cord injury outcome: a prospective pilot study","volume":"164","author":"Thygesen","year":"2022","journal-title":"Acta Neurochir."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/s0896-6273(03)00758-x","article-title":"Diffusion MRI of complex neural architecture","volume":"40","author":"Tuch","year":"2003","journal-title":"Neuron"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"100029","DOI":"10.1016\/j.arrct.2019.100029","article-title":"Association Between SCIM III Total Scores and Individual Item Scores to Predict Independence With ADLs in Persons With Spinal Cord Injury","volume":"1","author":"Unai","year":"2019","journal-title":"Arch Rehabil Res Clin Transl."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.neuroimage.2016.08.016","article-title":"Denoising of diffusion MRI using random matrix theory","volume":"142","author":"Veraart","year":"2016","journal-title":"NeuroImage"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/mrm.26124","article-title":"The importance of correcting for signal drift in diffusion MRI","volume":"77","author":"Vos","year":"2017","journal-title":"Magn. Reson. Med."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"2941","DOI":"10.1002\/hbm.21417","article-title":"Degeneration of corpus callosum and recovery of motor function after stroke: a multimodal magnetic resonance imaging study","volume":"33","author":"Wang","year":"2012","journal-title":"Hum. Brain Mapp."},{"key":"ref71","year":"2024"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.nicl.2018.04.005","article-title":"Altered white matter microarchitecture in amyotrophic lateral sclerosis: a voxel-based meta-analysis of diffusion tensor imaging","volume":"19","author":"Zhang","year":"2018","journal-title":"Neuroimage Clin."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.neuroimage.2019.04.015","article-title":"MK-curve \u2013 Characterizing the relation between mean kurtosis and alterations in the diffusion MRI signal","volume":"196","author":"Zhang","year":"2019","journal-title":"NeuroImage"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/4671607","article-title":"Brain White Matter Impairment in Patients with Spinal Cord Injury","volume":"2017","author":"Zheng","year":"2017","journal-title":"Neural Plast."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.neuroimage.2011.07.050","article-title":"Diffusion kurtosis as an in vivo imaging marker for reactive astrogliosis in traumatic brain injury","volume":"59","author":"Zhuo","year":"2012","journal-title":"NeuroImage"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"e1257","DOI":"10.1212\/WNL.0000000000005258","article-title":"Progressive neurodegeneration following spinal cord injury: Implications for clinical trials","volume":"90","author":"Ziegler","year":"2018","journal-title":"Neurology"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2025.1652416\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T06:28:06Z","timestamp":1764311286000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2025.1652416\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":75,"alternative-id":["10.3389\/fnins.2025.1652416"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2025.1652416","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,28]]},"article-number":"1652416"}}