{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:47:31Z","timestamp":1784126851171,"version":"3.55.0"},"reference-count":219,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>In the central nervous system, astrocytes are highly specialized non-neuronal cells that are key elements in maintaining neuronal microenvironment homeostasis. These cells provide structural and metabolic support to other brain cells and regulate ion concentrations and the local levels of neurotransmitters such as glutamate. Astrogliosis, characterized by morphological and functional abnormalities, has been implicated in various neuronal disorders. Similarly, hepatic stellate cells drive the initiation and the progression of liver fibrosis. After liver injury, hepatic stellate cells are activated through inflammatory mediators and differentiate into activated myofibroblasts. Hepatic stellate cells express several glial-related molecules, suggesting functional similarities between these two cell types, which paves the way for a better understanding of crucial targets for neuronal and liver repair. We present herein a compressive update of our current knowledge of the transcriptome of activated hepatic stellate cells during liver injury and contrast it with that of reactive astrocytes in neuronal diseases. Furthermore, we summarize the plausible involvement of long non-coding and microRNAs in the transcriptional regulation of specific genes during neuronal and liver injuries. Finally, we discuss possible common targets and novel strategies to diminish the activation of stellate cells and astrocytes as therapeutic strategies. In addition, we highlight new insights into the brain-liver axis.<\/jats:p>","DOI":"10.3389\/fnins.2025.1733612","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T06:30:12Z","timestamp":1770100212000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuronal injury and hepatotoxicity: astrocytes and stellate cells convergence and their role in tissue repair"],"prefix":"10.3389","volume":"19","author":[{"given":"Ana Catya","family":"Jimenez-Torres","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University","place":["Augusta, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Ortega","sequence":"additional","affiliation":[{"name":"Departamento de Toxicolog\u00eda, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (Cinvestav-IPN)","place":["Mexico City, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha","family":"Najimi","sequence":"additional","affiliation":[{"name":"Laboratory of Pediatric Hepatology and Cell Therapy, Institute of Experimental and Clinical Research (IREC), UCLouvain","place":["Brussels, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier.","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1007\/s42242-021-00126-7","article-title":"Recent advances in chemically defined and tunable hydrogel platforms for organoid culture.","volume":"4","author":"Agarwal","year":"2021","journal-title":"Biodes Manuf."},{"key":"B3","doi-asserted-by":"publisher","first-page":"104733","DOI":"10.1016\/j.yexmp.2021.104733","article-title":"TGF-\u03b21 signaling can worsen NAFLD with liver fibrosis backdrop.","volume":"124","author":"Ahmed","year":"2022","journal-title":"Exp. Mol. Pathol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"122","DOI":"10.31083\/j.jin2205122","article-title":"EEF1A1 is involved the regulating neuroinflammatory processes in Parkinson\u2019s disease","volume":"22","author":"Aisha","year":"2023","journal-title":"JIN."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e0248027","DOI":"10.1371\/journal.pone.0248027","article-title":"Polymorphic SERPINA3 prolongs oligomeric state of amyloid beta.","volume":"16","author":"Akbor","year":"2021","journal-title":"PLoS One"},{"key":"B6","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.ijsu.2013.05.030","article-title":"CDKN2A promoter hypermethylation in astrocytomas is associated with age and sex.","volume":"11","author":"Alves","year":"2013","journal-title":"Int. J. Surg."},{"key":"B7","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3389\/fmed.2020.00062","article-title":"Hepatic autonomic nervous system and neurotrophic factors regulate the pathogenesis and progression of non-alcoholic fatty liver disease.","volume":"7","author":"Amir","year":"2020","journal-title":"Front. Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"222","DOI":"10.5607\/en21013","article-title":"Adenovirus-induced reactive astrogliosis exacerbates the pathology of Parkinson\u2019s disease.","volume":"30","author":"An","year":"2021","journal-title":"Exp. Neurobiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1101\/gad.1653708","article-title":"Role of platelet-derived growth factors in physiology and medicine.","volume":"22","author":"Andrae","year":"2008","journal-title":"Genes Dev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"111200","DOI":"10.1016\/j.celrep.2022.111200","article-title":"APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-\u03baB activation.","volume":"40","author":"Arnaud","year":"2022","journal-title":"Cell Rep."},{"key":"B11","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.orcp.2020.07.004","article-title":"Influence of LGALS3 and PNPLA3 genes in non-alcoholic steatohepatitis (NASH) in patients undergone bariatric surgery.","volume":"14","author":"Azevedo Foinquinos","year":"2020","journal-title":"Obes. Res. Clin. Pract."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e108505","DOI":"10.1371\/journal.pone.0108505","article-title":"Regulator of G-protein signaling-5 is a marker of hepatic stellate cells and expression mediates response to liver injury.","volume":"9","author":"Bahrami","year":"2014","journal-title":"PLoS One"},{"key":"B13","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s12974-020-01746-z","article-title":"Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-\u03baB pathway.","volume":"17","author":"Balzano","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1101\/2023.01.11.523573","article-title":"Molecular identification of ALDH1A1 and SIRT2 in the astrocytic putrescine-to-GABA metabolic pathway.","author":"Bhalla","year":"2023","journal-title":"bioRxiv [Preprint]"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1002\/hep.30696","article-title":"Pharmacologic inhibition of epidermal growth factor receptor suppresses nonalcoholic fatty liver disease in a murine fast-food diet model.","volume":"70","author":"Bhushan","year":"2019","journal-title":"Hepatology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1002\/glia.22317","article-title":"Aquaporin-4 and epilepsy.","volume":"60","author":"Binder","year":"2012","journal-title":"Glia"},{"key":"B17","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.bbalip.2008.11.001","article-title":"Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage.","volume":"1791","author":"Blaner","year":"2009","journal-title":"Biochim Biophys. Acta"},{"key":"B18","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.celrep.2017.12.039","article-title":"The aging astrocyte transcriptome from multiple regions of the mouse brain.","volume":"22","author":"Boisvert","year":"2018","journal-title":"Cell Rep."},{"key":"B19","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.tins.2017.04.001","article-title":"The role of astrocyte dysfunction in Parkinson\u2019s disease pathogenesis.","volume":"40","author":"Booth","year":"2017","journal-title":"Trends Neurosci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"26000","DOI":"10.1074\/jbc.M709829200","article-title":"RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis.","volume":"283","author":"Bourd-Boittin","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B21","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries.","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"B22","doi-asserted-by":"publisher","first-page":"5789","DOI":"10.3390\/molecules25245789","article-title":"Comprehensive review on Alzheimer\u2019s disease: Causes and treatment.","volume":"25","author":"Breijyeh","year":"2020","journal-title":"Molecules"},{"key":"B23","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/s0197-0186(00)00116-9","article-title":"Acquisition of blood\u2013tissue barrier\u2013supporting features by hepatic stellate cells and astrocytes of myofibroblastic phenotype. Inverse dynamics of metallothionein and glial fibrillary acidic protein expression.","volume":"38","author":"Buniatian","year":"2001","journal-title":"Neurochem. Int."},{"key":"B24","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.bbi.2017.12.013","article-title":"Increasing extracellular cGMP in cerebellum in vivo reduces neuroinflammation, GABAergic tone and motor in-coordination in hyperammonemic rats.","volume":"69","author":"Cabrera-Pastor","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1007\/s00415-017-8593-x","article-title":"Astrocyte and Alzheimer\u2019s disease.","volume":"264","author":"Cai","year":"2017","journal-title":"J. Neurol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1002\/lt.21436","article-title":"Glial fibrillary acidic protein as an early marker of hepatic stellate cell activation in chronic and posttransplant recurrent hepatitis C.","volume":"14","author":"Carotti","year":"2008","journal-title":"Liver Transpl."},{"key":"B27","doi-asserted-by":"publisher","first-page":"867940","DOI":"10.3389\/fendo.2022.867940","article-title":"Hepatic stellate cell-immune interactions in NASH.","volume":"13","author":"Carter","year":"2022","journal-title":"Front. Endocrinol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1053\/jhep.2001.20793","article-title":"Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors.","volume":"33","author":"Cassiman","year":"2001","journal-title":"Hepatology"},{"key":"B29","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-801238-3.04074-5","article-title":"Prohormone convertases?","volume-title":"Reference Module in Biomedical Sciences.","author":"Cawley","year":"2014"},{"key":"B30","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.rgmx.2014.05.003","article-title":"Garc\u00eda de Le\u00f3n M\u00e9ndez MC. [Biomarkers for liver fibrosis: Advances, advantages and disadvantages].","volume":"79","author":"Cequera","year":"2014","journal-title":"Rev. Gastroenterol. Mex."},{"key":"B31","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.neuron.2017.06.029","article-title":"Neural circuit-specialized astrocytes: Transcriptomic, proteomic, morphological, and functional evidence.","volume":"95","author":"Chai","year":"2017","journal-title":"Neuron"},{"key":"B32","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.gendis.2021.12.006","article-title":"Mechanisms of NLRP3 inflammasome-mediated hepatic stellate cell activation: Therapeutic potential for liver fibrosis.","volume":"10","author":"Charan","year":"2023","journal-title":"Genes Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"e147552","DOI":"10.1172\/JCI147552","article-title":"Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma.","volume":"131","author":"Chen","year":"2021","journal-title":"J. Clin. Invest."},{"key":"B34","doi-asserted-by":"publisher","first-page":"5178","DOI":"10.1096\/fj.201902307RRR","article-title":"Exosomal miR-103-3p from LPS-activated THP-1 macrophage contributes to the activation of hepatic stellate cells.","volume":"34","author":"Chen","year":"2020","journal-title":"FASEB J."},{"key":"B35","doi-asserted-by":"publisher","first-page":"745066","DOI":"10.3389\/fnmol.2021.745066","article-title":"Long non-coding RNAs and circular RNAs: Insights into microglia and astrocyte mediated neurological diseases.","volume":"14","author":"Chen","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e2916","DOI":"10.1038\/cddis.2017.309","article-title":"MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice.","volume":"8","author":"Cheng","year":"2017","journal-title":"Cell Death Dis."},{"key":"B37","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/s41575-023-00821-z","article-title":"Friend or foe? The elusive role of hepatic stellate cells in liver cancer.","volume":"20","author":"Cogliati","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.1002\/cam4.1180","article-title":"A comprehensive genome-wide analysis of long noncoding RNA expression profile in hepatocellular carcinoma.","volume":"6","author":"Cui","year":"2017","journal-title":"Cancer Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1212\/wnl.51.1_suppl_1.s2","article-title":"Alzheimer\u2019s disease: Etiologies, pathophysiology, cognitive reserve, and treatment opportunities.","volume":"51","author":"Cummings","year":"1998","journal-title":"Neurology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.jhep.2006.04.010","article-title":"Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice.","volume":"45","author":"Czochra","year":"2006","journal-title":"J. Hepatol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.nbd.2018.04.008","article-title":"Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson\u2019s disease.","volume":"115","author":"De Miranda","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"B42","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/s41419-023-06043-0","article-title":"NPM promotes hepatotoxin-induced fibrosis by inhibiting ROS-induced apoptosis of hepatic stellate cells and upregulating lncMIAT-induced TGF-\u03b22.","volume":"14","author":"Ding","year":"2023","journal-title":"Cell Death Dis."},{"key":"B43","doi-asserted-by":"publisher","first-page":"16163","DOI":"10.1038\/srep16163","article-title":"MiR-146a-5p suppresses activation and proliferation of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis through directly targeting Wnt1 and Wnt5a.","volume":"5","author":"Du","year":"2015","journal-title":"Sci. Rep."},{"key":"B44","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.jhep.2010.03.025","article-title":"The NF-kappaB p50:p50:hdac-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes.","volume":"53","author":"Elsharkawy","year":"2010","journal-title":"J. Hepatol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"896172","DOI":"10.3389\/fncel.2022.896172","article-title":"Astrocytes profiling in acute hepatic encephalopathy: Possible enrolling of glial fibrillary acidic protein, tumor necrosis factor-alpha, inwardly rectifying potassium channel (Kir 4.1) and aquaporin-4 in rat cerebral cortex.","volume":"16","author":"Elsherbini","year":"2022","journal-title":"Front. Cell Neurosci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/s41593-020-00783-4","article-title":"Reactive astrocyte nomenclature, definitions, and future directions.","volume":"24","author":"Escartin","year":"2021","journal-title":"Nat. Neurosci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.cdtm.2021.08.002","article-title":"Identification of key genes and pathways in mild and severe nonalcoholic fatty liver disease by integrative analysis.","volume":"7","author":"Feng","year":"2021","journal-title":"Chronic Dis. Transl. Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver.","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol. Rev."},{"key":"B49","first-page":"29","article-title":"Role of LncRNA-activated by transforming growth factor beta in the progression of hepatitis C virus-related liver fibrosis.","volume":"22","author":"Fu","year":"2016","journal-title":"Discov. Med."},{"key":"B50","first-page":"1615","article-title":"Hypermethylation of the CpG island of p16\/CDKN2 correlates with gene inactivation in gliomas.","volume":"13","author":"Fueyo","year":"1996","journal-title":"Oncogene"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1002\/hep.26422","article-title":"miR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells.","volume":"58","author":"Gailhouste","year":"2013","journal-title":"Hepatology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41392-024-02072-z","article-title":"Liver diseases: Epidemiology, causes, trends and predictions.","volume":"10","author":"Gan","year":"2025","journal-title":"Signal Transduct. Target Ther."},{"key":"B53","doi-asserted-by":"publisher","first-page":"3967","DOI":"10.1073\/pnas.87.10.3967","article-title":"Expression of microtubule-associated protein 2 by reactive astrocytes.","volume":"87","author":"Geisert","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B54","doi-asserted-by":"publisher","first-page":"111256","DOI":"10.1016\/j.biopha.2021.111256","article-title":"microRNA-140: A miRNA with diverse roles in human diseases.","volume":"135","author":"Ghafouri-Fard","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"B55","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1038\/nri2423","article-title":"New regulators of NF-kappaB in inflammation.","volume":"8","author":"Ghosh","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"3995","DOI":"10.3390\/ijms25073995","article-title":"Neuroinflammation in neurodegenerative disorders: Current knowledge and therapeutic implications.","volume":"25","author":"Giri","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1038\/labinvest.2017.65","article-title":"Paired related homeobox protein 1 regulates PDGF-induced chemotaxis of hepatic stellate cells in liver fibrosis.","volume":"97","author":"Gong","year":"2017","journal-title":"Lab Invest."},{"key":"B58","doi-asserted-by":"publisher","first-page":"e42051","DOI":"10.1016\/j.heliyon.2025.e42051","article-title":"A single-cell transcriptome analysis reveals astrocyte heterogeneity and identifies CHI3L1 as a diagnostic biomarker in Parkinson\u2019s disease.","volume":"11","author":"Gong","year":"2025","journal-title":"Heliyon"},{"key":"B59","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1756-6606-3-12","article-title":"Astrocytic expression of Parkinson\u2019s disease-related A53T alpha-synuclein causes neurodegeneration in mice.","volume":"3","author":"Gu","year":"2010","journal-title":"Mol. Brain"},{"key":"B60","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.puhe.2025.02.028","article-title":"The trend in incidence of non-alcoholic fatty liver disease and its impact on cirrhosis and liver cancer: An analysis from Global Burden of Disease 2021.","volume":"242","author":"Gu","year":"2025","journal-title":"Public Health"},{"key":"B61","doi-asserted-by":"publisher","first-page":"159540","DOI":"10.1016\/j.bbalip.2024.159540","article-title":"Early activation of hepatic stellate cells induces rapid initiation of retinyl ester breakdown while maintaining lecithin:retinol acyltransferase (LRAT) activity.","volume":"1869","author":"Haaker","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/j.jhep.2017.07.027","article-title":"Fibrosis stage but not NASH predicts mortality and time to development of severe liver disease in biopsy-proven NAFLD.","volume":"67","author":"Hagstr\u00f6m","year":"2017","journal-title":"J. Hepatol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s12974-018-1139-z","article-title":"LncRNA H19 contributes to hippocampal glial cell activation via JAK\/STAT signaling in a rat model of temporal lobe epilepsy.","volume":"15","author":"Han","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"B64","doi-asserted-by":"publisher","first-page":"e12856","DOI":"10.1111\/cpr.12856","article-title":"The lncRNA H19 binding to let-7b promotes hippocampal glial cell activation and epileptic seizures by targeting Stat3 in a rat model of temporal lobe epilepsy.","volume":"53","author":"Han","year":"2020","journal-title":"Cell Prolif."},{"key":"B65","doi-asserted-by":"publisher","first-page":"6242","DOI":"10.1111\/jcmm.15261","article-title":"LncRNA HOTTIP facilitates the stemness of breast cancer via regulation of miR-148a-3p\/WNT1 pathway.","volume":"24","author":"Han","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"B66","doi-asserted-by":"publisher","first-page":"S88","DOI":"10.1111\/j.1440-1746.2006.04586.x","article-title":"Matrix metalloproteinases, the pros and cons, in liver fibrosis.","volume":"21","author":"Han","year":"2006","journal-title":"J. Gastroenterol. Hepatol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"e2302916","DOI":"10.1002\/advs.202302916","article-title":"Inhibition of NFAT5-dependent astrocyte swelling alleviates neuropathic pain","volume":"11","author":"He","year":"2024","journal-title":"Adv. Sci."},{"key":"B68","doi-asserted-by":"publisher","first-page":"e220502","DOI":"10.1530\/EC-22-0502","article-title":"Single-cell transcriptomics of hepatic stellate cells uncover crucial pathways and key regulators involved in non-alcoholic steatohepatitis.","volume":"12","author":"He","year":"2023","journal-title":"Endocr. Connect."},{"key":"B69","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3390\/cells10020252","article-title":"Unexpected pro-fibrotic effect of MIF in non-alcoholic steatohepatitis is linked to a shift in NKT cell populations.","volume":"10","author":"Heinrichs","year":"2021","journal-title":"Cells"},{"key":"B70","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1002\/glia.23908","article-title":"Astrocytes are necessary for blood-brain barrier maintenance in the adult mouse brain.","volume":"69","author":"Heithoff","year":"2021","journal-title":"Glia"},{"key":"B71","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41531-024-00851-7","article-title":"Park7 deletion leads to sex-specific transcriptome changes involving NRF2-CYP1B1 axis in mouse midbrain astrocytes.","volume":"11","author":"Helgueta","year":"2024","journal-title":"NPJ Parkinsons Dis."},{"key":"B72","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s42242-021-00150-7","article-title":"Organoids: A novel modality in disease modeling.","volume":"4","author":"Heydari","year":"2021","journal-title":"Biodes. Manuf."},{"key":"B73","doi-asserted-by":"publisher","first-page":"104390","DOI":"10.1016\/j.phrs.2019.104390","article-title":"miR-140 targeting CTSB signaling suppresses the mesenchymal transition and enhances temozolomide cytotoxicity in glioblastoma multiforme.","volume":"147","author":"Ho","year":"2019","journal-title":"Pharmacol. Res."},{"key":"B74","doi-asserted-by":"publisher","first-page":"5530","DOI":"10.1093\/emboj\/cdg534","article-title":"Genetic analysis of NF-kappaB\/Rel transcription factors defines functional specificities.","volume":"22","author":"Hoffmann","year":"2003","journal-title":"EMBO J."},{"key":"B75","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3727\/105221618X15341831737687","article-title":"Bioinformatics analysis of key differentially expressed genes in nonalcoholic fatty liver disease mice models.","volume":"19","author":"Hou","year":"2018","journal-title":"Gene Expr."},{"key":"B76","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1042\/CS20140012","article-title":"The role of the miR-31\/FIH1 pathway in TGF-\u03b2-induced liver fibrosis.","volume":"129","author":"Hu","year":"2015","journal-title":"Clin. Sci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"690151","DOI":"10.3389\/fmolb.2021.690151","article-title":"Identification of Arp2\/3 complex subunits as prognostic biomarkers for hepatocellular carcinoma.","volume":"8","author":"Huang","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"B78","doi-asserted-by":"publisher","first-page":"2556","DOI":"10.1038\/s41591-025-03834-0","article-title":"The global neurodegeneration proteomics consortium: Biomarker and drug target discovery for common neurodegenerative diseases and aging.","volume":"31","author":"Imam","year":"2025","journal-title":"Nat. Med."},{"key":"B79","doi-asserted-by":"publisher","first-page":"102459","DOI":"10.1016\/j.arr.2024.102459","article-title":"MicroRNA-455-3P as a peripheral biomarker and therapeutic target for mild cognitive impairment and Alzheimer\u2019s disease.","volume":"100","author":"Islam","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"B80","doi-asserted-by":"publisher","first-page":"106327","DOI":"10.1016\/j.nbd.2023.106327","article-title":"Metabolic remodeling in astrocytes: Paving the path to brain tumor development.","volume":"188","author":"Jara\u00edz-Rodr\u00edguez","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"B81","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.canlet.2016.08.009","article-title":"Long non-coding RNA H19 regulates glioma angiogenesis and the biological behavior of glioma-associated endothelial cells by inhibiting microRNA-29a.","volume":"381","author":"Jia","year":"2016","journal-title":"Cancer Lett."},{"key":"B82","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.ncrna.2024.01.001","article-title":"The role of lncRNA-mediated ceRNA regulatory networks in liver fibrosis.","volume":"9","author":"Jiang","year":"2024","journal-title":"Noncoding RNA Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3171\/2014.12.JNS1426.test","article-title":"Increased level of H19 long noncoding RNA promotes invasion, angiogenesis, and stemness of glioblastoma cells.","volume":"2016","author":"Jiang","year":"2016","journal-title":"J. Neurosurg."},{"key":"B84","doi-asserted-by":"publisher","first-page":"13052","DOI":"10.1073\/pnas.91.26.13052","article-title":"Molecular characterization of an aquaporin cDNA from brain: Candidate osmoreceptor and regulator of water balance.","volume":"91","author":"Jung","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B85","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1002\/hep.28367","article-title":"Differentiation therapy for hepatocellular carcinoma: Multifaceted effects of miR-148a on tumor growth and phenotype and liver fibrosis.","volume":"63","author":"Jung","year":"2016","journal-title":"Hepatology"},{"key":"B86","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.molcel.2013.08.027","article-title":"The imprinted H19 lncRNA antagonizes let-7 microRNAs.","volume":"52","author":"Kallen","year":"2013","journal-title":"Mol. Cell"},{"key":"B87","doi-asserted-by":"publisher","first-page":"105028","DOI":"10.1016\/j.nbd.2020.105028","article-title":"Microglia and astrocyte dysfunction in Parkinson\u2019s disease.","volume":"144","author":"Kam","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1113\/JP281061","article-title":"Hepatic stellate cells in physiology and pathology.","volume":"600","author":"Kamm","year":"2022","journal-title":"J. Physiol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"4688","DOI":"10.1038\/s41467-019-12701-9","article-title":"Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1.","volume":"10","author":"Kendall","year":"2019","journal-title":"Nat. Commun."},{"key":"B90","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.jhep.2024.10.044","article-title":"Multi-modal analysis of human hepatic stellate cells identifies novel therapeutic targets for metabolic dysfunction-associated steatotic liver disease.","volume":"82","author":"Kim","year":"2024","journal-title":"J. Hepatol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"28823","DOI":"10.1038\/srep28823","article-title":"DJ-1 deficiency impairs glutamate uptake into astrocytes via the regulation of flotillin-1 and caveolin-1 expression.","volume":"6","author":"Kim","year":"2016","journal-title":"Sci. Rep."},{"key":"B92","doi-asserted-by":"publisher","first-page":"675","DOI":"10.3390\/ijms24010675","article-title":"Transcriptome profile in the mouse brain of hepatic encephalopathy and Alzheimer\u2019s disease.","volume":"24","author":"Kim","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B93","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s004180000150","article-title":"Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat.","volume":"113","author":"Knittel","year":"2000","journal-title":"Histochem. Cell Biol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/s0168-8278(02)00050-8","article-title":"Expression of reelin in hepatic stellate cells and during hepatic tissue repair: A novel marker for the differentiation of HSC from other liver myofibroblasts.","volume":"36","author":"Kobold","year":"2002","journal-title":"J. Hepatol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"6638915","DOI":"10.1155\/2021\/6638915","article-title":"Effects of miRNA-140 on the growth and clinical prognosis of SMMC-7721 hepatocellular carcinoma cell line.","volume":"2021","author":"Kong","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"B96","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.parkreldis.2015.09.007","article-title":"Autosomal dominant Parkinson\u2019s disease caused by SNCA duplications.","volume":"22","author":"Konno","year":"2016","journal-title":"Parkinson. Relat Disord."},{"key":"B97","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.msard.2016.11.006","article-title":"17 signalling in astrocytes promotes glutamate excitotoxicity: Indications for the link between inflammatory and neurodegenerative events in multiple sclerosis","volume":"11","author":"Kostic","year":"2017","journal-title":"Mult. Scler. Relat. Disord."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1002\/ijc.25466","article-title":"CHI3L1 (YKL-40) is expressed in human gliomas and regulates the invasion, growth and survival of glioma cells.","volume":"128","author":"Ku","year":"2011","journal-title":"Int. J. Cancer"},{"key":"B99","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1034\/j.1600-0676.2002.01503.x","article-title":"Intrahepatic expression of the hepatic stellate cell marker fibroblast activation protein correlates with the degree of fibrosis in hepatitis C virus infection.","volume":"22","author":"Levy","year":"2002","journal-title":"Liver"},{"key":"B100","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1016\/j.gendis.2022.08.013","article-title":"Interplays of liver fibrosis-associated microRNAs: Molecular mechanisms and implications in diagnosis and therapy.","volume":"10","author":"Li","year":"2023","journal-title":"Genes Dis."},{"key":"B101","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s10620-020-06174-w","article-title":"MicroRNA-489-3p represses hepatic stellate cells activation by negatively regulating the JAG1\/Notch3 signaling pathway.","volume":"66","author":"Li","year":"2021","journal-title":"Dig. Dis. Sci."},{"key":"B102","doi-asserted-by":"publisher","first-page":"5885","DOI":"10.2147\/OTT.S179509","article-title":"MicroRNA-140-3p enhances the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting pregnenolone X receptor.","volume":"11","author":"Li","year":"2018","journal-title":"Onco Targets Ther."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.3892\/mmr.2020.10997","article-title":"Gli3 is a novel downstream target of miR-200a with an anti-fibrotic role for progression of liver fibrosis in vivo and in vitro.","volume":"21","author":"Li","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"B104","doi-asserted-by":"publisher","first-page":"155106","DOI":"10.1016\/j.cyto.2020.155106","article-title":"The LncRNA H19\/miR-1-3p\/CCL2 axis modulates lipopolysaccharide (LPS) stimulation-induced normal human astrocyte proliferation and activation.","volume":"131","author":"Li","year":"2020","journal-title":"Cytokine"},{"key":"B105","doi-asserted-by":"publisher","first-page":"2814","DOI":"10.1159\/000496012","article-title":"Long noncoding RNA HOTTIP promotes mouse hepatic stellate cell activation via downregulating miR-148a.","volume":"51","author":"Li","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"B106","doi-asserted-by":"publisher","first-page":"100088","DOI":"10.59717\/j.xinn-life.2024.100088","article-title":"Organoids: Principle, application and perspective.","volume":"2","author":"Liu","year":"2024","journal-title":"Innov. Life"},{"key":"B107","doi-asserted-by":"publisher","first-page":"696069","DOI":"10.3389\/fimmu.2021.696069","article-title":"MiR-130a-3p alleviates liver fibrosis by suppressing HSCs activation and skewing macrophage to Ly6Clo phenotype.","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Immunol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.bbrc.2015.05.040","article-title":"RACK1-mediated translation control promotes liver fibrogenesis.","volume":"463","author":"Liu","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B109","doi-asserted-by":"publisher","first-page":"396","DOI":"10.3390\/biom13020396","article-title":"Cellular pathogenesis of hepatic encephalopathy: An update.","volume":"13","author":"Lu","year":"2023","journal-title":"Biomolecules"},{"key":"B110","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.bbrc.2015.08.012","article-title":"MicroRNA-130a and -130b enhance activation of hepatic stellate cells by suppressing PPAR\u03b3 expression: A rat fibrosis model study.","volume":"465","author":"Lu","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B111","first-page":"583","article-title":"LncRNA FLJ33360 accelerates the metastasis in hepatocellular carcinoma by targeting miRNA-140\/MMP9 axis.","volume":"12","author":"Lu","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"B112","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nrgastro.2010.213","article-title":"NF-\u03baB in the liver\u2013linking injury, fibrosis and hepatocellular carcinoma.","volume":"8","author":"Luedde","year":"2011","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"887","DOI":"10.4103\/1673-5374.322475","article-title":"HOTTIP downregulation reduces neuronal damage and microglial activation in Parkinson\u2019s disease cell and mouse models.","volume":"17","author":"Lun","year":"2022","journal-title":"Neural Regen. Res."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.3350\/cmh.2023.0244","article-title":"The role of the hepatic autonomic nervous system.","volume":"29","author":"Luo","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.neuint.2015.10.006","article-title":"PFKFB3-mediated glycolysis is involved in reactive astrocyte proliferation after oxygen-glucose deprivation\/reperfusion and is regulated by Cdh1.","volume":"91","author":"Lv","year":"2015","journal-title":"Neurochem. Int."},{"key":"B116","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.bbi.2024.11.023","article-title":"The vagus nerve: An old but new player in brain-body communication.","volume":"124","author":"Ma","year":"2025","journal-title":"Brain Behav. Immun."},{"key":"B117","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/s41419-024-06971-5","article-title":"Astrocytes and the tumor microenvironment inflammatory state dictate the killing of glioblastoma cells by Smac mimetic compounds.","volume":"15","author":"Malone","year":"2024","journal-title":"Cell Death Dis."},{"key":"B118","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology.","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nat. Commun."},{"key":"B119","doi-asserted-by":"publisher","first-page":"101223","DOI":"10.1016\/j.jhepr.2024.101223","article-title":"Hepatic stellate cell single cell atlas reveals a highly similar activation process across liver disease aetiologies.","volume":"7","author":"Merens","year":"2025","journal-title":"JHEP Rep."},{"key":"B120","doi-asserted-by":"publisher","first-page":"3513","DOI":"10.1002\/hep.32055","article-title":"Hepatic nervous system in development, regeneration, and disease.","volume":"74","author":"Miller","year":"2021","journal-title":"Hepatology"},{"key":"B121","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1002\/hep.22753","article-title":"Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential.","volume":"49","author":"Moles","year":"2009","journal-title":"Hepatology"},{"key":"B122","doi-asserted-by":"publisher","first-page":"e2303809120","DOI":"10.1073\/pnas.2303809120","article-title":"Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway.","volume":"120","author":"Nakano-Kobayashi","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B123","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/BF02833599","article-title":"The role of astrocytes in hepatic encephalopathy.","volume":"6","author":"Norenberg","year":"1987","journal-title":"Neurochem. Pathol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1038\/s41395-018-0088-6","article-title":"NASH leading cause of liver transplant in women: Updated analysis of indications for liver transplant and ethnic and gender variances.","volume":"113","author":"Noureddin","year":"2018","journal-title":"Am. J. Gastroenterol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1136\/gut.2003.026658","article-title":"Hepatic fibrogenesis requires sympathetic neurotransmitters.","volume":"53","author":"Oben","year":"2004","journal-title":"Gut"},{"key":"B126","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/s0006-291x(02)02773-0","article-title":"Acetylcholine promotes the proliferation and collagen gene expression of myofibroblastic hepatic stellate cells.","volume":"300","author":"Oben","year":"","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B127","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/s0006-291x(03)00232-8","article-title":"Norepinephrine and neuropeptide Y promote proliferation and collagen gene expression of hepatic myofibroblastic stellate cells.","volume":"302","author":"Oben","year":"","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.3390\/cancers6031220","article-title":"Fibrogenesis and carcinogenesis in nonalcoholic steatohepatitis (NASH): Involvement of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinase (TIMPs)","volume":"6","author":"Okazaki","year":"2014","journal-title":"Cancers"},{"key":"B129","doi-asserted-by":"publisher","first-page":"e65251","DOI":"10.1371\/journal.pone.0065251","article-title":"Tumor necrosis factor-\u03b1 promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells","volume":"8","author":"Osawa","year":"2013","journal-title":"PLoS One"},{"key":"B130","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.3233\/JPD-230284","article-title":"Astrocytes and Alpha-Synuclein: Friend or Foe?","volume":"13","author":"Ozoran","year":"2023","journal-title":"J. Parkinsons. Dis."},{"key":"B131","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13041-024-01113-6","article-title":"MicroRNAs as the pivotal regulators of Temozolomide resistance in glioblastoma.","volume":"17","author":"Palizkaran Yazdi","year":"2024","journal-title":"Mol. Brain"},{"key":"B132","doi-asserted-by":"publisher","first-page":"8921","DOI":"10.3390\/ijms23168921","article-title":"Low-Density lipoprotein receptor-related protein 8 at the crossroad between cancer and neurodegeneration.","volume":"23","author":"Passarella","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B133","doi-asserted-by":"publisher","first-page":"200785","DOI":"10.1016\/j.omton.2024.200785","article-title":"The crosstalk between non-coding RNAs and cell-cycle events: A new frontier in cancer therapy.","volume":"32","author":"Pathania","year":"2024","journal-title":"Mol. Ther. Oncol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s12079-022-00713-y","article-title":"CCN2\/CTGF promotes liver fibrosis through crosstalk with the Slit2\/Robo signaling.","volume":"17","author":"Pi","year":"2023","journal-title":"J. Cell Commun. Signal."},{"key":"B135","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.neulet.2010.03.054","article-title":"Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation.","volume":"476","author":"Pogue","year":"2010","journal-title":"Neurosci. Lett."},{"key":"B136","doi-asserted-by":"publisher","first-page":"e7743","DOI":"10.1097\/MD.0000000000007743","article-title":"Candidate genes investigation for severe nonalcoholic fatty liver disease based on bioinformatics analysis.","volume":"96","author":"Qi","year":"2017","journal-title":"Medicine"},{"key":"B137","doi-asserted-by":"publisher","first-page":"ENEURO.0336-23.2024","DOI":"10.1523\/ENEURO.0336-23.2024","article-title":"Astrocyte-Derived exosomal miR-148a-3p suppresses neuroinflammation and restores neurological function in traumatic brain injury by regulating the microglial phenotype.","volume":"11","author":"Qian","year":"2024","journal-title":"eNeuro"},{"key":"B138","doi-asserted-by":"publisher","first-page":"549","DOI":"10.3892\/ol.2021.12810","article-title":"MIF promoter polymorphism increases peripheral blood expression levels, contributing to increased susceptibility and poor prognosis in hepatocellular carcinoma.","volume":"22","author":"Qin","year":"2021","journal-title":"Oncol. Lett."},{"key":"B139","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s1386-6346(03)00115-3","article-title":"Connective tissue growth factor (CTGF\/CCN2) in hepatic fibrosis.","volume":"26","author":"Rachfal","year":"2003","journal-title":"Hepatol. Res."},{"key":"B140","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.3390\/life12091439","article-title":"MicroRNA: A linking between astrocyte dysfunction, mild cognitive impairment, and neurodegenerative diseases.","volume":"12","author":"Ram\u00edrez","year":"2022","journal-title":"Life"},{"key":"B141","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s11523-020-00717-x","article-title":"MicroRNAs (miRNAs) and Long Non-Coding RNAs (lncRNAs) as new tools for Cancer therapy: First steps from bench to bedside.","volume":"15","author":"Ratti","year":"2020","journal-title":"Target Oncol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1021\/acschemneuro.0c00142","article-title":"Overexpression of astrocytes-specific GJA1-20k enhances the viability and recovery of the neurons in a rat model of traumatic brain injury.","volume":"11","author":"Ren","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"B143","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/jcbfm.2013.30","article-title":"\u2018Hit & Run\u2019 model of closed-skull Traumatic Brain Injury (TBI) reveals complex patterns of post-traumatic AQP4 dysregulation.","volume":"33","author":"Ren","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B144","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1053\/j.gastro.2004.08.028","article-title":"From quiescence to activation: Gene regulation in hepatic stellate cells.","volume":"127","author":"Rippe","year":"2004","journal-title":"Gastroenterology"},{"key":"B145","doi-asserted-by":"publisher","first-page":"e77166","DOI":"10.1371\/journal.pone.0077166","article-title":"Smooth muscle \u03b1 actin (Acta2) and myofibroblast function during hepatic wound healing.","volume":"8","author":"Rockey","year":"2013","journal-title":"PLoS One"},{"key":"B146","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1016\/j.jhep.2020.07.013","article-title":"Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy.","volume":"73","author":"Rose","year":"2020","journal-title":"J. Hepatol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"861","DOI":"10.2353\/ajpath.2006.050767","article-title":"A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis.","volume":"169","author":"Ruddell","year":"2006","journal-title":"Am. J. Pathol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1093\/brain\/awab311","article-title":"Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis.","volume":"145","author":"Salman","year":"2022","journal-title":"Brain"},{"key":"B149","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.4161\/cc.10.11.15828","article-title":"Hepatic stellate cells and astrocytes: Stars of scar formation and tissue repair.","volume":"10","author":"Schachtrup","year":"2011","journal-title":"Cell Cycle"},{"key":"B150","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s00401-024-02787-x","article-title":"PRDM16-DT is a novel lncRNA that regulates astrocyte function in Alzheimer\u2019s disease.","volume":"148","author":"Schr\u00f6der","year":"2024","journal-title":"Acta Neuropathol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"979","DOI":"10.3390\/cells12070979","article-title":"The glymphatic system may play a vital role in the pathogenesis of hepatic encephalopathy: A narrative review.","volume":"12","author":"Sepehrinezhad","year":"2023","journal-title":"Cells"},{"key":"B152","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1038\/s41593-024-01791-4","article-title":"Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer\u2019s disease.","volume":"27","author":"Serrano-Pozo","year":"2024","journal-title":"Nat. Neurosci."},{"key":"B153","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1002\/hep.27348","article-title":"Mouse hepatocyte overexpression of NF-\u03baB-inducing kinase (NIK) triggers fatal macrophage-dependent liver injury and fibrosis.","volume":"60","author":"Shen","year":"2014","journal-title":"Hepatology"},{"key":"B154","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1038\/2101178a0","article-title":"Reciprocal influences of the ventromedial and lateral hypothalamic nuclei on blood glucose level and liver glycogen content.","volume":"210","author":"Shimazu","year":"1966","journal-title":"Nature"},{"key":"B155","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/s41389-018-0064-4","article-title":"NNMT depletion contributes to liver cancer cell survival by enhancing autophagy under nutrient starvation.","volume":"7","author":"Shin","year":"2018","journal-title":"Oncogenesis"},{"key":"B156","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1002\/hep.20667","article-title":"Anandamide induces necrosis in primary hepatic stellate cells.","volume":"41","author":"Siegmund","year":"2005","journal-title":"Hepatology"},{"key":"B157","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.bbadis.2015.10.014","article-title":"Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease.","volume":"1862","author":"Simon","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"B158","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1097\/HEP.0000000000000466","article-title":"AASLD practice guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma.","volume":"78","author":"Singal","year":"2023","journal-title":"Hepatology"},{"key":"B159","doi-asserted-by":"publisher","first-page":"114226","DOI":"10.1016\/j.celrep.2024.114226","article-title":"Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus.","volume":"43","author":"Song","year":"2024","journal-title":"Cell Rep."},{"key":"B160","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1590\/1414-431X20143962","article-title":"Sorafenib prevents liver fibrosis in a non-alcoholic steatohepatitis (NASH) rodent model","volume":"48","author":"Stefano","year":"2015","journal-title":"Braz. J. Med. Biol. Res."},{"key":"B161","doi-asserted-by":"publisher","first-page":"e080952","DOI":"10.1136\/bmj-2024-080952","article-title":"Projections for prevalence of Parkinson\u2019s disease and its driving factors in 195 countries and territories to 2050: Modelling study of global burden of disease study 2021.","volume":"388","author":"Su","year":"2025","journal-title":"BMJ"},{"key":"B162","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s41419-019-1329-3","article-title":"Astrocytic miR-324-5p is essential for synaptic formation by suppressing the secretion of CCL5 from astrocytes.","volume":"10","author":"Sun","year":"2019","journal-title":"Cell Death Dis."},{"key":"B163","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s40537-024-00899-5","article-title":"Integration of transcriptomic analysis and multiple machine learning approaches identifies NAFLD progression-specific hub genes to reveal distinct genomic patterns and actionable targets.","volume":"11","author":"Sun","year":"2024","journal-title":"J. Big Data"},{"key":"B164","doi-asserted-by":"publisher","first-page":"113124","DOI":"10.1016\/j.colsurfb.2023.113124","article-title":"KRTCAP2 as an immunological and prognostic biomarker of hepatocellular carcinoma.","volume":"222","author":"Sun","year":"2023","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"B165","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1038\/nn.4326","article-title":"Lrp4 in astrocytes modulates glutamatergic transmission.","volume":"19","author":"Sun","year":"2016","journal-title":"Nat. Neurosci."},{"key":"B166","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/s41522-024-00610-9","article-title":"Unlocking gut-liver-brain axis communication metabolites: Energy metabolism, immunity and barriers.","volume":"10","author":"Sun","year":"2024","journal-title":"NPJ Biofilms Microb."},{"key":"B167","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.3390\/antiox9121203","article-title":"Peroxiredoxins in neurodegenerative diseases.","volume":"9","author":"Szeliga","year":"2020","journal-title":"Antioxidants"},{"key":"B168","doi-asserted-by":"publisher","first-page":"285","DOI":"10.14740\/wjon1608","article-title":"FOS-Like antigen 1 expression was associated with survival of hepatocellular carcinoma patients.","volume":"14","author":"Taha","year":"2023","journal-title":"World J. Oncol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"3243","DOI":"10.1007\/s10072-023-06764-2","article-title":"Chitinase-3-like 1-protein in CSF: A novel biomarker for progression in patients with multiple sclerosis.","volume":"44","author":"Talaat","year":"2023","journal-title":"Neurol. Sci."},{"key":"B170","doi-asserted-by":"publisher","first-page":"117572","DOI":"10.1016\/j.lfs.2020.117572","article-title":"Peroxisome proliferator-activated receptor \u03b3 inhibits hepatic stellate cell activation regulated by miR-942 in chronic hepatitis B liver fibrosis.","volume":"253","author":"Tao","year":"2020","journal-title":"Life Sci."},{"key":"B171","doi-asserted-by":"publisher","first-page":"154725","DOI":"10.1016\/j.metabol.2021.154725","article-title":"The S100 calcium-binding protein A11 promotes hepatic steatosis through RAGE-mediated AKT-mTOR signaling.","volume":"117","author":"Teng","year":"2021","journal-title":"Metabolism"},{"key":"B172","doi-asserted-by":"publisher","first-page":"eabd1707","DOI":"10.1126\/sciadv.abd1707","article-title":"Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases.","volume":"7","author":"Trapecar","year":"2021","journal-title":"Sci. Adv."},{"key":"B173","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/toxsci\/kfv081","article-title":"MicroRNA-30 protects against carbon tetrachloride-induced liver fibrosis by attenuating transforming growth factor beta signaling in hepatic stellate cells.","volume":"146","author":"Tu","year":"2015","journal-title":"Toxicol. Sci."},{"key":"B174","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.biopha.2017.05.016","article-title":"MiR-140\/BDNF axis regulates normal human astrocyte proliferation and LPS-induced IL-6 and TNF-\u03b1 secretion.","volume":"91","author":"Tu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"B175","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1002\/ar.a.20086","article-title":"Neural connections between the hypothalamus and the liver.","volume":"280","author":"Uyama","year":"2004","journal-title":"Anat. Rec. A Discov. Mol. Cell Evol. Biol."},{"key":"B176","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1021\/bi00859a034","article-title":"Influence of L-tryptophan and its metabolites on gluconeogenesis in the isolated, perfused liver.","volume":"6","author":"Veneziale","year":"1967","journal-title":"Biochemistry"},{"key":"B177","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.nurt.2010.05.017","article-title":"Astrocytes in Alzheimer\u2019s disease.","volume":"7","author":"Verkhratsky","year":"2010","journal-title":"Neurotherapeutics"},{"key":"B178","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1002\/hep.27210","article-title":"Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the american association for the study of liver diseases and the European association for the study of the liver.","volume":"60","author":"Vilstrup","year":"2014","journal-title":"Hepatology"},{"key":"B179","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.toxlet.2021.11.014","article-title":"MicroRNA-195-3p promotes hepatic stellate cell activation and liver fibrosis by suppressing PTEN expression.","volume":"355","author":"Wang","year":"2022","journal-title":"Toxicol. Lett."},{"key":"B180","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1002\/glia.22743","article-title":"MicroRNA-145 as one negative regulator of astrogliosis.","volume":"63","author":"Wang","year":"2015","journal-title":"Glia"},{"key":"B181","doi-asserted-by":"publisher","first-page":"4261","DOI":"10.1002\/jcb.29634","article-title":"LncRNA-UCA1 inhibits the astrocyte activation in the temporal lobe epilepsy via regulating the JAK\/STAT signaling pathway.","volume":"121","author":"Wang","year":"2020","journal-title":"J. Cell Biochem."},{"key":"B182","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12967-022-03263-4","article-title":"Single-cell transcriptomic analysis reveals a novel cell state and switching genes during hepatic stellate cell activation in vitro.","volume":"20","author":"Wang","year":"2022","journal-title":"J. Transl. Med."},{"key":"B183","doi-asserted-by":"publisher","first-page":"1785738","DOI":"10.1080\/20013078.2020.1785738","article-title":"Sja-miR-71a in Schistosome egg-derived extracellular vesicles suppresses liver fibrosis caused by schistosomiasis via targeting semaphorin 4D.","volume":"9","author":"Wang","year":"2020","journal-title":"J. Extracell. Vesicles"},{"key":"B184","doi-asserted-by":"publisher","first-page":"513","DOI":"10.3389\/fcell.2020.00513","article-title":"MicroRNA-98 inhibits hepatic stellate cell activation and attenuates liver fibrosis by regulating HLF expression.","volume":"8","author":"Wang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B185","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1053\/j.gastro.2004.07.007","article-title":"Regulation of hepatic stellate cell activation and growth by transcription factor myocyte enhancer factor 2.","volume":"127","author":"Wang","year":"2004","journal-title":"Gastroenterology"},{"key":"B186","doi-asserted-by":"publisher","first-page":"988","DOI":"10.7150\/thno.89602","article-title":"Palmitoylation of PKC\u03b4 by ZDHHC5 in hypothalamic microglia presents as a therapeutic target for fatty liver disease.","volume":"14","author":"Wang","year":"2024","journal-title":"Theranostics"},{"key":"B187","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3389\/fcimb.2020.00101","article-title":"A MicroRNA derived from schistosoma japonicum promotes schistosomiasis hepatic fibrosis by targeting host secreted frizzled-related protein 1.","volume":"10","author":"Wang","year":"2020","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B188","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.omtn.2019.05.001","article-title":"miR-455-3p alleviates hepatic stellate cell activation and liver fibrosis by suppressing HSF1 expression.","volume":"16","author":"Wei","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"B189","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.jcmgh.2023.02.010","article-title":"Hepatic stellate cells: Dictating outcome in nonalcoholic fatty liver disease.","volume":"15","author":"Wiering","year":"2023","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"B190","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1159\/000111235","article-title":"Expression of the brain creatine kinase gene is low in neuroblastoma cell lines.","volume":"19","author":"Wilson","year":"1997","journal-title":"Dev. Neurosci."},{"key":"B191","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1101\/gad.1800909","article-title":"Long noncoding RNAs: Functional surprises from the RNA world.","volume":"23","author":"Wilusz","year":"2009","journal-title":"Genes Dev."},{"key":"B192","doi-asserted-by":"publisher","first-page":"772487","DOI":"10.3389\/fgene.2021.772487","article-title":"Bioinformatics analysis explores potential hub genes in nonalcoholic fatty liver disease.","volume":"12","author":"Wu","year":"2021","journal-title":"Front. Genet."},{"key":"B193","doi-asserted-by":"publisher","first-page":"561","DOI":"10.3349\/ymj.2019.60.6.561","article-title":"miR-140-3p knockdown suppresses cell proliferation and fibrogenesis in hepatic stellate cells via PTEN-Mediated AKT\/mTOR signaling.","volume":"60","author":"Wu","year":"2019","journal-title":"Yonsei Med. J."},{"key":"B194","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s13071-021-04663-z","article-title":"The NF-\u03baB signalling pathway and TM7SF3 contribute to liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis.","volume":"14","author":"Wu","year":"2021","journal-title":"Parasit Vec."},{"key":"B195","doi-asserted-by":"publisher","first-page":"351","DOI":"10.3892\/etm.2021.9782","article-title":"Regulatory long non-coding RNAs of hepatic stellate cells in liver fibrosis (Review).","volume":"21","author":"Wu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"B196","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1007\/s10620-020-06460-7","article-title":"MicroRNA-503 targets mothers against decapentaplegic homolog 7 enhancing hepatic stellate cell activation and hepatic fibrosis.","volume":"66","author":"Xie","year":"2021","journal-title":"Dig. Dis. Sci."},{"key":"B197","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1089\/cbr.2019.2996","article-title":"SNHG7 facilitates hepatocellular carcinoma occurrence by sequestering miR-9-5p to upregulate CNNM1 expression.","volume":"35","author":"Xie","year":"2020","journal-title":"Cancer Biother. Radiopharm."},{"key":"B198","doi-asserted-by":"publisher","first-page":"101469","DOI":"10.1016\/j.clinre.2020.05.017","article-title":"LncRNA-SNHG7\/miR-29b\/DNMT3A axis affects activation, autophagy and proliferation of hepatic stellate cells in liver fibrosis.","volume":"45","author":"Xie","year":"2021","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"B199","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1186\/s13046-016-0431-y","article-title":"Over-expression of the long non-coding RNA HOTTIP inhibits glioma cell growth by BRE.","volume":"35","author":"Xu","year":"2016","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B200","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1002\/glia.22645","article-title":"Inhibition of cysteine cathepsin B and L activation in astrocytes contributes to neuroprotection against cerebral ischemia via blocking the tBid-mitochondrial apoptotic signaling pathway.","volume":"62","author":"Xu","year":"2014","journal-title":"Glia"},{"key":"B201","doi-asserted-by":"publisher","first-page":"172927","DOI":"10.1016\/j.ejphar.2020.172927","article-title":"MicroRNA-708 represses hepatic stellate cells activation and proliferation by targeting ZEB1 through Wnt\/\u03b2-catenin pathway.","volume":"871","author":"Yang","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"B202","doi-asserted-by":"publisher","first-page":"109386","DOI":"10.1016\/j.biopha.2019.109386","article-title":"LncRNA SNHG7 accelerates the proliferation, migration and invasion of hepatocellular carcinoma cells via regulating miR-122-5p and RPL4.","volume":"118","author":"Yang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"B203","doi-asserted-by":"publisher","first-page":"95660","DOI":"10.1007\/s11356-023-29134-z","article-title":"An insight into the hepatoprotective role of Velpatasvir and Sofosbuvir per se and in combination against carbon tetrachloride-induced hepatic fibrosis in rats.","volume":"30","author":"Yasmeen","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"B204","doi-asserted-by":"publisher","first-page":"415","DOI":"10.2147\/OTT.S175176","article-title":"Long noncoding RNA SNHG16 induces sorafenib resistance in hepatocellular carcinoma cells through sponging miR-140-5p.","volume":"12","author":"Ye","year":"2019","journal-title":"Onco Targets Ther."},{"key":"B205","doi-asserted-by":"publisher","first-page":"107394","DOI":"10.1016\/j.pharmthera.2019.107394","article-title":"Roles of chitinase 3-like 1 in the development of cancer, neurodegenerative diseases, and inflammatory diseases.","volume":"203","author":"Yeo","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"B206","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1111\/j.1478-3231.2009.02060.x","article-title":"Gene expression profile associated with superimposed non-alcoholic fatty liver disease and hepatic fibrosis in patients with chronic hepatitis C.","volume":"29","author":"Younossi","year":"2009","journal-title":"Liver Int."},{"key":"B207","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/labinvest.2015.58","article-title":"MicroRNA-17-5p activates hepatic stellate cells through targeting of Smad7.","volume":"95","author":"Yu","year":"2015","journal-title":"Lab Invest."},{"key":"B208","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1159\/000472410","article-title":"LincRNA-p21 inhibits the Wnt\/\u03b2-Catenin pathway in activated hepatic stellate cells via sponging MicroRNA-17-5p.","volume":"41","author":"Yu","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"B209","doi-asserted-by":"publisher","first-page":"3778","DOI":"10.1007\/s12035-022-02817-3","article-title":"Serpin signatures in prion and Alzheimer\u2019s diseases.","volume":"59","author":"Zattoni","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"B210","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1186\/s13071-016-1562-x","article-title":"Hydatid cyst fluid promotes peri-cystic fibrosis in cystic echinococcosis by suppressing miR-19 expression.","volume":"9","author":"Zhang","year":"2016","journal-title":"Parasit Vec."},{"key":"B211","doi-asserted-by":"publisher","first-page":"BSR20170755","DOI":"10.1042\/BSR20170755","article-title":"MicroRNA-211\/BDNF axis regulates LPS-induced proliferation of normal human astrocyte through PI3K\/AKT pathway.","volume":"37","author":"Zhang","year":"2017","journal-title":"Biosci. Rep."},{"key":"B212","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.7150\/ijbs.66184","article-title":"Exosome-depleted MiR-148a-3p derived from hepatic stellate cells promotes tumor progression via ITGA5\/PI3K\/Akt axis in hepatocellular carcinoma.","volume":"18","author":"Zhang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"B213","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.conb.2010.06.005","article-title":"Astrocyte heterogeneity: An underappreciated topic in neurobiology.","volume":"20","author":"Zhang","year":"2010","journal-title":"Curr. Opin. Neurobiol."},{"key":"B214","doi-asserted-by":"publisher","first-page":"1499915","DOI":"10.3389\/fgene.2024.1499915","article-title":"Identification of potential biomarkers from amino acid transporter in the activation of hepatic stellate cells via bioinformatics.","volume":"15","author":"Zhao","year":"2024","journal-title":"Front. Genet."},{"key":"B215","doi-asserted-by":"publisher","first-page":"4810","DOI":"10.1111\/febs.13544","article-title":"lincRNA-p21 inhibits hepatic stellate cell activation and liver fibrogenesis via p21.","volume":"282","author":"Zheng","year":"2015","journal-title":"FEBS J."},{"key":"B216","doi-asserted-by":"publisher","first-page":"62886","DOI":"10.18632\/oncotarget.11709","article-title":"Long non-coding RNA PVT1 activates hepatic stellate cells through competitively binding microRNA-152.","volume":"7","author":"Zheng","year":"2016","journal-title":"Oncotarget"},{"key":"B217","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1002\/glia.24569","article-title":"Characterization of reduced astrocyte creatine kinase levels in Alzheimer\u2019s disease.","volume":"72","author":"Zheng","year":"2024","journal-title":"Glia"},{"key":"B218","doi-asserted-by":"publisher","first-page":"4798","DOI":"10.1096\/fj.201700520RR","article-title":"rSjP40 protein promotes PPAR\u03b3 expression in LX-2 cells through microRNA-27b.","volume":"32","author":"Zhu","year":"2018","journal-title":"FASEB J."},{"key":"B219","doi-asserted-by":"publisher","first-page":"e12980","DOI":"10.1111\/nan.12980","article-title":"Regulation of CNS pathology by Serpina3n\/SERPINA3: The knowns and the puzzles.","volume":"50","author":"Zhu","year":"2024","journal-title":"Neuropathol. Appl. Neurobiol."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2025.1733612\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T06:30:14Z","timestamp":1770100214000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2025.1733612\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,3]]},"references-count":219,"alternative-id":["10.3389\/fnins.2025.1733612"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2025.1733612","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,3]]},"article-number":"1733612"}}