{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T06:24:25Z","timestamp":1786947865315,"version":"build-2736575974"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High-altitude environments impose unique physiological and cognitive demands that may reorganize brain\u2013body communication. Our study investigates whether chronic high-altitude exposure is associated with a shift in perceptual priority toward internally-directed processing, rather than merely modifying external processing speed or accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited 112 Han immigrants residing at high altitude to complete assessments of visual imagery vividness under eyes-open (externally-oriented) and eyes-closed (internally-oriented) conditions, along with attention network tests. We also collected a comprehensive panel of multimodal physiological indices, including markers of inflammation, erythrocytic parameters, liver function, cardiovascular metrics, and heart rate variability (as a proxy for autonomic regulation). Analyses employed latent profile analysis and regression mixture modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that prolonged high-altitude exposure showed a trend toward selectively enhancing internally-oriented imagery vividness under eyes-closed conditions, while externally-oriented processing remained stable. Critically, enhanced internally-oriented imagery was differentially associated with improved orienting attention, whereas externally-oriented imagery was linked to alerting attention, suggesting a functional differentiation in attentional reorganization. Physiologically, interleukin-6 levels were associated with externally-oriented vividness, whereas erythrocytic heterogeneity, liver function, and high-frequency heart rate variability (an index of parasympathetic-associated cardiac regulation) selectively correlated with internally-oriented processing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggest that chronic high-altitude exposure may be associated with a reweighting of perceptual resource allocation toward an internally-oriented processing bias, with parasympathetic-associated autonomic regulation as a potential brain\u2013body integrative mechanism. This work extends prior findings by proposing a shift in perceptual priority rather than merely processing efficiency, advancing a multi-system framework for understanding human brain\u2013body adaptation in extreme environments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2026.1901035","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T05:26:32Z","timestamp":1786944392000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic high-altitude exposure is associated with an internally-directed perceptual shift: differential links with attention networks and autonomic regulation"],"prefix":"10.3389","volume":"20","author":[{"given":"Xia-Qian","family":"Jian","sequence":"first","affiliation":[{"name":"School of Psychology, Center for Studies of Psychological Application, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian-Nian","family":"Wang","sequence":"additional","affiliation":[{"name":"Xizang Key Laboratory of Plateau Hypoxic Environment and Life Health, Xizang University","place":["Lhasa, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Psychology, Center for Studies of Psychological Application, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Su","sequence":"additional","affiliation":[{"name":"Xizang Key Laboratory of Plateau Hypoxic Environment and Life Health, Xizang University","place":["Lhasa, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Xizang Key Laboratory of Plateau Hypoxic Environment and Life Health, Xizang University","place":["Lhasa, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Anhui Provincial College Student Mental Health Education Research Center, School of Humanities and Management, Wannan Medical College","place":["Wuhu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Lin","family":"Ma","sequence":"additional","affiliation":[{"name":"Xizang Key Laboratory of Plateau Hypoxic Environment and Life Health, Xizang University","place":["Lhasa, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Psychology, Center for Studies of Psychological Application, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Long","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Educational Sciences, Kashi University","place":["Kashi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1126\/science.6166045","article-title":"Power spectrum analysis of heart rate fluctuation: A quantitative probe of beat-to-beat cardiovascular control.","volume":"213","author":"Akselrod","year":"1981","journal-title":"Science"},{"key":"B2","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s12031-019-01288-x","article-title":"The association between neuropsychological function with serum vitamins A, D, and E and hs-CRP concentrations.","volume":"68","author":"Bahrami","year":"2019","journal-title":"J. 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