{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:55:12Z","timestamp":1775804112114,"version":"3.50.1"},"reference-count":179,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>The convergence of neuroscience and bone biology has led to the profound conceptualization of the \u201cbrain-bone axis,\u201d revealing the intricate connection between the central nervous system and bone metabolism. Central nuclei, defined as structures composed of neurons with similar functions, play a pivotal role in the regulation of bone metabolism. Research has demonstrated that central nuclei can modulate bone metabolism either directly via nerve fiber projections or indirectly through neuroendocrine pathways. Despite significant progress, the precise mechanisms by which central nuclei regulate bone metabolism and the collaborative communication networks among these nuclei remain poorly understood. This review systematically summarizes recent advances in central nuclei across the entire brain that regulate bone metabolism and their complex mechanisms. Moreover, it discusses current challenges and potential future research directions in the field. The ultimate aim is to provide novel insights for developing neuromodulatory therapeutic strategies against bone metabolic disorders.<\/jats:p>","DOI":"10.3389\/fnins.2026.1801524","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:00:01Z","timestamp":1775800801000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in the regulation of bone metabolism by central nuclei: a new perspective on the brain-bone axis"],"prefix":"10.3389","volume":"20","author":[{"given":"Guanhao","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Naval Medical University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Naval Medical University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duorun","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Second Affiliated Hospital of Naval Medical University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anzhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Naval Medical University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denghui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The 906th Hospital of the Joint Logistics Support Force of PLA","place":["Ningbo, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongtang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Naval Medical University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.reth.2019.07.006","article-title":"The period circadian clock 2 gene responds to glucocorticoids and regulates osteogenic capacity","volume":"11","author":"Abe","year":"2019","journal-title":"Regenerative Ther."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"3196","DOI":"10.1210\/en.2006-0281","article-title":"Cart overexpression is the only identifiable cause of high bone mass in melanocortin 4 receptor deficiency","volume":"147","author":"Ahn","year":"2006","journal-title":"Endocrinology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1148\/rg.210153","article-title":"Imaging aspects of the hippocampus","volume":"42","author":"Alves","year":"2022","journal-title":"Radiographics"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/nature07181","article-title":"UCP2 mediates ghrelin's action on NPY\/AgRP neurons by lowering free radicals","volume":"454","author":"Andrews","year":"2008","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3389\/fonc.2020.00199","article-title":"Insights about circadian clock and molecular pathogenesis in gliomas","volume":"10","author":"Arafa","year":"2020","journal-title":"Front. 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Physiol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"8630","DOI":"10.3390\/ijms21228630","article-title":"Locus coeruleus modulates neuroinflammation in Parkinsonism and dementia","volume":"21","author":"Giorgi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"e85064","DOI":"10.7554\/eLife.85064","article-title":"Ventral striatum dopamine release encodes unique properties of visual stimuli in mice","volume":"12","author":"Gonzalez","year":"2023","journal-title":"eLife"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.2147\/DDDT.S363286","article-title":"Orexin-a reverse bone mass loss induced by chronic intermittent hypoxia through OX1R-Nrf2\/HIF-1alpha pathway","volume":"16","author":"Gu","year":"2022","journal-title":"Drug Des. Devel. Ther."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41413-023-00270-z","article-title":"Causal associations of brain structure with bone mineral density: a large-scale genetic correlation study","volume":"11","author":"Guo","year":"2023","journal-title":"Bone Res."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41398-022-02297-y","article-title":"Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression","volume":"13","author":"Guo","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"e2309951","DOI":"10.1002\/advs.202309951","article-title":"Targeting MCH neuroendocrine circuit in lateral hypothalamus to protect against skeletal senescence","volume":"11","author":"Guo","year":"2024","journal-title":"Adv. Sci. (Weinh)."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1172\/JCI69395","article-title":"Leptin-promoted cilia assembly is critical for normal energy balance","volume":"124","author":"Han","year":"2014","journal-title":"J. Clin. Invest."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1111\/joim.13541","article-title":"Deep brain stimulation for Parkinson's disease","volume":"292","author":"Hariz","year":"2022","journal-title":"J. Intern. Med."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2183\/pjab.92.1","article-title":"From migration to settlement: the pathways, migration modes and dynamics of neurons in the developing brain","volume":"92","author":"Hatanaka","year":"2016","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41413-025-00424-1","article-title":"Bone-derived factors mediate crosstalk between skeletal and extra-skeletal organs","volume":"13","author":"He","year":"2025","journal-title":"Bone Res."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"bqac101","DOI":"10.1210\/endocr\/bqac101","article-title":"Hypothalamic expression of Estrogen receptor isoforms underlies Estradiol control of luteinizing hormone in female rats","volume":"163","author":"Henriques","year":"2022","journal-title":"Endocrinology"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1055\/s-0039-3400238","article-title":"Should we make more bone or not, as told by kisspeptin neurons in the arcuate nucleus","volume":"37","author":"Herber","year":"2019","journal-title":"Semin. Reprod. Med."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/s41467-018-08046-4","article-title":"Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones","volume":"10","author":"Herber","year":"2019","journal-title":"Nat. Commun."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1002\/jcb.20935","article-title":"Unloading-induced bone loss was suppressed in gold-thioglucose treated mice","volume":"99","author":"Hino","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neures.2016.07.007","article-title":"Sodium sensing in the subfornical organ and body-fluid homeostasis","volume":"113","author":"Hiyama","year":"2016","journal-title":"Neurosci. Res."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.jchemneu.2003.10.002","article-title":"The human raphe nuclei and the serotonergic system","volume":"26","author":"Hornung","year":"2003","journal-title":"J. Chem. Neuroanat."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.bone.2018.05.018","article-title":"Brain to bone: what is the contribution of the brain to skeletal homeostasis?","volume":"115","author":"Idelevich","year":"2018","journal-title":"Bone"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1002\/jbmr.3967","article-title":"Both NPY-expressing and CART-expressing neurons increase energy expenditure and trabecular bone mass in response to AP1 antagonism, but have opposite effects on bone resorption","volume":"35","author":"Idelevich","year":"2020","journal-title":"J. Bone Miner. Res."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.1172\/JCI99350","article-title":"Neuronal hypothalamic regulation of body metabolism and bone density is galanin dependent","volume":"128","author":"Idelevich","year":"2018","journal-title":"J. Clin. Invest."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.pnpbp.2004.05.034","article-title":"Noradrenaline storage function of species-specific protein bodies, markers of monoamine neurons in human locus coeruleus demonstrated by dopamine-beta-hydroxylase immunogold localization","volume":"28","author":"Issidorides","year":"2004","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"218","DOI":"10.2174\/1570159X11311020008","article-title":"Vasopressin and oxytocin in control of the cardiovascular system","volume":"11","author":"Japund\u017ei\u0107-\u017digon","year":"2013","journal-title":"Curr. 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Psychiatry"},{"key":"ref173","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1016\/j.neuron.2023.03.030","article-title":"Bidirectional control of parathyroid hormone and bone mass by subfornical organ","volume":"111","author":"Zhang","year":"2023","journal-title":"Neuron"},{"key":"ref174","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/j.bbrc.2018.04.192","article-title":"Protective role of AgRP neuron's PDK1 against salt-induced hypertension","volume":"500","author":"Zhang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref175","doi-asserted-by":"publisher","first-page":"e63333","DOI":"10.7554\/eLife.63333","article-title":"Estrogen receptor alpha in the brain mediates tamoxifen-induced changes in physiology in mice","volume":"10","author":"Zhang","year":"2021","journal-title":"eLife"},{"key":"ref176","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1038\/s41467-024-45436-3","article-title":"Secretin-dependent signals in the ventromedial hypothalamus regulate energy metabolism and bone homeostasis in mice","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat. Commun."},{"key":"ref177","doi-asserted-by":"publisher","first-page":"eadz9329","DOI":"10.1126\/sciadv.adz9329","article-title":"A central CeA-LC-PVH circuit mediates stress-induced osteopenia via skeletal sympathetic nerves in male mice","volume":"11","author":"Zhao","year":"2025","journal-title":"Sci. Adv."},{"key":"ref178","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.tins.2023.12.003","article-title":"Tuning neural circuits and behaviors by microglia in the adult brain","volume":"47","author":"Zhao","year":"2024","journal-title":"Trends Neurosci."},{"key":"ref179","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1007\/s11154-023-09812-6","article-title":"Targeting aging with the healthy skeletal system: the endocrine role of bone","volume":"24","author":"Zheng","year":"2023","journal-title":"Rev. Endocr. Metab. 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