{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T17:23:53Z","timestamp":1794331433073,"version":"4.9.0"},"reference-count":82,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Cerebrospinal fluid (CSF) is increasingly recognized as an active regulator of brain function rather than a passive mechanical buffer. Beyond its classical roles in cushioning the brain and removing metabolic waste, CSF participates in a tightly coupled system linking neural activity, vascular dynamics, molecular signaling, and tissue mechanics. Here, we present an integrated theoretical framework that unifies three major conceptual strategies in contemporary CSF research: metabolic clearance, neuromodulatory signaling, and bidirectional coupling between fluid dynamics and neural activity. We argue that these processes form a closed-loop regulatory system in which brain state governs CSF flow, while CSF dynamics reciprocally shape neural function and long-term brain health. Disruptions to this integrated CSF-brain system underlie a wide spectrum of neurological disorders, including Alzheimer\u2019s disease, stroke, sleep disorders, and hydrocephalus. By synthesizing evidence across scales and disciplines, this framework provides a coherent conceptual foundation for future experimental, diagnostic, and therapeutic advances targeting CSF physiology.<\/jats:p>","DOI":"10.3389\/fnins.2026.1775240","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:42:16Z","timestamp":1770709336000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Cerebrospinal fluid dynamics and brain function regulation: from homeostasis to neurological disorders"],"prefix":"10.3389","volume":"20","author":[{"given":"Yu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Systems Science, Faculty of Arts and Sciences, Beijing Normal University","place":["Zhuhai, China"]},{"name":"International Academic Center of Complex Systems, Beijing Normal University","place":["Zhuhai, China"]},{"name":"School of Systems Science, Beijing Normal University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixia","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Systems Science, Faculty of Arts and Sciences, Beijing Normal University","place":["Zhuhai, China"]},{"name":"International Academic Center of Complex Systems, Beijing Normal University","place":["Zhuhai, China"]},{"name":"School of Systems Science, Beijing Normal University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Systems Science, Faculty of Arts and Sciences, Beijing Normal University","place":["Zhuhai, China"]},{"name":"International Academic Center of Complex Systems, Beijing Normal University","place":["Zhuhai, China"]},{"name":"School of Systems Science, Beijing Normal University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s00401-018-1812-4","article-title":"The role of brain barriers in fluid movement in the CNS: is there a \u2018glymphatic\u2019 system?","volume":"135","author":"Abbott","year":"2018","journal-title":"Acta Neuropathologica"},{"key":"B2","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3390\/ph17020243","article-title":"2023 FDA TIDES (Peptides and Oligonucleotides) harvest.","volume":"17","author":"Al Shaer","year":"2024","journal-title":"Pharmaceuticals"},{"key":"B3","doi-asserted-by":"publisher","first-page":"38635","DOI":"10.1038\/srep38635","article-title":"Glymphatic solute transport does not require bulk flow.","volume":"6","author":"Asgari","year":"2016","journal-title":"Sci. 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