{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:49:14Z","timestamp":1782107354677,"version":"3.54.5"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is the most prevalent form of dementia, characterized by progressive memory loss, cognitive decline, and emotional dysregulation. Adult hippocampal neurogenesis (AHN) critically contributes to cognition and mood but undergoes precipitous decline during AD progression. Here, we investigated whether enhancing AHN through genetic expansion of endogenous neural stem cells (NSC) ameliorates AD-related phenotypes. Using lentiviral overexpression of the cell cycle regulators Cdk4 and CyclinD1 in the dentate gyrus of 3xTg-AD mice, we show that enhancing AHN is accompanied by partial improvements in selected behavioral measures associated with hippocampal function, including in the open-field test and Morris water maze. These findings indicate that the AD-compromised neurogenic niche remains responsive to NSC-targeted stimulation and support the use of AHN as a potential additional avenue for multi-modal therapeutic strategies for AD.<\/jats:p>","DOI":"10.3389\/fnins.2026.1833016","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:38:07Z","timestamp":1782106687000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhancing adult neurogenesis attenuates hippocampal-related behavioral deficits in an Alzheimer\u2019s mouse model"],"prefix":"10.3389","volume":"20","author":[{"given":"Chi-Chieh","family":"Lee","sequence":"first","affiliation":[{"name":"Center for Regenerative Therapies Dresden (CRTD), Technische Universit\u00e4t Dresden","place":["Dresden, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Calegari","sequence":"additional","affiliation":[{"name":"Center for Regenerative Therapies Dresden (CRTD), Technische Universit\u00e4t Dresden","place":["Dresden, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e98791","DOI":"10.15252\/embj.201798791","article-title":"An increase in neural stem cells and olfactory bulb adult neurogenesis improves discrimination of highly similar odorants","volume":"38","author":"Alonso","year":"2019","journal-title":"EMBO J."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nrn.2017.45","article-title":"Adult hippocampal neurogenesis and cognitive flexibility \u2014 linking memory and mood","volume":"18","author":"Anacker","year":"2017","journal-title":"Nat. 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