{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:13:19Z","timestamp":1793812399846,"version":"4.6.1"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the associations between magnetic resonance imaging (MRI) quantitative parameters with neuropsychiatric systemic lupus erythematosus (NPSLE), and to evaluate the exploratory classification performance for NPSLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study recruited 60 systemic lupus erythematosus (SLE) patients and 20 healthy controls (HC). Participants underwent multimodal MRI and clinical assessment. The diffusion tensor imaging analysis along the perivascular spaces value (DTI-ALPS) and Normalized Wall Index (NWI) were derived using Diffusion Tensor Imaging (DTI) and high-resolution vessel wall imaging (HR-VWI). MRI quantitative parameters were analyzed using Kruskal-Wallis test and Dunn\u2019s test pairwise comparisons. Partial correlation analysis was conducted on MRI parameters and clinical data. An exploratory multimodal classification model was developed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The NPSLE group showed lower DTI-ALPS values and lumen area (LA), and higher NWI compared to the other groups (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.01). After adjusting for age, gender, and body mass index (BMI), DTI-ALPS correlated negatively with total cholesterol (TC) and immunoglobulin A (IgA) (\n                      <jats:italic>r<\/jats:italic>\n                      = \u20130.308,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.025;\n                      <jats:italic>r<\/jats:italic>\n                      = \u20130.301,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.028). LA correlated negatively with low-density lipoprotein (LDL) and disease duration (\n                      <jats:italic>r<\/jats:italic>\n                      = \u20130.293,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.032;\n                      <jats:italic>r<\/jats:italic>\n                      = \u20130.474,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001). The exploratory multimodal classification model combining clinical data, white matter hyperintensities (WMH) status, and MRI parameters showed excellent classification performance (area under the curve (AUC) = 0.933).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NPSLE patients exhibited low DTI-ALPS values and high NWI compared to other groups. The exploratory model based on multimodal MRI quantitative parameters may provide imaging insights into cerebrovascular alterations and glymphatic dysfunction associated with NPSLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2026.1773928","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:40:26Z","timestamp":1773758426000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluating the exploratory classification performance of multimodal magnetic resonance imaging in neuropsychiatric systemic lupus erythematosus: a prospective cohort study"],"prefix":"10.3389","volume":"20","author":[{"given":"Haoyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medical Imaging, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MengFan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Chongqing Emergency Medical Center","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiling","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Chongqing Emergency Medical Center","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1002\/1529-0131(199904)42:4<599::AID-ANR2>3.0.CO;2-F","article-title":"The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes.","volume":"42","year":"1999","journal-title":"Arthritis Rheum."},{"key":"B2","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cca.2018.05.026","article-title":"Proteomic approach to profiling immune complex antigens in cerebrospinal fluid samples from patients with central nervous system autoimmune diseases.","volume":"484","author":"Aibara","year":"2018","journal-title":"Clin. 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