{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:16:02Z","timestamp":1783577762366,"version":"3.55.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate whether local field potential (LFP) spectral profiles can serve as a candidate \u201cspectral fingerprint\u201d for physiological confirmation of centromedian-parafascicular (CM\u2013Pf) targeting during thalamic deep brain stimulation (DBS) for drug resistant epilepsy (DRE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective study of 10 patients (20 leads) who underwent CM-DBS implantation for DRE at a single tertiary center. Postoperative CT and preoperative MRI were co-registered, normalized to the Montreal Neurological Institute (MNI) space, and reconstructed using Lead-DBS software to anatomically localize contacts. BrainSense\u2122 Survey recordings were obtained at least 3\u202fweeks post-implant during routine programming. LFP frequency content was analyzed, and prominent peaks were identified and classified into canonical frequency bands (theta, alpha, beta). These spectral profiles were then mapped to MRI-based anatomical localizations, and statistical tests were applied to assess associations between peak patterns, contact localizations and thalamic subregions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Contacts were distributed as follows: 50 in the CM, 16 in the Parafascicular (Pf), 15 in the Centrolateral, 8 in the Mediodorsal, and 7 in the Ventrolateral (VL) nuclei. Of the 10 representative spectral localizations confined to the CM\/CM-Pf region, 8 (80%) displayed a distinct dual-peak spectral profile with peaks in the theta\/low alpha (5.5\u20139\u202fHz) and high beta (20\u201330\u202fHz) bands (mean frequencies: 7.63\u202fHz and 21.02\u202fHz, Fisher\u2019s exact test,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). Single-peak profiles showed no significant association with specific nuclei (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.871). Contacts overlapping other thalamic nuclei more frequently exhibited narrow 10\u201315\u202fHz peaks (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.005) or triple-peak profiles (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.02), suggesting mixed structural contributions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A dual- band candidate spectral pattern consisting of theta\/low alpha and high beta peaks was associated with the CM-Pf region in this cohort. This finding provides early evidence supporting the feasibility of incorporating passive LFP recordings as a physiologic marker of target engagement. Future work to prospectively compare bipolar survey-based localization with monopolar recording strategies could enable development of a state-based, physiologically informed spectral atlas to refine CM-Pf targeting in thalamic neuromodulation for DRE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2026.1855048","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:36:23Z","timestamp":1783575383000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Local field potentials for target localization in centromedian deep brain stimulation for epilepsy"],"prefix":"10.3389","volume":"20","author":[{"given":"Shruti","family":"Agashe","sequence":"first","affiliation":[{"name":"Department of Neurology, Duke University","place":["Durham, NC, United States"]},{"name":"Department of Neurosurgery, Duke University","place":["Durham, NC, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipali","family":"Nemade","sequence":"additional","affiliation":[{"name":"Department of Neurology, Orlando Health Neuroscience Institute","place":["Orlando, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihyeong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic","place":["Rochester, MN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie Iniya John Benedict","family":"Ashok","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Duke University","place":["Durham, NC, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Vestal","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Dartmouth Hitchcock Medical Center","place":["Lebanon, NH, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Southwell","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Duke University","place":["Durham, NC, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Duke University","place":["Durham, NC, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1212\/Wnl.0000000000202111","article-title":"A single-center experience with local field potential-guided initial deep brain stimulation programming in Parkinson's disease","volume":"100","author":"Abu-Hadid","year":"2023","journal-title":"Neurology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"858413","DOI":"10.3389\/fnhum.2022.858413","article-title":"Centromedian nucleus of the thalamus deep brain stimulation for genetic generalized epilepsy: a case report and review of literature","volume":"16","author":"Agashe","year":"2022","journal-title":"Front. Hum. Neurosci."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2796","DOI":"10.1212\/Wnl.0000000000202804","article-title":"Utilization of intraoperative subthalamic nucleus local field potential recordings to guide postoperative deep brain stimulation programming in Parkinson's disease","volume":"100","author":"Anwer","year":"2023","journal-title":"Neurology"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1002\/mds.29626","article-title":"Local field potentials predict motor performance in deep brain stimulation for Parkinson's disease","volume":"38","author":"Busch","year":"2023","journal-title":"Mov. Disord."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nrn3241","article-title":"The origin of extracellular fields and currents--EEG, ECoG, LFP and spikes","volume":"13","author":"Buzsaki","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1111\/epi.17722","article-title":"Initial case series of a novel sensing deep brain stimulation device in drug-resistant epilepsy and consistent identification of alpha\/beta oscillatory activity: a feasibility study","volume":"64","author":"Chua","year":"2023","journal-title":"Epilepsia"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.seizure.2020.08.028","article-title":"Seizure outcome during bilateral, continuous, thalamic centromedian nuclei deep brain stimulation in patients with generalized epilepsy: a prospective, open-label study","volume":"81","author":"Cukiert","year":"2020","journal-title":"Seizure"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/ana.26280","article-title":"DBS of thalamic centromedian nucleus for Lennox-Gastaut syndrome (ESTEL trial)","volume":"91","author":"Dalic","year":"2021","journal-title":"Ann. Neurol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/ner.13520","article-title":"Local field potential-based programming: a proof-of-concept pilot study","volume":"25","author":"Fasano","year":"2022","journal-title":"Neuromodulation"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"106045","DOI":"10.1016\/j.nbd.2023.106045","article-title":"Deep brain stimulation of thalamus for epilepsy","volume":"179","author":"Fisher","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1111\/j.1528-1167.2010.02536.x","article-title":"Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy","volume":"51","author":"Fisher","year":"2010","journal-title":"Epilepsia"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s12021-022-09581-8","article-title":"Separating neural oscillations from aperiodic 1\/f activity: challenges and recommendations","volume":"20","author":"Gerster","year":"2022","journal-title":"Neuroinformatics"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e158","DOI":"10.1111\/epi.17047","article-title":"Anterior nucleus of the thalamus seizure detection in ambulatory humans","volume":"62","author":"Gregg","year":"2021","journal-title":"Epilepsia"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.neuroimage.2014.12.002","article-title":"Lead-DBS: a toolbox for deep brain stimulation electrode localizations and visualizations","volume":"107","author":"Horn","year":"2015","journal-title":"NeuroImage"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.neuroimage.2018.08.068","article-title":"Lead-DBS v2: towards a comprehensive pipeline for deep brain stimulation imaging","volume":"184","author":"Horn","year":"2019","journal-title":"NeuroImage"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jocn.2019.01.050","article-title":"The centromedian nucleus: anatomy, physiology, and clinical implications","volume":"63","author":"Ilyas","year":"2019","journal-title":"J. Clin. Neurosci."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.neuron.2011.09.029","article-title":"How local is the local field potential?","volume":"72","author":"Kajikawa","year":"2011","journal-title":"Neuron"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1111\/epi.18003","article-title":"Long-term evaluation of anterior thalamic deep brain stimulation for epilepsy in the European MORE registry","volume":"65","author":"Kaufmann","year":"2024","journal-title":"Epilepsia"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1016\/j.neuroimage.2009.10.042","article-title":"A mean three-dimensional atlas of the human thalamus: generation from multiple histological data","volume":"49","author":"Krauth","year":"2010","journal-title":"NeuroImage"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"6601","DOI":"10.3390\/s22176601","article-title":"Estimation of ANT-DBS electrodes on target positioning based on a new percept\u2122 PC LFP signal analysis","volume":"22","author":"Lopes","year":"2022","journal-title":"Sensors"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.1111\/epi.18070","article-title":"Centromedian region thalamic responsive neurostimulation mitigates idiopathic generalized and multifocal epilepsy with focal to bilateral tonic-clonic seizures","volume":"65","author":"Nanda","year":"2024","journal-title":"Epilepsia"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e197","DOI":"10.1111\/epi.18122","article-title":"Centromedian thalamic deep brain stimulation for idiopathic generalized epilepsy: connectivity and target optimization","volume":"65","author":"Park","year":"2024","journal-title":"Epilepsia"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"3347","DOI":"10.1093\/brain\/awac234","article-title":"Towards network-guided neuromodulation for epilepsy","volume":"145","author":"Piper","year":"2022","journal-title":"Brain"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"17562864231202064","DOI":"10.1177\/17562864231202064","article-title":"Structural connections of the centromedian nucleus of thalamus and their relevance for neuromodulation in generalized drug-resistant epilepsy: insight from a tractography study","volume":"16","author":"Remore","year":"2023","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1111\/epi.16895","article-title":"The SANT\u00c9 study at 10 years of follow-up: effectiveness, safety, and sudden unexpected death in epilepsy","volume":"62","author":"Salanova","year":"2021","journal-title":"Epilepsia"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"012001","DOI":"10.1088\/1741-2552\/ad1dc3","article-title":"Neural signal data collection and analysis of percept\u2122 PC BrainSense recordings for thalamic stimulation in epilepsy","volume":"21","author":"Sanger","year":"2024","journal-title":"J. Neural Eng."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.neurom.2025.02.005","article-title":"Mapping healthy and epileptic states in the centromedian nucleus region","volume":"29","author":"Satzer","year":"2025","journal-title":"Neuromodulation"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1159\/000529961","article-title":"Ambulatory local field potential recordings from the thalamus in epilepsy: a feasibility study","volume":"101","author":"Satzer","year":"2023","journal-title":"Stereotact. Funct. Neurosurg."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.3390\/brainsci12121726","article-title":"Local field potential-guided contact selection using chronically implanted sensing devices for deep brain stimulation in Parkinson's disease","volume":"12","author":"Strelow","year":"2022","journal-title":"Brain Sci."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1007\/s00415-022-11388-1","article-title":"A systematic review of local field potential physiomarkers in Parkinson's disease: from clinical correlations to adaptive deep brain stimulation algorithms","volume":"270","author":"van Wijk","year":"2023","journal-title":"J. Neurol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/ana.26368","article-title":"The optimal target and connectivity for deep brain stimulation in Lennox-Gastaut syndrome","volume":"92","author":"Warren","year":"2022","journal-title":"Ann. Neurol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1136\/jnnp-2019-322030","article-title":"Targeting the centromedian thalamic nucleus for deep brain stimulation","volume":"91","author":"Warren","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/epi.13251","article-title":"Ictal onset patterns of local field potentials, high frequency oscillations, and unit activity in human mesial temporal lobe epilepsy","volume":"57","author":"Weiss","year":"2016","journal-title":"Epilepsia"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"745","DOI":"10.3969\/j.issn.1673-5374.2013.08.009","article-title":"The role of local field potential coupling in epileptic synchronization","volume":"8","author":"Wu","year":"2013","journal-title":"Neural Regen. Res."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.3171\/2022.2.JNS212237","article-title":"Centromedian thalamic deep brain stimulation for drug-resistant epilepsy: single-center experience","volume":"137","author":"Yang","year":"2022","journal-title":"J. Neurosurg."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.1111\/epi.17758","article-title":"Sensing with deep brain stimulation device in epilepsy: aperiodic changes in thalamic local field potential during seizures","volume":"64","author":"Yang","year":"2023","journal-title":"Epilepsia"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2026.1855048\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:36:25Z","timestamp":1783575385000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2026.1855048\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":36,"alternative-id":["10.3389\/fnins.2026.1855048"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2026.1855048","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,9]]},"article-number":"1855048"}}