{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T21:34:37Z","timestamp":1781732077041,"version":"3.54.5"},"reference-count":95,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the therapeutic mechanism of electroacupuncture (EA) in a mouse model of Parkinson\u2019s disease (PD) induced by 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Motor functions were evaluated using open field test and pole tests. Tyrosine hydroxylase (TH) expression in the substantia nigra and striatum was detected by immunohistochemistry. Intestinal barrier integrity was assessed via immunofluorescence staining of tight junction proteins ZO-1 and Occludin. Gut microbiota composition was analyzed by 16S rRNA sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>EA treatment significantly improved motor deficits, restored TH expression in nigrostriatal regions, and enhanced colonic ZO-1 and Occludin levels. EA reversed MPTP-induced dysbiosis, notably normalizing the abundances of Dubosiella, Lactobacillus, Enterococcus, Desulfovibrio, Bacteroides, Allobaculum, and Parasutterella. Microbial co-occurrence network analysis revealed that EA simplified hyperconnected interactions and improved network stability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EA treatment attenuated PD progression, which was associated with the remodeling of gut microbiota structure and restoration of microbial network stability. The concomitant protection of dopaminergic function suggests a potential link mediated by the gut\u2013brain axis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2025.1702912","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T06:33:44Z","timestamp":1768372424000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Electroacupuncture exerts neuroprotective effects and alters gut microbiota in a MPTP-induced mouse model of Parkinson\u2019s disease"],"prefix":"10.3389","volume":"19","author":[{"given":"Xi-Chen","family":"Wu","sequence":"first","affiliation":[{"name":"LongHua Hospital, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Yue","family":"Dong","sequence":"additional","affiliation":[{"name":"LongHua Hospital, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chen","family":"Ying","sequence":"additional","affiliation":[{"name":"LongHua Hospital, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Gansu Provincial People\u2019s Hospital, Jangsu University","place":["Gansu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[{"name":"LongHua Hospital, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Fan","sequence":"additional","affiliation":[{"name":"LongHua Hospital, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yin","sequence":"additional","affiliation":[{"name":"LongHua Hospital, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Lai","family":"Chen","sequence":"additional","affiliation":[{"name":"LongHua Hospital, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1212\/wnl.57.3.456","article-title":"Frequency of bowel movements and the future risk of Parkinson\u2019s disease.","volume":"57","author":"Abbott","year":"2001","journal-title":"Neurology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1111\/j.1471-4159.1989.tb09224.x","article-title":"Differential effect of stress on in vivo dopamine release in striatum, nucleus accumbens, and medial frontal cortex.","volume":"52","author":"Abercrombie","year":"1989","journal-title":"J. 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