{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:56:52Z","timestamp":1790751412395,"version":"4.1.0"},"reference-count":87,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>Aneurysmal subarachnoid hemorrhage is a devastating neurological disease that occurs downstream of abnormal dilation of cerebral vessels and weakening of the vessel wall due to underlying inflammation. Vascular endothelial inflammation has been identified as a critical driver of aneurysm growth and progression, with numerous immune cell populations proposed to have a role in this process. The innate immune cells that partake in the process of aneurysm growth, primarily macrophages, can adopt pro-inflammatory or anti-inflammatory phenotypes. A recent line of work implicates an imbalance in macrophage phenotypes as a critical feature in the progression of cerebral aneurysmal disease. An imbalance in immune cell states is also observed in neurodegenerative processes, where the inflammatory phenotypes of microglia and astrocytes appear to be involved in disease progression. Understanding cerebral aneurysms and neurodegeneration as processes that involve inflammatory imbalances may provide a window for future research and identification of therapeutic targets, where modulating immune phenotypes has the potential to reduce both aneurysm rupture risk and neurodegenerative progression. Further, advances in treatments for one disease could be cautiously applied in preclinical models for the other.<\/jats:p>","DOI":"10.3389\/fnins.2026.1916561","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:05:41Z","timestamp":1790748341000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroimmune phenotypes in brain aneurysms and neurodegenerative diseases"],"prefix":"10.3389","volume":"20","author":[{"given":"Francis J.","family":"Lauzier","sequence":"first","affiliation":[{"name":"Department of Neurology, Detroit Medical Center, Wayne State University School of Medicine","place":["Detroit, MI, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Lauzier","sequence":"additional","affiliation":[{"name":"Division of Neuropathology, University of California, Los Angeles","place":["Los Angeles, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1111\/imr.13176","article-title":"N1 versus N2 and PMN-MDSC: a critical appraisal of current concepts on tumor-associated neutrophils and new directions for human oncology","volume":"314","author":"Antuamwine","year":"2023","journal-title":"Immunol. 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Signal."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1161\/STROKEAHA.108.532556","article-title":"Impact of monocyte chemoattractant protein-1 deficiency on cerebral aneurysm formation","volume":"40","author":"Aoki","year":"2009","journal-title":"Stroke"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1161\/STROKEAHA.124.049969","article-title":"Long-term cognitive decline after subarachnoid hemorrhage: pathophysiology, management, and future directions","volume":"56","author":"Aydin","year":"2025","journal-title":"Stroke"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"15558","DOI":"10.1073\/pnas.0807419105","article-title":"CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS","volume":"105","author":"Beers","year":"2008","journal-title":"Proc. Natl. Acad. Sci. 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Immunol."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1097\/00006123-199911000-00024","article-title":"Inflammation and intracranial aneurysms","volume":"45","author":"Chyatte","year":"1999","journal-title":"Neurosurgery"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","article-title":"Microglia function in the central nervous system during health and neurodegeneration","volume":"35","author":"Colonna","year":"2017","journal-title":"Annu. Rev. 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Commun."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.3389\/fimmu.2019.01084","article-title":"Macrophage polarization: different gene signatures in M1 (LPS+) vs. classically and M2 (LPS-) vs. alternatively activated macrophages","volume":"10","author":"Orecchioni","year":"2019","journal-title":"Front. Immunol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"3152","DOI":"10.1093\/brain\/awp239","article-title":"Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity","volume":"132","author":"Palazuelos","year":"2009","journal-title":"Brain"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"3458","DOI":"10.1016\/j.neuron.2022.10.020","article-title":"Microglia states and nomenclature: a field at its crossroads","volume":"110","author":"Paolicelli","year":"2022","journal-title":"Neuron"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"23426","DOI":"10.1073\/pnas.1916318116","article-title":"N,N'-diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer's disease transgenic mice","volume":"116","author":"Park","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"7389","DOI":"10.1038\/s41467-022-35095-7","article-title":"Integrated proteomic and transcriptomic landscape of macrophages in mouse tissues","volume":"13","author":"Qie","year":"2022","journal-title":"Nat. Commun."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/nn.4338","article-title":"A polarizing question: do M1 and M2 microglia exist?","volume":"19","author":"Ransohoff","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1750-1326-8-19","article-title":"TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease","volume":"8","author":"Rayaprolu","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1038\/s41590-018-0232-x","article-title":"Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration","volume":"19","author":"Ryu","year":"2018","journal-title":"Nat. Immunol."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1002\/ana.21226","article-title":"Primary central nervous system vasculitis: analysis of 101 patients","volume":"62","author":"Salvarani","year":"2007","journal-title":"Ann. 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(Tokyo)"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.neuroscience.2026.02.021","article-title":"Metabolic dysregulation in cerebral small vessel disease: pathogenesis and therapeutic targets","volume":"599","author":"Si","year":"2026","journal-title":"Neuroscience"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.wneu.2018.04.143","article-title":"Hemodynamic stress, inflammation, and intracranial aneurysm development and rupture: a systematic review","volume":"115","author":"Signorelli","year":"2018","journal-title":"World Neurosurg."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1038\/s41423-023-01053-6","article-title":"Brain macrophage development, diversity and dysregulation in health and disease","volume":"20","author":"Silvin","year":"2023","journal-title":"Cell. Mol. 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