{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T22:44:53Z","timestamp":1794091493667,"version":"4.8.0"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post-translational modifications, particularly SUMOylation, plays a crucial role in \u03b1-synuclein (\u03b1-syn) aggregation, a key pathological feature of Parkinson\u2019s disease (PD). Curcumin, a natural polyphenol, has shown neuroprotective potential, but its effects on SUMOylation-related signaling in PD remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate whether curcumin modulates \u03b1-syn SUMOylation and to elucidate the underlying molecular mechanisms in PD model mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A PD model was established in male C57BL\/6 mice via unilateral intrastriatal injection of \u03b1-syn preformed fibrils (PFFs). Six months after \u03b1-syn PFFs injection, mice were treated intravenously with curcumin (25\u202fmg\/kg\/day) or vehicle for 1\u202fmonth. Behavioral tests (open field, rotarod) assessed motor function. Neuropathology was evaluated by immunohistochemistry and western blotting for tyrosine hydroxylase (TH), phosphorylated \u03b1-syn (p-syn), SUMOylation pathway components (SUMO1, SAE2, UBC9, PIAS1\/2), and ubiquitin. Striatal dopamine levels were measured by HPLC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Curcumin treatment ameliorated motor deficits and anxiety-like behaviors in PD mice. It partially preserved dopaminergic neurons and reduced p-syn aggregation in the substantia nigra, accompanied by increased striatal dopamine levels. Mechanistically, curcumin was associated with reduced SUMO1 and increased ubiquitin levels, suggesting modulation of SUMOylation-related signaling. Among SUMOylation enzymes, UBC9 expression was decreased, whereas E1 (SAE2) and E3 (PIAS1\/2) components were not substantially affected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings demonstrated that curcumin exerted neuroprotective effects in a PD model by attenuating \u03b1-syn pathology. The protective mechanism involves the inhibition of \u03b1-syn SUMOylation, primarily through the downregulation of the UBC9 enzyme. This study identifies UBC9-mediated SUMOylation as a potential target for curcumin and highlight a promising strategy for modifying \u03b1-syn-associated pathology in PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2026.1885786","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T05:36:10Z","timestamp":1784612170000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Curcumin attenuates \u03b1-synuclein pathology in Parkinson\u2019s disease model mice through modulation of UBC9-associated SUMOylation signaling"],"prefix":"10.3389","volume":"20","author":[{"given":"Yao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital with Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital with Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kezhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital with Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1051\/bmdcn\/2019090423","article-title":"Curcumin reduces malondialdehyde and improves antioxidants in humans with diseased conditions: a comprehensive meta-analysis of randomized controlled trials","volume":"9","author":"Alizadeh","year":"2019","journal-title":"Biomedicine (Taipei)"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"683920","DOI":"10.1155\/2013\/683920","article-title":"Neuroprotective function of DJ-1 in Parkinson's disease","volume":"2013","author":"Ariga","year":"2013","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and treatment of Parkinson disease: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/s1474-4422(16)30230-7","article-title":"The epidemiology of Parkinson's disease: risk factors and prevention","volume":"15","author":"Ascherio","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.intimp.2010.11.013","article-title":"Curcumin promotes degradation of inducible nitric oxide synthase and suppresses its enzyme activity in RAW 264.7 cells","volume":"11","author":"Ben","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s00401-015-1504-2","article-title":"Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes","volume":"131","author":"Bliederhaeuser","year":"2016","journal-title":"Acta Neuropathol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/s0140-6736(21)00218-x","article-title":"Parkinson's disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"114066","DOI":"10.1016\/j.bcp.2020.114066","article-title":"The pivotal role of SUMO-1-JNK-tau axis in an in vitro model of oxidative stress counteracted by the protective effect of curcumin","volume":"178","author":"Buccarello","year":"2020","journal-title":"Biochem. 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Chem."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1007\/s12017-013-8258-6","article-title":"SUMO rules: regulatory concepts and their implication in neurologic functions","volume":"15","author":"Droescher","year":"2013","journal-title":"NeuroMolecular Med."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1001\/jamaneurol.2019.3446","article-title":"Risk of developing Parkinson disease in bipolar disorder: a systematic review and Meta-analysis","volume":"77","author":"Faustino","year":"2020","journal-title":"JAMA Neurol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1111\/cns.13805","article-title":"Neuroprotective effects of curcumin on the cerebellum in a rotenone-induced Parkinson's disease model","volume":"28","author":"Fikry","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.chembiol.2009.01.009","article-title":"Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate","volume":"16","author":"Fukuda","year":"2009","journal-title":"Chem. Biol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1255555","DOI":"10.1126\/science.1255555","article-title":"NEURODEGENERATION. Alzheimer's and Parkinson's diseases: the prion concept in relation to assembled a\u03b2, tau, and \u03b1-synuclein","volume":"349","author":"Goedert","year":"2015","journal-title":"Science"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1124\/pharmrev.123.001111","article-title":"Posttranslational modifications of \u03b1-Synuclein, their therapeutic potential, and crosstalk in health and neurodegenerative diseases","volume":"76","author":"Hassanzadeh","year":"2024","journal-title":"Pharmacol. 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Biol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.neulet.2013.04.050","article-title":"SUMO-1 conjugation blocks beta-amyloid-induced astrocyte reactivity","volume":"546","author":"Hoppe","year":"2013","journal-title":"Neurosci. Lett."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s40035-022-00294-1","article-title":"Genetic heterogeneity on sleep disorders in Parkinson's disease: a systematic review and meta-analysis","volume":"11","author":"Huang","year":"2022","journal-title":"Transl Neurodegener"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.ijbiomac.2017.03.174","article-title":"Antimicrobial and physical properties of chitosan films incorporated with turmeric extract","volume":"101","author":"Kalayc\u0131o\u011flu","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"22892","DOI":"10.1038\/s41598-024-74130-z","article-title":"Analysis and comparison of post-translational modifications of \u03b1-synuclein filaments in multiple system atrophy and dementia with Lewy bodies","volume":"14","author":"Kametani","year":"2024","journal-title":"Sci. Rep."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"16533","DOI":"10.1038\/s41598-017-15813-8","article-title":"Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice","volume":"7","author":"Karampetsou","year":"2017","journal-title":"Sci. Rep."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1136\/annrheumdis-2012-201746","article-title":"Inhibition of sumoylation prevents experimental fibrosis","volume":"71","author":"Khodzhigorova","year":"2012","journal-title":"Ann. Rheum. 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Chem."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"5012129","DOI":"10.1155\/2017\/5012129","article-title":"The contribution of \u03b1-Synuclein spreading to Parkinson's disease Synaptopathy","volume":"2017","author":"Longhena","year":"2017","journal-title":"Neural Plast."},{"key":"ref36","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.physbeh.2009.04.021","article-title":"Behavior, neurotransmitters and inflammation in three regimens of the MPTP mouse model of Parkinson's disease","volume":"98","author":"Luchtman","year":"2009","journal-title":"Physiol. Behav."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1126\/science.1227157","article-title":"Pathological \u03b1-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice","volume":"338","author":"Luk","year":"2012","journal-title":"Science"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"3395","DOI":"10.3390\/cells11213395","article-title":"Role of SUMOylation in neurodegenerative diseases","volume":"11","author":"Mandel","year":"2022","journal-title":"Cells"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/s1474-4422(25)00085-7","article-title":"Biological effects of pathologies in Lewy body diseases: why timing matters","volume":"24","author":"Matar","year":"2025","journal-title":"Lancet Neurol."},{"key":"ref40","first-page":"435","article-title":"A simple quantitative bradykinesia test in MPTP-treated mice","volume":"50","author":"Ogawa","year":"1985","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.brainres.2011.01.039","article-title":"Human Polycomb protein 2 promotes \u03b1-synuclein aggregate formation through covalent SUMOylation","volume":"1381","author":"Oh","year":"2011","journal-title":"Brain Res."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"3454","DOI":"10.1093\/brain\/awac171","article-title":"Tau accelerates \u03b1-synuclein aggregation and spreading in Parkinson's disease","volume":"145","author":"Pan","year":"2022","journal-title":"Brain"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41582-024-01043-w","article-title":"\u03b1-Synuclein pathology as a target in neurodegenerative diseases","volume":"21","author":"Park","year":"2025","journal-title":"Nat. Rev. Neurol."},{"key":"ref44","volume-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2003"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00706","article-title":"Curcumin modulates p62-Keap1-Nrf2-mediated autophagy in rotenone-induced Parkinson's disease mouse models","author":"Rathore","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"13176","DOI":"10.1073\/pnas.1704351114","article-title":"SUMOylation and ubiquitination reciprocally regulate \u03b1-synuclein degradation and pathological aggregation","volume":"114","author":"Rott","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.semcancer.2020.09.004","article-title":"Curcumin: a therapeutic strategy for colorectal cancer?","volume":"73","author":"Ruiz de Porras","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.tibs.2009.01.004","article-title":"Sumoylation and human disease pathogenesis","volume":"34","author":"Sarge","year":"2009","journal-title":"Trends Biochem. Sci."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1001\/jamaneurol.2016.0947","article-title":"Time trends in the incidence of Parkinson disease","volume":"73","author":"Savica","year":"2016","journal-title":"JAMA Neurol."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3389\/fnagi.2020.00167","article-title":"SUMOylation in \u03b1-Synuclein homeostasis and pathology","volume":"12","author":"Savyon","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.3390\/molecules23112755","article-title":"HSP70 acetylation prevents combined mTORC1\/2 inhibitor and curcumin treatment-induced apoptosis","volume":"23","author":"Seo","year":"2018","journal-title":"Molecules"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/s41586-020-1984-7","article-title":"Discriminating \u03b1-synuclein strains in Parkinson\u2019s disease and multiple system atrophy","volume":"578","author":"Shahnawaz","year":"2020","journal-title":"Nature"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"31224","DOI":"10.1074\/jbc.M114.559237","article-title":"Interplay between sumoylation and phosphorylation for protection against \u03b1-synuclein inclusions","volume":"289","author":"Shahpasandzadeh","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"104335","DOI":"10.1016\/j.phrs.2019.104335","article-title":"Curcumin and its analogues protect from endoplasmic reticulum stress: mechanisms and pathways","volume":"146","author":"Shakeri","year":"2019","journal-title":"Pharmacol. Res."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s10787-017-0402-8","article-title":"Curcumin affords neuroprotection and inhibits \u03b1-synuclein aggregation in lipopolysaccharide-induced Parkinson's disease model","volume":"26","author":"Sharma","year":"2018","journal-title":"Inflammopharmacology"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.3390\/nu17091444","article-title":"Crosstalk among gut microbiota, fecal metabolites, and amygdala neuropathology genes after ginger polyphenol Administration in Female Rats with neuropathic pain: evidence for microbiota-gut-brain connection","volume":"17","author":"Shen","year":"2025","journal-title":"Nutrients"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.jneumeth.2010.03.026","article-title":"A rotarod test for evaluation of motor skill learning","volume":"189","author":"Shiotsuki","year":"2010","journal-title":"J. Neurosci. Methods"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.3390\/nu13051697","article-title":"Coenzyme Q(10): clinical applications beyond cardiovascular diseases","volume":"13","author":"Testai","year":"2021","journal-title":"Nutrients"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.arr.2019.01.012","article-title":"The prion-like spreading of \u03b1-synuclein: from in vitro to in vivo models of Parkinson's disease","volume":"50","author":"Vargas","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"103416","DOI":"10.1016\/j.mcn.2019.103416","article-title":"Ginkgolic acid promotes autophagy-dependent clearance of intracellular alpha-synuclein aggregates","volume":"101","author":"Vijayakumaran","year":"2019","journal-title":"Mol. Cell. Neurosci."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.3390\/biom5031697","article-title":"Direct and\/or indirect roles for SUMO in modulating alpha-Synuclein toxicity","volume":"5","author":"Vijayakumaran","year":"2015","journal-title":"Biomolecules"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1038\/nprot.2014.143","article-title":"Addition of exogenous \u03b1-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous \u03b1-synuclein to Lewy body and Lewy neurite-like aggregates","volume":"9","author":"Volpicelli-Daley","year":"2014","journal-title":"Nat. Protoc."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.neuron.2011.08.033","article-title":"Exogenous \u03b1-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death","volume":"72","author":"Volpicelli-Daley","year":"2011","journal-title":"Neuron"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.biopsych.2015.12.016","article-title":"A human open field test reveals Thigmotaxis related to agoraphobic fear","volume":"80","author":"Walz","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.tins.2024.01.002","article-title":"Protein-protein interactions regulating \u03b1-synuclein pathology","volume":"47","author":"Wang","year":"2024","journal-title":"Trends Neurosci."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12974-025-03447-x","article-title":"Inverted day-night feeding during pregnancy affects the brain health of both maternal and fetal brains through increasing inflammation levels associated with dysbiosis of the gut microbiome in rats","volume":"22","author":"Wang","year":"2025","journal-title":"J. Neuroinflammation"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.neulet.2013.03.057","article-title":"Increased SUMO-1 expression in the unilateral rotenone-lesioned mouse model of Parkinson's disease","volume":"544","author":"Weetman","year":"2013","journal-title":"Neurosci. Lett."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"dev175703","DOI":"10.1242\/dev.175703","article-title":"SUMOylation in development and neurodegeneration","volume":"147","author":"Yau","year":"2020","journal-title":"Development"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"657","DOI":"10.3389\/fnins.2017.00657","article-title":"Neurochemical and behavior deficits in rats with Iron and rotenone co-treatment: role of redox imbalance and neuroprotection by Biochanin a","volume":"11","author":"Yu","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"111119","DOI":"10.1016\/j.biopha.2020.111119","article-title":"The role of curcumin in aging and senescence: molecular mechanisms","volume":"134","author":"Zia","year":"2021","journal-title":"Biomed. 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