{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:05:44Z","timestamp":1784009144068,"version":"3.55.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare electrooculogram (EOG) parameters between eyes with reticular macular disease (RMD) and eyes with early-to-intermediate age-related macular degeneration (AMD) without reticular pseudodrusen (RPD), and to assess whether RMD is associated with generalized RPE\u2013photoreceptor complex dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this observational cross-sectional study, 42 eyes from 21 patients were analyzed (without-RPD group: 28 eyes; RMD group: 14 eyes). RMD was diagnosed using multimodal imaging (infrared reflectance and SD-OCT). EOGs were recorded with the RETI-port\/scan 21 system according to ISCEV standards. Extracted parameters included dark trough (DT), light peak (LP), light rise time (Light Rise), and the LP:DT ratio. Group comparisons used the Wilcoxon rank-sum test. Linear regression evaluated the association between RMD and LP:DT ratio with and without adjustment for age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Age did not differ between groups (median 69 vs. 72 years;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.5). Absolute standing potentials were similar (DT: 598 vs. 681 \u03bcV,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.2; LP: 1,092 vs. 1,150 \u03bcV,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.8). Light rise time was also similar (8.00 [IQR 7.50\u20139.00] vs. 8.00 [IQR 7.00\u20139.00] min;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.6). In contrast, the LP:DT ratio was significantly reduced in RMD (1.65 [1.50\u20131.80]) compared with without-RPD controls (1.90 [1.80\u20132.10];\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0043). RMD was independently associated with a lower LP:DT ratio (\u03b2 = \u22120.25, 95% CI [\u22120.41 to \u22120.09];\n                      <jats:italic>P<\/jats:italic>\n                      = 0.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared with AMD eyes without RPD, RMD eyes demonstrate a selectively reduced LP:DT ratio without a change in absolute standing potentials or light rise timing. This EOG pattern supports attenuated light response consistent with generalized dysfunction of the RPE\u2013photoreceptor complex in RMD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2026.1865041","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:40:26Z","timestamp":1784007626000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Selective reduction of the light peak-to-dark trough ratio in reticular macular disease: an electrooculography study"],"prefix":"10.3389","volume":"20","author":[{"given":"Lin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Guangzhou Medical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Ophthalmic Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Guangzhou Medical University","place":["Guangzhou, China"]},{"name":"Department of Ophthalmology, The First Affiliated Hospital, Sun Yat-sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Guangzhou Medical University","place":["Guangzhou, China"]},{"name":"Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Guangzhou Medical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"6073","DOI":"10.1167\/iovs.13-13804","article-title":"Longitudinal structure\/function analysis in reticular pseudodrusen.","volume":"55","author":"Alten","year":"2014","journal-title":"Invest. 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