{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T06:49:22Z","timestamp":1765349362388,"version":"3.46.0"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study investigated the brain functional characteristics of patients with neuropathic pain (NP) following spinal cord injury (SCI) using functional near-infrared spectroscopy (fNIRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 35 subjects were enrolled, including 10 able-bodied controls, 12 patients with SCI and NP (SCI-NP), and 13 patients with SCI (without NP). fNIRS was used to detected blood oxygen signals during motor tasks and resting-state (RS) functional connectivity (FC) in the subjects. We also performed Pearson correlation analyses of pain scores (NPS) and the Pittsburgh Sleep Quality Index (PSQI) in patients with SCI-NP. Statistical analyses were performed using Shapiro-Wilk test for normality; paired\n                      <jats:italic>t-<\/jats:italic>\n                      test for intra-group differences; ANOVA (LSD\n                      <jats:italic>post-hoc<\/jats:italic>\n                      , Bonferroni-corrected) for multi-group comparisons; Cohen's d\/partial \u03b7\n                      <jats:sup>2<\/jats:sup>\n                      for effect size; independent samples\n                      <jats:italic>t<\/jats:italic>\n                      -test (FDR-corrected) for inter-group FC differences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the task state, patients with SCI-NP activated bilateral primary somatosensory cortex (S1, L\/R\n                      <jats:italic>P<\/jats:italic>\n                      = 0.044\/0.032), bilateral supplementary motor area (SMA, L\/R\n                      <jats:italic>P<\/jats:italic>\n                      = 0.041\/0.037), right primary motor cortex and left parietal lobe (LPL,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.047). Hemodynamic changes in the bilateral S1, secondary somatosensory cortex, SMA, and right prefrontal cortex of patients with SCI-NP were significantly stronger than those in the other two groups. During RS, the whole-brain and most inter\/intra-regional FC strength trended able-bodied controls &amp;gt; patients with SCI &amp;gt; patients with SCI-NP. NPS strongly correlated with LPL (r = 0.977,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.004); PSQI correlated with motor cortex HbO changes (r = 0.889\u22120.975,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.005\u22120.043).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with SCI-NP exhibit significant abnormal cerebral cortical excitation and reduced FC. HbO is a potential biomarker for evaluating NP. fNIRS supports objective assessment of SCI-NP and rehabilitation strategy formulation [ChiCTR2500097098].<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2025.1699161","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T06:47:49Z","timestamp":1765349269000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Characteristic of cerebral hemodynamics and functional connectivity in patients with neuropathic pain after spinal cord injury: an exploratory study"],"prefix":"10.3389","volume":"19","author":[{"given":"Yang","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiling","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zebin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honghui","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sitong","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fubiao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangyong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/S1474-4422(18)30071-1","article-title":"Diagnosis and assessment of neuropathic pain through questionnaires","volume":"17","author":"Attal","year":"2018","journal-title":"Lancet Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1038\/nn.3153","article-title":"Corticostriatal functional connectivity predicts transition to chronic back pain","volume":"15","author":"Baliki","year":"2012","journal-title":"Nat. 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