{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T06:10:20Z","timestamp":1783923020745,"version":"3.55.0"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Temporal processing, including duration discrimination, is essential for survival and communication across species. Intellectual disability (ID), which can arise from diverse causes, including mutation in Cereblon (CRBN) gene, impairs duration discrimination. CRBN-related ID is associated with abnormal cognitive behaviors and may disrupt both perceptual and behavioral processes involved in duration discrimination. However, cross-species behavioral strategies, their variation with ID, and the behavioral indices underlying these strategies remain unclear. Here, humans and wild-type (WT) mice with typical intelligence and CRBN knockout (KO) mice with ID, all females across species, performed an auditory duration discrimination task involving 10-s and 2-s cues. All groups successfully distinguished the 10-s and 2-s cues, but their latency-based behavioral strategies diverged. In humans and WT mice, reaction time and latency for both stimuli clustered between 2 and 5\u202fs, whereas in KO mice, they varied depending on the stimulus duration. WT mice and humans consistently delayed their responses by approximately 2\u202fs relative to the 2-s cue length, reflecting response inhibition and alignment between group-level and individual-level responses. In contrast, KO mice exhibited more variable response patterns, consistent with impulsivity and misalignment between group-level and individual-level responses. These findings suggest that CRBN-related ID preserves duration discrimination while altering the behavioral response pattern associated with typical intelligence.<\/jats:p>","DOI":"10.3389\/fnins.2026.1782687","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:33:47Z","timestamp":1783920827000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cereblon-related mild intellectual disability disrupts response inhibition and uniformity of group\u2013individual strategies"],"prefix":"10.3389","volume":"20","author":[{"given":"Chan Hee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Physiology, Dental Research Institute, Seoul National University School of Dentistry","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyogu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Intelligence and Information, Artificial Intelligence Institute, Seoul National University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Eun","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Musicology, College of Music, Seoul National University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Jeong","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Korean Music, Seoul National University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se-Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Physiology, Dental Research Institute, Seoul National University School of Dentistry","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"148054","DOI":"10.1016\/j.brainres.2022.148054","article-title":"Effects of cereblon on stress-activated redox proteins and core behavior","volume":"1793","author":"Akber","year":"2022","journal-title":"Brain Res."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1037\/a0022038","article-title":"A comparison of adult and adolescent rat behavior in operant learning, extinction, and behavioral inhibition paradigms","volume":"125","author":"Andrzejewski","year":"2011","journal-title":"Behav. 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