{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:50:37Z","timestamp":1791521437366,"version":"4.3.4"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Non-invasive imaging of brain function and energy supply is crucial for diagnosing and treating brain disorders. Conventional imaging struggles to capture altered relationships between energy supply and demand caused by brain diseases. A novel method, thus far only tested non-invasively in human subjects, is to calculate relative power (rPWR) and relative cost (rCST) to assess cerebral energy efficiency. However, whether rPWR\/rCST tracks individual changes and relate to neural activity remains unproven.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Our study examines awake and anesthetized male mice and compares rPWR\/rCST with invasive two-photon microscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that rPWR\/rCST distributions were similar between awake mice and humans, but changed in anesthetized mice, indicating a shift in the brain\u2019s economic balance. Furthermore, changes in rPWR\/rCST were linked to the reorganization of microscopic neural networks, observed with two-photon microscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our work highlights the potential of rPWR\/rCST for medical applications, and that neural network reorganization is linked to the brain\u2019s economic balance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnins.2026.1949911","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:27:10Z","timestamp":1791520030000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Macroscopic cerebral energy efficiency corresponds to neuron reorganization in awake and anesthetized mice"],"prefix":"10.3389","volume":"20","author":[{"given":"Da","family":"Wang","sequence":"first","affiliation":[{"name":"iHuman Institute, ShanghaiTech University","place":["Shanghai, China"]},{"name":"School of Life Science and Technology, ShanghaiTech University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"iHuman Institute, ShanghaiTech University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinggui","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Zeng","sequence":"additional","affiliation":[{"name":"iHuman Institute, ShanghaiTech University","place":["Shanghai, China"]},{"name":"School of Life Science and Technology, ShanghaiTech University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyang","family":"Xu","sequence":"additional","affiliation":[{"name":"iHuman Institute, ShanghaiTech University","place":["Shanghai, China"]},{"name":"School of Life Science and Technology, ShanghaiTech University","place":["Shanghai, China"]},{"name":"Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences","place":["Shanghai, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binshi","family":"Bo","sequence":"additional","affiliation":[{"name":"CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengchao","family":"Pei","sequence":"additional","affiliation":[{"name":"CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifeng","family":"Liang","sequence":"additional","affiliation":[{"name":"CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhou","sequence":"additional","affiliation":[{"name":"iHuman Institute, ShanghaiTech University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garth J.","family":"Thompson","sequence":"additional","affiliation":[{"name":"iHuman Institute, ShanghaiTech University","place":["Shanghai, China"]},{"name":"School of Pharmacy, Anhui University of Chinese Medicine","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s10571-019-00735-y","article-title":"Role of delayed neuroglial activation in impaired cerebral blood flow restoration following comorbid injury","volume":"40","author":"Amtul","year":"2020","journal-title":"Cell. 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