{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:05:02Z","timestamp":1789538702773,"version":"build-2803163510"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:p>\n                    A pH-responsive CEC\/PEG-(CHO)\n                    <jats:sub>2<\/jats:sub>\n                    hydrogel scaffold was engineered for local delivery of neuropeptide S (NPS) to modulate the hostile microenvironment after spinal cord injury (SCI). The scaffold exhibited accelerated degradation under acidic conditions mimicking the injured site, enabling controlled release of NPS. Its porous microstructure (50\u2212150 \u03bcm pore size) and compressive elastic modulus (0.081 MPa, slightly softer than that of a native spinal cord) provide a mechanical microenvironment conducive to neuronal survival and differentiation. In a T11 complete transection mouse model, the NPS-loaded scaffold significantly attenuated local inflammation (reduced MMP-9, TNF-\u03b1, CD68; increased IL-10), suppressed glial scar formation, recruited endogenous Nestin\n                    <jats:sup>+<\/jats:sup>\n                    neural stem\/progenitor cells (NSPCs), and promoted their differentiation into mature MAP2\n                    <jats:sup>+<\/jats:sup>\n                    neurons with enhanced myelination (MBP\n                    <jats:sup>+<\/jats:sup>\n                    ) and synaptic integration (SYP\n                    <jats:sup>+<\/jats:sup>\n                    \/MAP2\n                    <jats:sup>+<\/jats:sup>\n                    ). These effects were mediated through the NPS-NPSR axis and downstream Ca\n                    <jats:sup>2 +<\/jats:sup>\n                    \/cAMP signaling pathways. This study demonstrates that a rationally designed pH-responsive hydrogel can effectively remodel the SCI microenvironment and activate endogenous neural repair mechanisms, offering a promising strategy for SCI treatment.\n                  <\/jats:p>","DOI":"10.3389\/fnins.2026.1933351","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:33:04Z","timestamp":1789536784000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A pH-responsive and self-healing CEC\/PEG-(CHO)2 hydrogel for controlled neuropeptide S delivery and endogenous neural repair after spinal cord injury"],"prefix":"10.3389","volume":"20","author":[{"given":"Bai","family":"Xu","sequence":"first","affiliation":[{"name":"Neuroscience Center, Wuxi School of Medicine, Jiangnan University, Wuxi","place":["Jiangsu, China"]},{"name":"Department of Neurosurgery, Jiangnan University Medical Center, Wuxi","place":["Jiangsu, China"]},{"name":"Wuxi Neurosurgical Institute, Wuxi","place":["Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Neuroscience Center, Wuxi School of Medicine, Jiangnan University, Wuxi","place":["Jiangsu, China"]},{"name":"Department of Neurosurgery, Jiangnan University Medical Center, Wuxi","place":["Jiangsu, China"]},{"name":"Wuxi Neurosurgical Institute, Wuxi","place":["Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[{"name":"Neuroscience Center, Wuxi School of Medicine, Jiangnan University, Wuxi","place":["Jiangsu, China"]},{"name":"Department of Neurosurgery, Jiangnan University Medical Center, Wuxi","place":["Jiangsu, China"]},{"name":"Wuxi Neurosurgical Institute, Wuxi","place":["Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nanjing Brain Hospital, Nanjing","place":["Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Affiliated Hospital of Jiangnan University, Wuxi","place":["Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Shi","sequence":"additional","affiliation":[{"name":"Nanjing Gaochun People\u2019s Hospital, Nanjing","place":["Jiangsu, China"]},{"name":"School of Food Science and Technology, Jiangnan University, Wuxi","place":["Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Neuroscience Center, Wuxi School of Medicine, Jiangnan University, Wuxi","place":["Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Lu","sequence":"additional","affiliation":[{"name":"Neuroscience Center, Wuxi School of Medicine, Jiangnan University, Wuxi","place":["Jiangsu, China"]},{"name":"Department of Neurosurgery, Jiangnan University Medical Center, Wuxi","place":["Jiangsu, China"]},{"name":"Wuxi Neurosurgical Institute, Wuxi","place":["Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7533","DOI":"10.3390\/ijms21207533","article-title":"Spinal cord injury: Pathophysiology, multimolecular interactions, and underlying recovery mechanisms.","volume":"21","author":"Anjum","year":"2020","journal-title":"Int. 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