{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:39:35Z","timestamp":1777041575392,"version":"3.51.4"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>\n                    Chronic psychological stress is known to induce functional and molecular alterations in central circuits regulating micturition. Here, we investigated whether odor-specific olfactory stimulation modulates stress-associated bladder dysfunction and related brain transcriptional responses. Female C57BL\/6J mice were subjected to repeated water avoidance stress (WAS) and exposed to inhalated essential oils derived from\n                    <jats:italic>Alpinia zerumbet<\/jats:italic>\n                    (Gettou) or\n                    <jats:italic>Citrus depressa<\/jats:italic>\n                    (Shikuwasa). Bladder function was assessed by continuous cystometry, spontaneous locomotor activity was evaluated during the dark phase, and whole-brain transcriptional responses were analyzed using exploratory RNA sequencing to characterize stress-associated transcriptional patterns. WAS was associated with bladder overactivity characterized by shortened contraction intervals, together with a tendency toward increased bladder weight and reduced locomotor activity. Transcriptomic analysis identified stress-associated upregulation of immediate-early genes and suppression of synapse-related gene categories. Gettou inhalation was associated with attenuation of stress-related immediate-early gene expression and partial normalization of bladder contraction dynamics, whereas Shikuwasa inhalation induced broad transcriptional changes without measurable improvement in bladder function. These findings suggest that odor-specific transcriptional modulation may be associated with partial functional improvement of stress-evoked bladder overactivity.\n                  <\/jats:p>","DOI":"10.3389\/fnins.2026.1811702","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T12:35:07Z","timestamp":1777034107000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Odor-specific olfactory stimulation is associated with selective transcriptional changes and partial improvement of stress-evoked bladder overactivity in mice"],"prefix":"10.3389","volume":"20","author":[{"given":"Saori","family":"Nishijima","sequence":"first","affiliation":[{"name":"Southern Knights\u2019 Laboratory","place":["Okinawa, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Kadekawa","sequence":"additional","affiliation":[{"name":"Southern Knights\u2019 Laboratory","place":["Okinawa, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Ashitomi","sequence":"additional","affiliation":[{"name":"Southern Knights\u2019 Laboratory","place":["Okinawa, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je Tae","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, College of Bioscience and Biotechnology, Chubu University, Kasugai","place":["Aichi, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kitano","sequence":"additional","affiliation":[{"name":"Integrated Open Systems Unit, Okinawa Institute of Science and Technology","place":["Okinawa, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimio","family":"Sugaya","sequence":"additional","affiliation":[{"name":"Southern Knights\u2019 Laboratory","place":["Okinawa, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"G42","DOI":"10.1152\/ajpgi.00500.2004","article-title":"Repeated exposure to water avoidance stress in rats: A new model for sustained visceral hyperalgesia.","volume":"289","author":"Bradesi","year":"2005","journal-title":"Am. 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