{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T04:54:15Z","timestamp":1776315255100,"version":"3.50.1"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Traumatic brain injury (TBI) is one of the leading causes of mortality and disability, with many patients developing long-term sequelae. Depression is among the most common psychiatric complications following TBI, yet its underlying mechanisms remain unclear. Transient receptor potential canonical 1 (TRPC1) has been implicated in neurological disorders, but its role in post-TBI depression is not well understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A controlled cortical impact (CCI) model was used to induce moderate TBI in mice. At 4\u202fweeks post-injury, depressive-like behaviors were assessed using the tail suspension test (TST), forced swim test (FST), and sucrose preference test (SPT). Subsequently, reactive astrocytes and microglia were quantified, along with the expression of inflammatory cytokines, in the ipsilateral hippocampus. Synaptic function was also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Behavioral tests revealed that TBI mice exhibited significant depressive- and anxiety-like behaviors at 4\u202fweeks post-injury. Concurrently, TRPC1 expression was downregulated in the ipsilateral hippocampus, accompanied by reduced levels of synaptic-associated proteins, elevated pro-inflammatory cytokines, and increased reactive astrocytes and microglia. Further experiments demonstrated that TRPC1 overexpression attenuated neuroinflammation, restored synaptic function, and ameliorated depressive-like behaviors in TBI mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study suggests that TBI may trigger depression by downregulating TRPC1, thereby promoting neuroinflammation and synaptic dysfunction. Conversely, TRPC1 overexpression mitigates these effects, highlighting its potential as a therapeutic target for post-TBI depression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2026.1774265","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T04:20:44Z","timestamp":1776313244000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of TRPC1 in the pathogenesis of depression induced by traumatic brain injury"],"prefix":"10.3389","volume":"20","author":[{"given":"Qi-Hang","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-Han","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology","place":["Wuhan, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Bo","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Long","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Hospital of Hubei Province","place":["Wuhan, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China\/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China\/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiu-Zhi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Zhu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Key Laboratory for Molecular 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via inhibition of oxidative stress, inflammation and targeting TRPC1\/CHOP Signalling pathway","volume":"15","author":"Abdelzaher","year":"2022","journal-title":"Pharmaceuticals"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"E352","DOI":"10.1097\/htr.0000000000000551","article-title":"Incidence of new neuropsychiatric disorder diagnoses following traumatic brain injury","volume":"35","author":"Albrecht","year":"2020","journal-title":"J. Head Trauma Rehabil."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1042\/bst0350096","article-title":"TRPC1: a core component of store-operated calcium channels","volume":"35","author":"Ambudkar","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ceca.2016.12.009","article-title":"TRPC1, Orai1, and STIM1 in SOCE: friends in tight spaces","volume":"63","author":"Ambudkar","year":"2017","journal-title":"Cell Calcium"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"114711","DOI":"10.1016\/j.bbr.2023.114711","article-title":"Neurobehavioral and inflammatory responses following traumatic brain injury in male and female mice","volume":"456","author":"Bahader","year":"2024","journal-title":"Behav. Brain Res."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13054-025-05258-1","article-title":"Metabolomic in severe traumatic brain injury: exploring primary, secondary injuries, diagnosis, and severity","volume":"29","author":"Banoei","year":"2025","journal-title":"Crit. Care"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.jsr.2017.04.002","article-title":"CDC'S efforts to improve traumatic brain injury surveillance","volume":"62","author":"Bell","year":"2017","journal-title":"J. Saf. Res."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.4103\/1673-5374.238604","article-title":"Depression following a traumatic brain injury: uncovering cytokine dysregulation as a pathogenic mechanism","volume":"13","author":"Bodnar","year":"2018","journal-title":"Neural Regen. Res."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"115310","DOI":"10.1016\/j.psychres.2023.115310","article-title":"Network analysis of anxiety and depressive symptoms one year after traumatic brain injury","volume":"326","author":"Carmichael","year":"","journal-title":"Psychiatry Res."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"8017","DOI":"10.1038\/s41598-023-35017-7","article-title":"Bifactor analysis of the hospital anxiety and depression scale (HADS) in individuals with traumatic brain injury","volume":"13","author":"Carmichael","year":"","journal-title":"Sci. Rep."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1007\/s10753-021-01494-z","article-title":"Schisandrin B attenuates airway inflammation and airway remodeling in asthma by inhibiting NLRP3 Inflammasome activation and reducing Pyroptosis","volume":"44","author":"Chen","year":"2021","journal-title":"Inflammation"},{"key":"ref12","first-page":"390","article-title":"Incidence of depression after traumatic brain injury: a Nationwide longitudinal study of 2.2 million adults","volume-title":"J. Neurotrauma","author":"Choi","year":"2022"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1001\/jamaneurol.2014.3558","article-title":"Inflammation and neuroprotection in traumatic brain injury","volume":"72","author":"Corps","year":"2015","journal-title":"JAMA Neurol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40345-018-0128-6","article-title":"Clinical characteristics of patients with bipolar disorder and premorbid traumatic brain injury: a cross-sectional study","volume":"6","author":"Drange","year":"2018","journal-title":"Int J Bipolar Disord"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"13000","DOI":"10.3390\/ijms232113000","article-title":"Oxidative stress in traumatic brain injury","volume":"23","author":"Fesharaki-Zadeh","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.pnpbp.2008.10.005","article-title":"Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression","volume":"33","author":"Feyissa","year":"2009","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1038\/nprot.2009.148","article-title":"Mouse closed head injury model induced by a weight-drop device","volume":"4","author":"Flierl","year":"2009","journal-title":"Nat. Protoc."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/s1474-4422(20)30182-4","article-title":"Clinical characteristics and outcomes in patients with traumatic brain injury in China: a prospective, multicentre, longitudinal, observational study","volume":"19","author":"Gao","year":"2020","journal-title":"Lancet Neurol."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1038\/mp.2016.3","article-title":"A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression","volume":"21","author":"Goldsmith","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1080\/15548627.2023.2167689","article-title":"Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes","volume":"19","author":"Hegdekar","year":"2023","journal-title":"Autophagy"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.biopsych.2021.09.024","article-title":"Mental health consequences of traumatic brain injury","volume":"91","author":"Howlett","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12974-024-03146-z","article-title":"Traumatic brain injury alters the effects of class II invariant peptide (CLIP) antagonism on chronic meningeal CLIP\u202f+\u202fB cells, neuropathology, and neurobehavioral impairment in 5xFAD mice","volume":"21","author":"Iannucci","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.neuron.2017.07.010","article-title":"Neuroimmunology of traumatic brain injury: time for a paradigm shift","volume":"95","author":"Jassam","year":"2017","journal-title":"Neuron"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/s1474-4422(18)30469-1","article-title":"Traumatic brain injury in China","volume":"18","author":"Jiang","year":"2019","journal-title":"Lancet Neurol."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/bph.13125","article-title":"The contribution of astrocytes and microglia to traumatic brain injury","volume":"173","author":"Karve","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"4162","DOI":"10.1016\/j.neuron.2022.09.029","article-title":"Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes","volume":"110","author":"Kollewe","year":"2022","journal-title":"Neuron"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"318","DOI":"10.3389\/fncel.2018.00318","article-title":"Activation of TRPC1 channel by metabotropic glutamate receptor mGluR5 modulates synaptic plasticity and spatial working memory","volume":"12","author":"Lepannetier","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"134364","DOI":"10.1016\/j.neulet.2019.134364","article-title":"Synaptic structure and alterations in the hippocampus in neonatal rats exposed to lipopolysaccharide","volume":"709","author":"Lin","year":"2019","journal-title":"Neurosci. Lett."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1038\/s41596-018-0011-z","article-title":"Sucrose preference test for measurement of stress-induced anhedonia in mice","volume":"13","author":"Liu","year":"2018","journal-title":"Nat. Protoc."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s12974-020-01761-0","article-title":"Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injury","volume":"17","author":"Long","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/s1474-4422(17)30371-x","article-title":"Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research","volume":"16","author":"Maas","year":"2017","journal-title":"Lancet Neurol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/s1474-4422(22)00309-x","article-title":"Traumatic brain injury: progress and challenges in prevention, clinical care, and research","volume":"21","author":"Maas","year":"2022","journal-title":"Lancet Neurol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/j.2051-5545.2008.tb00139.x","article-title":"Neurobehavioral sequelae of traumatic brain injury: evaluation and management","volume":"7","author":"McAllister","year":"2008","journal-title":"World Psychiatry"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"106785","DOI":"10.1016\/j.nbd.2024.106785","article-title":"Astrocytic NLRP3 cKO mitigates depression-like behaviors induced by mild TBI in mice","volume":"205","author":"Miao","year":"2025","journal-title":"Neurobiol. Dis."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"e301181","DOI":"10.1136\/bmjment-2024-301181","article-title":"Prognostic models for depression and post-traumatic stress disorder symptoms following traumatic brain injury: a CENTER-TBI study","volume":"28","author":"Mikoli\u0107","year":"2025","journal-title":"BMJ Ment. Health"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"114009","DOI":"10.1016\/j.expneurol.2022.114009","article-title":"A review of the pathology and treatment of TBI and PTSD","volume":"351","author":"Monsour","year":"2022","journal-title":"Exp. Neurol."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"jcs237610","DOI":"10.1242\/jcs.237610","article-title":"Loss of ca(2+) entry via Orai-TRPC1 induces ER stress, initiating immune activation in macrophages","volume":"133","author":"Nascimento Da Conceicao","year":"2019","journal-title":"J. Cell Sci."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1089\/neu.2019.6436","article-title":"Acid sphingomyelinase inhibition mitigates histopathological and behavioral changes in a murine model of traumatic brain injury","volume":"37","author":"Niziolek","year":"2020","journal-title":"J. Neurotrauma"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.wneu.2024.01.084","article-title":"Traumatic brain injury: a comprehensive review of biomechanics and molecular pathophysiology","volume":"185","author":"Orr","year":"2024","journal-title":"World Neurosurg."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.apmr.2021.08.021","article-title":"Depression in older adults 12 months after traumatic brain injury: a TRACK-TBI study","volume":"103","author":"Passler","year":"2022","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s10571-016-0400-1","article-title":"Pathophysiology associated with traumatic brain injury: current treatments and potential novel therapeutics","volume":"37","author":"Pearn","year":"2017","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"511","DOI":"10.3171\/2015.2.Jns14503","article-title":"Association of traumatic brain injury with subsequent neurological and psychiatric disease: a meta-analysis","volume":"124","author":"Perry","year":"2016","journal-title":"J. Neurosurg."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3389\/fnbeh.2019.00006","article-title":"Long-term effects of traumatic brain injury on anxiety-like behaviors in mice: behavioral and neural correlates","volume":"13","author":"Popovitz","year":"2019","journal-title":"Front. Behav. Neurosci."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/jad-191150","article-title":"Inflammation in traumatic brain injury","volume":"74","author":"Postolache","year":"2020","journal-title":"J. Alzheimer's Dis"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1016\/j.celrep.2014.02.015","article-title":"Caspase-11 controls interleukin-1\u03b2 release through degradation of TRPC1","volume":"6","author":"Py","year":"2014","journal-title":"Cell Rep."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.jss.2020.12.016","article-title":"STIM1 regulates endothelial calcium overload and cytokine upregulation during Sepsis","volume":"263","author":"Qiu","year":"2021","journal-title":"J. Surg. Res."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.biopsych.2021.11.012","article-title":"Role of inflammation in traumatic brain injury-associated risk for neuropsychiatric disorders: state of the evidence and where do we go from Here","volume":"91","author":"Risbrough","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.bbi.2020.11.010","article-title":"Infiltrated regulatory T cells and Th2 cells in the brain contribute to attenuation of sepsis-associated encephalopathy and alleviation of mental impairments in mice with polymicrobial sepsis","volume":"92","author":"Saito","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1523\/jneurosci.0718-19.2019","article-title":"Aberrant ER stress induced neuronal-IFN\u03b2 elicits white matter injury due to microglial activation and T-cell infiltration after TBI","volume":"40","author":"Sen","year":"2020","journal-title":"J. Neurosci."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"eadn4556","DOI":"10.1126\/scisignal.adn4556","article-title":"Targeting the postsynaptic scaffolding protein PSD-95 enhances BDNF signaling to mitigate depression-like behaviors in mice","volume":"17","author":"Shi","year":"2024","journal-title":"Sci. Signal."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.36922\/an.8356","article-title":"A review of current status of epilepsy after traumatic brain injuries: pathophysiology, clinical outcomes, and emerging treatment strategies","volume":"4","author":"Shrivastava","year":"2025","journal-title":"Adv Neurol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1089\/neu.2018.6149","article-title":"Clinical relevance of behavior testing in animal models of traumatic brain injury","volume":"37","author":"Shultz","year":"2020","journal-title":"J. Neurotrauma"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/nrneurol.2017.13","article-title":"The far-reaching scope of neuroinflammation after traumatic brain injury","volume":"13","author":"Simon","year":"","journal-title":"Nat. Rev. Neurol."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1038\/nrneurol.2017.116","article-title":"The far-reaching scope of neuroinflammation after traumatic brain injury","volume":"13","author":"Simon","year":"","journal-title":"Nat. Rev. Neurol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1080\/02699052.2017.1376756","article-title":"Prevalence of depression after TBI in a prospective cohort: the SHEFBIT study","volume":"32","author":"Singh","year":"2018","journal-title":"Brain Inj."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3389\/fnins.2014.00315","article-title":"Inflammasomes in neuroinflammation and changes in brain function: a focused review","volume":"8","author":"Singhal","year":"2014","journal-title":"Front. Neurosci."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"102933","DOI":"10.1016\/j.ceca.2024.102933","article-title":"TRPC1: the housekeeper of the hippocampus","volume":"123","author":"Skerjanz","year":"2024","journal-title":"Cell Calcium"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.jad.2013.08.009","article-title":"Zinc, magnesium and NMDA receptor alterations in the hippocampus of suicide victims","volume":"151","author":"Sowa-Ku\u0107ma","year":"2013","journal-title":"J. Affect. Disord."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1001\/jamapsychiatry.2018.4288","article-title":"Risk of posttraumatic stress disorder and major depression in civilian patients after mild traumatic brain injury: a TRACK-TBI study","volume":"76","author":"Stein","year":"2019","journal-title":"JAMA Psychiatry"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1002\/jnr.24331","article-title":"Neuroinflammation and blood-brain barrier disruption following traumatic brain injury: pathophysiology and potential therapeutic targets","volume":"98","author":"Sulhan","year":"2020","journal-title":"J. Neurosci. Res."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.bbi.2021.08.228","article-title":"Behavioural adaptations after antibiotic treatment in male mice are reversed by activation of the aryl hydrocarbon receptor","volume":"98","author":"Vicentini","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/s1474-4422(08)70294-1","article-title":"Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances","volume":"8","author":"Volpe","year":"2009","journal-title":"Lancet Neurol."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"107497","DOI":"10.1016\/j.pharmthera.2020.107497","article-title":"TRPC channels: structure, function, regulation and recent advances in small molecular probes","volume":"209","author":"Wang","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.3233\/jad-210297","article-title":"T217-phosphorylation exacerbates tau pathologies and tau-induced cognitive impairment","volume":"81","author":"Wang","year":"2021","journal-title":"J. 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