{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:52:06Z","timestamp":1768589526506,"version":"3.49.0"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the clinical features and treatment approaches for leukoencephalopathy with calcifications and cysts (LCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed a 22-year-old male patient with genetically confirmed LCC admitted to Qingdao University Affiliated Hospital in April 2019. The patient\u2019s clinical presentation, imaging characteristics, treatment course, and outcomes were summarized alongside a comprehensive literature review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patient underwent resection of bilateral frontal lobe cysts followed later by resection of a parietal lobe cyst. Postoperative pathology confirmed LCC with calcification and cystic changes. No severe postoperative complications occurred. Follow-up imaging demonstrated gradual cyst regression and symptom resolution. Genetic testing identified heterozygous SNORD118 variants (n.3C&amp;gt;T and n.74G&amp;gt;A).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Surgical resection is an effective treatment for LCC cysts causing significant mass effect or neurological deficits, requiring regular follow-up. For smaller, asymptomatic cysts without mass effect, treatment with VEGF inhibitors (e.g., bevacizumab) may be beneficial. Management should be individualized.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2026.1686818","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:32:47Z","timestamp":1768545167000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Literature review of leukoencephalopathy with calcifications and cysts and a case report"],"prefix":"10.3389","volume":"20","author":[{"given":"Chao","family":"Guan","sequence":"first","affiliation":[{"name":"Qingdao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanting","family":"Li","sequence":"additional","affiliation":[{"name":"Qingdao University","place":["Qingdao, China"]},{"name":"The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zechen","family":"Wang","sequence":"additional","affiliation":[{"name":"Qingdao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunqing","family":"Chen","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yugong","family":"Feng","sequence":"additional","affiliation":[{"name":"Qingdao University","place":["Qingdao, China"]},{"name":"The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenwen","family":"Cui","sequence":"additional","affiliation":[{"name":"Qingdao University","place":["Qingdao, China"]},{"name":"The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Shen","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pin","family":"Guo","sequence":"additional","affiliation":[{"name":"Qingdao University","place":["Qingdao, China"]},{"name":"The Affiliated Hospital of Qingdao University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/ng.1084","article-title":"Mutations in CTC1, encoding conserved telomere maintenance component 1, cause coats plus","volume":"44","author":"Anderson","year":"2012","journal-title":"Nat. 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Literature review","volume":"190","author":"Novegno","year":"2024","journal-title":"World Neurosurg."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12883-021-02531-y","article-title":"Leukoencephalopathy with brain calcifications and cysts (Labrune syndrome) case report: diagnosis and management of a rare neurological disease","volume":"22","author":"Paff","year":"2022","journal-title":"BMC Neurol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e62029","DOI":"10.7759\/cureus.62029","article-title":"Unraveling Labrune syndrome: a case report on the neurological phenotype in SNORD118-negative patients","volume":"16","author":"Rohatgi","year":"2024","journal-title":"Cureus"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1245014","DOI":"10.3389\/fneur.2023.1245014","article-title":"Case report: clinical and neuroradiological longitudinal follow-up in leukoencephalopathy with calcifications and cysts during treatment with bevacizumab","volume":"14","author":"Scaffei","year":"2023","journal-title":"Front. 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Neurol."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2026.1686818\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:32:48Z","timestamp":1768545168000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2026.1686818\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,16]]},"references-count":15,"alternative-id":["10.3389\/fnins.2026.1686818"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2026.1686818","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,16]]},"article-number":"1686818"}}