{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:12:57Z","timestamp":1780485177805,"version":"3.54.1"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Temporal lobe epilepsy (TLE) manifests with diverse seizure symptoms, including focal to bilateral tonic\u2014clonic seizures (FBTCS), linked to widespread brain network disruptions. The role of cortical morphometric similarity (MS) network gradients and their relationship with gene expression in TLE remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied MS network gradient abnormalities through group comparisons among 87 left TLE patients (48 FBTCS\u2212, 39 FBTCS+) and 63 healthy controls (HC). In addition, partial least squares (PLS) regression analysis was performed to investigate the association between gradient changes and whole-brain gene expression in left FBTCS+ TLE patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>FBTCS+ patients showed significant reductions in the principal MS network gradient within default mode network (DMN) regions compared to healthy controls, while FBTCS\u2212 patients exhibited no such abnormalities. Gradient alterations in FBTCS+ were linked to whole-brain expression of genes involved in neurobiological pathways, cell types, and cortical layers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FBTCS+ TLE is associated with distinct MS network gradient alterations, which may reflect underlying molecular mechanisms contributing to structural changes linked to severe seizure symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2026.1833695","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:54:27Z","timestamp":1780484067000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcriptional signatures of the cortical morphometric similarity network gradient in left temporal lobe epilepsy with different seizure symptoms"],"prefix":"10.3389","volume":"20","author":[{"given":"Kanlin","family":"Lin","sequence":"first","affiliation":[{"name":"Fuzong Teaching Hospital of Fujian University of Traditional Chinese Medicine","place":["Fuzhou, China"]},{"name":"900th Hospital of PLA Joint Logistic Support Force","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taipeng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Fuzong Teaching Hospital of Fujian University of Traditional Chinese Medicine","place":["Fuzhou, China"]},{"name":"900th Hospital of PLA Joint Logistic Support Force","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Zhang","sequence":"additional","affiliation":[{"name":"900th Hospital of PLA Joint Logistic Support Force","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"900th Hospital of PLA Joint Logistic Support Force","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfan","family":"Yang","sequence":"additional","affiliation":[{"name":"900th Hospital of PLA Joint Logistic Support Force","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifeng","family":"Huang","sequence":"additional","affiliation":[{"name":"900th Hospital of PLA Joint Logistic Support Force","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuozhen","family":"Chen","sequence":"additional","affiliation":[{"name":"900th Hospital of PLA Joint Logistic Support Force","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Fuzong Teaching Hospital of Fujian University of Traditional Chinese Medicine","place":["Fuzhou, China"]},{"name":"900th Hospital of PLA Joint Logistic Support Force","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Fu","sequence":"additional","affiliation":[{"name":"Fuzong Teaching Hospital of Fujian University of Traditional Chinese Medicine","place":["Fuzhou, China"]},{"name":"900th Hospital of PLA Joint Logistic Support Force","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangwen","family":"Xu","sequence":"additional","affiliation":[{"name":"Fuzong Teaching Hospital of Fujian University of Traditional Chinese Medicine","place":["Fuzhou, China"]},{"name":"900th Hospital of PLA Joint Logistic Support Force","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/978-1-62703-059-5_23","article-title":"Partial least squares methods: partial least squares correlation and partial least square regression","volume":"930","author":"Abdi","year":"2013","journal-title":"Methods Mol. 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