{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T16:05:29Z","timestamp":1782489929114,"version":"3.54.5"},"reference-count":94,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Hypertension and chronic kidney disease frequently coexist and mutually accelerate cardiovascular and renal injury. This narrative review prioritizes direct human autonomic phenotyping (Level 1: microneurography, HRV\/BRS), human vascular correlates (Level 2: PWV, FMD), and complementary preclinical evidence (Level 3) to elucidate autonomic-vascular mechanisms. Autonomic imbalance, characterized by sympathetic overactivity and reduced parasympathetic restraint, represents a key interface between neural control and vascular pathology in this setting. This narrative review synthesizes experimental and clinical evidence on how the autonomic nervous system shapes vascular function in hypertension and CKD. We outline physiological autonomic control of vascular tone (baroreflex pathways, central networks, brain\u2013kidney communication), characteristic autonomic alterations in hypertension (elevated MSNA, impaired HRV\/BRS), and their vascular consequences (endothelial dysfunction, arterial stiffness). We emphasize CKD-specific autonomic drivers (renal afferents, uremic toxins, inflammation) and their translation to exaggerated vascular injury and adverse BP phenotypes. Finally, we discuss pharmacological\/device-based strategies targeting autonomic\u2013vascular pathways, highlighting opportunities for neuromodulation, biomarker-guided risk stratification, and individualized treatment. By integrating multidisciplinary evidence, this review frames CKD hypertension as amplified autonomic\u2013vascular injury and positions the autonomic nervous system as a promising therapeutic target.<\/jats:p>","DOI":"10.3389\/fnins.2026.1808065","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:52:04Z","timestamp":1777441924000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Autonomic-vascular dysregulation in CKD-associated hypertension: a narrative review with evidence hierarchy"],"prefix":"10.3389","volume":"20","author":[{"given":"Omar Z.","family":"Ameer","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, Alfaisal University","place":["Riyadh, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"949260","DOI":"10.3389\/fphar.2022.949260","article-title":"Hypertension in chronic kidney disease: what lies behind the scene","volume":"13","author":"Ameer","year":"2022","journal-title":"Front. 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Kidney Dis."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1159\/000443615","article-title":"New insight into effects of \u03b2-blockers on arterial functions","volume":"3","author":"Eguchi","year":"2016","journal-title":"Pulse"},{"key":"ref9002","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1681\/ASN.2006050445","article-title":"Albuminuria Is a Target for Renoprotective Therapy Independent from Blood Pressure in Patients with Type 2 Diabetic Nephropathy: Post Hoc: Analysis from the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) Trial","volume":"18","author":"Eijkelkamp","year":"2007","journal-title":"Journal of the American Society of Nephrology"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1113\/expphysiol.2010.052332","article-title":"The sympathetic nervous system through the ages: from Thomas Willis to resistant hypertension","volume":"96","author":"Esler","year":"2011","journal-title":"Exp. 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Heart Fail."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"R79","DOI":"10.1152\/ajpregu.00351.2014","article-title":"Role of renal sensory nerves in physiological and pathophysiological conditions","volume":"308","author":"Kopp","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref43","volume-title":"Heart Rate Variability-Current Practices and Clinical Applications","author":"Kumar","year":"2025"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/j.jfma.2018.09.006","article-title":"Short-term heart rate variability as a predictor of long-term survival in patients with chronic hemodialysis: a prospective cohort study","volume":"117","author":"Kuo","year":"2018","journal-title":"J. Formos. Med. 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Hypertens."},{"key":"ref9004","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/S0140-6736(22)00455-X","article-title":"Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial","volume":"399","author":"Mahfoud","year":"2022","journal-title":"The Lancet"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1161\/circresaha.114.302524","article-title":"The autonomic nervous system and hypertension","volume":"114","author":"Mancia","year":"2014","journal-title":"Circ. Res."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1007\/s11906-014-0476-2","article-title":"Chemoreflexes, sleep apnea, and sympathetic dysregulation","volume":"16","author":"Mansukhani","year":"2014","journal-title":"Curr. Hypertens. Rep."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"153","DOI":"10.3892\/etm.2023.11852","article-title":"Role of arterial hypertension and angiotensin II in chronic kidney disease","volume":"25","author":"Maranduca","year":"2023","journal-title":"Exp. Ther. Med."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1097\/HJH.0b013e328305e1a5","article-title":"Impaired baroreflex sensitivity as a potential marker of cardiovascular risk in hypertension","volume":"26","author":"Narkiewicz","year":"2008","journal-title":"J. Hypertens."},{"key":"ref9005","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1093\/eurheartj\/ehab497","article-title":"Effects of canagliflozin on serum potassium in people with diabetes and chronic kidney disease: the CREDENCE trial","volume":"42","author":"Neuen","year":"2021","journal-title":"European heart journal"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"F1431","DOI":"10.1152\/ajprenal.00079.2011","article-title":"Aortic stiffness is associated with vascular calcification and remodeling in a chronic kidney disease rat model","volume":"300","author":"Ng","year":"2011","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"e0282344","DOI":"10.1371\/journal.pone.0282344","article-title":"Predictive value of heart rate variability on long-term mortality in end-stage kidney disease on hemodialysis","volume":"18","author":"Osataphan","year":"2023","journal-title":"PLoS One"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1093\/joneph\/22.2.208","article-title":"Sympathetic hyperactivity and clinical outcome in chronic kidney disease patients during standard treatment","volume":"22","author":"Penne","year":"2009","journal-title":"J. Nephrol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1056\/nejmoa1811744","article-title":"Canagliflozin and renal outcomes in type 2 diabetes and nephropathy","volume":"380","author":"Perkovic","year":"2019","journal-title":"N. Engl. J. 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Rep."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1093\/ajh\/hpaa054","article-title":"Amlodipine improves vessel function and remodeling in the Lewis polycystic kidney rat mesenteric artery","volume":"33","author":"Quek","year":"2020","journal-title":"Am. J. Hypertens."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.vph.2015.12.004","article-title":"Progressive vascular remodelling, endothelial dysfunction and stiffness in mesenteric resistance arteries in a rodent model of chronic kidney disease","volume":"81","author":"Quek","year":"2016","journal-title":"Vasc. Pharmacol."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1042\/CS20200279","article-title":"Microvascular disease in chronic kidney disease: the base of the iceberg in cardiovascular comorbidity","volume":"134","author":"Querfeld","year":"2020","journal-title":"Clin. Sci."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.3390\/jcm9082359","article-title":"Endothelial dysfunction in chronic kidney disease, from biology to clinical outcomes: a 2020 update","volume":"9","author":"Roumeliotis","year":"2020","journal-title":"J. Clin. Med."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1093\/ndt\/gfn732","article-title":"Restoration of baroreflex function in patients with end-stage renal disease after renal transplantation","volume":"24","author":"Rubinger","year":"2009","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s10286-023-00979-1","article-title":"Augmented resting beat-to-beat blood pressure variability in patients with chronic kidney disease","volume":"33","author":"Sabino-Carvalho","year":"2023","journal-title":"Clin. Auton. Res."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"zqae036","DOI":"10.1093\/function\/zqae036","article-title":"Impaired neurocirculatory control in chronic kidney disease: new evidence for blunted sympathetic baroreflex and reduced sympathetic transduction","volume":"5","author":"Sabino-Carvalho","year":"2024","journal-title":"Function"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s11906-015-0571-z","article-title":"Cardiovascular autonomic dysfunction in chronic kidney disease: a comprehensive review","volume":"17","author":"Salman","year":"2015","journal-title":"Curr. Hypertens. Rep."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s11906-016-0625-x","article-title":"Major autonomic neuroregulatory pathways underlying short-and long-term control of cardiovascular function","volume":"18","author":"Salman","year":"2016","journal-title":"Curr. Hypertens. 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