{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T06:00:24Z","timestamp":1785218424821,"version":"3.55.0"},"reference-count":204,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>\n                    Despite the brain\u2019s use of adenosine triphosphate (ATP) to perform various intracellular processes, its major energy consumption occurs during neuronal communication. It is estimated that the majority of energy expenditure occurs at excitatory synapses via the activity of energy-dependent pumps (ATPases), which are involved in maintaining and restoring ion gradients after receptor activity. Inhibitory synapses are believed to contribute insignificantly to energy consumption because of their indirect energy consumption via cation-coupled chloride cotransporters (CCCs) and the subsequent function of Na\n                    <jats:sup>+<\/jats:sup>\n                    , K\n                    <jats:sup>+<\/jats:sup>\n                    ATPase. Recent findings concerning the properties of inhibitory receptors suggest that they directly contribute to energy consumption. Fast synaptic inhibition in the brain is mediated by type A GABA\n                    <jats:sub>\n                      <jats:italic>A<\/jats:italic>\n                    <\/jats:sub>\n                    receptors (GABA\n                    <jats:sub>\n                      <jats:italic>A<\/jats:italic>\n                    <\/jats:sub>\n                    Rs), which are ligand-gated, anion-selective channels that are open upon the binding of the neurotransmitter and that play a key role in regulating neuronal excitation. Impairment of their function during network\/seizure activity is accompanied by changes in the ionic and energy levels in neurons, the mechanisms of which remain largely unclear. Clarification of these processes is crucial for the treatment of neurodegenerative disorders that are linked with dysregulation of the inhibition\/excitation (I\/E) balance and energy deficiency. Recent evidence has shown the presence of an ATP-hydrolyzing site in the structure of GABA\n                    <jats:sub>\n                      <jats:italic>A<\/jats:italic>\n                    <\/jats:sub>\n                    Rs, which is involved in network activity. We hypothesized that this ATPase activity can directly contribute to energy use. This hypothesis is supported by data indicating that \u03b3-phosphate analogs targeting distinct ATP binding and hydrolysis stages can reduce the receptor function under certain conditions. Moreover, some GABA\n                    <jats:sub>\n                      <jats:italic>A<\/jats:italic>\n                    <\/jats:sub>\n                    Rs assemblies have the capacity to participate in both the passive and active transport of Cl\n                    <jats:sup>\u2013<\/jats:sup>\n                    against the electrochemical gradient. Finally, under conditions of brain hypoxia or glucose deficiency syndrome, the function of inhibitory neurons is primarily impaired. Here, we explore the ATPase hypothesis that some GABA\n                    <jats:sub>\n                      <jats:italic>A<\/jats:italic>\n                    <\/jats:sub>\n                    R subtypes may be directly involved in reducing the energy budget, and we present arguments for and against this theory while highlighting gaps in our knowledge of this neurobiological process.\n                  <\/jats:p>","DOI":"10.3389\/fnins.2026.1834375","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:37:41Z","timestamp":1785217061000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Direct energy consumption by inhibitory GABAA receptors: from synaptic mechanisms to network activity"],"prefix":"10.3389","volume":"20","author":[{"given":"Sergey A.","family":"Menzikov","sequence":"first","affiliation":[{"name":"Institute of General Pathology and Pathophysiology","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danila M.","family":"Zaichenko","sequence":"additional","affiliation":[{"name":"Institute of General Pathology and Pathophysiology","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksey A.","family":"Moskovtsev","sequence":"additional","affiliation":[{"name":"Institute of General Pathology and Pathophysiology","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey G.","family":"Morozov","sequence":"additional","affiliation":[{"name":"Institute of General Pathology and Pathophysiology","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aslan A.","family":"Kubatiev","sequence":"additional","affiliation":[{"name":"Institute of General Pathology and Pathophysiology","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.3390\/antiox10081316","article-title":"The alteration of chloride homeostasis\/GABAergic signaling in brain disorders: Could oxidative stress play a role?","volume":"10","author":"Abruzzo","year":"2021","journal-title":"Antioxidants"},{"key":"B2","doi-asserted-by":"publisher","first-page":"769S","DOI":"10.1002\/j.1550-8528.1995.tb00498.x","article-title":"Time-dependent rundown of GABA response in mammalian cns neuron during experimental anoxia.","volume":"3","author":"Akaike","year":"1995","journal-title":"Obes. 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