{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:35:06Z","timestamp":1787502906235,"version":"build-2736575974"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Three subgroups of mild cognitive impairment (MCI) may be identified based on the deposition of A\u03b2 and tau proteins: A-T-, A\u202f+\u202fT+, and A\u202f+\u202fT-. The key hub for information processing and control, the anterior cingulate cortex (ACC), is essential for both healthy aging and MCI. The objective of this research is to systematically investigate changes in the functional connectivity (FC) of ACC subregions across different MCI subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Overall, 54 A-T- patients, 28 A\u202f+\u202fT- patients, and 52 A\u202f+\u202fT\u202f+\u202fpatients underwent FC analysis of ACC subregions. Correlation analyses were conducted to explore the relationship among pathological biomarkers, cognitive function, and FC changes in ACC subnetworks. The diagnostic utility of ACC-cortical FC in differentiating MCI subtypes was evaluated using receiver operating characteristic (ROC) curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the A-T- group, the A\u202f+\u202fT- group demonstrated reduced FC in the right precuneus and left dorsal ACC, whereas the A\u202f+\u202fT\u202f+\u202fgroup demonstrated increased FC in the left hippocampus, right precuneus and left dorsal ACC, the left superior frontal gyrus and right subgenual ACC. Compared with the A\u202f+\u202fT- group, the A\u202f+\u202fT\u202f+\u202fgroup demonstrated increased FC in the right precuneus and left dorsal ACC. The altered FC in ACC subnetworks was significantly correlated with pathological biomarkers in the cerebrospinal fluid. The ROC curve analysis suggested that changes in ACC FC effectively distinguished between the various pathological subtypes of MCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In summary, different MCI subtypes have distinctive changes in the FC of ACC subregions, providing valuable insights into the mechanisms underlying MCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2026.1748031","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T15:36:45Z","timestamp":1770046605000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Alterations in functional connectivity of the anterior cingulate cortex associated with different levels of tau and amyloid-\u03b2 deposition in patients with mild cognitive impairment"],"prefix":"10.3389","volume":"20","author":[{"given":"Wenzhang","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Radiology, The Affiliated Brain Hospital of Nanjing Medical University","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Yixing Traditional Chinese Medicine Hospital of Yangzhou University","place":["Wuxi, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Brain Hospital of Nanjing Medical University","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Brain Hospital of Nanjing Medical University","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Chest Hospital of Nanjing Medical University","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Brain Hospital of Nanjing Medical University","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Brain Hospital of Nanjing Medical University","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1159\/000492945","article-title":"The Precuneus - a witness for excessive Abeta gathering in Alzheimer's Disease pathology","volume":"18","author":"Aghakhanyan","year":"2018","journal-title":"Neurodegener Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1038\/s42003-024-06673-w","article-title":"Disrupted brain functional connectivity as early signature in cognitively healthy individuals with pathological CSF amyloid\/tau","volume":"7","author":"Al-Ezzi","year":"2024","journal-title":"Commun. Biol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1093\/brain\/awaa068","article-title":"Medial temporal lobe connectivity and its associations with cognition in early Alzheimer's disease","volume":"143","author":"Berron","year":"2020","journal-title":"Brain"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1196\/annals.1440.011","article-title":"The brain's default network: anatomy, function, and relevance to disease","volume":"1124","author":"Buckner","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1523\/JNEUROSCI.5062-08.2009","article-title":"Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease","volume":"29","author":"Buckner","year":"2009","journal-title":"J. Neurosci."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1093\/brain\/awl004","article-title":"The precuneus: a review of its functional anatomy and behavioural correlates","volume":"129","author":"Cavanna","year":"2006","journal-title":"Brain"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e14857","DOI":"10.1111\/cns.14857","article-title":"Novel diagnostic and prognostic approach for rapidly progressive dementias: indicators based on amyloid\/tau\/neurodegeneration (ATN) framework","volume":"30","author":"Cheng","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1093\/brain\/awaa165","article-title":"ATN status in amnestic and non-amnestic Alzheimer's disease and frontotemporal lobar degeneration","volume":"143","author":"Cousins","year":"2020","journal-title":"Brain"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1037\/bul0000096","article-title":"Emotion and the prefrontal cortex: an integrative review","volume":"143","author":"Dixon","year":"2017","journal-title":"Psychol. Bull."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"8431","DOI":"10.1038\/s41598-018-26151-8","article-title":"The a\/T\/N biomarker scheme and patterns of brain atrophy assessed in mild cognitive impairment","volume":"8","author":"Ekman","year":"2018","journal-title":"Sci. Rep."},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsae145","article-title":"The interplay between insomnia symptoms and Alzheimer's disease across three main brain networks","volume":"47","author":"Elberse","year":"2024","journal-title":"Sleep"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1002\/alz.12491","article-title":"Predictive value of ATN biomarker profiles in estimating disease progression in Alzheimer's disease dementia","volume":"17","author":"Ezzati","year":"2021","journal-title":"Alzheimers Dement."},{"key":"ref13","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.neuroimage.2010.10.081","article-title":"Predictive markers for AD in a multi-modality framework: an analysis of MCI progression in the ADNI population","volume":"55","author":"Hinrichs","year":"2011","journal-title":"NeuroImage"},{"key":"ref14","first-page":"1","article-title":"The limbic system in Alzheimer's disease. A neuropathologic investigation","volume":"85","author":"Hopper","year":"1976","journal-title":"Am. J. Pathol."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1007\/s40520-024-02805-8","article-title":"A mediation approach in resting-state connectivity between the medial prefrontal cortex and anterior cingulate in mild cognitive impairment","volume":"36","author":"Huang","year":"2024","journal-title":"Aging Clin. Exp. Res."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA research framework: toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e0285346","DOI":"10.1371\/journal.pone.0285346","article-title":"Gut microbiome dysbiosis in Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis","volume":"18","author":"Jemimah","year":"2023","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1093\/cercor\/bhn117","article-title":"Development of anterior cingulate functional connectivity from late childhood to early adulthood","volume":"19","author":"Kelly","year":"2009","journal-title":"Cereb. Cortex"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.neuroimage.2017.12.048","article-title":"Transcranial magnetic stimulation of the precuneus enhances memory and neural activity in prodromal Alzheimer's disease","volume":"169","author":"Koch","year":"2018","journal-title":"NeuroImage"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.cortex.2016.11.009","article-title":"The cingulate cortex of older adults with excellent memory capacity","volume":"86","author":"Lin","year":"2017","journal-title":"Cortex"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e87880","DOI":"10.1371\/journal.pone.0087880","article-title":"Abnormal intrinsic brain activity patterns in patients with subcortical ischemic vascular dementia","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/s41467-017-01150-x","article-title":"Earliest accumulation of beta-amyloid occurs within the default-mode network and concurrently affects brain connectivity","volume":"8","author":"Palmqvist","year":"2017","journal-title":"Nat. Commun."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e70005","DOI":"10.1002\/alz.70005","article-title":"Associations of hippocampal volumes, brain hypometabolism, and plasma NfL with amyloid, tau, and cognitive decline","volume":"21","author":"Pan","year":"2025","journal-title":"Alzheimers Dement."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1017\/S0033291720000434","article-title":"Sub-regional anterior cingulate cortex functional connectivity revealed default network subsystem dysfunction in patients with major depressive disorder","volume":"51","author":"Peng","year":"2021","journal-title":"Psychol. Med."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/alz.13438","article-title":"Successful cognitive aging is associated with thicker anterior cingulate cortex and lower tau deposition compared to typical aging","volume":"20","author":"Pezzoli","year":"2024","journal-title":"Alzheimers Dement."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.3233\/JAD-231174","article-title":"Shared and specific changes of cortico-striatal functional connectivity in stable mild cognitive impairment and progressive mild cognitive impairment","volume":"98","author":"Ruan","year":"2024","journal-title":"J Alzheimer's Dis"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"9507193","DOI":"10.1155\/2019\/9507193","article-title":"Cloud-based brain magnetic resonance image segmentation and parcellation system for individualized prediction of cognitive worsening","volume":"2019","author":"Sakamoto","year":"2019","journal-title":"J. Healthc. Eng."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1093\/brain\/awac158","article-title":"Biomarker a+T-: is this Alzheimer's disease or not? A combined CSF and pathology study","volume":"146","author":"Vromen","year":"2023","journal-title":"Brain"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e241463","DOI":"10.1148\/radiol.241463","article-title":"Modulation of cortical and hippocampal functional MRI connectivity following transcranial alternating current stimulation in mild Alzheimer disease","volume":"315","author":"Wang","year":"2025","journal-title":"Radiology"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jns.2016.10.021","article-title":"Neural correlates of anxiety symptoms in mild Parkinson's disease: a prospective longitudinal voxel-based morphometry study","volume":"371","author":"Wee","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/j.1365-2796.2004.01380.x","article-title":"Mild cognitive impairment--beyond controversies, towards a consensus: report of the international working group on mild cognitive impairment","volume":"256","author":"Winblad","year":"2004","journal-title":"J. Intern. Med."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e3550","DOI":"10.1002\/brb3.3550","article-title":"Brain functional specialization and cooperation in Alzheimer's disease","volume":"14","author":"Wu","year":"2024","journal-title":"Brain Behav."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"602","DOI":"10.3389\/fnins.2020.00602","article-title":"Asymmetric differences in the gray matter volume and functional connections of the amygdala are associated with clinical manifestations of Alzheimer's disease","volume":"14","author":"Wu","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"711009","DOI":"10.3389\/fnagi.2021.711009","article-title":"Disrupted dynamic functional connectivity in distinguishing subjective cognitive decline and amnestic mild cognitive impairment based on the triple-network model","volume":"13","author":"Xue","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.21037\/qims-22-582","article-title":"Cortical connectivity of cholinergic basal forebrain in Parkinson's disease with mild cognitive impairment","volume":"13","author":"Zhang","year":"2023","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1506478","DOI":"10.3389\/fnagi.2025.1506478","article-title":"The abnormal accumulation of pathological proteins and compensatory functional connectivity enhancement of insula subdivisions in mild cognitive impairment","volume":"17","author":"Zheng","year":"2025","journal-title":"Front. Aging Neurosci."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1093\/brain\/awq075","article-title":"Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease","volume":"133","author":"Zhou","year":"2010","journal-title":"Brain"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2026.1748031\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T09:29:47Z","timestamp":1771925387000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2026.1748031\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":37,"alternative-id":["10.3389\/fnins.2026.1748031"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2026.1748031","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,2]]},"article-number":"1748031"}}