{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T09:59:41Z","timestamp":1781690381283,"version":"3.54.5"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Currently, prospective evidence on how sleep habits specifically affect scoliosis is nearly nonexistent. We therefore sought to clarify the association between comprehensive sleep behavior patterns and the incidence of this disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study conducted a prospective cohort study based on the UK Biobank (UKB), including 408,870 participants who did not have scoliosis at baseline. We have constructed a comprehensive sleep scoring system that integrates the following five key indicators: sleep chronotype, sleep duration, insomnia, snoring, and daytime sleepiness. To evaluate the association between healthy sleep patterns and the risk of scoliosis, we conducted a statistical analysis using the Cox proportional hazards regression model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a mean follow-up of 15.82 years, 2,976 incident cases of scoliosis were recorded (0.73%). The 408,870 participants who were free of scoliosis at baseline had a mean age of 56.48 years. Distribution of the healthy sleep score was as follows: 9,939 participants (2.43%) had 0\u20131 of the five healthy sleep behaviors, 46,175 (11.29%) had 2 behaviors, 115,094 (28.15%) had 3 behaviors, 150,287 (36.76%) had 4 behaviors, and 87,375 (21.37%) had all five. In multivariable models, each 1-point increase in the healthy sleep score was associated with a 10% lower risk of scoliosis [hazard ratio (HR) = 0.90; 95% confidence interval (CI) = 0.87, 0.93]. Compared with the 0\u20131 score group, the multivariable-adjusted HR (95% CI) for participants with a score of 5 was 0.64 (0.52, 0.80). In subgroup analyses, the inverse association between sleep score and scoliosis risk persisted among participants without diabetes but was absent among those with diabetes (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>interaction<\/jats:italic>\n                      <\/jats:sub>\n                      &amp;lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cohort analysis results confirm that adherence to a healthy sleep-behavior pattern significantly reduces the risk of scoliosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2026.1839503","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T09:50:32Z","timestamp":1781689832000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The relationship between healthy sleep patterns and the risk of scoliosis: a large prospective cohort study"],"prefix":"10.3389","volume":"20","author":[{"given":"Wanyue","family":"Li","sequence":"first","affiliation":[{"name":"Henan Provincial People\u2019s Hospital and People\u2019s Hospital of Zhengzhou University","place":["Zhengzhou, China"]},{"name":"Department of Rehabilitation, Henan Provincial People\u2019s Hospital and People\u2019s Hospital of Zhengzhou University","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxiao","family":"Ma","sequence":"additional","affiliation":[{"name":"Henan Provincial People\u2019s Hospital and People\u2019s Hospital of Zhengzhou University","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Hu","sequence":"additional","affiliation":[{"name":"Henan Provincial People\u2019s Hospital and People\u2019s Hospital of Zhengzhou University","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhao","family":"Hao","sequence":"additional","affiliation":[{"name":"Henan Provincial People\u2019s Hospital and People\u2019s Hospital of Zhengzhou University","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Henan Provincial People\u2019s Hospital and People\u2019s Hospital of Zhengzhou University","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiguo","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Henan Provincial People\u2019s Hospital and People\u2019s Hospital of Zhengzhou University","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weisheng","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Henan Provincial People\u2019s Hospital and People\u2019s Hospital of Zhengzhou University","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihua","family":"Sun","sequence":"additional","affiliation":[{"name":"Henan Provincial People\u2019s Hospital and People\u2019s Hospital of Zhengzhou University","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1007\/s00586-012-2245-8","article-title":"The metabolic basis of adolescent idiopathic scoliosis: 2011 report of the \u201cmetabolic\u201d workgroup of the Fondation Yves Cotrel.","volume":"21","author":"Acaroglu","year":"2012","journal-title":"Eur. 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