{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:30:50Z","timestamp":1793136650592,"version":"4.5.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parkinson\u2019s disease (PD) involves motor impairment and neurochemical changes, necessitating neuroprotective agents to enhance nursing care outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Iron oxide nanoparticles (IONPs) were biosynthesized via green chemistry and characterized by TEM, UV-Vis, photoluminescence, XRD, and VSM. Antioxidant activity used DPPH assay; biocompatibility involved MTT and hemolysis assays. Efficacy was tested in an MPTP-induced mouse model of PD, assessing motor function, antioxidant capacity, and dopaminergic neuron protection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IONPs exhibited spherical morphology (39.0\u202f\u00b1\u202f11.3 nm), zeta potential of \u221213\u202fmV, and saturation magnetization of 42.32 emu\/g. They showed concentration-dependent DPPH scavenging and no significant cytotoxicity or hemolysis up to 10 \u00b5g\/mL.\n                      <jats:italic>In vitro<\/jats:italic>\n                      , IONPs improved motor performance, boosted antioxidants, and reduced apoptosis in dopamine neurons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Biosynthesized IONPs offer promise as a complementary PD therapy by mitigating motor deficits and neurochemical damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2025.1692707","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T07:51:58Z","timestamp":1768204318000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Neuroprotective, eco-friendly iron oxide nanoparticles to alleviate Parkinson\u2019s disease symptoms and improve nursing care"],"prefix":"10.3389","volume":"19","author":[{"given":"Shuangyan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"4644","DOI":"10.3390\/ma13204644","article-title":"Magnetic iron oxide nanoparticle (IONP) synthesis to applications: present and future","volume":"13","author":"Ajinkya","year":"2020","journal-title":"Materials"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"822","DOI":"10.5530\/pj.2021.13.104","article-title":"Peppermint, (Mentha \u00d7 piperita): role in Management of Diseases through modulating various biological activities","volume":"13","author":"Almatroodi","year":"2021","journal-title":"Pharm. 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